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Minerva Endocrinologica

Qing Zhu, Dekang Zeng, Faqi Li
BACKGROUND: To explore the regulatory role of ghrelin combined with sodium tanshinone IIA sulfonate (STS) pretreatment in cell apoptosis and fractalkine (FKN) expression of human umbilical vein endothelial cells (HUVECs) induced with high-dose glucose. METHODS: HUVECs were assigned into control group, high-dose glucose group (HG group), high-dose glucose with ghrelin group (Gr+HG group), and high-dose glucose companied with ghrelin and STS group (Gr+STS+HG group)...
March 4, 2019: Minerva Endocrinologica
Antonio Pico
No abstract text is available yet for this article.
February 6, 2019: Minerva Endocrinologica
Catherine D Zhang, Danae A Delivanis, Patrick W Eiken, Thomas D Atwell, Irina Bancos
The widespread use of cross-sectioning abdominal imaging in recent years has led to the increased detection of adrenal masses. In each case, determining whether a newly identified adrenal mass is benign or malignant is essential for management, but can be challenging. A significant proportion of adrenal lesions remain indeterminate after initial evaluation due to limitations of current imaging modalities. Adrenal biopsy can be considered for further diagnostic workup in select cases, particularly in patients with an active or previously diagnosed extra-adrenal malignancy...
February 6, 2019: Minerva Endocrinologica
Antonio C Fuentes-Fayos, Araceli García-Martínez, Aura D Herrera-Martínez, Juan M Jiménez-Vacas, Mari C Vazquez-Borrego, Justo P Castaño, Antonio Picó, Manuel D Gahete, Raúl M Luque
Acromegaly is a chronic systemic disease mainly caused by a growth hormone (GH)- secreting pituitary neuroendocrine tumor (PitNETs), which is associated with many health complications and increased mortality when not adequately treated. Transsphenoidal surgery is considered the treatment of choice in GH-secreting PitNETs, but patients in whom surgery cannot be considered or with persistent disease after surgery require medical therapy. Treatment with available synthetic somatostatin analogues (SSAs) is considered the mainstay in the medical management of acromegaly which exert their beneficial effects through the binding to a family of G-protein coupled receptors encoded by 5 genes (SSTR1- 5)...
January 16, 2019: Minerva Endocrinologica
Raffaella Mormile
No abstract text is available yet for this article.
March 2019: Minerva Endocrinologica
Beatrice Feragalli, Mark Dugall, Roberta Luzzi, Andrea Ledda, Morio Hosoi, Gianni Belcaro, Maria R Cesarone
BACKGROUND: The aim of the present observational registry study was to evaluate the efficacy of a thin polycarbonate patch of Pycnogenol® in alleviating symptoms of knee arthrosis, in comparison to the standard management usually applied to treat osteoarthritis (OA). METHODS: A total of 67 subjects were included in the registry: 34 formed the control group, and 33 entered the active management group in which the Pycnogenol® patch was used. Two Pycnogenol® patches were used every day for three weeks...
March 2019: Minerva Endocrinologica
Cristina Lamas, Araceli García-Martínez, Rosa Cámara, Carmen Fajardo-Montanana, Legna Viguera, Ignacio Aranda
Silent somatotroph pituitary neuroendocrine tumors (or silent growth hormone pituitary neuroendocrine tumors, SGH-PitNET) are neoplasias with positive immunostaining for growth hormone (GH), in patients with no signs and symptoms of acromegaly nor biochemical evidence of GH hypersecretion. From a clinical stand-point they are considered and managed as non-functioning pituitary tumors, since they usually come to evidence due to mass-effects (headache, visual impairment, hypopituitarism) or as asymptomatic pituitary incidentalomas...
December 7, 2018: Minerva Endocrinologica
Manuel Puig-Domingo, Monica Marazuela
Acromegaly is a chronic disorder usually diagnosed late in the disease evolution, leading to substantial morbidity and mortality related to this long period of undiagnosed state as well as the difficulty in achieving normalization of GH hypersecretion and controlling tumour mass. First generation somatostatin analogues (SSA) are accepted as the first-line medical therapy or as second-line therapy in patients undergoing unsuccessful surgery. However, because a high percentage of patients experience SSA treatment failure, the inclusion of biomarkers associated with a successful or non-successful response to these drug ( as well as to all classes of medical therapy) is necessary to better guide the choice of treatment, potentially allowing for a quicker achievement of disease control...
December 7, 2018: Minerva Endocrinologica
Jacqueline Trouillas, Alexandre Vasiljevic, Marion Lapoirie, Laura Chinezu, Emmanuel Jouanneau, Gérald Raverot
Acromegaly is mainly due to the somatotroph pituitary neuroendocrine tumors (PitNET)s. These have been subtyped into densely granulated (DG) and sparsely granulated (SG) tumors, which differ in clinical, histological and biological characteristics and in response to somatostatin analogs (SA)s. The variable remission rate after surgical resection, as first line treatment, has increased interest in identifying pathological markers to better predict the response to medical treatment. Several techniques have shown somatotroph tumors to express somatostatin receptors (SSTR)s, and mainly SSTR2 and SSTR5...
December 7, 2018: Minerva Endocrinologica
Yanfang Guo, Ling Zhu, Yi Ge, Hao Zhang
BACKGROUND: Vitamin D, a fat-soluble secosteroid, plays a key role in several metabolic diseases like diabetes. Diabetes is becoming a third leading chronic disease in the world, which seriously threatens human health. METHODS: In current study, we found the beneficial effects of vitamin D supplementation in obesity-related diabetes rat. Enzyme-linked immunosorbent assay, biochemical testing, real-time PCR and western blot were carried to investigate the effect of vitamin D supplementation on diabetes...
