journal
https://read.qxmd.com/read/38719694/nanogel-mediated-antigen-delivery-biocompatibility-immunogenicity-and-potential-for-tailored-vaccine-design-across-species
#21
JOURNAL ARTICLE
Maria Laura Soriano Pérez, Ivana Montironi, Javier Alejandro Funes, Carlos Margineda, Noelia Campra, Laura Noelia Cariddi, Juan José Garrido, Maria Molina, Fabrisio Alustiza
Nanotechnology has emerged as a promising avenue for enhancing the efficacy of vaccine delivery systems. This study investigates the utilization of nanogels as carriers for the model antigen ovalbumin, with a focus on in vivo assessments in equine and murine models. Nanogels, owing to their biocompatibility and tunable physicochemical properties, offer a versatile platform for efficient antigen encapsulation and controlled release. The encapsulation efficiency and physicochemical characteristics of ovalbumin-loaded nanogels were comprehensively characterized...
May 7, 2024: Vaccine
https://read.qxmd.com/read/38719693/evaluation-of-antibody-responses-in-healthcare-workers-before-after-meningococcal-vaccine-and-determination-of-meningococcal-carriage-rates
#22
JOURNAL ARTICLE
Dilsah Baskol Elik, Cigdem Yıldırım, Deniz Akyol Seyhan, Huseyin Aytac Erdem, Aysin Zeytinoglu, Husnu Pullukcu, Sabire Sohret Aydemir, Meltem Tasbakan
The rates of nasopharyngeal meningococcal carriage in healthcare workers are unknown. Meningococcal vaccine is recommended for risk groups but healthcare workers are not included in risk groups for many countries. Herein, we aimed to investigate the nasopharyngeal meningococcal carriage rates, basal and after one dose of Men-ACWY-DT vaccine response on the 30th day by evaluating meningococcus IgG antibody levels and decolonization at month six after vaccination among the detected carriers. Nasopharyngeal swab samples were taken before vaccination to evaluate meningococcal carriage in healthcare workers...
May 7, 2024: Vaccine
https://read.qxmd.com/read/38719692/strategies-to-strengthen-covid-19-vaccine-uptake-and-improve-vaccine-equity-in-u-s-territories-and-freely-associated-states-during-the-first-six-months-of-vaccine-rollout
#23
JOURNAL ARTICLE
Ashley Tippins, Jeniffer Concepción Acevedo, Francisco S Palomeque, Kelsey C Coy, Phillippa Chadd, Daniel Stowell, Oluwatomiloba Ademokun, Carter Apaisam, Merlyn Basilius, Richard Brostrom, Ivan O Garcia Collazo, Justa Encarnacion, Iris Cardona Gerena, Thane Hancock, Tai Hunte-Ceasar, Peter Judicpa, Michele Leon-Guerrero, Milton Martinez, Yolanda Masunu, Heather Pangelinan, Emman Parian, Daisy Pedro
The eight U.S. territories and freely associated states (TFAS) have historically faced unique social and structural barriers in the implementation of vaccination programs due to geographic remoteness, a high prevalence of socioeconomic disparities, increasing prevalence of natural disasters, limited vaccine providers and clinics, difficulties with procurement and shipping, and difficulty tracking highly mobile populations. In the months leading up to emergency authorizations for the use of COVID-19 vaccines, the TFAS developed tailored vaccination strategies to ensure that key at-risk populations received timely vaccination, and successfully implemented these strategies during the first six months of the vaccine rollout...
May 7, 2024: Vaccine
https://read.qxmd.com/read/38719691/dominant-b-cell-t-cell-epitopes-instigated-robust-immune-response-in-silico-against-scrub-typhus
#24
JOURNAL ARTICLE
Shalini Agarwal, Hitesh Harsukhbhai Chandpa, Shovan Naskar, Chhuttan Lal Meena, Amulya Kumar Panda, Jairam Meena
Scrub typhus, a potentially life-threatening infectious disease, is attributed to bacteria Orientia tsutsugamushi (O. tsutsugamushi). The transmission of this illness to humans occurs through the bite of infected chiggers, which are the larval forms of mites belonging to the genus Leptotrombidium. In this research, we developed a subunit vaccine specifically designed to target outer membrane proteins. Immunodominant cytotoxic T-lymphocytes (CTLs), B- lymphocytes (BCLs), and major histocompatibility complex (MHC)- II epitopes were identified using machine learning and bioinformatics approaches...
