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Journal of Microencapsulation

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https://read.qxmd.com/read/30836029/microencapsulation-of-an-indigenous-isolate-of-bacillus-thuringiensis-by-spray-drying
#1
Ardahan Eski, Zihni Demirbağ, İsmail Demir
In this study, microencapsulation by spray drying was performed to protect spores and crystals of indigenous isolate of Bacillus thuringiensis Se13 from environmental stress. The effects of wall material, inlet temperature, and outlet temperature on microencapsulation of Bt-Se13 were investigated using Taguchi's orthogonal array. The most suitable wall material determined as maltodextrin DE10. The optimum inlet and outlet temperatures of spray drier were determined as 160 °C and 70 °C, respectively. The number of viable spores, mean particle size, wetting time, percentage of suspensibility and moisture content of the product produced under optimum conditions were determined as 8...
March 5, 2019: Journal of Microencapsulation
https://read.qxmd.com/read/30836027/%C3%AE-carotene-and-%C3%AE-tocopherol-coencapsulated-in-nanostructured-lipid-carriers-of-murumuru-astrocaryum-murumuru-butter-produced-by-phase-inversion-temperature-method-characterization-dynamic-in-vitro-digestion-and-cell-viability-study
#2
G V L Gomes, M R Sola, A L Rochetti, H Fukumasu, A A Vicente, S C Pinho
Hydrophobic bioactives can be more easily incorporated into food and have their bioavailability enhanced if nanostructured lipid carriers (NLC) are used as carriers. In the present study, beta-carotene-loaded NLC were produced by low emulsificationusing murumuru butter and a mixture of Span 80 and Cremophor RH40 as surfactants. Their average diameter was 35 nm andalpha-tocopherol was required to protect the encapsulated β-carotene. Besides the evaluation of their physicochemical stability, NLC were submitted to dynamic in vitrodigestion and cell viability assays with Caco-2 and HEPG cells...
March 5, 2019: Journal of Microencapsulation
https://read.qxmd.com/read/30784339/encapsulation-of-tagitinin-c-in-liposomes-coated-by-tithonia-diversifolia-pectin
#3
Thi Thanh Thuy Tran, Van Hieu Tran, Thi Tho Lam
Tagitinin C, a sesquiterpene lactone compound from Tithonia diversifolia, is known to have various bioactivities including anticancer effects. The disadvantages of tagitinin C which make its therapeutic application limited are low water solubility and poor stability. In this work, we encapsulated tagitinin C in the form of liposomal nanoparticles to overcome its limitations and evaluated its anticancer activity. Liposomes were prepared using phosphatidylcholine, tween 80 and with/without T. diversifolia pectin...
February 20, 2019: Journal of Microencapsulation
https://read.qxmd.com/read/30758259/preparation-characterization-and-in-vitro-antibacterial-property-of-ciprofloxacin-loaded-nanostructured-lipid-carrier-for-treatment-of-bacillus-subtilis-infection
#4
Petra Nnamani, Agatha Ugwu, Emmanuel Ibezim, Simon Onoja, Amelia Odo, Maike Windbergs, Chiara Rossi, Claus-Michael Lehr, Anthony Attama
OBJECTIVE: Study of controlled ciprofloxacin (CIPRO) nanostrustructured lipid carriers of Precirol® ATO 5/Transcutol® HP (batch A) and tallow fat/Transcutol® HP (batch B). METHOD: CIPRO concentrations C1-5 , (0.0, 0.2, 0.5, 0.8 and 1.0%w/w) as AC1-5 and BC1-5 were prepared by hot homogenization and characterized by Zeta sizer, Differential Scanning-calorimetry, Fourier-Transform-Infra-red-spectroscopy, in vitro drug release and growth inhibitory activity (IZD) on agar-seeded Bacillus subtilis...
February 13, 2019: Journal of Microencapsulation
https://read.qxmd.com/read/30757946/influence-of-drying-processes-on-the-structures-morphology-and-in-vitro-release-profiles-of-risperidone-loaded-plga-microspheres
#5
Zhaoying Wu, Mengqing Zhao, Wei Zhang, Zhao Yang, Shuxin Xu, Qing Shang
The purpose of this study was to investigate the influences of drying methods on the risperidone (RIS) release profiles of RIS-loaded PLGA microspheres. These microspheres were fabricated with an O/W emulsion solvent evaporation method. The wet microspheres were dried with freeze drying and vacuum drying methods, respectively. The microspheres were mono-dispersed spheres with an average diameter of 100 μm. Studies found that drying methods had great influence on the porosity, morphology, and release profiles of RIS-loaded PLGA microspheres...
