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Journal of Environmental Pathology, Toxicology and Oncology

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https://read.qxmd.com/read/30806293/reduction-of-gamma-radiation-induced-damage-by-hydro-alcoholic-extract-of-nardostachys-jatamansi
#1
Aditya Menon, Tiju Chacko, Praseetha R Nair, Teeju Majeed, Cherupally Krishnan Krishnan Nair
The search for a nontoxic radioprotector has not yielded any promising results. Many antioxidant compounds, though effective under in vitro conditions as radioprotectors, have failed under in vivo settings due to their toxicity. The Indian medical system of Ayurveda uses a variety of plants with antioxidant potential, and these may be harboring molecules with radioprotective properties. In the present work, the radioprotective property of Nardostachys jatamansi was investigated. A hydro-alcoholic extract of this plant provided protection to the cellular DNA and membrane from 4 Gy gamma radiation...
2019: Journal of Environmental Pathology, Toxicology and Oncology
https://read.qxmd.com/read/30806292/pi3k-akt-pathway-and-mir-21-are-involved-in-n-ethyl-n-nitrosourea-induced-f1-mouse-lung-tumorigenesis-effect-of-inositol-hexaphosphate
#2
Satya Sahay, Prakash Tiwari, Manuraj Pandey, Krishna P Gupta
The risk of cancer development in offspring due to carcinogen exposure during pregnancy is a serious issue. In this study, we explored the involvement of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway and microRNA-21 (miR-21) in transplacental lung tumorigenesis and its prevention by dietary compound inositol hexaphosphate (IP6) in F1 mice. Balb/c mice were exposed to the N-ethyl-N-nitrosourea (ENU) intraperitoneally on the 17th day of gestation. After weaning, half of the litters were fed with oral 2% IP6...
2019: Journal of Environmental Pathology, Toxicology and Oncology
https://read.qxmd.com/read/30806291/common-variants-rs3815188-and-rs1043994-on-notch3-gene-confer-susceptibility-to-lung-cancer-a-hospital-based-case-control-study
#3
Emine Yagci, Irfan Degirmenci, Cansu Ozbayer, Guntulu Ak, Faruk Saydam, Muzaffer Metintas
The Notch signaling pathway is a mechanism that plays a role in the determination of cell fate during cell development. Signals between neighbor cells are amplified through the Notch receptors. Notch activity is related to general growth stages such as organogenesis and morphogenesis and has effects on cell differentiation, cell proliferation, and apoptosis. Lung cancer associated with degradation of proteins which regulate cellular activities such as cell growth, differentiation, proliferation and apoptosis or the loss of function of proteins due to mutations in the genes which that express these proteins...
2019: Journal of Environmental Pathology, Toxicology and Oncology
https://read.qxmd.com/read/30806290/mitogen-activated-protein-kinase-mapk-new-insights-in-breast-cancer
#4
Huanyu Lu, Yue Guo, Gaurav Gupta, Xingsong Tian
The eukaryotic cell cycle via mitogen-activated protein kinase (MAPK) has been considered as an effective signaling cascade pathway for anticancer therapy. In addition to the MAPK signaling pathway, the Rat Sarcoma Virus (Ras)/Rapidly Accelerated Fibrosarcoma (Raf)/MAPK-ERK kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway is a signaling cascade that has a crucial role to play in cell survival and development of cancer, especially breast cancer. Novel drugs and clinical trials need to be investigated, taking into consideration the already studied genetic defects related to genesis of tumors in certain populations...
2019: Journal of Environmental Pathology, Toxicology and Oncology
https://read.qxmd.com/read/30806289/asthma-alleviating-potential-of-6-gingerol-effect-on-cytokines-related-mrna-and-c-myc-and-nfat1-expression-in-ovalbumin-sensitized-asthma-in-rats
#5
Zaoni Li, Zhongxi Liu, V V Sathibabu Uddandrao, Ponmurugan Ponnusamy, Santhanaraj Balakrishnan, P Brahmanaidu, S Vadivukkarasi, Saravanan Ganapathy
In this study, we aimed at assessing the therapeutical potential of 6-gingerol ([5S]-5-hydroxy-1-[4-hydroxy- 3-methoxyphenyl]-3-decanone) against ovalbumin-sensitized asthma in rats. The rats were treated intraperitoneally with 6-gingerol (75 mg/kg body weight) for 30 days and a theophylline (200 mg/kg body weight)-treated group as a control. Changes in the levels of T-cell-linked cytokines (interleukin-4 [IL-4], IL-5, IL-13, and interferon-gamma [IFN-?]), total immunoglobulin E (IgE), gene expressions of bitter taste-sensing type 2-receptor 10 (T2R10), inositol 1,4,5-triphosphate receptor 1 (IP3R1), Orai1 and protein expressions of nuclear factor of activated T cells 1 (NFAT1), c-Myc and histopathological changes were observed in rats...
