journal
https://read.qxmd.com/read/38410930/astaxanthin-loaded-alginate-chitosan-gel-beads-activate-nrf2-and-pro-apoptotic-signalling-pathways-against-oxidative-stress
#1
JOURNAL ARTICLE
Hamieh Goshtasbi, Elaheh Dalir Abdolahinia, Marziyeh Fathi, Ali Movafeghi, Hossein Omidian, Jaleh Barar, Yadollah Omidi
Oxidative stress (OS) plays a crucial role in disease development. Astaxanthin (ATX), a valuable natural compound, may reduce OS and serve as a treatment for diseases like neurodegenerative disorders and cancer. Nuclear factor-erythroid 2-related factor 2 (Nrf2) regulates antioxidant enzymes and OS management. We evaluated ATX's antioxidant activity via Alg-CS/ATX gel beads in vitro. ATX-encapsulated alginate-chitosan (Alg-CS/ATX) gel beads were synthesized and structurally/morphologically characterized by SEM, FT-IR, and XRD...
February 27, 2024: Journal of Microencapsulation
https://read.qxmd.com/read/38410926/enhanced-in-vitro-and-ex-vivo-transdermal-permeation-of-microemulsion-gel-of-tapentadol-hydrochloride
#2
JOURNAL ARTICLE
Nimmathota Madhavi, Heera Battu
Aim of the current study is to develop a microemulsion gel for transdermal delivery of tapentadol hydrochloride. Microemulsion was developed using phase diagram and subjected to assay, globule size, PDI, zeta potential, TEM and in vitro drug release studies. The optimized microemulsion was converted into gel using carbopol 934 NF and evaluated for viscosity, spreadability, in vitro , ex vivo , FTIR, DSC, stability and skin irritation studies. The mean globule size, PDI, zeta potential and in vitro drug release of microemulsion were found 247...
February 27, 2024: Journal of Microencapsulation
https://read.qxmd.com/read/38410890/gelatine-nanoparticles-encapsulating-three-edible-plant-extracts-as-potential-nanonutraceutical-agents-against-type-2-diabetes-mellitus
#3
JOURNAL ARTICLE
Akurange Sujeevi Dammadinna Wickramasinghe, Anoja Priyadarshani Attanayake, Pabasara Kalansuriya
AIM: To optimise, and characterise gelatine nanoparticles (GNPs) encapsulating plant extracts and evaluate the glucose-lowering potential. METHODS: GNPs encapsulating plant extracts were prepared by desolvation method followed by adsorption. The GNPs were characterised by loading efficiency, loading capacity, particle size, zeta potential, SEM and FTIR. The glucose-lowering activity of GNPs was determined using oral glucose tolerance test in high-fat diet fed streptozotocin-induced Wistar rats...
February 27, 2024: Journal of Microencapsulation
https://read.qxmd.com/read/38345078/spray-dried-acerola-malpighia-emarginata-dc-juice-particles-to-produce-phytochemical-rich-starch-based-edible-films
#4
JOURNAL ARTICLE
Dayene Nunes Ribeiro, Kátia Cristina Borges, Kátia Nicolau Matsui, Roberta Targino Hoskin
This study aimed to produce spray dried acerola juice microparticles with different protein carriers to be incorporated into edible starch films. The microparticles were evaluated for solids recovery, polyphenol retention, solubility, hygroscopicity, particle size distribution, X-ray diffraction, phytochemical compounds and antioxidant activity. Acerola microparticles produced with WPI/hydrolysed collagen carriers (AWC) with higher solids recovery (53.5 ± 0.34% w/w), polyphenol retention (74...