May 7, 2024: Vaccine
https://read.qxmd.com/read/38719690/hypothetical-adhesin-cam87009-1-formulated-in-alum-or-biogenic-silver-nanoparticles-protects-mice-from-lethal-infection-by-multidrug-resistant-acinetobacter-baumannii
#25
JOURNAL ARTICLE
Stella Buchhorn de Freitas, Amilton Clair Pinto Seixas Neto, Luciano Aparecido Panagio, Mauro Pereira Soares, Daiane Drawanz Hartwig
Due to its antimicrobial resistance characteristics, the World Health Organization (WHO) classifies A. baumannii as one of the critical priority pathogens for the development of new therapeutic strategies. Vaccination has been approached as an interesting strategy to overcome the lack of effective antimicrobials and the long time required to develop and approve new drugs. In this study, we aimed to evaluate as a vaccine the hypothetical adhesin protein CAM87009.1 in its recombinant format (rCAM87009.1) associated with aluminum hydroxide (Alhydrogel®) or biogenic silver nanoparticles (bio-AgNP) as adjuvant components against lethal infection by A...
May 7, 2024: Vaccine
https://read.qxmd.com/read/38714451/impact-of-interventions-to-improve-hpv-vaccination-acceptance-and-uptake-in-school-based-programs-findings-of-a-pilot-project-in-quebec
#26
JOURNAL ARTICLE
Maude Dionne, Doriane Étienne, Holly O Witteman, Chantal Sauvageau, Ève Dubé
CONTEXT: Vaccination coverage against human papillomavirus (HPV) in school-based programs in Quebec, Canada, is suboptimal despite more than a decade of introduction. Three interventions to improve HPV vaccine acceptability and coverage in school-based programs were developed, implemented as part of a multicomponent strategy and evaluated. METHOD: Sixty-four (64) schools were recruited, of which 32 received the interventions (pilot schools), and 32 received usual vaccination activities (control schools)...
May 6, 2024: Vaccine
https://read.qxmd.com/read/38714450/trust-in-governments-public-health-institutions-and-other-information-sources-as-determinants-of-covid-19-vaccine-uptake-behavior-in-japan
#27
JOURNAL ARTICLE
Alton Cao, Mami Ueta, Manae Uchibori, Michio Murakami, Hiroyuki Kunishima, Rauniyar Santosh Kumar, Prapichaya Prommas, Hana Tomoi, Stuart Gilmour, Haruka Sakamoto, Masahiro Hashizume, Wataru Naito, Tetsuo Yasutaka, Keiko Maruyama-Sakurai, Hiroaki Miyata, Shuhei Nomura
OBJECTIVES: Trust in governments and public institutions as a determinant of public health outcomes has gained increased attention since the COVID-19 pandemic. Provided historically low confidence in vaccines in Japan, investigating the role of trust in information sources and actual COVID-19 vaccination uptake behavior will be invaluable for future vaccine promotion policymaking. Therefore, the objective of this study was to elucidate the determinants of COVID-19 vaccination uptake and evaluate the relationship between trust in different information sources and COVID-19 vaccination behavior in Japan...
May 6, 2024: Vaccine
https://read.qxmd.com/read/38714449/low-neutralization-of-sars-cov-2-omicron-ba-5-2-48-and-xbb-1-sub-variants-in-response-to-breakthrough-infection-by-booster
#28
JOURNAL ARTICLE
Jianhua Li, Liming Gong, Jiaxuan Li, Zhenyu Gong, Xiaoxiao Wang, Hao Yan, Yanjun Zhang, Haiyan Mao, Keda Chen
To assess the levels of and neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its mutants in serum samples from patients with breakthrough infection. Sixty-four patients with breakthrough infections were recruited for this cross-sectional study. All samples were used to neutralizing antibodies (nAbs) against SARS-CoV-2 and its mutants using a focused reduction neutralization assay. A total of 512 serum samples were obtained from unvaccinated patients who received one dose of vaccine (n = 12), received two doses of vaccine (n = 15), and received three doses of vaccine (n = 37)...
