journal
https://read.qxmd.com/read/38411623/broad-spectrum-defenders-%C3%AE-%C3%AE-t-cells-take-on-a-multitude-of-immune-challenges
#41
JOURNAL ARTICLE
Julian J Freen-van Heeren
In a recent PNAS article, Guo et al. investigate γδ T cell antigen specificity in mice and humans, in which they show that γδ T cell antigen specificity is not constrained to one epitope. Rather, γδ T cells recognize a broad range of diverse antigens containing similar chemical structures or properties. In this News and Views, the importance of γδ T cell antigen polyspecificity during immune responses is highlighted.
February 27, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38394343/how-murine-neutrophils-are-hijacked-within-the-microenvironment-of-pancreatic-cancer
#42
JOURNAL ARTICLE
Marco Antonio Cassatella, Patrizia Scapini, Nicola Tamassia
Discoveries made in the last decades have brought out that, in addition to their classical primary defensive functions against infections, polymorphonuclear neutrophils play key effector roles not only in chronic inflammatory and immune-mediated diseases but also in cancer. In addition, depending on their differentiation/activation status, and/or on the physiological or pathological microenvironment in which they reside, neutrophils have been shown to behave as highly plastic cells, able to acquire new phenotypes/functional states...
February 23, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38393298/construction-of-an-immune-related-prognostic-signature-and-lncrna%C3%A2-mirna-mrna-cerna-network-in-acute-myeloid-leukaemia
#43
JOURNAL ARTICLE
Ling Qin, Boya Li, Shijie Wang, Yulai Tang, Aamir Fahira, Yanqi Kou, Tong Li, Zhigang Hu, Zunnan Huang
The progression of acute myeloid leukaemia (AML) is influenced by the immune microenvironment in the bone marrow and dysregulated intracellular competing endogenous RNA (ceRNA) networks. Our study utilized data from UCSC Xena, Cancer Genome Atlas Program, Gene Expression Omnibus, Immunology Database and Analysis Portal. Using Cox regression analysis, we identified an immune-related prognostic signature. Genomic analysis of prognostic mRNA was conducted through Gene Set Cancer Analysis (GSCA), and a prognostic ceRNA network was constructed using the Encyclopedia of RNA Interactomes...
February 23, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38374693/differential-requirement-for-il-2-and-il-23-in-the-differentiation-and-effector-functions-of-th17-ilc3-like-cells-in-a-human-t-cell-line
#44
JOURNAL ARTICLE
Momtazkari Sarah, Dev Choudhury Anahita, Wei Ern Yong Zachary, Dong Le Thanh, Nguyen Canh Hiep, Harada Kenichi, Toshiyuki Hori, Osato Motomi, Takahashi Chiaki, Cai Ping Koh, Chih-Cheng Voon Dominic
A well-documented Achilles heel of current cancer immunotherapy approaches is T cell exhaustion within solid tumor tissues. The pro-inflammatory cytokine interleukin-23 (IL-23) has been utilised to augment chimeric antigen receptor (CAR)-T cells survival and tumor immunity. However, in-depth interrogation of molecular events downstream of IL-23/IL23R signaling is hampered by a paucity of suitable cell models. The current study investigates the differential contribution of IL-2 and IL-23 to the maintenance and differentiation of the IL-23 responsive Kit225 T-cell line...
February 20, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38373017/anlotinib-and-anti-pd-1-mabs-perfected-cik-cell-therapy-for-lung-adenocarcinoma-in-preclinical-trials
#45
JOURNAL ARTICLE
Yingge Lv, Hua Zhao, Shaochuan Liu, Yuan Meng, Wenwen Yu, Ting Liu, Qian Sun, Meng Shen, Xiubao Ren, Liang Liu
Murine cytokine-induced killer (CIK) cells are heterologous cells that kill various allogeneic and isogenic tumors and have functional and phenotypic characteristics of natural killer cells and T lymphocytes. However, the effect of CIK alone on solid tumor therapy is only limited. To enhance the therapeutic effect, it is vital to discover a mix of several therapy approaches. Immune cell function is inhibited by abnormal tumor vessels and the tumor microenvironment, which block lymphocyte entry into tumor tissue...
February 19, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38372596/systemic-immune-response-to-a-cd40-agonist-antibody-in-nonhuman-primates
#46
JOURNAL ARTICLE
David L Caudell, Gregory O Dugan, Galina Babitzki, Christine Schubert, Annamaria Braendli-Baiocco, Ken Wasserman, Gonzalo Acona, Martin Stern, Alexandre Passioukov, J Mark Cline, Jehad Charo
The cell surface molecule CD40 is a member of the tumor necrosis factor receptor superfamily and is broadly expressed by immune cells including B cells, dendritic cells (DC), and monocytes, as well as other normal cells and some malignant cellsCD40 is constitutively expressed on antigen-presenting cells (APCs) and ligation promotes functional maturation leading to an increase in antigen presentation, cytokine production, and a subsequent increase in the activation of antigen specific T cells. It is postulated that CD40 agonists can mediate both T-cell-dependent and T-cell-independent immune mechanisms of tumor regression in mice and patients...
