Maryam Mahmoudian Esfahani, Maryam Mostashfi, Shiva Vaheb Hosseinabadi, Motahare-Sadat Hashemi, Maryam Peymani, Dina Zohrabi, Seyed Abdolhamid Angaji, Mohammad Hossein Nasr-Esfahani, Kamran Ghaedi
In this study, we explored the regulatory role of microRNA miR-101-3p on the zinc finger protein 746 (ZNF746), also known as PARIS, which is implicated in both sporadic and familial forms of Parkinson's disease. In a Parkinson's disease cell model, utilizing SH-SY5Y cells treated with 1-methyl-4-phenylpyridine (MPP+), we observed that miR-101-3p was downregulated, while ZNF746 was upregulated. To investigate the direct impact of miR-101-3p on ZNF746, our team conducted overexpression experiments, successfully reversing ZNF746's expression at both the mRNA and protein levels, as confirmed through quantitative PCR and western blotting...
December 14, 2023: Neuroscience Research