2019: Journal of Environmental Pathology, Toxicology and Oncology
https://read.qxmd.com/read/30806288/daidzein-ameliorates-dextran-sulfate-sodium-induced-experimental-colitis-in-mice-by-regulating-nf-%C3%AE%C2%BAb-signaling
#6
Jiangli Shen, Na Li, Xi Zhang
Ulcerative colitis (UC) and Crohn's disease (CD) are collectively referred to as inflammatory bowel diseases (IBDs). The increased pathogenesis of UC leads to a series of complications. We aimed to analyze the anticolitic effect of daidzein (DA) in a dextran sulfate sodium (DSS)-induced colitis mouse model and in activated macrophage RAW264.7 cells. Thirty BALB/c male mice were randomly divided into three groups: control, DSS-treated, and DSS DA (10 mg/kg body weight for seven days). DA supplementation was found to improve the disease activity index, colon length, and spleen weight...
2019: Journal of Environmental Pathology, Toxicology and Oncology
https://read.qxmd.com/read/30806287/predicting-the-efficacy-of-5-fluorouracil-based-adjuvant-chemotherapy-in-gastric-cancer-by-microsatellite-instability-a-meta-analysis
#7
Fuxing Zhao, Xinyue Yuan, Dengfeng Ren, Guoshuang Shen, Ziyi Wang, Fangchao Zheng, Raees Ahmad, Zhijun Ma, Jiuda Zhao
Microsatellite instability (MSI) implies the deletion of mismatch repair genes caused by DNA methylation or gene mutation. MSI is a good predictor for efficacy of 5-fluorouracil (FU)-based chemotherapy in the treatment of colorectal cancer. Some gastric cancer studies have reported that MSI has no apparent impact on prognosis after patients receive 5-FU-based adjuvant chemotherapy. However, other studies suggest that high-frequency MSI (MSI-H) status reduced survival in patients receiving 5-FU-based adjuvant chemotherapy...
2019: Journal of Environmental Pathology, Toxicology and Oncology
https://read.qxmd.com/read/30806286/autophagy-is-required-to-regulate-mitochondria-renewal-cell-attachment-and-all-trans-retinoic-acid-induced-differentiation-in-nb4-acute-promyelocytic-leukemia-cells
#8
Ibrahim Tekedereli, Ugur Akar, S Neslihan Alpay, Gabriel Lopez-Berestein, Bulent Ozpolat
All-trans-retinoic acid (ATRA) is a potent inducer of cellular differentiation, growth arrest, and apoptosis as well as a front-line therapy for acute promyelocytic leukemia (APL). The present study provides evidence that induction of autophagy is required for ATRA to induce differentiation of APL (NB4) cells into granulocytes. ATRA treatment causes ~12-fold increase in the number of acidic vesicular organelles and induces marked up-regulation of LC3-II, autophagy-related 5 (ATG5), and Beclin-1. Transmission electron microscopy (TEM) revealed a decrease in mitochondria and ATRA-induced differentiation...
2019: Journal of Environmental Pathology, Toxicology and Oncology
https://read.qxmd.com/read/30806285/mangiferin-attenuated-diethynitrosamine-induced-hepatocellular-carcinoma-in-sprague-dawley-rats-via-alteration-of-oxidative-stress-and-apoptotic-pathway
#9
Guang Yang, Xiao Shang, Guozhen Cui, Lingling Zhao, Hengjun Zhao, Nanya Wang
Liver cancer is the fifth commonly occurring cancer worldwide with the annual death rate of 9.1%. Hepatocellular carcinoma is the most frequent kind of primary liver cancer and occurs mostly in patients with chronic liver disease and cirrhosis. Because the cancer is generally detected only in the later stages, it is often treated with therapies such as radiation, ablation, and chemotherapy, which produces serious side effects and has a low recovery rate. Therefore, researchers are now focused on herbal-based drugs with increased efficacy and with no side effects to treat cancer...
2019: Journal of Environmental Pathology, Toxicology and Oncology
https://read.qxmd.com/read/30806241/evaluation-of-anti-nociceptive-and-anti-inflammatory-effect-of-luteolin-in-mice
#10
Xiaoying Fan, Kexin Du, Na Li, Zhonglei Zheng, Yan Qin, Jing Liu, Rong Sun, Yuqiang Su
Flavonoids are polyphenolic compounds that not only impart coloration to plants and fruits, but also protect plants from pathogens, radiation, etc. They serve as a nutrient to plants and possess immense anti-oxidant properties. Research has shown that they exhibit anti-inflammatory, anti-cancer, and neuroprotective properties in both in vitro and in vivo analyses. Luteolin is one such flavonoid belongs to the group of flavones present in herbs such as thyme, chamomile, celery, and green pepper. The epidemiological data on luteolin consumption show that luteolin has anti-inflammatory activity and protects from diseases associated with inflammation...
