Christoph Schwartner, Matthias Mehdorn, Ines Gockel, Manuel Florian Struck, Jakob Leonhardi, Markus Rositzka, Sebastian Ebel, Timm Denecke, Hans-Jonas Meyer
INTRODUCTION: Body composition comprising Low-skeletal muscle mass (LSMM) and subcutaneous and visceral adipose tissue (SAT and VAT) can be assessed by using cross-sectional imaging modalities. Aim of this study was to analyze possible associations of body composition parameters on mortality in patients with clinically suspected acute mesenteric ischemia (AMI). METHODS: Overall, 137 patients (52 female patients, 37.9%) with a median age of 71 years were included...
September 14, 2023: Digestive Surgery
Isabella Frigerio, Giulia Capelli, Valentina Chiminazzo, Gaya Spolverato, Giulia Lorenzoni, Silvia Mancini, Alessandro Giardino, Paolo Regi, Roberto Girelli, Giovanni Butturini
Introduction Hepatic artery anomalies (HAA) and may have an impact on surgical and oncological outcomes of patients undergoing pancreaticoduodenectomy (PD). Methods Patients undergone PD at our Institution between July 2015 and January 2020 were retrospectively reviewed and classified into two groups: Group 1, presence of HAA and Group 2, no HAA. A weighted logistic regression model employed to assess the association between HAA and postoperative complications, and to assess the association between HAA and R status in patients with pancreatic cancer...
September 12, 2023: Digestive Surgery
Bin Sato, Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Koki Nakanishi, Dai Shimizu, Chie Tanaka, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera
INTRODUCTION: Carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) are widely used for various cancers, with the cut-off values of 5.0 ng/mL and 37.0 IU/mL, respectively. However, these cutoff values are not for specific diseases or purposes but are uniformly used for any disease and any purpose . It is also unclear as to whether patients are at equal risk of recurrence if they are below the cutoff values. This study aimed to investigate the optimal cutoff of serum tumor markers in the stratification of recurrence risk after curative resection of gastric cancer...
September 12, 2023: Digestive Surgery
Jasmijn R van Doesburg, Marianne C Kalff, Daan M Voeten, Anton F Engelsman, Saskia Jol, Mark I van Berge Henegouwen, Freek Daams, Suzanne S Gisbertz
Thyroid incidentalomas are often encountered during imaging performed for the workup of esophageal cancer. Their oncological significance is unknown. This study aimed to establish incidence and etiology of thyroid incidentalomas found during the diagnostic workup of esophageal cancer. All esophageal cancer patients referred to or diagnosed in the Amsterdam UMC between January 2012 and December 2016 were included. Radiology and multidisciplinary team meeting reports were reviewed for presence of thyroid incidentalomas...
September 7, 2023: Digestive Surgery
Yuya Nakamura, Tadayoshi Yamaura, Yousuke Kinjo, Kazu Harada, Makoto Kawase, Yusuke Kawabata, Satoshi Kanto, Yasumasa Ogo, Nobukazu Kuroda
INTRODUCTION: Whether high or low ligation of the inferior mesenteric artery (IMA) is optimal for treating sigmoid colon and rectal cancers is controversial. The present study aimed to compare outcomes of high and low ligation of the IMA and determine the adequate extent of IMA lymph node dissection. METHODS: Subjects were 455 consecutive stage I-III colorectal cancer patients who underwent curative surgery between 2011 and 2019. We assessed the association between the level of IMA ligation and overall survival and recurrence-free survival (RFS) by using propensity score matching analysis...
August 7, 2023: Digestive Surgery
Shunsuke Yamagishi, Yukiyasu Okamura, Woodae Kang, Masataka Shindate, Mitsugu Kochi, Yusuke Mitsuka, Megumu Watabe, Nao Yoshida, Masahito Ikarashi, Shintaro Yamazaki, Osamu Aramaki, Hisashi Nakayama, Masamichi Moriguchi, Tokio Higaki, Hiroharu Yamashita
INTRODUCTION: Several studies have indicated that sarcopenia affects the short- and long-term outcomes of cancer patients, including those with gastric cancer. In recent years, sarcopenic obesity and its effects have been reported in cancer patients. This study aimed to evaluate the impact of sarcopenic obesity on postoperative complications in patients with gastric cancer undergoing gastrectomy. METHODS: This single-center, retrospective study included 155 patients who underwent curative gastrectomy for gastric cancer from January 2015 to July 2021...
August 1, 2023: Digestive Surgery
Satoshi Nishi, Yuichiro Miki, Takumi Imai, Mikio Nambara, Hironari Miyamoto, Tatsuro Tamura, Mami Yoshii, Takahiro Toyokawa, Hiroaki Tanaka, Shigeru Lee, Kiyoshi Maeda
INTRODUCTION: Sarcopenia is often observed in patients with esophageal cancer (EC). However, the influence of sarcopenia during neoadjuvant chemotherapy (NAC) on complications has not been fully investigated. Thus, we aimed to investigate the best way of evaluating sarcopenia for predicting complications, especially postoperative pneumonia (PP), in patients with EC undergoing NAC and esophagectomy. METHODS: We retrospectively reviewed 36 patients. The skeletal muscle mass index (SMI) was evaluated by both BIA and CT...
