Journal of Microencapsulation

This study aims to evaluate the radioprotective effects of liposomes encapsulating curcumin (Lip-CUR), silibinin (Lip-SIL), α-tocopherol (Lip-TOC), quercetin (Lip-QUE) and resveratrol (Lip-RES) in alleviating the adverse effects of ionizing irradiation on human lymphoctyes and skin cells in radiotherapy. Liposomes encapsulating the above natural radioprotectants (Lip-NRPs) were prepared by the film hydration method combined with sonication. Their radioprotective effects for the cells against X-irradiation was evaluated using trypan-blue assay and γ-H2AX assay...

Aim- The goal of this study is to optimization and evaluation of dopamine-loaded NLC (NLC-DOPA) for achieve dopamine concentrations into brain for treatment of Parkinson's disease which causes progressive neuronal death. Method- NLC-DOPA prepared by homogenization method using solid lipids (Cholesterol and Soya lecithin), liquid lipid (Oleic acid) and surfactant (Poloxamer- 188) as major excipients, optimized by central composite design using design expert-13 software. The optimized formulations were characterized by particle size, zeta potential, entrapment efficiency, SEM, TEM, FTIR, DSC, XRD, stability study and in-vitro drug release...

AIMS: The aim of this study was to enhance the dissolution rate and oral bioavailability of Herpetetrone (HPT) by preparing nanosuspensions (NSs) and evaluate the changes in its anti-hepatic fibrosis effect. METHODS: Herpetetrone nanosuspension (HPT-NSs) was prepared using the ultrasound-precipitation technique, and characterized on the basis of mean diameter, zeta potential (ZP), encapsulation efficiency percent (EE%), scanning electronic microscopy (SEM), X-ray powder diffraction (XRPD)...

Osteoarthritis is considered a degenerative joint disease that is characterised by inflammation, chronic pain, and functional limitation. The increasing development of nanotechnology in drug delivery systems has provided new ideas and methods for osteoarthritis therapy. This review aimed to evaluate patents that have developed innovations, therapeutic strategies, and alternatives using nanotechnology in osteoarthritis treatment. The results show patents deposited from 2015 to November 2021 in the online databases European Patent Office and World Intellectual Property Organisation...

The aim of this work was to investigate novel formulations containing diruthenium(II-III)-ibuprofen (RuIbp) metallodrug encapsulated into chitosan (CT) biopolymer. Microparticles (RuIbp/CT MPs, ∼1 μm) were prepared by spray-drying, and RuIbp/CT-crosslinked nanoparticles (NPs) by ionic gelation (RuIbp/CT-TPP; TPP, tripolyphosphate (1) , RuIbp/CT-TPP-PEG; PEG, poly(ethyleneglycol (2) ) or pre-gel/polyelectrolyte complex method (RuIbp/CT-ALG; ALG, alginate (3) ). Ru analysis was conducted by energy dispersive x-ray fluorescence or inductively coupled plasma atomic emission spectroscopy, and physicochemical characterization by powder x-ray diffraction, electronic absorption and FTIR spectroscopies, electrospray ionization mass spectrometry, thermal analysis, scanning electron, transition electron and atomic force microscopies, and dynamic light scattering...

AIM: Present study focuses on the development of P80 coated PLGA Nanoparticles loaded with drugs, paroxetine (P80-Par-PLGA-NPs) and clonidine (P80-CLD-PLGA-NPs) for in-vitro evaluation of Cellular Uptake & Cytotoxicity on Neuro-2a cells. METHOD: P80-Par-PLGA-NPs and P80-CLD-PLGA-NPs were developed and characterized for zeta size, potential, PDI, EE%, DL%, TEM, SEM, FTIR, DSC, i n-vitro release, cytotoxicity, histopathological and cell uptake studies using rhodamine loaded P80-NPs...

The aims of this study were to systematically optimize a formula for eugenol emulsions via face-centered central composite design and to assess the activity against two-different bacterial strains ( Staphylococcus aureus and Propionibacterium acnes ) present at planktonic and biofilm forms. The molecular interaction of excipients, mean particle size (MPS) including zeta potential (ZP), drug entrapment efficiency (DEE) and in vitro drug release of optimized emulsions was done using FT-IR, Malvern Zetasizer, ultracentrifugation technique and membrane-free dissolution model, respectively...

The proposed research aims to develop Tacrolimus-loaded nanostructured lipid carriers (TAC-loaded NLCs) to overcome poor aqueous solubility and dissolution rate to enhance its oral absorption. A central composite design was used to optimize the amount of Poloxamer 188 and D-α-Tocopherol-polyethylene-glycol-succinate (TPGS). The optimized TAC-loaded NLCs contain stearic acid (250 mg), Moringa oleifera (MO) seed oil (50 mg), TAC (Tacrolimus: 10 mg), TPGS (60 mg), and Poloxamer 188 (1% w/v) with a mean diameter of 393...

To improve survival during storage and exposure to adverse conditions, Bacillus subtilis was microencapsulated with oat β-glucan by spray-drying technology. The characterization of the microcapsules was designed to compare free and microencapsulated cells through exposure to simulated gastric fluids (SGF) throughout storage for 90 days at different temperatures. The characterization included analysis of efficiency, morphology, moisture, water activity, hygroscopicity, particle size, and zeta potential...

AIMS: To evaluate the potential applications of soy protein-glucan-catechin (SGC) complexes prepared with different ultrasound times in stabilizing high internal phase Pickering emulsion (HIPPE) and delivering curcumin. METHODS: The SGC complexes were characterized by particle size, morphology, zeta potential, Fourier transform infrared and fluorescence spectroscopy. Formation and stability of curcumin emulsions were monitored by droplet size, microstructure, rheological property, lipid oxidation, and in vitro digestion...

