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Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology

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https://read.qxmd.com/read/30710219/effect-of-sofosbuvir-and-daclatasvir-on-lipid-profile-glycemic-control-and-quality-of-life-index-in-chronic-hepatitis-c-genotype-3-patients
#1
Ayush Jain, Bhupinder Singh Kalra, Siddharth Srivastava, Shalini Chawla
OBJECTIVES: The management of hepatitis C has progressed from interferon-based therapy to oral direct acting antiviral therapy. Deranged lipid levels (total cholesterol, triglyceride) after treatment with interferon-based therapy are well known. There is a paucity of data on changes in lipid profile, glycemic parameters and alteration in quality of life with the newer regimen. This study was designed to assess the changes in lipid profile, glycemic parameters, quality of life in chronic hepatitis C patients with genotype 3 after treatment with sofosbuvir and daclatasvir...
February 2, 2019: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://read.qxmd.com/read/30707420/fecal-evacuation-disorders-in-anal-fissure-hemorrhoids-and-solitary-rectal-ulcer-syndrome
#2
Mayank Jain, Rajiv Baijal, M Srinivas, Jayanthi Venkataraman
The causative factors for hemorrhoids, anal fissure, and solitary rectal ulcer syndrome (SRUS) are poorly understood. The study was done to identify the prevalence of fecal evacuation disorders in patients with anal fissure, hemorrhoids, and SRUS using anorectal manometry (ARM). Retrospective analysis of ARM data from three centers across India was done. Baseline demographic details and symptoms pertaining to bowel movements were noted. Limited colonoscopy details pertaining to hemorrhoids, fissure-in-ano, and SRUS were noted...
February 1, 2019: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://read.qxmd.com/read/30701442/the-metabolic-syndrome-and-its-components-as-prognostic-factors-in-metastatic-colorectal-cancer
#3
Melissa Reed, Caitlyn Patrick, Brianna Croft, Natalie Walde, Ioannis A Voutsadakis
BACKGROUND: Components of the metabolic syndrome (MetS) are involved in colorectal cancer development and the incidence of the disease is higher in obese and diabetic patients. Nevertheless, the value of these diseases or the MetS as a whole as prognostic markers once colorectal cancer is diagnosed is controversial. METHODS: Patients with metastatic colorectal cancer treated in our center over a 6-year period were reviewed and data on baseline characteristics of the patients and their cancers were extracted...
January 30, 2019: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://read.qxmd.com/read/30671786/primary-aortoesophageal-fistula-a-rare-cause-of-upper-gastrointestinal-bleeding
#4
Ankur Gupta, Arjun Poptani, Ambarish Satwik
No abstract text is available yet for this article.
January 22, 2019: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://read.qxmd.com/read/30671785/the-role-of-endoscopic-ultrasound-and-contrast-enhanced-endoscopy-ultrasound-in-a-case-of-cholangiocarcinoma
#5
Joana Rita Oliveira Alves Santos Carvalho, Flávio Pereira, Ana Caldeira, Eduardo Pereira, António Banhudo
No abstract text is available yet for this article.
January 22, 2019: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://read.qxmd.com/read/30645725/effectiveness-and-safety-of-adalimumab-biosimilar-in-inflammatory-bowel-disease-a-multicenter-study
#6
Nagesh Kamat, Saurabh Kedia, Uday C Ghoshal, Abhimanyu Nehra, Govind Makharia, Ajit Sood, Vandana Midha, Varun Gupta, Gourdas Choudhuri, Vineet Ahuja
BACKGROUND: Adalimumab has emerged as a useful drug for treating patients with Crohn's disease (CD) and ulcerative colitis (UC), not responding to conventional therapy. There is limited data on effectiveness and safety of adalimumab biosimilar in patients with inflammatory bowel disease (IBD). METHODS: Patients with IBD who received at least one dose of adalimumab biosimilar from October 2015 to February 2018 were retrospectively included in this multicenter data analysis...
January 15, 2019: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://read.qxmd.com/read/30637537/comparative-efficacy-of-sofosbuvir-ribavirin-versus-sofosbuvir-daclatasvir-for-treatment-of-chronic-hepatitis-c-in-an-area-with-limited-ns5a-inhibitor-availability
#7
Juferdy Kurniawan, Rino Alvani Gani, Irsan Hasan, Andri Sanityoso Sulaiman, Cosmas Rinaldi A Lesmana, Chynthia Olivia Maurine Jasirwan, Kemal Fariz Kalista, Saut Horas Hatoguan Nababan, Steven Zulkifly
INTRODUCTION: Sofosbuvir (SOF) and daclatasvir (DCV) regimens are recommended for all genotypes of hepatitis C virus (HCV) infection. However, DCV accessibility is still low in several low- and middle-income countries. Ribavirin (RBV) is more affordable and has been known for chronic HCV treatment along with SOF or interferon. The aim of this study was to assess the efficacy of SOF + RBV and SOF + DCV regimens for treatment of chronic HCV in Indonesia. METHODS: We conducted a retrospective study among patients with chronic HCV who were treated with SOF...