2018: Journal of Environmental Pathology, Toxicology and Oncology
https://read.qxmd.com/read/30806240/lutein-inhibits-cell-growth-and-activates-apoptosis-via-the-pi3k-akt-mtor-signaling-pathway-in-a549-human-non-small-cell-lung-cancer-cells
#11
Wen-Long Zhang, Ya-Nan Zhao, Zhang-Zhen Shi, Dan Cong, Yuan-Song Bai
Cancer, the uncontrolled growth of cells, is a major disease that threatens the worldwide population. Among all cancer types, lung cancer has the highest morbidity rate, with a survival rate of less than 5%. Various studies have focused on discovering a potent anticancer drug that will increase the survival rate of lung cancer patients. Lutein (3,3'-dihydroxy-β, ε-carotene), a carotenoid present in fruits and vegetables, is one such compound that possesses excellent antioxidant properties. The present study was designed to determine the anticancer effect of lutein against A549, a non-small-cell lung cancer cell line...
2018: Journal of Environmental Pathology, Toxicology and Oncology
https://read.qxmd.com/read/30806239/studying-the-in-silico-effect-of-ellagic-acid-on-hif-2%C3%AE-to-improve-efficacy-of-anticancer-therapy
#12
Vidhula Ahire, Devashish Das, Shashank Arora, Anurag Kumar, Guruprasad Ramakrishna, Kaushala Prasad Mishra
The hypoxic tumor microenvironment is one of the major causes of the enhanced chemoresistant and radioresistant behavior of cancer cells. Therefore, the hypoxia-induced factor (HIF) pathway can be endorsed, for not only the malignant phenotype of the cells, but also its metastatic potential. Many drugs targeting the HIF pathways have failed in the clinical setting to demonstrate therapeutic efficacy. Such failures occur due to lack of specificity or redundancy in the complexity of tumor signaling/metabolism that can overcome the inhibitory effects...
2018: Journal of Environmental Pathology, Toxicology and Oncology
https://read.qxmd.com/read/30806238/investigating-the-role-of-mitochondrial-respiratory-dysfunction-during-hexavalent-chromium-induced-lung-carcinogenesis
#13
James T F Wise, Lei Wang, Michael C Alstott, Ntube N O Ngalame, Yuting Wang, Zhuo Zhang, Xianglin Shi
Hexavalent chromium [Cr(VI)] is a lung carcinogen and its complete mechanism of action remains to be investigated. Metabolic reprogramming of key energy metabolism pathways (e.g., increased anaerobic glycolysis in the presence of oxygen or "Warburg effect", dysregulated mitochondrial function, and lipogenesis) are important to cancer cell and tumor survival and growth. In our current understanding of Cr(VI)-induced carcinogenesis, the role for metabolic reprogramming remains unclear. In this study, we treated human lung epithelial cells (BEAS-2B) with Cr(VI) for 6 months and obtained malignantly transformed cells from an isolated colony grown in soft agar...
2018: Journal of Environmental Pathology, Toxicology and Oncology
https://read.qxmd.com/read/30806237/potential-role-of-induced-pluripotent-stem-cells-as-regenerative-medicine-in-retinal-cell-damage
#14
Ying-Jian Sun, Yi-Ran Pan, Bin Fan, Guang-Yu Li
Induced pluripotent stem cells (also called iPSCs) are somatic cells reprogrammed by overexpressing four nuclear transcriptional factors containing Sox2, Klf4, c-myc and Oct4 is the one of research hotspots. Its pluripotency, self-renewal capacity and wide accessibility to donor tissues have made possible the means for modified regenerative medicine. They are considered a possible basis of healthy tissue to cure diseases, like ophthalmic diseases, degenerative diseases, age-related macular degeneration (AMD), are primarily because of the weakening capability of photoreceptor cells, retinal ganglion cells (RGCs), retinal pigmented epithelium (RPE) or other retinal cells...
2018: Journal of Environmental Pathology, Toxicology and Oncology
https://read.qxmd.com/read/30806236/antiarthritic-activity-of-diallyl-disulfide-against-freund-s-adjuvant-induced-arthritic-rat-model
#15
Yuqing Chen, Rong Xue, Xiaochen Jin, Xiangqi Tan
Diallyl disulfide (DADS) is an organosulfur compound derived mainly from garlic and genus Allium plants, which possess diverse biological properties. The aim of the present study was to evaluate the antiarthritic activity of DADS in rats with arthritis induced using complete Freund's adjuvant (CFA). DADS (20 mg/kg and 50 mg/kg) was administered and tested against CFA-induced arthritic rats by assessing various parameters: body weight, paw volume, arthritic score, organ indices (spleen and thymus), hematological and biochemical parameters, and proinflammatory cytokines...
