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Endocrine Research

Yan Tan, Wei Chen, Chun Liu, Xiaoya Zheng, Ai Guo, Jian Long
Graves' disease (GD) is a common organ-specific autoimmune disease, and its pathogenesis is still unclear. The aim of this study is to investigate the role of interleukin (IL)-21 in the regulation of Th17/Treg cells in GD. We recruited 28 newly diagnosed GD patients, 27 GD patients in remission (eGD), and 24 normal controls (NC). Thyroid function and autoantibodies were evaluated by electrochemical luminescence. Peripheral blood mononuclear cells (PBMCs) were isolated and cultured with or without recombinant human interleukin-21 (rhIL-21), and mRNA and protein levels were quantified by real-time PCR and ELISA, respectively...
May 4, 2019: Endocrine Research
Rita A Gómez-Díaz, Martha Rodríguez-Moran, Rafael Mondragón-González, Niels H Wacher, Fernando Guerrero-Romero
Given that adipocytokines may play an important role in the pathophysiology of high blood pressure (HBP) and because related reports in children are scarce and controversial, we evaluated the relationship of leptin, resistin, tumor necrosis factor-α, interleukin-6, adiponectin, and interferon-γ with HBP. MATERIALS AND METHODS: A total of 129 (53.8%) girls and 111 (46.2%) boys, with average ages of 10.8 ± 0.9 and 10.6 ± 1.0 years, respectively, were enrolled in a cross-sectional study...
May 1, 2019: Endocrine Research
Shuying Li, Jiangfeng Mao, Xi Wang, Min Nie, Xueyan Wu
OBJECTIVE: Pituitary hormones are critical for bone development and maturation. It is currently unknown whether congenital multiple pituitary hormone deficiency (CMPHD) is associated with osteonecrosis of femoral head (ONFH). METHODS: Clinical presentations and hormonal profiles of three patients with CMPHD and ONFH were retrospectively described. The incidence of ONFH in this population was studied. RESULTS: (1) Congenital hypopituitarism was diagnosed in three patients...
April 10, 2019: Endocrine Research
Hung-Yun Lin, Heng-Yuan Tang, Matthew Leinung, Shaker A Mousa, Aleck Hercbergs, Paul J Davis
BACKGROUND: Reverse T3 (rT3; 3,3',5'-triiodo-L-thyronine) is widely regarded as an inactive naturally occurring analog of thyroid hormone. rT3 is known to bind to the thyroid hormone analog receptor on plasma membrane integrin αvβ3. This integrin is generously expressed by tumor cells and is the initiation site for the stimulation by L-thyroxine (T4) at physiological free concentrations on cancer cell proliferation. RESULTS: In the present studies, we show that rT3 caused increases of proliferation in vitro of 50% to 80% (P < 0...
April 3, 2019: Endocrine Research
Saori Kashima, Kazuo Inoue, Masatoshi Matsumoto, Kimihiko Akimoto
AIM: White blood cell (WBC) count or C-reactive protein (CRP) level alone may not fully indicate the chronic inflammation causing type 2 diabetes. We examined both WBC count and CRP level, independently and in combination, as predictive markers for type 2 diabetes and also considered the influence of obesity and other individual characteristics on the relationship. MATERIALS AND METHODS: In total, 9,706 participants were enrolled with WBC < 10*109 /L and CRP < 10 mg/L using data from the Yuport Medical Checkup Center Study...
March 21, 2019: Endocrine Research
Jihong Ma, Xiaodong Wang, Mao Zheng, Haizhu Yu, Junmin Ma, Xiaohang Li, Jingye Pan, Yueyue Huang
AIMS: To investigate the association between body mass index (BMI) and all-cause mortality in patients with type 2 diabetes mellitus (T2DM) and to determine any sex-specific differences in this association. METHODS: We retrospectively enrolled patients with T2DM and investigated the annual death data for seven years starting from 2010. All-cause mortality was calculated using Life Tables analysis. Multivariate Cox proportional hazards analysis was performed to identify the association between BMI and mortality...
February 18, 2019: Endocrine Research
Tsuyoshi Ohishi, Tomotada Fujita, Tatsuya Nishida, Mitsuru Asukai, Daisuke Suzuki, Kaori Sugiura, Yukihiro Matsuyama
PURPOSE: The correlation between serum levels of homocysteine and bone mineral density remains controversial. The aim of this study was to identify the potential factors associated with the levels of serum total homocysteine (S-Hcy) and urinary N-terminal telopeptide of type I collagen (U-NTX) in female osteoporotic patients. MATERIALS AND METHODS: This cross-sectional study included 163 female osteoporotic patients, aged between 48 and 91 years, who had never been treated with anti-osteoporosis therapy...
