Christian Stoess, Benjamin Mirschinka, Johanna Ollesky, Marcella Steffani, Nick Seyfried, Benedikt Kaufmann, Helmut Friess, Norbert Hüser, Ulrich Nitsche, Daniel Hartmann
INTRODUCTION: Resection of colorectal liver metastasis has emerged as the standard treatment. Our study compares oncological outcomes of patients with resected synchronous bilobar versus unilobar colorectal liver metastasis. METHODS: This retrospective study presents long-term follow-up data of 105 consecutive patients with primary colorectal cancer and synchronous liver metastasis. All patients underwent primary tumor and metastasis resections between 2007 and 2019...
May 3, 2024: Digestive Surgery
Anna Muñoz Campaña, Pau Farre-Alins, Raquel Gracia-Roman, Andrea Campos-Serra, Heura Llaquet-Bayo, Giulia Vitiello, Victoria Lucas-Guerrero, Enrico Marrano, Ana-Maria Gonzalez-Castillo, Marina Vila-Tura, Francisco-Javier García-Borobia, Laura Mora Lopez
INTRODUCTION: Laparoscopic cholecystectomy is one of the most common gastrointestinal surgeries, and bile duct injury is one of its main complications. The use of real-time indocyanine green fluorescence cholangiography allows the identification of extrahepatic biliary structures, facilitating the procedure and reducing the risk of bile duct lesions. A better visualization of the bile duct may help to reduce the need for conversion to open surgery, and may also shorten operating time...
April 24, 2024: Digestive Surgery
Ashraf Tokhi, Sam V George, Carlos S Cabalag, David S Liu, Cuong P Duong
Radical gastrectomy is associated with significant functional complications. In appropriate patients may be amenable to less invasive resection aimed at preserving the vagal trunks. The aim of this systematic review and meta-analysis is to assess the functional consequences and oncological safety of vagal sparing gastrectomy (VSG) compared to conventional non-vagal sparing gastrectomy (CG). A systematic review of four databases was undertaken for studies published between 1/11990 and 15/122021, comparing patients who underwent VSG to CG...
February 27, 2024: Digestive Surgery
Emeka Ray-Offor, Stella-Maris Egboh, Rex Ijah Foa Ijah, Sameh Hany Emile, Steven D Wexner
BACKGROUND: There is need to ascertain any epidemiologic shift of diverticulosis among Africans with traditionally high fiber diet consumption patterns and rare diverticulosis prevalence. METHODS: We systematically searched PubMed, Scopus, Cochrane Library, African Journal Online (AJOL) and Google Scholar. Eligibility criteria included full text observational and experimental human colonoscopy studies on asymptomatic and symptomatic African population from 1985-2022...
February 20, 2024: Digestive Surgery
Li Xu, Zhuo Shao, Hanchun Huang, Duo Li, Tianxiao Wang, Manar Atyah, Wenying Zhou, Zhiying Yang
INTRODUCTION: This study aimed to evaluate associations between frailty and outcomes in patients with ICC undergoing hepatic lobectomy using a large, nationally representative sample. METHODS: This population-based, retrospective observational study extracted the data of adults ≥ 20 years old with ICC undergoing hepatic lobectomy from the US Nationwide Inpatient Sample (NIS) database between 2005 and 2018. Frailty was assessed by the validated Hospital Frailty Risk Score (HFRS)...
January 31, 2024: Digestive Surgery
Kosuke Nishio, Shohei Komatsu, Keitaro Sofue, Masahiro Kido, Kaori Kuramitsu, Hidetoshi Gon, Kenji Fukushima, Takeshi Urade, Hiroaki Yanagimoto, Hirochika Toyama, Takumi Fukumoto
INTRODUCTION: The usefulness of gadolinium-ethoxybenzyl diethylenetriamine pentaacetate acid-enhanced magnetic resonance imaging (EOB-MRI) in assessing the functional future remnant liver volume (fFRLV) to predict post-hepatectomy liver failure (PHLF) has been previously reported. Herein, we evaluated the efficacy of this technique in patients with hepatocellular carcinoma (HCC) with a major portal vein tumor thrombus (PVTT). METHODS: This study included 21 patients with PVTT in the ipsilateral first-order branch (Vp3) and 30 patients with PVTT in the main trunk/contralateral branch (Vp4)...
January 12, 2024: Digestive Surgery
Leena-Mari Mäntymäki, Juha Grönroos, Anu Aronen, Jukka Karvonen, Mika Ukkonen
Introduction Since the assessment of the disease severity in acute diverticulitis (AD) is of utmost importance to determine the optimal treatment and the need for follow-up investigations, we wanted to investigate whether the first CT report is compatible with daytime reassessment report and whether the value of initial report changes according to the experience of the radiologist. Methods Consecutive patients from tertiary referral center with AD were included. CT images done in the emergency department were initially analysed by either resident radiologists or consultant radiologists and then later reanalysed by consultant abdominal radiologists...