February 13, 2019: Journal of Microencapsulation
https://read.qxmd.com/read/30719944/enhanced-dissolution-of-valsartan-vanillin-binary-co-amorphous-system-loaded-in-mesoporous-silica-particles
#6
Khan Hashim Ali, Muhammad Mohsin Ansari, Fawad Ali Shah, Fakhar Ud Din, Muhammad Abdul Basit, Jin-Ki Kim, Alam Zeb
The study was aimed to prepare co-amorphous system of valsartan (VAL) with vanillin (VAN) for improving its solubility and dissolution followed by its confinement in mesoporous silica particles (MSPs) to stabilize the co-amorphous system and prevent its recrystallization. Amorphous VAL and VAN were obtained through quench-cooling and VAL/VAN binary co-amorphous system (VAL/VAN-CAS) was prepared through solvent evaporation technique. The particle size and morphology of VAL/VAN-CAS-MSPs were studied using scanning electron microscopy (SEM) and solid-state characterization was performed by differential scanning calorimetry (DSC) and X-ray powder diffraction (XRPD)...
February 5, 2019: Journal of Microencapsulation
https://read.qxmd.com/read/30719943/soy-extract-and-maltodextrin-as-microencapsulating-agents-for-lactobacillus-acidophilus-a-model-approach
#7
Leidiane Andreia Acordi Menezes, Carlos Antonio Matias de Almeida, Nayra Mendes de Souza Mattarugo, Elídia A Vetter Ferri, Paulo Rodrigo Stival Bittencourt, Eliane Colla, Deisy Alessandra Drunkler
The present study aimed to optimize the microencapsulation of Lactobacillus acidophilus La-05 by spray drying, using soy extract and maltodextrin as encapsulants. Air inlet temperature, maltodextrin/soy extract ratio and feed flow rate were investigated through Central Composite Rotational Design (CCRD). Probiotic viability increased with increasing the proportion of soy extract. Temperature and feed flow rate had a negative effect. Particle diameter ranged from 4.97 to 8.82 μm, water actvity from 0.25 to 0...
February 5, 2019: Journal of Microencapsulation
https://read.qxmd.com/read/30702369/surface-modified-kokum-butter-lipid-nanoparticles-for-the-brain-targeted-delivery-of-nevirapine
#8
Sunita Lahkar, Malay Kumar Das
AIM: The present work investigates the efficacy of Polysorbate 80(P80) coated Kokum butter (KB) solid lipid nanoparticles (P80NvKLNs) for the brain targeted delivery of Nevirapine (Nv). METHODS: Solid lipid nanoparticles (SLNs) prepared by nanoprecipitation technique and evaluated for drug excipient compatibility studies, z- average particle size (nm), zeta potential (mv), percentage drug entrapment efficiency (%EE), surface morphology and in-vitro drug release properties...
January 31, 2019: Journal of Microencapsulation
https://read.qxmd.com/read/30699002/solid-lipid-nanoparticles-for-targeted-delivery-of-triclosan-into-skin-for-infection-prevention
#9
Pratibha G Kakadia, Barbara R Conway
Healthcare-associated infections are a concern for health service providers, exacerbated by poor delivery of antimicrobials to target sites within the skin. The dermal route is attractive for local and systemic delivery of drugs however; permeation, penetration and access to deeper skin layers are restricted due to the barrier function of the stratum corneum. Solid lipid nanoparticles present several benefits for topical delivery for therapeutic applications, especially via the follicular route. Hair follicles, surrounded by a close network of blood capillaries and dendritic cells, are an important target for delivery of antimicrobials and present a unique microbial nidus for endogenous infections in situations where the barrier is disrupted, such as after surgery, for example...
January 30, 2019: Journal of Microencapsulation
https://read.qxmd.com/read/30669915/evaluation-of-the-anticancer-activity-of-sprout-extract-loaded-nanoemulsion-of-n-sativa-against-hepatocellular-carcinoma
#10
Heena Tabassum, Iffat Zareen Ahmad
Nigella sativa L. belonging to Ranunculaceae family is an important medicinal spice which has been utilized to treat various chronic diseases. Lipid nanoemulsions containing oil from medicinal plants have shown to enhance drug dissolvability, diminish symptoms of different powerful medications and enhance the bioavailability of medications, in contrast with conventional formulations. In the present study, aqueous titration method was used to prepare nanoemulsion. The optimized formulation (NE11 ) with the mean particle size of 37...