AIM: The aim of this manuscript was to fabricate Agomelatine (AGM) loaded elastosomes to improve their corneal permeation and ocular bioavailability. AGM is a BCS class II with low water solubility and high membrane permeability. It has a potent agonistic action on melatonin receptors, so it is used for glaucoma treatment. METHODS: Elastosomes were made using modified ethanol injection technique according to a 22 x 41 Full Factorial design. The chosen factors were: Edge activators (EAs) type, surfactant percent (SAA %w/w), and cholesterol: surfactant ratio...

ABSTRACT：This study aimed to improve control over the curing behavior of cold mix epoxy asphalt by using a microencapsulated curing agent (2-PZ@PC). Prepared through solvent evaporation, the 2-PZ@PC microcapsules had 2-phenylimidazole as the core material and polycarbonate as the shell material. The research examined the impact of core-shell mass ratio on microcapsule morphology and composition. Various equations, including the kinetics equation, Kisinger equation, Flynn-Wall-Ozawa, and Crane equations, were employed to assess the sustained release effect of 2-PZ@PC microcapsules on epoxy resin curing behavior...

AIM: This work aimed to encapsulate Hypercium perforatum extract (HPE) into nanophytosomes (NPs) and assess therapeutic efficacy of this nanocarrier in neuropathic pain induced by PSNL (Partial Sciatic Nerve Ligation). METHODS: Hydroalcholic extract of Hypercium perforatum was prepared and encapsulated into nanophytosomes by thin layer hydration method. Particle size, zeta potential, TEM, DSC %EE (Entrapment efficiency) and LC (Loading Capacity) of NPs were reported...

UNLABELLED: Objective Encapsulation of esculetin into DSPE-MPEG2000 carrier was performed to improve its water solubility and oral bioavailability, as well as enhance its anti-inflammatory effect on mouse model of ulcerative colitis that was induced with dextran sulfate sodium (DSS). METHODS: We determined the in-vitro and in-vivo high performance liquid chromatographic (HPLC) analysis method of esculetin; Esculetin-loaded nanostructure lipid carrier (Esc-NLC) was prepared using a thin-film dispersion method, wherein a particle size analyzer was used to measure the particle size (PS) and zeta potential (ZP) of the Esc-NLC, while a transmission electron microscope (TEM) was employed to observe its morphology...

AIM: N-acetylcysteine (NAC) as an antioxidant used to moderate liposome and chitosan-Induced cell cytotoxicity at their high concentrations. METHODS: liposome and chitosan were prepared and characterized. The cytotoxicity effect of liposome with NAC-loaded liposome (liposome-NAC) and chitosan solution with chitosan solution containing NAC (chitosan-NAC) on the A549 cell line was compared. RESULTS: Particle size, zeta potential, and NAC drug release for liposome were 125...

AIM: To determine the optimum condition for preparing chitooligosaccharide-catechin conjugate (COS-CAT) liposomes using different stabilising agents. METHODS: COS-CAT liposomes (0.1-1%, w/v) were prepared using soy phosphatidylcholine (SPC) (50-200 mM) and glycerol or cholesterol (25-100 mg). Encapsulation efficiency (EE), loading capacity (LC), physicochemical characteristics, FTIR spectra, thermal stability, and structure of COS-CAT liposomes were assessed...

This research aims to develop bitter taste masking microcapsules containing azithromycin by a simpler and familiar method, fluid-bed coating technology, in comparison with Zithromax®. Cores of microcapsules, azithromycin microparticles, were prepared by fluid-bed granulation, then taste-masking polymer was covered on by fluid-bed coating technique. Eudragit L100, Eudragit RL100, ethyl cellulose in single and combined with Eudragit L100, Eudragit E100 were used as taste-masking polymers. The obtained microcapsules were characterized by taste masking ability, in-vitro release, SEM, coating thickness and coating efficiency...

AIMS: Preparation and evaluation of new formulations based on the encapsulation of Ruta essential oil (REO) in chitosan (CHS-REO) and alginate (ALG-REO) biopolymeric matrices for its potential use as a nematicide of the genus Meloidogyne spp . METHODS: Controlled release formulations of REO obtained by ionic gelation were characterized by Scanning Electron Microscopy (SEM), Fourier-Transform Infrared Spectroscopy (FTIR), Zeta Potential, and thermal analysis. Their swelling (Sw) and release rate (RR) were evaluated at different pH, with their corresponding nematicidal activity...

AIM: Several shreds of evidence have supported the growth-inhibitory effect of resveratrol in breast cancer. Owing to the low efficiency, we aimed to fabricate an ACN nanoparticle containing resveratrol to target the proliferation of breast cancer cells. METHODS: Resveratrol encapsulation was characterized using spectrophotometry, FTIR, and SEM. The cytotoxicity and antioxidant activities of compounds were evaluated by MTT, NO, FRAP, and qRT-PCR assays on MCF7 and SKBr3 cells...

Oxidative stress from reactive oxygen species is the main cause of skin aging. Cordycepin, a bioactive compound of Cordyceps militaris , contains antioxidant activity. This study examined extracellular matrix, antioxidant effect, autophagy activity, and skin regeneration in human dermal fibroblasts (HDFs) under normal and oxidative stress conditions. Slow disintegration was used to create nano-encapsulated cordyceps extract. HDFs were cultured and treated with 1 M cordycepin, 1 M medium, 0.1 M CMP, or 1 mM H2O2...