February 14, 2019: Endocrine Research
Louise Justesen, Rasmus Ribel-Madsen, Linn Gillberg, Ninna S Hansen, Anne Louise Wulff, Louise G Grunnet, Charlotte Brøns
AIM: The TCF7L2 gene variant rs7903146 has the largest effect on type 2 diabetes risk reported in genome-wide association studies, however its role in adipose tissue development and function is unknown. We investigate the association between gene variant rs7903146 and metabolic parameters and examine in vitro and ex vivo gene expression of TCF7L2 in human adipose tissue and progenitor cells from two independent populations of young healthy men with increased risk of type 2 diabetes due to low birth weight (LBW)...
February 5, 2019: Endocrine Research
Marcella D Walker, Haley M Zylberberg, Peter H R Green, Michael S Katz
PURPOSE: The purpose of this article is to review recent literature regarding endocrine disorders related to celiac disease (CD). METHODS: We describe a case report and review existing literature on the endocrine manifestations of CD. RESULTS: CD is an autoimmune disorder characterized by intestinal inflammation in response to gluten. CD can cause a wide range of extra-intestinal complications, including endocrine manifestations. Metabolic bone disease including osteoporosis and osteopenia, vitamin D deficiency, secondary hyperparathyroidism and less frequently osteomalacia can be seen...
February 2019: Endocrine Research
Elizabeth Langley, Rafael Velazquez-Cruz, Alma Parra-Torres, Juana Enríquez
PURPOSE: It has been proposed that DHEA influences bone formation through, bioconversion to 17β-estradiol; however, DHEA is converted to Δ5-androstenediol (Δ5-Adiol), a metabolite with estrogenic potential involved in diverse biological process. To gain new insight into the role of Δ5-Adiol in bone cells, we examined DHEA and Δ5-Adiol effects in neonatal rat and human hFOB1.19 osteoblasts. METHODS: Osteoblast activity was assessed by analyzing proliferation, alkaline phosphatase activity, and expression of OSX and ALPL...
December 24, 2018: Endocrine Research
Sorin Ioacara, Cristian Guja, Constantin Ionescu-Tirgoviste, Sorina Martin, Cristina Tiu, Simona Fica
AIMS: To study the age and sex-dependent mortality rates and causes of death in a large Romanian diabetes cohort as compared with the general population. METHODS: All adult patients aged 20-64 years, receiving a free diabetes prescription in a major urban area during 2001-2008 were included and followed-up for death until December 31, 2011. Crude mortality rates and standardized mortality rate ratios (SMR) against general population (data from the National Institute of Statistics) were calculated...
November 13, 2018: Endocrine Research
Farah Al-Ansari, Hooshang Lahooti, Leanne Stokes, Senarath Edirimanne, Jack Wall
Purpose/aim of the study: Graves' ophthalmopathy (GO) is closely related to the thyroid autoimmune disorder Graves' disease. Previous studies have suggested roles for thyroidal CD8+  T cells and autoimmunity against calsequestrin-1 (CASQ)-1 in the link between thyroidal and orbital autoimmune reactions in GO. A role for autoimmunity against CollXIII has also been suggested. In this study, we aimed to investigate correlations between some thyroidal and peripheral blood T-cell subsets and thyroidal T-cell reactivity against CASQ1 and CollXIII in patients with GO...
November 2018: Endocrine Research
Elizabeth F Sutton, Christopher D Morrison, Jacqueline M Stephens, Leanne M Redman
AIM OF THE STUDY: The regulation and actions of fibroblast growth factor 21 (FGF21) are responsive to energy status and macronutrient balance, and investigations of FGF21 in normal pregnancy, which could be informative for FGF21 biology, are seldom. The goal of our study was to examine FGF21 levels in a contemporary healthy, pregnant population. METHODS: We phenotyped 43 women with overweight and obesity during pregnancy for weight, body composition, and fasting blood...
November 2018: Endocrine Research
Banu Yurekli, Nilufer Ozdemir Kutbay, Canan Altay, Sadiye Mehtat Unlu, Sait Sen, Huseyin Onay, Tahir Atik, Baris Akinci
PURPOSE: To describe an interesting subtype of familial partial lipodystrophy (FPLD). METHODS: The phenotype of this distinctive FPLD subtype was studied in three Turkish female siblings. RESULTS: Mutation testing was negative for the genes associated with lipodystrophy syndromes. In MRI studies, fat loss was prominent in the posterior aspects of the proximal lower limbs, whilst some fat was preserved in the anterior, medial and lateral aspects...