January 12, 2019: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://read.qxmd.com/read/30635887/comparison-between-daily-single-dose-triple-therapy-and-conventional-triple-therapy-on-patient-compliance-and-helicobacter-pylori-eradication-a-randomized-controlled-trial
#8
Shaahin Shahbazi, Zahra Vahdat Shariatpanahi
OBJECTIVE: The poor compliance to treatment of Helicobacter pylori-infected patients is well-known. We evaluated the efficacy of daily single-dose triple therapy as compared to conventional triple therapy on patient compliance and eradication of H. pylori infection. METHODS: In the study group, 105 patients received esomeprazole 40 mg, tinidazole 1 g, and levofloxacin 500 mg once-daily for 14 days. One hundred and seven patients in the control group received lansoprazole 30 mg, amoxicillin 1 g, and clarithromycin 500 mg twice-daily for 14 days...
January 12, 2019: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://read.qxmd.com/read/30628006/association-between-metabolic-syndrome-and-hepatobiliary-cancers-a-case-control-study
#9
Shyam Menon, Ray Mathew
BACKGROUND: The incidence of hepatobiliary cancer is steadily increasing. It is unclear if this rise is related to increasing trends in obesity, metabolic syndrome, and lifestyle changes. METHODS: A case-control study was performed using the Health Improvement Network (THIN) database. Cases with a diagnosis of liver, bile duct, and gallbladder cancers were matched in a 1:2 fashion with controls and analyzed for potential associations between hepatobiliary cancer and obesity/metabolic syndrome...
January 10, 2019: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://read.qxmd.com/read/30617919/indian-consensus-on-chronic-constipation-in-adults-a-joint-position-statement-of-the-indian-motility-and-functional-diseases-association-and-the-indian-society-of-gastroenterology
#10
Uday C Ghoshal, Sanjeev Sachdeva, Nitesh Pratap, Abhai Verma, Arun Karyampudi, Asha Misra, Philip Abraham, Shobna J Bhatia, Naresh Bhat, Abhijit Chandra, Karmabir Chakravartty, Sujit Chaudhuri, T S Chandrasekar, Ashok Gupta, Mahesh Goenka, Omesh Goyal, Govind Makharia, V G Mohan Prasad, N K Anupama, Maneesh Paliwal, Balakrishnan S Ramakrishna, D N Reddy, Gautam Ray, Akash Shukla, Rajesh Sainani, Shine Sadasivan, Shivaram P Singh, Rajesh Upadhyay, Jayanthi Venkataraman
The Indian Motility and Functional Diseases Association and the Indian Society of Gastroenterology developed this evidence-based practice guideline for management of chronic constipation. A modified Delphi process was used to develop this consensus containing 29 statements, which were generated by electronic voting iteration as well as face to face meeting and review of the supporting literature primarily from India. These statements include 9 on epidemiology, clinical presentation, and diagnostic criteria; 8 on pathophysiology; and the remaining 12 on investigations and treatment...
January 8, 2019: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://read.qxmd.com/read/30617470/esophageal-abrikossoff-tumor
#11
Rita Slim, Antoine Assaf, Claude Ghorra, Cesar Yaghi, Raymond Sayegh, Khalil Honein, Roger Noun
No abstract text is available yet for this article.
January 8, 2019: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://read.qxmd.com/read/30617918/multiple-rapid-swallow-testing-in-patients-with-gastroesophageal-reflux-disease
#12
Mayank Jain, Melpakkam Srinivas, Piyush Bawane, Jayanthi Venkataraman
Patients with gastroesophageal reflux disease are commonly referred to a gastrointestinal motility unit for assessment of esophageal physiology tests prior to an anti-reflux procedure. On esophageal manometry, most patients have normal peristalsis; however, minor disorders of motility such as ineffective esophageal motility and fragmented peristalsis are not uncommon. Multiple rapid swallow (MRS) test is a provocative method for assessing peristaltic reserve in such patients. We report our single-center experience on MRS testing...
January 7, 2019: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://read.qxmd.com/read/30593649/staging-systems-of-hepatocellular-carcinoma-a-review
#13
REVIEW
Sreeshma Tellapuri, Patrick D Sutphin, Muhammad S Beg, Amit G Singal, Sanjeeva P Kalva
Staging of hepatocellular carcinoma (HCC) is necessary for guiding prognostication, management, and research purposes that further aid in the improvement of existing clinical and epidemiological health services. Though there are some new staging systems for HCC developed in different parts of the world, there is no globally accepted staging system that allows for comparison of current management protocols among heterogeneous populations. In this review, we discuss the evolution and applicability in clinical practice of different clinical staging systems of HCC-Okuda, CLIP (Cancer of the Liver Italian Program) score, MESIAH (Model to Estimate Survival In Ambulatory HCC patients) score, ITA...