May 6, 2024: Vaccine
https://read.qxmd.com/read/38714448/virus-like-particle-based-multipathogen-vaccine-of-fmd-and-sva-elicits-balanced-and-broad-protective-efficacy-in-mice-and-pigs
#29
JOURNAL ARTICLE
Hetao Song, Sahibzada Waheed Abdullah, Shuanghui Yin, Hu Dong, Yun Zhang, Shuzhen Tan, Manyuan Bai, Yaozhong Ding, Zhidong Teng, Shiqi Sun, Huichen Guo
Inactivated vaccines lack the capability to serologically differentiate between infected and vaccinated animals, thereby impeding the effective eradication of pathogen. Conversely, vaccines based on virus-like particles (VLPs) emulate natural viruses in both size and antigenic structure, presenting a promising alternative to overcome these limitations. As the complexity of swine infectious diseases increases, the increase of vaccine types and doses may intensify the stress response. This exacerbation can lead to diminished productivity, failure of immunization, and elevated costs...
May 6, 2024: Vaccine
https://read.qxmd.com/read/38714447/mrna-covid-19-vaccine-safety-among-older-adults-from-the-canadian-national-vaccine-safety-network
#30
JOURNAL ARTICLE
Phyumar Soe, Hubert Wong, Monika Naus, Matthew P Muller, Otto G Vanderkooi, James D Kellner, Karina A Top, Manish Sadarangani, Jennifer E Isenor, Kimberly Marty, Gaston De Serres, Louis Valiquette, Allison McGeer, Julie A Bettinger
This study examined short-to-medium term safety of COVID-19 vaccines among adults aged ≥65 years using the Canadian National Vaccine Safety Network active safety surveillance data. Both vaccinated and unvaccinated older adult participants recruited from seven provinces and territories were included in the analysis. Safety was assessed at 7 days after COVID-19 vaccination (dose 1, 2 and 3), and 7 months after dose 1. Multivariable logistic regression was used to examine the association between BNT162b2/mRNA-1273 COVID-19 vaccines and two short-term health events: 1) health event preventing daily activities and/or required medical consultation, 2) serious health events resulting in an emergency department visit and/or hospitalization within 7 days following each dose...
May 6, 2024: Vaccine
https://read.qxmd.com/read/38714446/intranasal-immunization-with-the-bivalent-sars-cov-2-vaccine-effectively-protects-mice-from-nasal-infection-and-completely-inhibits-disease-development
#31
JOURNAL ARTICLE
Tuksin Jearanaiwitayakul, Panya Sunintaboon, Anuwat Kittiayuwat, Jitra Limthongkul, Jidapar Wathanaphol, Yada Janhirun, Hatairat Lerdsamran, Witthawat Wiriyarat, Sukathida Ubol
With the continuous emergence of coronavirus disease 2019 (COVID-19) waves, the scientific community has developed a vaccine that offers broad-spectrum protection at virus-targeted organs for inhibiting the transmission and protection of disease development. In the present study, a bivalent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine containing receptor-binding domain (RBD) protein of spike from Wuhan-1 and omicron BA.1 loaded in nanoparticles, bivalent RBD NPs, was developed. The immunogenicity and protective efficacy of this vaccine candidate were evaluated using an in vivo model...
May 6, 2024: Vaccine
https://read.qxmd.com/read/38714445/insufficient-vaccine-coverage-and-vaccine-hesitancy-in-people-living-with-hiv-a-prospective-study-in-outpatient-clinics-in-the-paris-region
#32
JOURNAL ARTICLE
Agnieszka Kolakowska, Esaïe Marshall, Evguenia Krastinova, Agnès Cros, Claudine Duvivier, Pierre Leroy, Fabienne Caby, David Zucman, Arthur Maka, Dominique Salmon, Antoine Chéret
Vaccine prevention strategies play a crucial role in the management of people living with HIV (PLWH). The aim of this study was to assess vaccination coverage and identify barriers to vaccine uptake in PLWH in the Paris region. A cross-sectional survey was conducted in PLWH in 16 hospitals in the Paris region. The vaccination status, characteristics, opinions, and behaviors of participants were collected using a face-to-face questionnaire and from medical records. A total of 338 PLWH were included (response rate 99...