January 23, 2019: Journal of Microencapsulation
https://read.qxmd.com/read/30669907/spectroscopic-and-computational-insights-into-theophylline-%C3%AE-cyclodextrin-complexation-inclusion-accomplished-by-diverse-methods
#11
Subhraseema Das, Jitendra Maharana, Subhrajit Mohanty, Usharani Subuddhi
Current scenario in asthmatic prevalence worldwide calls for a facile, cost effective and energy efficient methodology to formulate the potent bronchodilator, theophylline (THP), into an effective dosage forms. Since the uses of THP are severely impeded by its poor aqueous solubility and low bioavailability; solid inclusion complexes (ICs) of THP in β - cyclodextrin (β - CD) were prepared to overcome the limitations. The ICs were developed by conventional methods and also by microwave irradiation method, which is environmentally more benign and requires lesser reaction time...
January 23, 2019: Journal of Microencapsulation
https://read.qxmd.com/read/30669903/mesoporous-particle-based-microcontainers-for-intranasal-delivery-of-imidazopyridine-drugs
#12
Irina Marchenko, Tatiana Borodina, Daria Trushina, Irina Rassokhina, Yulia Volkova, Valerii Shirinian, Igor Zavarzin, Andrey Gogin, Tatiana Bukreeva
The aim of this study was to develop mesoporous containers for entrapment of imidazopyridines, such as sedative-hypnotic medicine zolpidem, anxiolytic agent alpidem and their derivatives. For this purpose, calcium carbonate (size 1.2 µm (PDI 0.6), Z-potential -10 mV), manganese carbonate (2.5 µm (PDI 0.5), Z-potential -12 mV) and titanium dioxide particles (3.7 µm (PDI 0.4), Z-potential -15 mV) were used. The compounds were encapsulated applying two techniques: adsorption on the preformed particles and coprecipitation during the synthesis of the particles...
January 23, 2019: Journal of Microencapsulation
https://read.qxmd.com/read/30592243/low-temperature-organic-phase-change-material-microcapsules-for-asphalt-pavement-preparation-characterization-and-application
#13
Feng Li, Siqi Zhou, Sai Chen, Jian Yang, Xingyi Zhu, Yuchuan Du, Zhenglong Yang
Low-temperature phase change material (PCM) is a material that stores additional heat at elevated temperatures and releases energy when the temperature is below the limit. A way to solve the low-temperature disaster of asphalt pavement is desired to be developed. In this article, a two-component organic low-temperature PCM was encapsulated by melamine-urea-formaldehyde resin and finally reinforced with polypropylene. The reinforced PCM microcapsules were mixed with 70# SBS (Styrene-Butadiene-Styrene) modified asphalt in SMA-10 (Stone Matrix Asphalt-10) to form aggregates...
December 28, 2018: Journal of Microencapsulation
https://read.qxmd.com/read/30582428/two-level-delivery-systems-based-on-caco3-cores-for-oral-administration-of-therapeutic-peptides
#14
Natalia Sudareva, Olga Suvorov, Natalia Saprykina, Natalia Smirnova, Petr Bel'tyukov, Sergey Petunov, Andrey Radilov, Alexander Vilesov
Two-level systems for oral delivery of therapeutic peptides were developed; the carriers consist of CaCO3 cores included into alginate granules. Such systems were first used for the delivery of low molecular weight drugs. It was shown that efficiency of encapsulation of peptides depends on their pI value, hydrophobicity, characteristics of the compounds used for doping CaCO3 cores, their surface? -potential and the techniques employed for loading peptides into the first-level carriers. Doping CaCO3 cores with dextran sulfate saves their viability compared to the pristine CaCO3 cores, but ensures delivery of the desired quantity of peptide when using a smaller amount of delivery systems...
December 24, 2018: Journal of Microencapsulation
https://read.qxmd.com/read/30557070/water-in-oil-in-water-double-emulsions-loaded-with-chlorogenic-acid-release-mechanisms-and-oxidative-stability
#15
Cristian Dima, Stefan Dima
Chlorogenic acid (CA) is a natural compound used as an antioxidant in the preparation of food, drugs and cosmetics. Due to their low stability and bioavailability, many researchers have studied the encapsulation of CA in various delivery colloidal systems. The aim of this study was to evaluate the stability of water-in-oil-in-water (W/O/W) double emulsions loaded with CA and its antioxidant capacity. For this purpose, CA-W/O/W double emulsions were prepared using Span 80 and lecithin as lipophilic emulsifiers, and Tween 20 as a hydrophilic emulsifier...