December 29, 2018: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://read.qxmd.com/read/30560540/hepatitis-c-virus-infection-and-chronic-renal-disease-a-review
#14
REVIEW
Amit Goel, Dharmendra Singh Bhadauria, Rakesh Aggarwal
Hepatitis C virus (HCV) is a parenterally-transmitted hepatotropic virus that often causes chronic infection, which can progress to cirrhosis and hepatocellular carcinoma. Development of highly effective direct-acting anti-viral agents (DAAs) has led to a paradigm change in the treatment of HCV infection over the last 4-5 years. Patients with chronic kidney disease (CKD) are at a higher risk of acquiring HCV infection. In these patients, diagnosis of HCV infection, assessment of the consequent liver disease and management of HCV infection pose some specific problems...
December 18, 2018: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://read.qxmd.com/read/30543047/epidemiology-of-hepatitis-b-and-c-viral-infections-in-ladakh-region
#15
Mushtaq Ahmad Khan, Shoukat Ali Zargar, Jaya Upadhyay, Tasleem Arif Lone, Rakesh Aggarwal, Gulnaz Bashir, Mohamad Ali, Stanzen Rabyang, Tashi Namgyal, Zaffar Ali Wani
BACKGROUND: Little is known about the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in Ladakh, a mountainous region with low population density. We, therefore, determined these and tried to identify risk factors associated with these infections. METHODS: Randomly selected residents of Ladakh region were tested for hepatitis B surface antigen (HBsAg), antibodies to hepatitis B core antigen (anti-HBc) and antibodies to HCV (anti-HCV)...
December 12, 2018: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://read.qxmd.com/read/30535917/reply-to-the-letter-to-editor-on-comparison-of-continuous-versus-intermittent-infusions-of-terlipressin-for-the-control-of-acute-variceal-bleeding-in-patients-with-portal-hypertension-an-open-label-randomized-controlled-trial
#16
LETTER
Sanjeev Kumar Jha, Manish Mishra, Ashish Jha, Vishwa Mohan Dayal
No abstract text is available yet for this article.
December 10, 2018: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://read.qxmd.com/read/30535747/comparative-study-of-intestinal-malrotation-in-infant-children-and-adult-in-a-tertiary-care-center-in-india
#17
Utpal Anand, Ramesh Kumar, Rajeev N Priyadarshi, Bindey Kumar, Sanjay Kumar, Vijay Prakash Singh
BACKGROUND: Intestinal malrotation (IM) is an uncommon condition and has varied presentation in different age groups. The study was aimed to evaluate differences in the clinical presentation, diagnosis, treatment, and outcome of IM in infants, children, and adults. METHODS: Data were collected from records of 79 patients with IM. Based on the age of presentation, these patients were categorized into three age groups: infants (up to 1 year), children (1-18 years), and adults (> 18 years)...
December 7, 2018: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://read.qxmd.com/read/30535627/gastrointestinal-kaposi-sarcoma
#18
Varun Kesar, Uday Shergill, Vivek Kesar, Elena Ivanina
No abstract text is available yet for this article.
December 7, 2018: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://read.qxmd.com/read/30421393/study-of-glutathione-s-transferase-levels-in-patients-receiving-intravenous-paracetamol-perioperatively-a-randomized-controlled-trial
#19
Satyen Parida, Ramesh Panga, Medha Rajappa, Pankaj Kundra
BACKGROUND AND AIMS: Many studies have analyzed the effect of paracetamol on liver functions. The aim of this study was to measure glutathione S-transferase (GST) concentrations in patients receiving intravenous (IV) paracetamol infusions as part of their perioperative pain relief regimen to assess its effect on hepatocellular integrity. METHODS: Patients between the ages of 18 and 60 years of both sexes, of American Society of Anesthesiologists (ASA) grades 1 and 2, undergoing laparoscopic gastrointestinal (GI) surgeries were included in the study...
November 12, 2018: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://read.qxmd.com/read/30474827/preliminary-experience-with-single-fecal-microbiota-transplant-for-treatment-of-recurrent-overt-hepatic-encephalopathy-a-case-series
#20
Rajiv Mehta, Mayank Kabrawala, Subhash Nandwani, Parika Kalra, Chintan Patel, Pankaj Desai, Krishna Parekh
Experimental studies demonstrated that fecal microbiota transplant (FMT) may reverse intestinal microbial dysbiosis. In this retrospective case series, we share our experience of treating recurrent overt hepatic encephalopathy (HE) with single FMT treatment. A total of 10 patients, age ranged from 25 to 65 years, were treated with single FMT through colonoscopy using fecal material received from rigorously screened patient-identified donors. There was sustained clinical response with single FMT treatment in 6 patients at post-treatment week 20...
November 2018: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
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