November 2018: Endocrine Research
Eliza Pawlik-Pachucka, Monika Budzinska, Zofia Wicik, Anna Domaszewska-Szostek, Magdalena Owczarz, Malgorzata Roszkowska-Gancarz, Magdalena Gewartowska, Monika Puzianowska-Kuznicka
PURPOSE: It is not established if healthy aging of the thyroid axis is associated with alterations other than changes in hormone secretion. METHODS: The expression of thyroid hormone receptor β gene (THRB) was analyzed in peripheral blood mononuclear cells (PBMC) obtained from young, elderly, and long-lived individuals. The interaction between the 3'UTR of TRβ1 mRNA and selected miRNAs was measured using pmirGLO reporter vector. Methylation of the THRB CpG island was analyzed using methylation-sensitive restriction/RT-PCR and bisulfite sequencing methods...
November 2018: Endocrine Research
Marco Alessandro Minetto, Cristina Caresio, Valentina D'Angelo, Fabio Lanfranco, Lucia Ghizzoni, Silvestro Roatta, Emanuela Arvat, Santosh Kesari
PURPOSE: We present a patient with adrenal Cushing's syndrome causing steroid myopathy. The purpose of the case report is to illustrate the clinical usefulness of quantitative muscle ultrasonography for the assessment of glucocorticoid-induced changes in muscle mass (MM) and structure. METHODS: Assessments of physical performance, muscle strength, MM (i.e., total body skeletal MM, appendicular skeletal MM, and thickness of lower limb muscles), and muscle structure (i...
November 2018: Endocrine Research
Yen-Chun Chen, Chang-Hung Kuo, Ying-Ming Tsai, Yi-Ching Lin, Hui-Pin Hsiao, Bai-Hsiun Chen, Yi-Ting Chen, Shih-Ling Wang, Chih-Hsing Hung
PURPOSE OF THE STUDY: Type 1 and type 2 diabetes mellitus (DM) are chronic T-cell-mediated inflammatory diseases. Metformin is a widely used drug for type 2 DM that reduces the need for insulin in type 1 DM. However, whether metformin has an anti-inflammatory effect for treating DM is unknown. We investigated the anti-inflammatory mechanism of metformin in the human monocytic leukemia cell line THP-1. MATERIALS AND METHODS: The human monocytic leukemia cell line THP-1 was pretreated with metformin and stimulated with lipopolysaccharide (LPS)...
November 2018: Endocrine Research
Naciye Isbil-Buyukcoskun, Betul Cam, Guldal Gulec Suyen, Kasim Ozluk
PURPOSE: The present study aims to investigate the effects of intracerebroventricularly (i.c.v.)-injected glucagon-like peptide-2 (GLP-2) on ethanol-induced gastric mucosal damage and to reveal the mechanisms involved in this effect. MATERIALS AND METHODS: Rats received absolute ethanol orally via an orogastric tube 30 minutes after GLP-2 (1-200 ng/10 µl; i.c.v.) or saline (10 µl) injections. They were decapitated 1 hour later, their stomachs were removed, and the gastric mucosal damage was scored...
November 2018: Endocrine Research
John T Leith, Aleck Hercbergs, Susan Kenney, Shaker A Mousa, Paul J Davis
PURPOSE: Integrin αvβ3 is an important structural and signaling protein of the plasma membrane of cancer cells and dividing blood vessel cells. The plastic extracellular domain of the protein binds to extracellular matrix proteins and plasma membrane proteins, changing cell-cell interactions and generating intracellular signals that influence cell behavior. αvβ3 also contains a receptor for thyroid hormone and derivatives, including tetraiodothyroacetic acid (tetrac). MATERIALS AND METHODS: Human prostate cancer (PC3) cells were engrafted in the chicken chorioallantoic membrane model...
November 2018: Endocrine Research
Hyun Yoon, Yo Sang Yoon, Sung Gil Kim, Hye Jong Oh, Cheol Won Choi, Jeong Min Seong, Jong Park
AIMS: The present study was conducted to assess the association of metabolic syndrome (MetS) and the MetS score (MSS) with β-cell function by gender in Korean non-diabetic populations. METHODS: This study used the data from the 2015 Korean National Health and Nutrition Examination Survey including 4380 adults, aged 20 or older. RESULTS: After adjusting for related variables (with exception of body mass index [BMI]), MetS (p < 0.001) and MSS (p < 0...
October 19, 2018: Endocrine Research
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