2018: Journal of Environmental Pathology, Toxicology and Oncology
https://read.qxmd.com/read/30806235/colono-protective-potentiality-of-methanolic-bark-extract-of-acacia-catechu-a-medicinal-plant-against-1-2-dimethylhydrazine-induced-toxicity-in-wistar-rats
#16
Alpa Shree, Syed Kazim Hasan, Johirul Islam, Abul Vafa, Shekh Mohammad Afzal, Preeti Barnwal, Aisha Siddiqi, Rahat Ali, Sarwat Sultana
The protective efficacy of methanolic bark extract of Acacia catechu Willd. (MEBA) against 1,2-dimethylhydrazine (DMH)-induced colon toxicity was investigated. Acacia catechu is considered one of the most potent medicines for various diseases in Ayurveda, a traditional system of Indian medicine. It is a widely used herb that contains a variety of bioactive components such as phenolic acids, alkaloids, and flavonoids among others. In the present study, MEBA was used as a pretreatment orally at two doses (250 and 500 mg/kg body weight [b...
2018: Journal of Environmental Pathology, Toxicology and Oncology
https://read.qxmd.com/read/30317975/targeting-mapk-p38-erk-jnk-and-inflammatory-ck-gdf-15-gm-csf-in-uvb-activated-human-skin-cells-with-vitis-vinifera-seed-extract
#17
Hana Petra Decean, Ioana Carmen Brie, Corina Bianca Tatomir, Maria Perde-Schrepler, Eva Fischer-Fodor, Piroska Virag
Ultraviolet B radiation (UVB) activates mitogen-activated protein kinases (MAPK): p38, extracellular signal regulated (ERK), and c-Jun N-terminal (JNK) kinases in human skin cells. Human keratinocytes (KC) exposed to UVB secrete several cytokines (CK), among which the growth differentiation factor-15 (GDF-15) is augmented in inflammatory and aging processes and the granulocyte macrophage-colony stimulating factor (GM-CSF) is involved in cell proliferation, differentiation, and survival, and both CK have implications in skin carcinogenesis...
2018: Journal of Environmental Pathology, Toxicology and Oncology
https://read.qxmd.com/read/30317974/chronic-atrophic-gastritis-a-review
#18
REVIEW
Yifei Li, Ran Xia, Bo Zhang, Chunsheng Li
Chronic atrophic gastritis is a generally asymptomatic condition of great importance because it develops into gastric cancer in a number of patients. It is described as an atrophy of the gastric mucosa. There are two types of atrophic gastritis: a gastric body predominant type in patients with infection of Helicobacter pylori, and an autoimmune type, limited to the gastric body and fundus. The autoimmune type is quite rare and affects people of all ethnicities. Globally, H. pylori infection is very common and is considered a class I carcinogen due to the large number of patients who subsequently develop gastric cancer...
2018: Journal of Environmental Pathology, Toxicology and Oncology
https://read.qxmd.com/read/30317973/cytotoxic-effect-of-spondias-cytherea-fruit-extract-in-murine-melanoma-model-in-vivo-and-in-vitro
#19
Feudjio Ndemanou Yolande, Bhattacharyya Sayantan, Ghosh Paramita, Sarkar Deblina, Mouokeu Raymond Simplice, Tume B Christopher, Murmu Nabendu
Cancer is a disease resulting from the deregulation of cell growth control, caused by an interaction between dietary, genetic, and environmental risk factors. Melanoma accounts for about 4% of cancers diagnosed; however they represent 75% of skin cancer-related deaths, with the incidence and death rates having increased globally over the past few decades. Spondias cytherea is a plant from the family Anacardiaceae. Its usage in the treatment of wounds, sores, and burns is reported from several countries, but the anticancer effects of the fruit have not yet been studied...
2018: Journal of Environmental Pathology, Toxicology and Oncology
https://read.qxmd.com/read/30317972/nanoparticles-in-daily-life-applications-toxicity-and-regulations
#20
REVIEW
Ritu Gupta, Huan Xie
At nanoscale, man-made materials may show unique properties that differ from bulk and dissolved counterparts. The unique properties of engineered nanomaterials not only impart critical advantages but also confer toxicity because of their unwanted interactions with different biological compartments and cellular processes. In this review, we discuss various entry routes of nanomaterials in the human body, their applications in daily life, and the mechanisms underlying their toxicity. We further explore the passage of nanomaterials into air, water, and soil ecosystems, resulting in diverse environmental impacts...
2018: Journal of Environmental Pathology, Toxicology and Oncology
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