May 6, 2024: Vaccine
https://read.qxmd.com/read/38714444/cross-protective-efficacy-and-safety-of-an-adenovirus-based-universal-influenza-vaccine-expressing-nucleoprotein-hemagglutinin-and-the-ectodomain-of-matrix-protein-2
#33
JOURNAL ARTICLE
Jooyoung Kim, Jun Chang
It is necessary to develop universal vaccines that act broadly and continuously to combat regular seasonal epidemics of influenza and rare pandemics. The aim of this study was to find the optimal dose regimen for the efficacy and safety of a mixture of previously developed recombinant adenovirus-based vaccines that expressed influenza nucleoprotein, hemagglutinin, and ectodomain of matrix protein 2 (rAd/NP and rAd/HA-M2e). The vaccine efficacy and safety were measured in the immunized mice with the mixture of rAd/NP and rAd/HA-M2e intranasally or intramuscularly...
May 6, 2024: Vaccine
https://read.qxmd.com/read/38714443/a-recombinant-il-1%C3%AE-vaccine-attenuates-bleomycin-induced-pulmonary-fibrosis-in-mice
#34
JOURNAL ARTICLE
Hanchao Li, Qian Li, Zhaoyang Hao, Lijuan Zhang, Xiaoyan Zheng, Li Zhu, Yongwei Huo, Hong Tian, Lan He, Zhiming Hao
Interleukin-1β (IL-1β) contributes to interstitial lung disease (ILD) and pulmonary fibrosis (PF), thus representing a potential therapeutic target for PF. In this study, we first verified the increased expression of IL-1β in human fibrotic lung specimens and mouse lung tissues after intratracheal (i.t.) instillation of bleomycin (BLM), after which the pro-inflammatory and pro-fibrotic effects of recombinant IL-1β were tested in mice. The results above suggested that vaccination against IL-1β could be an effective strategy for managing PF...
May 6, 2024: Vaccine
https://read.qxmd.com/read/38714442/variation-in-incidence-rates-of-outcomes-relevant-to-vaccine-safety-monitoring-in-a-us-commercially-insured-population-by-case-identification-algorithm
#35
JOURNAL ARTICLE
Christopher L Crowe, Jill Dreyfus, Stephan Lanes, Haechung Chung, Wendy Watson
BACKGROUND: Large health insurance claims databases can be used to estimate rates of rare safety outcomes. We measured incidence rates of rare outcomes that could be used to contextualize adverse events among people receiving pneumococcal vaccines in clinical trials or clinical practice. However, algorithms used to identify outcomes in administrative databases are subject to error. Using two algorithms for each outcome, we assessed the influence of algorithm choice on the rates of the outcomes...
May 6, 2024: Vaccine
https://read.qxmd.com/read/38705805/immunogenicity-and-immunodominant-linear-b-cell-epitopes-of-a-new-dna-based-tetravalent-vaccine-against-four-major-enteroviruses-causing-hand-foot-and-mouth-disease
#36
JOURNAL ARTICLE
Aliyu Maje Bello, Khuanjit Chaimongkolnukul, Kanokwan Poomputsa, Phenjun Mekvichitsaeng, Yaowaluck Maprang Roshorm
Hand, foot, and mouth disease (HFMD) poses a significant public health threat primarily caused by four major enteroviruses: enterovirus 71 (EV71), coxsackieviruses A16, A10, and A6. Broadly protective immune responses are essential for complete protection against these major enteroviruses. In this study, we designed a new tetravalent immunogen for HFMD, validated it in silico, in vivo evaluated the immunogenicity of the DNA-based tetravalent vaccine in mice, and identified immunogenic B-cell and T-cell epitopes...