July 27, 2023: Digestive Surgery
Cassandra Mohr, Hailie Ciomperlik, Naila Dhanani, Oscar A Olavarria, Craig Hannon, William Hope, Scott Roth, Mike K Liang, Julie L Holihan
Introduction- Hiatal hernia repair is associated with substantial recurrence of both hiatal hernia and symptoms of gastroesophageal reflux (GER). While small randomized controlled trials demonstrate limited differences in outcomes with use of mesh or fundoplication type, uncertainty remains. Methods- A multicenter, retrospective review of patients undergoing surgical treatment of hiatal hernias between 2015-2020 was performed. Patients with mesh and with suture only repair were compared, and partial versus complete fundoplication was compared...
July 26, 2023: Digestive Surgery
Siri Rønholdt Henriksen, Jacob Rosenberg, Siv Fonnes
BACKGROUND: Diagnostic laparoscopy is often used when a patient is suspected of having acute appendicitis. The aim of this study was to assess the rate of other pathologies found during diagnostic laparoscopy for suspected acute appendicitis. METHODS: This systematic search included studies with ≥100 patients who received laparoscopy for suspected acute appendicitis and reported on the histopathologic and other intraabdominal findings. We performed a meta-analysis estimating the rate of other pathologies, and a sensitivity analysis excluding smaller cohorts (≤500 patients)...
July 18, 2023: Digestive Surgery
Seiji Ito, Takeshi Sano, Junki Mizusawa, Masanori Tokunaga, Tadayoshi Hashimoto, Hiroshi Imamura, Shin Teshima, Koei Nihei, Makoto Yamada, Yasuhiro Choda, Kazuhiro Imamura, Shinji Hato, Masanori Terashima, Mitsuru Sasako
INTRODUCTION: Splenectomy for proximal gastric cancer was found to offer no survival benefit in a randomized trial clarifying the role of splenectomy (JCOG0110 study). Although many studies have explored risk factors for morbidities following total gastrectomy, none have assessed the risk factors for postoperative complications in spleen-preserving total gastrectomy. METHODS: Using data from 505 patients enrolled in a previous randomized trial, risk factors for postoperative complications were identified by multivariable logistic regression analysis...
July 17, 2023: Digestive Surgery
Jacopo Weindelmayer, Valentina Mengardo, Lorena Torroni, Maria Clelia Gervasi, Selma Hetoja, Carlo Alberto De Pasqual, Davide Simion, Simone Giacopuzzi
INTRODUCTION: While Enhanced Recovery After Surgery (ERAS) protocol demonstrated to improve outcomes after gastrectomy, some papers evidenced a detrimental effect on postoperative morbidity related to the "weekday effect". We aimed to understand whether the day of gastrectomy could affect postoperative outcomes and compliance with ERAS items. METHODS: We included all patients that underwent gastrectomy for cancer between January 2017 and September 2021. Cohort was divided considering the day of surgery: Early group (Monday-Wednesday) and Late group (Thursday-Friday)...
July 3, 2023: Digestive Surgery
Kazushige Kawai, Shinya Hirakawa, Hisateru Tachimori, Taro Oshikiri, Hiroaki Miyata, Yoshihiro Kakeji, Yuko Kitagawa
INTRODUCTION: We previously developed risk models for mortality and morbidity after low anterior resection using a nationwide Japanese database. However, the milieu of low anterior resection in Japan has undergone drastic changes since then. This study aimed to construct risk models for 6 short-term postoperative outcomes after low anterior resection, i.e., in-hospital mortality, 30-day mortality, anastomotic leakage, surgical site infection except for anastomotic leakage, overall postoperative complication rate, and 30-day reoperation rate...
June 13, 2023: Digestive Surgery
Masahiro Shiihara, Yasuhiro Sudo, Norimasa Matsushita, Takeshi Kubota, Yasuhiro Hibi, Harushi Osugi, Tatsuo Inoue
INTRODUCTION: Complicated appendicitis (CA) is often indicated for emergency surgery; however, preoperative predictors of pathological complicated appendicitis (pCA) remain unclear. Furthermore, characteristics of CA that can be treated conservatively have not yet been established. METHODS: Three hundred and five consecutive patients diagnosed with acute appendicitis were reviewed. The patients were divided into two groups: an emergency surgery and a conservative treatment group...