February 19, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38369808/accumulation-of-circulating-myeloid-derived-suppressor-cell-subsets-predicting-poor-clinical-efficacy-and-prognosis-through-t-cell-suppression-in-non-hodgkin-s-lymphoma
#47
JOURNAL ARTICLE
Lian-Fang Pu, Man-Man Li, Xiang-Jiang Feng, Tun Zhang, Lin-Hui Hu, Hui-Min Zheng, Alice Charwudzi, Yang-Yang Ding, Jun Liu, Ze-Lin Liu, Shu-Dao Xiong
Myeloid-derived suppressor cells (MDSC) are implicated in the regulation of immune responses closely associated with poor clinical outcomes in cancer. However, the MDSC subtypes in non-Hodgkin's Lymphoma (NHL) has not been systematically investigated. So we investigated the percentage of MDSC subsets in 78 newly diagnosed NHL patients by flow cytometry. The results showed that all MDSC subsets increased in NHL patients compared to healthy donors. Notably, MDSC, M-MDSC, and CD14+CD66b+MDSC significantly increased in NHL patients compared to those with lymphadenitis...
February 19, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38366630/6-formylindolo-3-2-b-carbazole-a-potent-ligand-for-the-aryl-hydrocarbon-receptor-attenuates-concanavalin-induced-hepatitis-by-limiting-t-cell-activation-and-infiltration-of-proinflammatory-cd11b-kupffer-cells
#48
JOURNAL ARTICLE
Alkeiver S Cannon, Bryan L Holloman, Kiesha Wilson, Kathryn Miranda, Prakash S Nagarkatti, Mitzi Nagarkatti
FICZ (6-formylindolo[3,2-b]carbazole) is a potent aryl hydrocarbon receptor agonist that has a poorly understood function in the regulation of inflammation. In this study, we investigated the effect of aryl hydrocarbon receptor activation by FICZ in a murine model of autoimmune hepatitis induced by concanavalin A. High-throughput sequencing techniques such as single-cell RNA sequencing and assay for transposase accessible chromatin sequencing were used to explore the mechanisms through which FICZ induces its effects...
February 16, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38366559/along-with-pao2-fio2-ratio-and-lymphopenia-low-hla-dr-monocytes-are-the-only-additional-parameter-that-independently-predicts-the-clinical-course-of-undifferentiated-sars-cov-2-patients-in-emergency-departments
#49
JOURNAL ARTICLE
Thomas Lafon, Nicolas Chapuis, Estelle Guerin, Thomas Daix, Marcela Otranto, Ahmed Boumediene, Robin Jeannet, Michaela Fontenay, Henri Hani Karam, Philippe Vignon, Guillaume Monneret, Bruno François, Jean-Philippe Jais, Jean Feuillard
Since 1/3 of patients deteriorate after their admission to the emergency department (ED), assessing the prognosis of COVID-19 patients is of great importance. But to date, only lymphopenia and PaO2/FiO2 (P/F) ratio have been reported as partly predictive of COVID-19 further deterioration and their association has not been evaluated. We asked whether other key biomarkers of SARS-CoV2 immunologic defects - increase in circulating immature granulocytes (IGs), loss of monocyte HLA-DR (mHLA-DR) expression and monocyte differentiation blockade - could also predict further COVID-19 deterioration...
February 15, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38345417/pharmacological-evidences-that-the-inhibitory-effects-of-prostaglandin-e2-are-mediated-by-the-ep2-and-ep4-receptors-in-human-neutrophils
#50
JOURNAL ARTICLE
Jean-Philippe C Lavoie, Mélissa Simard, Hilal Kalkan, Volatiana Rakotoarivelo, Sandrine Huot, Vincenzo Di Marzo, Andréanne Côté, Marc Pouliot, Nicolas Flamand
Prostaglandin (PG) E2 is a recognized inhibitor of granulocyte functions. However, most of the data supporting this was obtained when available pharmacological tools mainly targeted the EP2 receptor. Herein, we revisited the inhibitory effect of PGE2 on reactive oxygen species production, leukotriene biosynthesis and migration in human neutrophils. Our data confirm the inhibitory effect of PGE2 on these functions and unravel that the effect of PGE2 on human neutrophils is obtained by the combined action of EP2 and EP4 agonism...