February 12, 2024: Journal of Microencapsulation
https://read.qxmd.com/read/38096025/investigating-the-effect-of-wall-material-and-pressure-homogenization-on-encapsulation-parameters-and-thermal-stability-in-chia-seed-oil-microcapsules
#5
JOURNAL ARTICLE
Vishnu Anand, Vikono Ksh, Sujata Vasudev, Manoj Kumar, Charanjit Kaur
AIM: To evaluate the effect of different wall material (WM) matrices followed by homogenization to encapsulate chia seed oil (CSO) using freeze-drying technology. METHODS: CSO was encapsulated using three ratios (100/0, 50/50, and 100/0) of two WM matrices: MTS/WPC (modified tapioca starch - whey protein concentrate) and MD/WPC (maltodextrin- whey protein concentrate). The evaluation included encapsulation efficiency (EE), oxidative stability, and α-linolenic acid (ALA) retention...
December 14, 2023: Journal of Microencapsulation
https://read.qxmd.com/read/38095892/tumor-specific-hybrid-nanoparticles-in-therapy-of-breast-cancer
#6
JOURNAL ARTICLE
E Kilicay, E Erdal, Pinar Elci, B Hazer, E B Denkbas
AIM: In this study, salicylic acid dopped into poly(3-hydroxybutyrate) and prepared nanoparticles (NPs) to increase encapsulation efficiency, anti-cancer activity of caffeic acid (Caff) and folic acid (FA) for breast cancer treatment. METHOD: NPs were prepared by solvent evaporation method and characterized by FTIR, DSC, SEM, entrapment-loading efficiencies. The mean diameter, polydispersity index and zeta potential (ZP) were evaluated by DLS. In vitro release and stability studies were done via eppendorf method...
December 14, 2023: Journal of Microencapsulation
https://read.qxmd.com/read/37129532/intranasal-spray-of-cubosomal-tizanidine-hydrochloride-for-brain-targeting-in%C3%A2-vitro-and-in%C3%A2-vivo-characterisation
#7
JOURNAL ARTICLE
Hetal Thakkar, Bhumi Modi, Brijesh Patel
Tizanidine HCl (TH) is used as first-line therapy for the treatment of muscular spasm. The intranasal cubosomal delivery system of TH for site-specific delivery, i.e. CNS was developed. Cubosomes of TH were prepared using glyceryl monooleate (GMO) as a lipid, poloxamer 407 as stabiliser, and ethanol and polyethylene glycol 200 as co-solvent. Optimised cubosomes of TH were characterised for vesicle size, zeta potential, % drug entrapment, and mucin binding efficiency, which were found to be 50.22 nm, -6...
December 2023: Journal of Microencapsulation
https://read.qxmd.com/read/37982590/quality-by-design-endorsed-atorvastatin-loaded-nanostructured-lipid-carriers-embedded-in-ph-responsive-gel-for-melanoma
#8
JOURNAL ARTICLE
Deepkumar Bagasariya, Kondasingh Charankumar, Saurabh Shah, Paras Famta, Valencia Fernandes, Syed Shahrukh, Dharmendra Kumar Khatri, Shashi Bala Singh, Saurabh Srivastava
Aim - Our aim was to repurpose atorvastatin for melanoma by encapsulating in nanostructured lipid carrier matrix to promote tumor cell internalization and skin permeation. pH-responsive chitosan gel was employed to restrict At-NLCs in upper dermal layers.Methods - We utilized a quality by design approach for encapsulating At within NLC matrix. Further, cellular uptake and cytotoxicity was evaluated along with pH-responsive release and ex vivo skin permeation.Results - Cytotoxicity assay showed 3.13-fold enhanced cytotoxicity on melanoma cells compared to plain drug with nuclear staining showing apoptotic markers...