May 4, 2024: Vaccine
https://read.qxmd.com/read/38705804/safety-and-immunogenicity-of-ad26-cov2-s-in-adults-a-randomised-double-blind-placebo-controlled-phase-2a-dose-finding-study
#37
JOURNAL ARTICLE
Vicky Cárdenas, Mathieu Le Gars, Carla Truyers, Javier Ruiz-Guiñazú, Frank Struyf, Alicia Colfer, Marc Bonten, Alberto Borobia, Emil C Reisinger, Ingrid M C Kamerling, Macaya Douoguih, Jerald Sadoff
BACKGROUND: A single dose of Ad26.COV2.S is well-tolerated and effective in preventing moderate-to-severe disease outcomes due to COVID-19. We evaluated the impact of dose level, number of doses, and dose interval on immunogenicity, reactogenicity, and safety of Ad26.COV2.S in adults. Anamnestic responses were also explored. METHODS: This randomised, double-blind, placebo-controlled, Phase 2a study was conducted in adults aged 18-55 years and ≥ 65 years (NCT04535453)...
May 4, 2024: Vaccine
https://read.qxmd.com/read/38704263/effectiveness-of-13-valent-pneumococcal-conjugate-vaccine-for-prevention-of-invasive-pneumococcal-disease-among-children-in-the-united-states-between-2010-and-2019-an-indirect-cohort-study
#38
JOURNAL ARTICLE
Kristin L Andrejko, Ryan Gierke, Jemma V Rowlands, Jennifer B Rosen, Ann Thomas, Zachary Q Landis, Maria Rosales, Sue Petit, William Schaffner, Corinne Holtzman, Meghan Barnes, Monica M Farley, Lee H Harrison, Lesley McGee, Sopio Chochua, Jennifer R Verani, Adam L Cohen, Tamara Pilishvili, Miwako Kobayashi
BACKGROUND: A U.S. case-control study (2010-2014) demonstrated vaccine effectiveness (VE) for ≥ 1 dose of the thirteen-valent pneumococcal conjugate vaccine (PCV13) against vaccine-type (VT) invasive pneumococcal disease (IPD) at 86 %; however, it lacked statistical power to examine VE by number of doses and against individual serotypes. METHODS: We used the indirect cohort method to estimate PCV13 VE against VT-IPD among children aged < 5 years in the United States from May 1, 2010 through December 31, 2019 using cases from CDC's Active Bacterial Core surveillance, including cases enrolled in a matched case-control study (2010-2014)...
May 3, 2024: Vaccine
https://read.qxmd.com/read/38704262/the-correlation-between-conspiracy-mentality-and-vaccine-intentions-is-moderated-by-social-events-evidence-from-longitudinal-data-during-covid-19-pandemic-in-the-uk
#39
JOURNAL ARTICLE
Indro Adinugroho, Tom Stafford, Richard P Bentall
Social events may provide important cues that influence the sense of reality, including the perception that conspiracy theories are plausible. Using longitudinal panel data collected in the UK from March 2020 to December 2021, this study aims to identify whether social events influenced the strength of the association between conspiracy mentality and vaccine intentions during the COVID-19 pandemic. Consistent with previous research, the conspiracy mentality was a significant predictor of vaccine intentions across three-time points, but also that conspiracy mentality measured in March 2020 predicted that participants were more hesitant to the vaccines in December 2020...
May 3, 2024: Vaccine
https://read.qxmd.com/read/38704261/factors-associated-with-vaccination-intention-and-uptake-over-time-in-a-sample-of-older-australians
#40
JOURNAL ARTICLE
Maria Christou-Ergos, Kerrin Bleicher, Julie Leask
This study sought to identify the behavioural and social drivers of vaccination in 16,745 older Australians. We analysed and compared influences on COVID-19 vaccination intention and uptake using prospectively collected survey data from the Sax Institute's 45 and Up Study. Vaccination intention increased with older age (adjusted odds ratio [aOR]:1.03; 95 % confidence interval [CI]: 1.01-1.04; p = .002), a belief that the vaccine is important for the person's own health (aOR: 5.17; 95 % CI: 4...
May 3, 2024: Vaccine
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