December 17, 2018: Journal of Microencapsulation
https://read.qxmd.com/read/30557069/preparation-optimization-and-storage-stability-of-nanoemulsion-based-lutein-delivery-systems
#16
Jinan Li, Rui Guo, Hao Hu, Xuejiao Wu, Lianzhong Ai, Yan Wu
The present work formed lutein-enriched nanoemulsions stabilized by sodium caseinate (SC) using a high-pressure homogenization process, and the influence of environmental conditions on the physicochemical stability of the nanoemulsion were investigated. The results showed that the droplet diameter of the nanoemulsion was largely dependent on homogenization conditions. Optimum results were obtained for 1.0% (w/w) SC, 100 MPa pressure, and 7 homogenization cycles, which produced a nanoemulsion with a mean droplet diameter of 234...
December 17, 2018: Journal of Microencapsulation
https://read.qxmd.com/read/30557060/development-and-evaluation-of-chrysin-phospholipid-complex-loaded-solid-lipid-nanoparticles-storage-stability-and-in-vitro-anti-cancer-activity
#17
Shahadali K, Anuj Garg, Wahajud Din
The aim of the present investigation was to prepare Chrysin-Phospholipid complex loaded solid lipid nanoparticles (Ch-PC-SLNs) for improving its encapsulation as compared to that of Chrysin loaded SLNs (Ch-SLNs) and evaluated for potential increase in the anti-cancer activity against MCF-7 cell line. The physiochemical characteristics and release kinetics for Ch-SLNs and Ch-PC-SLNs were evaluated and compared. Storage stability of Ch-PC-SLNs was evaluated up to 3 months. Solid state properties (DSC, XRD) and morphology (AFM) of Ch-PC-SLNs were also studied...
December 17, 2018: Journal of Microencapsulation
https://read.qxmd.com/read/30507316/glutathione-decorated-gold-magnetic-nanoparticles-efficient-and-recyclable-catalyst-for-biotechnological-and-pharmaceutical-applications
#18
Maryam Mohammadi, Reza Rezaei Mokarram, Hamed Hamishehkar
Nowadays, since the core-shell gold-magnetite nanoparticles include the saturation magnetization (iron oxide) and plasmon surface (gold shell) properties, they have been considered in biological and biomedicine research areas. In the present work, multifunctional glutathione decorated gold-coated iron oxide nanoparticles (GSH-AuMNPs) were successfully synthesized and fully characterized. From the absorption peak at 525, the formation of the core-shell GSH-AuMNPs was confirmed. Although the saturation magnetization value was slightly decreased during the formation process, they easily were recovered through magnetic decantation...
December 3, 2018: Journal of Microencapsulation
https://read.qxmd.com/read/30354849/microencapsulation-of-blackberry-pulp-with-arrowroot-starch-and-gum-arabic-mixture-by-spray-drying
#19
Gislaine Ferreira Nogueira, Luiz Gabriel Pereira Martin, Farayde Matta Fakhouri, Rafael Augustus de Oliveira
This research work aimed to obtain blackberry pulp powder by spray drying and, by an experimental design, evaluated the effect of inlet air temperature (100-150 °C) and blackberry pulp solids:arrowroot starch/gum arabic solids ratio of 1:0.5-1:2 on the physicochemical properties of the powders. Arrowroot starch and gum arabic present glass transition temperature (Tg) values above 100 °C; hence it was possible to employ them as carriers in blackberry pulp spray drying in order to increase Tg of the system...
November 30, 2018: Journal of Microencapsulation
https://read.qxmd.com/read/30332902/effects-of-polymerised-whey-protein-based-microencapsulation-on-survivability-of-lactobacillus-acidophilus-la-5-and-physiochemical-properties-of-yoghurt
#20
Mu Wang, Cuina Wang, Fen Gao, Mingruo Guo
Lactobacillus acidophilus LA-5 has poor survivability in yoghurts. This study aims to microencapsulate L. acidophilus LA-5 using polymerised whey protein as wall material and evaluate its survivability and effects on physiochemical properties of yoghurts. The microencapsulation yield was 92.90% and average beads size was 744 μm. Microencapsulated L. acidophilus LA-5 showed higher survival at simulated gastrointestinal conditions. Microencapsulated L. acidophilus LA-5 had improved survivability (∼106 cfu/mL) than free cells (∼104 cfu/mL) after digesting by simulated intestinal juice (6 h) in yoghurts during 10-week storage...
November 30, 2018: Journal of Microencapsulation
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