November 20, 2023: Journal of Microencapsulation
https://read.qxmd.com/read/37982588/production-and-investigation-of-pickering-emulsion-stabilized-by-casein-qodume-shirazi-alyssum-homolocarpum-seed-gum-complex-particles-gastrointestinal-digestion
#9
JOURNAL ARTICLE
Atena Modiri-Dovom, Akram Arianfar, Sara Naji-Tabasi, Vahid Hakimzadeh
AIMS: Recently, there has been growing research interests in designing Pickering emulsions. In this work, Alyssum homolocarpum seed gum (AHSG) and casein protein (CP) nanoparticles (NPs) fabricated as Pickering stabilizers. METHODS: AHSG (0.0, 0.05, 0.10, and 0.15% (w/w))-CP (2% (w/w)) nanoparticles were fabricated and their properties were investigated (mean diameter, morphology, zeta potential, Fourier transform infra-red, and contact angle). Formation and stability of Pickering emulsion (Pes) stabilized by AHSG-CP NPs were monitored by mean diameter, rheological properties, and in vitro digestion...
November 20, 2023: Journal of Microencapsulation
https://read.qxmd.com/read/37966713/a-new-approach-for-the-treatment-of-alzheimer-s-disease-insulin-quantum-dots
#10
JOURNAL ARTICLE
Gamze Camlik, Besa Bilakaya, Yildiz Ozsoy, Ismail Tuncer Degim
AIM: The potential use of insulin supplementation for Alzheimer's Disease(AD) was aimed to investigate and explore CQDs as an alternative delivery system. METHODS: CQDs were produced by microwave and characterized. Insulin-loaded Ins-CQDs and in-situ Gel-Ins-CQDs were developed. The in vitro release kinetics, penetrations of insulin through excised sheep nasal mucosa were determined. Toxicity of CQDs were calculated on SH-SY5Y cells. The stability and usability of the prepared formulations were assessed...
November 15, 2023: Journal of Microencapsulation
https://read.qxmd.com/read/37966469/synthesis-and-bioactivity-assessment-of-coccinia-grandis-l-extract-encapsulated-alginate-nanoparticles-as-an-antidiabetic-drug-lead
#11
JOURNAL ARTICLE
Nayomi Deshani De Silva, Anoja Priyadarshani Attanayake, Desiree Nedra Karunaratne, Liyanage Dona Ashanti Menuka Arawwawala, Geethi Kaushalya Pamunuwa
Aim: To prepare, characterize, and evaluate antidiabetic activity of Coccinia grandis (L.) extracts encapsulated alginate nanoparticles. Methods: Alginate nanoparticles were prepared using ionic gelation method and characterized by encapsulation efficiency %w/w, loading capacity %w/w, particle size analysis, zeta potential, FTIR, and SEM. In vitro antidiabetic activity was also evaluated. Results: Encapsulation efficiency %w/w, loading capacity %w/w, mean diameter, zeta potential of C. grandis encapsulated alginate nanoparticles ranged from 10...
November 15, 2023: Journal of Microencapsulation
https://read.qxmd.com/read/37867427/applications-of-propolis-encapsulation-in-food-products
#12
REVIEW
Cristina Jansen-Alves, Laura Martins Fonseca, Fernanda Doring Krumreich, Elessandra da Rosa Zavareze
Propolis has beneficial health properties attributed to of phenolic compounds. However, its application is limited. Thus, encapsulation protects the bioactive compounds of propolis from degradation, allowing their release under controlled and specific conditions and increasing their solubility. In addition to protecting flavonoids, encapsulation also minimizes the undesirable characteristics of propolis, such as strong odor. We brought attention to the high antioxidant and antimicrobial activities of encapsulated propolis, and its maintained biological activity enables more uses in different areas...
October 23, 2023: Journal of Microencapsulation
https://read.qxmd.com/read/37867421/sodium-alginate-and-chitosan-co-modified-fucoxanthin-liposomes-preparation-bioaccessibility-and-antioxidant-activity
#13
JOURNAL ARTICLE
Hongchun Dong, Siyuan Wang, Cong Fu, Yanxiaofan Sun, Tuantuan Wei, Dandan Ren, Qiukuan Wang
To improve the stability of fucoxanthin, fucoxanthin liposomes (L) were prepared by the thin-film ultrasound method, and fucoxanthin liposomes were modified with sodium alginate and chitosan by an electrostatic deposition method. The release characteristics of fucoxanthin in different types of liposomes with in vitro gastrointestinal simulation were studied. Under the optimum conditions, the results showed that the encapsulation efficiency of prepared liposomes could reach 88.56 ± 1.40% (m/m), with an average particle size of 295...