January 10, 2024: Digestive Surgery
Noel Cassar, Paul Cromwell, Sinead Duggan, Charlotte van Veldhuisen, Marja Boermeester, Marc Besselink, Kevin Conlon
BACKGROUND: Debate exists regarding the optimal treatment for painful chronic pancreatitis (CP). OBJECTIVES: This meta-analysis aims to determine the outcomes of surgical intervention as compared to endoscopy in patients with painful CP. METHODS: A systematic review and meta-analysis including studies from PubMed, Embase, Web of Science and Cochrane databases (1995 onwards) was done by two independent reviewers using PRISMA guidelines. Primary outcome was pain relief...
January 8, 2024: Digestive Surgery
Mario De Bellis, Maria Gaia Mastrosimini, Paola Capelli, Laura Alaimo, Simone Conci, Tommaso Campagnaro, Sara Pecori, Aldo Scarpa, Alfredo Guglielmi, Andrea Ruzzenente
BACKGROUND: Prognosis of perihilar cholangiocarcinoma (PHCC) is poor, and curative-intent resection is the most effective treatment associated with long-term survival. Surgery is technically demanding since it involves a major hepatectomy with en bloc resection of the caudate lobe and extrahepatic bile duct. Furthermore, to achieve negative margins, it may be necessary to perform concomitant vascular resection or pancreatoduodenectomy. Despite this aggressive approach, recurrence is often observed, considering 5-year recurrence-free survival below 15% and 5-year overall survival that barely exceeds 40%...
2024: Digestive Surgery
Eve K Abernethy, Emad H Aly
BACKGROUND: Postoperative ileus (POI) is one of the most common postoperative complications after colorectal surgery and prolongs hospital stays. Minimally invasive surgery (MIS) has reduced POI, but it remains common. This review explores the current methods for preventing and managing POI after MIS. SUMMARY: Preoperative interventions, including optimising nutrition, preoperative medicationn, and mechanical bowel preparation with oral antibiotics, may have a role in preventing POI...
2024: Digestive Surgery
Marcella Steffani, Ulrich Nitsche, Johanna Ollesky, Benedikt Kaufmann, Sarah Schulze, Alexander Novotny, Helmut Friess, Norbert Hüser, Christian Stoess, Daniel Hartmann
INTRODUCTION: Cholangiocarcinoma is the second most common primary liver tumour worldwide with an increasing incidence in recent decades. While the effects of fibrosis on hepatocellular carcinoma have been widely demonstrated, the impact on cholangiocarcinoma remains unclear. The aim of this study was to evaluate the impact of liver fibrosis on overall survival (OS) and disease-free survival (DFS) in patients who have undergone liver resection for cholangiocarcinoma. METHODS: Eighty patients with cholangiocarcinoma who underwent curatively intended liver surgery between January 2007 and December 2020 were included in this retrospective single-centre study...
2024: Digestive Surgery
Luke Traeger, Nagendra Dudi-Venkata, Sergei Bedrikovetski, Hidde M Kroon, James W Moore, Tarik Sammour
INTRODUCTION: Postoperative ileus (POI) is a significant complication following abdominal surgery, increasing morbidity and mortality. The cholinergic anti-inflammatory response is one of the major pathways involved in developing POI, but current recommendations to prevent POI do not target this. This review aims to summarise evidence for the use of acetylcholinesterase inhibitors, neostigmine and pyridostigmine, to reduce the time to return of gastrointestinal function (GI) following abdominal surgery...
2024: Digestive Surgery
Toshimichi Kobayashi, Satoshi Tabuchi, Itsuki Koganezawa, Masashi Nakagawa, Kei Yokozuka, Shigeto Ochiai, Takahiro Gunji, Yosuke Ozawa, Toru Sano, Koichi Tomita, Naokazu Chiba, Eiji Hidaka, Shigeyuki Kawachi
INTRODUCTION: We aimed to identify objective factors associated with failure of nonoperative management (NOM) of gastroduodenal peptic ulcer perforation (GDUP) and establish a scoring model for early identification of patients in whom NOM of GDUP may fail. METHODS: A total of 71 patients with GDUP were divided into NOM (cases of NOM success) and operation groups (cases requiring emergency operation or conversion from NOM to operation). Using logistic regression analysis, a scoring model was established based on the independent factors...
2024: Digestive Surgery
Yunda Song, Subo Zhang
INTRODUCTION: The identification of patients with low risk of clinically relevant postoperative pancreatic fistula (CR-POPF) and postoperative hemorrhage (PPH) can guide drain removal after pancreatoduodenectomy (PD). However, drain fluid amylase (DFA) ≤ 5000 U/L on postoperative day (POD) 1 does not robustly predict the absence of CR-POPF. METHODS: Consecutive patients undergoing PD at Sun Yat-sen University Cancer Center between July 2018 and October 2021 were analyzed...