December 7, 2018: Minerva Endocrinologica
Antonio Nicolucci, Giuseppe Prosperini, Raffaella Buzzetti, Salvatore De Cosmo, Carmine G Fanelli, Raffaele Napoli, Francesco Giorgino
INTRODUCTION: Hypoglycemia is the major limiting factor in the glycemic management of diabetes. Aim of this study was to produce a risk stratification tool to support the medical decision making, by facilitating the identification of patients at higher risk of hypoglycemia. EVIDENCE ACQUISITION: A multistep approach was adopted, including a systematic review of observational studies investigating risk factors for severe hypoglycemia in type 2 diabetes (T2DM), followed by an expert input forum to identify factors perceived as relevant and at the same time reliably detectable, to be used for the development of a risk score...
December 2018: Minerva Endocrinologica
Gianni Testino, Silvia Leone, Patrizia Balbinot, Rinaldo Pellicano
No abstract text is available yet for this article.
December 2018: Minerva Endocrinologica
Stephan Petersenn
Secondary adrenal insufficiency may pose specific challenges during pregnancy. The interpretation of diagnostic tests is hindered by physiological adaptations of the hypothalamic-pituitary-adrenal axis. Due the relevant increases in cortisol-binding globulin, measurement of salivary cortisol may be preferable, but lacks sufficiently established cut-offs both for early-morning evaluation and during dynamic testing. Hydrocortisone should be used for replacement to avoid overexposure of the fetus, with dose adjustments according to clinical judgement...
December 2018: Minerva Endocrinologica
Stephan Petersenn
No abstract text is available yet for this article.
December 2018: Minerva Endocrinologica
Greisa Vila, Anton Luger
Growth hormone (GH) is not approved for use during conception and pregnancy. Nevertheless, data from the clinical care practice reveal that most women concieve on GH replacement therapy (GHRT), and more than half continue on GHRT also during pregnancy. GH stimulates the hypothalamic-pituitary-gonadal axis at all levels, and there is evidence that GH deficiency impacts the morphology of reproductive organs, onset of puberty, ovarian function and fertility. Patients with hypopituitarism often conceive using assisted reproductive techniques and several studies support the benefit of GH supplementation for achieving fertility in women with GH deficiency...
December 2018: Minerva Endocrinologica
Jürgen Honegger, Sabrina Giese
Pregnancy-related hypophysitis (PR-Hy) that typically occurs during late pregnancy and the early postpartum period is considered an autoimmune disorder. Knowledge and awareness of characteristic clinical symptoms and specific endocrine and neuroradiological features mostly enables a correct diagnosis and guarantees best possible management. In the presence of mild clinical symptoms, a "wait-and-watch" approach is recommended. Transsphenoidal surgery or glucocorticoid therapy is indicated if progressive clinical signs or severe visual symptoms are observed...
December 2018: Minerva Endocrinologica
Elena Vorona, Eberhard Nieschlag
Despite the fact that sports organizations and legislators have introduced various mechanisms to discourage athletes from using performance and appearance enhancing substances a high percentage of athletes admits to their unabated application. In competitive athletics, bodybuilding and in recreational sports anabolic androgenic steroids (AAS) continue to be the substances most abused. This review summarizes the side effects of AAS abuse on organs and system functions in both sexes. High doses of AAS cause a significant increase of erythrocytes and hemoglobin concentration, which may lead to thromboembolism, intracardiac thrombosis and stroke...
December 2018: Minerva Endocrinologica
Julie Refardt, Mirjam Christ-Crain
Diabetes insipidus, characterized by polyuria and polydipsia, is a rare disease during pregnancy. Nevertheless, its recognition is important to avoid complications due to dehydration and hypernatremia. Its manifestation during pregnancy ranges from exacerbation of pre-existing central or nephrogenic diabetes insipidus to transient pregnancy-induced diabetes insipidus due to the increased metabolism of the antidiuretic hormone vasopressin (AVP) by the placental vasopressinase. Diagnosis can be challenging, as urinary frequency is common during pregnancy and primary polydipsia also needs to be excluded...
December 2018: Minerva Endocrinologica
Francisca Caimari, Rosa Corcoy, Susan M Webb
Pregnancy in women with a diagnosis of Cushing' syndrome (CS) is an extremely rare event and its diagnosis and treatment are a real medical challenge. During pregnancy, the hypothalamus-pituitary-adrenal axis undergoes major changes leading to a significant increase in plasma cortisol levels throughout gestation. The difficulties in diagnosis are related to the resemblance of symptoms of CS and those of pregnancy, and to the complex interpretation of the screening tests. Moreover, the diagnostic work up in the postnatal period may be difficult in the first weeks postpartum...
December 2018: Minerva Endocrinologica
Toshiki Nagasaki, Yuki Nagata, Yosuke Wakita, Shinsuke Yamada, Hitoshi Goto, Yasuo Imanishi, Naoyoshi Onoda, Masanori Emoto, Masaaki Inaba
BACKGROUND: Hashimoto's thyroiditis (HT) is highly prevalent in patients with rheumatoid arthritis (RA). The aim is to determine their relation, focusing on matrix metalloproteinase-3 (MMP-3), a marker predicting joint destruction and RA activity. METHODS: Fifty-three consecutive RA patients were prospectively separated into two groups based on the presence or absence of HT; those with and without TPO-Ab or Tg-Ab (34.0% and 66.0%, respectively). To estimate the extent of inflammation and destruction of the thyroid gland, Heterogeneity Index (HI) was determined ultrasonographically...
December 2018: Minerva Endocrinologica
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