Clinics in Dermatology

There are T-cell lymphomas, which exhibit unique homing properties of the neoplastic lymphocytes for the subcutaneous fat. Primary cutaneous gamma delta T-cell lymphomas of the fat (PGD-TCL) typically have an aggressive clinical course; the more indolent variant is subcutaneous panniculitis like T-cell lymphoma (SPTCL), comprising T-cells of the alpha beta subset. These t wo forms of subcutaneous T-cell neoplasms exhibit many overlapping histologic features with lupus profundus (LP); it has been previously suggested by one of the authors that lupus profundus is a form of a panniculitic T-cell dyscrasia...

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a severe and potentially life-threatening drug hypersensitivity reaction. The diagnosis and management of DRESS are complicated due to its heterogeneous clinical and pathologic presentations, delayed onset of symptoms, and unpredictable outcome. This retrospective study aims to analyze cases of DRESS from a single Italian referring tertiary hospital center ((Grande Ospedale Metropolitano Niguarda, Milan, Italy) with a focus on clinical features, causative drugs, histopathologic findings, and treatment...

No abstract text is available yet for this article.

Stefania Jabłońska (1920-2017) is remembered as physician extraordinaire, outstanding medical scientist, and a superb professor of dermatology. She served as Professor and Chairman of Dermatology at the Warsaw Medical School. Not only is she one of the most cited of Polish physicians, she also was world renown, being elected to honorary membership in innumerable dermatology societies. Jabłońska in 1972 was the first to describe the relationship between the HPV virus and skin cancer in epidermodysplasia verruciformis...

Collegiate athletes who play tennis and golf spend significant time outdoors and increase their risk of skin cancer. This study aimed to gain insight into the sun protection behaviors of collegiate golfers and tennis players competing in the NCAA Division I.1 A survey was distributed to NCAA Division I golf and tennis teams within Power 5 collegiate conferences. Of the 84 respondents, 50% indicated sunscreen use more than 75% of the time while playing their sport, yet, only 4.8% engaged in sunscreen reapplication...

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe drug-induced hypersensitivity reactions characterized by widespread epidermal necrosis, mucous membrane erosions, and systemic findings. We have provided our 11-year experience from a Milan, Italy tertiary hospital managing SJS/TEN, evaluating the clinical and histopathologic features plus the impact on mortality. We retrospectively analyzed 28 patients diagnosed with SJS/TEN based on the clinical and histopathologic findings, according to the classification criteria of Bastuji-Garin et al 1,2 ...

No abstract text is available yet for this article.

Some T cell lymphomas exhibit unique homing properties of the neoplastic lymphocytes for the subcutaneous fat. There are two primary forms of subcutaneous panniculitic lymphomas of T cell origin. The first falls under the designation of primary cutaneous gamma delta T cell lymphomas of the fat (PGD-TCL). The neoplastic cells are double negative for CD8+ gamma delta T cells and often have an aggressive clinical course. The other form of panniculitis, T cell lymphoma, falls under the designation of subcutaneous panniculitis-like T cell lymphoma (SPTCL)...

Clonally restricted non-epidermotropic low-grade CD8-positive T cell infiltrates of the skin have been recognized as a unique form of indolent CD8-positive lymphoproliferative disease in 2007 when it was first called as primary cutaneous indolent CD8-positive lymphoid proliferation. More recently, the designation of primary cutaneous acral CD8-positive T-cell lymphoproliferative disorder has been used. It is unique as a cutaneous lymphoproliferative disorder because of relative uniformity in its clinical presentation and histomorphology...

Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent skin disease affecting hair follicles in predominantly intertriginous areas, characterized by deep, painful nodules and abscesses, fistulas, sinus tracts, and scarring. The estimated global prevalence of HS is highly variable, as revealed in a growing body of published literature, and ranges from 0.053% to 4.1%. In North American and European patients, HS is three times more common in women than men, whereas in South Korea and Japan, male predominance is found...