October 20, 2023: Digestive Surgery
Bin Sato, Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Koki Nakanishi, Dai Shimizu, Chie Tanaka, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera
INTRODUCTION: Carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) are widely used for various cancers, with the cut-off values of 5.0 ng/mL and 37.0 IU/mL, respectively. However, these cutoff values are not for specific diseases or purposes but are uniformly used for any disease and any purpose . It is also unclear as to whether patients are at equal risk of recurrence if they are below the cutoff values. This study aimed to investigate the optimal cutoff of serum tumor markers in the stratification of recurrence risk after curative resection of gastric cancer...
September 12, 2023: Digestive Surgery
Yuya Nakamura, Tadayoshi Yamaura, Yousuke Kinjo, Kazu Harada, Makoto Kawase, Yusuke Kawabata, Satoshi Kanto, Yasumasa Ogo, Nobukazu Kuroda
INTRODUCTION: Whether high or low ligation of the inferior mesenteric artery (IMA) is optimal for treating sigmoid colon and rectal cancers is controversial. The present study aimed to compare outcomes of high and low ligation of the IMA and determine the adequate extent of IMA lymph node dissection. METHODS: Subjects were 455 consecutive stage I-III colorectal cancer patients who underwent curative surgery between 2011 and 2019. We assessed the association between the level of IMA ligation and overall survival and recurrence-free survival (RFS) by using propensity score matching analysis...
August 7, 2023: Digestive Surgery
Shunsuke Yamagishi, Yukiyasu Okamura, Woodae Kang, Masataka Shindate, Mitsugu Kochi, Yusuke Mitsuka, Megumu Watabe, Nao Yoshida, Masahito Ikarashi, Shintaro Yamazaki, Osamu Aramaki, Hisashi Nakayama, Masamichi Moriguchi, Tokio Higaki, Hiroharu Yamashita
INTRODUCTION: Several studies have indicated that sarcopenia affects the short- and long-term outcomes of cancer patients, including those with gastric cancer. In recent years, sarcopenic obesity and its effects have been reported in cancer patients. This study aimed to evaluate the impact of sarcopenic obesity on postoperative complications in patients with gastric cancer undergoing gastrectomy. METHODS: This single-center, retrospective study included 155 patients who underwent curative gastrectomy for gastric cancer from January 2015 to July 2021...
August 1, 2023: Digestive Surgery
Satoshi Nishi, Yuichiro Miki, Takumi Imai, Mikio Nambara, Hironari Miyamoto, Tatsuro Tamura, Mami Yoshii, Takahiro Toyokawa, Hiroaki Tanaka, Shigeru Lee, Kiyoshi Maeda
INTRODUCTION: Sarcopenia is often observed in patients with esophageal cancer (EC). However, the influence of sarcopenia during neoadjuvant chemotherapy (NAC) on complications has not been fully investigated. Thus, we aimed to investigate the best way of evaluating sarcopenia for predicting complications, especially postoperative pneumonia (PP), in patients with EC undergoing NAC and esophagectomy. METHODS: We retrospectively reviewed 36 patients. The skeletal muscle mass index (SMI) was evaluated by both BIA and CT...
July 27, 2023: Digestive Surgery
Siri Rønholdt Henriksen, Jacob Rosenberg, Siv Fonnes
BACKGROUND: Diagnostic laparoscopy is often used when a patient is suspected of having acute appendicitis. The aim of this study was to assess the rate of other pathologies found during diagnostic laparoscopy for suspected acute appendicitis. METHODS: This systematic search included studies with ≥100 patients who received laparoscopy for suspected acute appendicitis and reported on the histopathologic and other intraabdominal findings. We performed a meta-analysis estimating the rate of other pathologies, and a sensitivity analysis excluding smaller cohorts (≤500 patients)...
July 18, 2023: Digestive Surgery
Seiji Ito, Takeshi Sano, Junki Mizusawa, Masanori Tokunaga, Tadayoshi Hashimoto, Hiroshi Imamura, Shin Teshima, Koei Nihei, Makoto Yamada, Yasuhiro Choda, Kazuhiro Imamura, Shinji Hato, Masanori Terashima, Mitsuru Sasako
INTRODUCTION: Splenectomy for proximal gastric cancer was found to offer no survival benefit in a randomized trial clarifying the role of splenectomy (JCOG0110 study). Although many studies have explored risk factors for morbidities following total gastrectomy, none have assessed the risk factors for postoperative complications in spleen-preserving total gastrectomy. METHODS: Using data from 505 patients enrolled in a previous randomized trial, risk factors for postoperative complications were identified by multivariable logistic regression analysis...
July 17, 2023: Digestive Surgery
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