October 23, 2023: Journal of Microencapsulation
https://read.qxmd.com/read/37824702/dual-drug-loaded-polypeptide-delivery-systems-for-cancer-therapy
#14
JOURNAL ARTICLE
Natalia Zashikhina, Erik Gandalipov, Apollinariia Dzhuzha, Viktor Korzhikov-Vlakh, Evgenia Korzhikova-Vlakh
The present study was aimed to prepare and examine in vitro novel dual-drug loaded delivery systems. Biodegradable nanoparticles based on poly(L-glutamic acid- co -D-phenylalanine) were used as nanocarriers for encapsulation of two drugs from the paclitaxel, irinotecan and doxorubicin series. The developed delivery systems were characterised with hydrodynamic diameters less than 300 nm (PDI < 0.3). High encapsulation efficiencies (≥75%) were achieved for all single- and dual-drug formulations...
October 12, 2023: Journal of Microencapsulation
https://read.qxmd.com/read/37815151/comparison-of-the-radioprotective-effects-of-the-liposomal-forms-of-five-natural-radioprotectants-in-alleviating-the-adverse-effects-of-ionizing-irradiation-on-human-lymphoctyes-and-skin-cells-in-radiotherapy
#15
JOURNAL ARTICLE
Ngoc-Duy Pham, Thi-Huynh-Nga Nguyen, Ngoc-Bich-Dao Vu, Thi-Ngoc-Mai Tran, Bao-Ngoc Pham, Hoang-Sinh Le, Kim-Hai Vo, Xuan-Cuong Le, Le-Bao-Ha Tran, Minh-Hiep Nguyen
This study aims to evaluate the radioprotective effects of liposomes encapsulating curcumin (Lip-CUR), silibinin (Lip-SIL), α-tocopherol (Lip-TOC), quercetin (Lip-QUE) and resveratrol (Lip-RES) in alleviating the adverse effects of ionizing irradiation on human lymphoctyes and skin cells in radiotherapy. Liposomes encapsulating the above natural radioprotectants (Lip-NRPs) were prepared by the film hydration method combined with sonication. Their radioprotective effects for the cells against X-irradiation was evaluated using trypan-blue assay and γ-H2AX assay...
October 10, 2023: Journal of Microencapsulation
https://read.qxmd.com/read/37787159/design-and-evaluations-of-a-nanostructured-lipid-carrier-loaded-with-dopamine-hydrochloride-for-intranasal-bypass-drug-delivery-in-parkinson-s-disease
#16
JOURNAL ARTICLE
Neha Sl, Ashwini Kumar Mishra, Laxmi Rani, Shweta Paroha, Hitesh Kumar Dewangan, Pravat Kumar Sahoo
Aim- The goal of this study is to optimization and evaluation of dopamine-loaded NLC (NLC-DOPA) for achieve dopamine concentrations into brain for treatment of Parkinson's disease which causes progressive neuronal death. Method- NLC-DOPA prepared by homogenization method using solid lipids (Cholesterol and Soya lecithin), liquid lipid (Oleic acid) and surfactant (Poloxamer- 188) as major excipients, optimized by central composite design using design expert-13 software. The optimized formulations were characterized by particle size, zeta potential, entrapment efficiency, SEM, TEM, FTIR, DSC, XRD, stability study and in-vitro drug release...