The follicular occlusion tetrad (FOT) complex encompasses several entities (hidradenitis suppurativa, acne conglobata, dissecting cellulitis of the scalp, and pilonidal cyst) that share common clinical features, risk factors, and pathophysiology. Follicular occlusion is a crucial triggering mechanism in the etiology in each of these disorders, leading to development of distinctive skin lesion such as deep-seated nodules, abscesses, comedones, and draining sinuses, often with accompanying scaring. Despite the fact that the FOT components manifest multiple similarities, they also exhibit many differences among themselves and require individual approaches and treatment...

Hidradenitis suppurativa (HS) is a chronic inflammatory disease involving primarily intertriginous skin areas. Ectopic HS lesions are a reported phenomenon that is not fully understood. We present a case report of a 66-year-old patient with painful symmetric ulcerated plaques on the posterior surface of the ankles and lower lip. We further performed a systematic review on ectopic HS by conducting an electronic literature search to identify relevant manuscripts. Inclusion criteria included English language and full texts only using Pubmed, Embase, and the Cochrane Database...

BACKGROUND: Treatment of hidradenitis suppurativa (HS) requires a combination of medical, surgical, and lifestyle interventions. Intense Pulsed Light (IPL) and lasers have been reported as useful. The aim of this review is to find the evidence supporting IPL and laser treatment of HS and provide guidance for the management of specific HS lesions. METHODS: We searched Pubmed and Web of Science for "laser" and "hidradenitis suppurativa" on April 6, 2022. Inclusion criteria were: >10 patients, a follow-up, English language, human subjects with a diagnosis of HS...

The COVID-19 pandemic created a new set of challenges regarding the care of patients with hidradenitis suppurativa (HS). Access to safe, timely medical care and the use of immunosuppressive therapy were central topics of concern for patients and providers. In addition, the incidence and severity of SARS-CoV-2 infection in patients with hidradenitis suppurativa were critical to examine during the evolving pandemic to provide recommendations for patients to make informed decisions about their disease and its management...

The genetic aspects have a substantial role in HS pathogenesis. A positive family history of HS occurs in about one-third of HS cases and is significantly higher in patients with early onset of the disease. Recent twin studies have shown a high heritability in HS, fortifying the importance of genetic factors in disease pathogenesis. Based on existing knowledge on the genomics of HS, the disease can be categorized as familial, sporadic, syndromic HS, and "HS plus" associated with other syndromes. In familial HS, autosomal dominant transmission is proposed, and monogenic inheritance is rare...

Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent, and debilitating disease of the hair follicle. It presents with painful, deep-seated, inflamed lesions, such as nodules, abscesses, sinus tracts, and fistulas, generally located in the main folds. Clinical severity assessment alone can be reductive; non-invasive skin imaging technologies, such as ultrasound, magnetic resonance imaging, medical infrared thermography, computed tomography, and positron-emission tomography, provide subclinical anatomical and functional details...

Hidradenitis suppurativa (HS) is a clinically heterogeneous disease with a broad spectrum of clinical features. Attempts to classify HS into distinct clinical phenotypes could lead to a better understanding of the condition and the development of individualized treatment protocols. We summarize some of the existing phenotype classifications and present our experience with 250 patients and their many clinical presentations. We have emphasized the pathophysiologic and clinical overlap between hidradenitis suppurativa (HS) and pyoderma gangrenosum (PG)...

Hidradenitis suppurativa (HS) is a heterogeneous chronic relapsing skin disease. Several assessment tools are used to assess disease severity and to classify disease phenotype; however, no consensus currently exists. This review evaluates the various assessment tools and phenotypes, assessing their validity and reliability. Numerous assessment tools and phenotype classifications have been proposed for identifying various subtypes within the HS disease spectrum. Each has a with different purpose, such as use in daily practice or in clinical trial settings...

No abstract text is available yet for this article.

Ocular manifestations of psoriasis are generally underrepresented in the literature and can often be missed by clinicians. Appreciation of eye involvement in psoriasis is especially important for dermatologists and ophthalmologists who may be closely involved with treating afflicted patients. Depending on the involved site and severity of the condition, signs and symptoms of ocular psoriasis can vary from asymptomatic erythema to debilitating scarring and vision loss. Treatment is critical to prevent disease progression and to improve the quality of life for these patients...