June 7, 2023: Digestive Surgery
Gustavo Martínez-Mier, Daniel Mendez-Rico, José Manuel Reyes-Ruiz, Pedro Ivan Moreno-Ley, Victor Bernal-Dolores, Octavio Avila-Mercado
INTRODUCTION: This study aimed to evaluate the use of LC operative time (CholeS score) and conversion to an open procedure (CLOC score) outside their validation dataset in Mexican population. METHODS: Patients >18 years who underwent elective LC were analyzed in a single-center retrospective chart review study. Association between scores (CholeS and CLOC) with operative time and conversion to open procedures was assessed with Spearman correlation. The predictive accuracy of the CholeS Score and CLOC score was evaluated by Receiver Operator Characteristic (ROC)...
May 22, 2023: Digestive Surgery
Kammy Keywani, Alexander B J Borgstein, Djamila Boerma, Stijn van Esser, Wietse J Eshuis, Mark I Van Berge Henegouwen, Johanna van Sandick, Suzanne S Gisbertz
INTRODUCTION: Curative therapy for gastric cancer usually consists of perioperative chemotherapy combined with a radical (R0) gastrectomy. In addition to a modified D2-lymphadenectony, a complete omentectomy is recommended. However, there is little evidence for a survival benefit of omentectomy. This study presents the follow-up data of the OMEGA-study. METHODS: This multicenter prospective cohort study included 100 consecutive patients with gastric cancer undergoing (sub)total gastrectomy with complete en bloc omentectomy and modified D2 lymphadenectomy...
May 10, 2023: Digestive Surgery
Brenda Monaghan, Ann Monaghan, Qurat Ul Ain, Sinead N Duggan, Kevin C Conlon, John Gormley
Introduction The beneficial effects of exercise and physical activity (PA) have been demonstrated in many chronic inflammatory diseases. Knowledge on physical activity levels is unknown in the chronic pancreatitis population and there are currently no specific PA recommendations for this condition. Methods Physical activity was measured objectively over a 7- day period in 17 individuals with chronic pancreatitis using an accelerometer (Acti-graph) and in 15 controls, matched for age, sex, and body mass index...
April 21, 2023: Digestive Surgery
Takuya Oba, Shinichi Tomioka, Norihiro Sato, Makoto Otani, Akiko Sakurai, Yasuki Akiyama, Jun Nagata, Takayuki Torigoe, Shinya Matsuda, Keiji Hirata
Introduction Laparoscopic low anterior resection (L-LAR) has become widely accepted for the treatment of rectal cancer. However, little is known about the superiority of L-LAR in a real-world setting (including low-volume hospitals) and the association between the short-term outcomes and hospital volume focusing on L-LAR. Methods This is a retrospective cohort study. A total of 37,821 patients who underwent LAR for rectal cancer were analyzed using the Diagnosis Procedure Combination (DPC) database from January 2014 to December 2017...
March 22, 2023: Digestive Surgery
Masahiro Sasahara, Mitsuro Kanda, Dai Shimizu, Hideki Takami, Yoshikuni Inokawa, Norifumi Hattori, Masamichi Hayashi, Chie Tanaka, Michitaka Fujiwara, Goro Nakayama, Yasuhiro Kodera
BACKGROUND: Neoadjuvant treatment is currently the gold standard for advanced esophageal squamous cell carcinoma (ESCC). Several studies have examined the value of blood count-based indexes for predicting short- and long-term outcomes after esophagectomy for ESCC, but the relative predictive value of pretreatment, preoperative, and postoperative indexes has not yet been examined. METHODS: This study included 320 patients with thoracic ESCC who underwent subtotal esophagectomy after neoadjuvant chemotherapy or chemoradiotherapy at our institution...
March 9, 2023: Digestive Surgery
B Feike Kingma, Eliza R C Hagens, Mark I Van Berge Henegouwen, Alicia S Borggreve, Jelle P Ruurda, Suzanne S Gisbertz, Richard van Hillegersberg
INTRODUCTION: The balance between potential oncological merits and surgical risks is unclear for the additional step of performing paratracheal lymphadenectomy during esophagectomy for cancer. This study aimed to investigate the impact of paratracheal lymphadenectomy on lymph node yield and short-term outcomes in patients who underwent this procedure in The Netherlands. METHODS: Patients who underwent neoadjuvant chemoradiotherapy followed by transthoracic esophagectomy were included from the Dutch Upper Gastrointestinal Cancer Audit (DUCA)...
March 7, 2023: Digestive Surgery
Ken Kurisaki, Akihiko Soyama, Takanobu Hara, Hajime Matsushima, Hajime Imamura, Takayuki Tanaka, Tomohiko Adachi, Shinichiro Ito, Kengo Kanetaka, Masaaki Hidaka, Shinji Okano, Susumu Eguchi
We report a case of pathologic complete response after successful treatment for advanced hepatocellular carcinoma (HCC) complicated with portal venous tumor thrombus by atezolizumab and bevacizumab followed by radical resection. The patient was a male in his 60s. During follow-up for chronic hepatitis B, abdominal ultrasonography revealed a huge tumor located in the right lobe of the liver with the portal vein thrombosed by the tumor. The tumor thrombus extended to the proximal side of the left branch of the portal vein...
February 27, 2023: Digestive Surgery
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