October 3, 2023: Journal of Microencapsulation
https://read.qxmd.com/read/37733492/herpetetrone-nanosuspensions-enhance-drug-solubility-and-bioavailability-to-improve-anti-hepatic-fibrosis-effects
#17
JOURNAL ARTICLE
Yuji Zhong, Lingyu Hang, Fang Wang, Baode Shen, Chengying Shen, Yuye Xue, Haiqiang Jia, Liqiang Wang, Hailong Yuan
AIMS: The aim of this study was to enhance the dissolution rate and oral bioavailability of Herpetetrone (HPT) by preparing nanosuspensions (NSs) and evaluate the changes in its anti-hepatic fibrosis effect. METHODS: Herpetetrone nanosuspension (HPT-NSs) was prepared using the ultrasound-precipitation technique, and characterized on the basis of mean diameter, zeta potential (ZP), encapsulation efficiency percent (EE%), scanning electronic microscopy (SEM), X-ray powder diffraction (XRPD)...
September 21, 2023: Journal of Microencapsulation
https://read.qxmd.com/read/37698545/the-management-of-osteoarthritis-symptomatology-through-nanotechnology-a-patent-review
#18
REVIEW
Mariana Mendonça Santos, Anamaria Mendonça Santos, José Adão Carvalho Nascimento Júnior, Tatianny De Araujo Andrade, Gomathi Rajkumar, Luiza Abrahão Frank, Mairim Russo Serafini
Osteoarthritis is considered a degenerative joint disease that is characterised by inflammation, chronic pain, and functional limitation. The increasing development of nanotechnology in drug delivery systems has provided new ideas and methods for osteoarthritis therapy. This review aimed to evaluate patents that have developed innovations, therapeutic strategies, and alternatives using nanotechnology in osteoarthritis treatment. The results show patents deposited from 2015 to November 2021 in the online databases European Patent Office and World Intellectual Property Organisation...
September 12, 2023: Journal of Microencapsulation
https://read.qxmd.com/read/37698449/diruthenium-ii-iii-ibuprofen-loaded-chitosan-based-microparticles-and-nanoparticles-systems-encapsulation-characterization-anticancer-activity-of-the-nanoformulations-against-u87mg-human-glioma-cells
#19
JOURNAL ARTICLE
Hanif Ur-Rehman, Bárbara Fornaciari, Samara R Alves, Alison Colquhoun, Denise de Oliveira Silva
The aim of this work was to investigate novel formulations containing diruthenium(II-III)-ibuprofen (RuIbp) metallodrug encapsulated into chitosan (CT) biopolymer. Microparticles (RuIbp/CT MPs, ∼1 μm) were prepared by spray-drying, and RuIbp/CT-crosslinked nanoparticles (NPs) by ionic gelation (RuIbp/CT-TPP; TPP, tripolyphosphate (1) , RuIbp/CT-TPP-PEG; PEG, poly(ethyleneglycol (2) ) or pre-gel/polyelectrolyte complex method (RuIbp/CT-ALG; ALG, alginate (3) ). Ru analysis was conducted by energy dispersive x-ray fluorescence or inductively coupled plasma atomic emission spectroscopy, and physicochemical characterization by powder x-ray diffraction, electronic absorption and FTIR spectroscopies, electrospray ionization mass spectrometry, thermal analysis, scanning electron, transition electron and atomic force microscopies, and dynamic light scattering...
September 12, 2023: Journal of Microencapsulation
https://read.qxmd.com/read/37530105/polysorbate-80-surface-modified-plga-nanoparticles-an-in-vitro-evaluation-of-cellular-uptake-cytotoxicity-on-neuro-2a-cells
#20
JOURNAL ARTICLE
Surbhi Sharma, Shweta Dang
AIM: Present study focuses on the development of P80 coated PLGA Nanoparticles loaded with drugs, paroxetine (P80-Par-PLGA-NPs) and clonidine (P80-CLD-PLGA-NPs) for in-vitro evaluation of Cellular Uptake & Cytotoxicity on Neuro-2a cells. METHOD: P80-Par-PLGA-NPs and P80-CLD-PLGA-NPs were developed and characterized for zeta size, potential, PDI, EE%, DL%, TEM, SEM, FTIR, DSC, i n-vitro release, cytotoxicity, histopathological and cell uptake studies using rhodamine loaded P80-NPs...
August 2, 2023: Journal of Microencapsulation
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