February 12, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38334307/a-comprehensively-prognostic-and-immunological-analysis-of-parp11-in-pan-cancer
#51
JOURNAL ARTICLE
Shengli Wang, Mingyue Zhang, Tao Li, Xinru Chen, Qinhan Wu, Dan Tian, Zvi Granot, Hongbiao Xu, Jianlei Hao, Hongru Zhang
Poly (ADP ribose) polymerase family member 11(PARP11) has important immune regulatory functions in viral infection and tumor immune response. Particularly, PARP11 showed protumor activities in multiple preclinical murine models. However, no systematic pan-cancer analysis has been conducted to explore PARP11 function. In this study we used multiple databases to assess PARP11 expression, which associations with clinical outcomes, immune checkpoint factors, prognostic significance, genomic characteristics, and immunological aspects...
February 9, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38324004/tumor-infiltrating-%C3%AE-%C3%AE-t-cells-as-targets-of-immune-checkpoint-blockade-in-melanoma
#52
JOURNAL ARTICLE
Marta Di Simone, Anna Maria Corsale, Francesca Toia, Mojtaba Shekarkar Azgomi, Anna Barbara Di Stefano, Elena Lo Presti, Adriana Cordova, Luigi Montesano, Francesco Dieli, Serena Meraviglia
Melanoma is one of the most sensitive tumors to immune modulation and the major challenge for melanoma patients' survival is immune checkpoint inhibitors therapy. γδ T lymphocytes play an antitumoral role in a broad variety of tumors including melanoma and they are optimal candidates for cellular immunotherapy. Thus, a comprehensive analysis of the correlation between γδ T cells and immune checkpoint receptors in the context of melanoma was conducted, with the aim of devising an innovative combined immunotherapeutic strategy...
February 7, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38323674/exploring-risk-factors-and-molecular-targets-in-leukemia-patients-with-covid-19-a-bioinformatics-analysis-of-differential-gene-expression
#53
JOURNAL ARTICLE
Md Asad Ullah, Abu Tayab Moin, Jannatul Ferdous Nipa, Nafisa Nawal Islam, Fatema Tuz Johora, Rahee Hasan Chowdhury, Saiful Islam
The molecular mechanism of COVID-19's pathogenic effects in leukemia patients is still poorly known. Our study investigated the possible disease mechanism of COVID-19 and its associated risk factors in patients with leukemia utilizing differential gene expression analysis. We also employed network-based approaches to identify molecular targets that could potentially diagnose and treat COVID-19-infected leukemia patients. Our study demonstrated a shared set of 60 genes that are expressed differentially among patients with leukemia and COVID-19...
February 7, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38315716/abnormal-expression-of-cux1-influences-autophagy-activation-in-paroxysmal-nocturnal-hemoglobinuria
#54
JOURNAL ARTICLE
Junshu Wu, Liyan Li, Zhaoyun Liu, Honglei Wang, Yingying Chen, Lijie Zeng, Guanrou Wang, Hui Liu, Rong Fu
The mechanism underlying autophagy in paroxysmal nocturnal hemoglobinuria (PNH) remains largely unknown. We previously sequenced the entire genome exon of the CD59- cells from 13 patients with PNH and found genes such as CUX1 encoding Cut-like homeobox 1. Peripheral blood samples from nine patients with PNH and seven healthy controls were obtained to measure CUX1 expression. The correlation between CUX1 mRNA expression and PNH clinical indicators was analyzed. To simulate CUX1 expression in patients with PNH, we generated a panel of PNH cell lines by knocking out PIGA in K562 cell lines and transfected lentivirus with CUX1...
February 5, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38315633/tissue-damage-from-chronic-liver-injury-inhibits-peripheral-nk-cell-abundance-and-proinflammatory-function
#55
JOURNAL ARTICLE
Zonghao You, Shaoxue Ling, Shuwu Zhao, Haixing Han, Yuhong Bian, Yongzhi He, Xi Chen
One of the difficulties in the treatment of hepatocellular carcinoma is that it is impossible to eliminate the inhibitory effect of tumor microenvironment on immune response. Therefore, it is particularly important to understand the formation process of tumor microenvironment. Chronic inflammation is the core factor of cancer occurrence and the leading stage of inflammation-cancer transformation, and the NK cell subsets play an important role in it. Our study confirmed that in the stage of chronic liver injury, the local immunosuppressive microenvironment of the liver, that is, the damaged microenvironment, has been formed, but this inhibitory effect is only for peripheral NK cells and has no effect on tissue resident NK subsets...
February 5, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38301269/epigenetic-regulation-of-innate-immune-dynamics-during-inflammation
#56
JOURNAL ARTICLE
Blake A Caldwell, Liwu Li
Innate immune cells play essential roles in modulating both immune defense and inflammation by expressing a diverse array of cytokines and inflammatory mediators, phagocytizing pathogens to promote immune clearance, and assisting with the adaptive immune processes through antigen presentation. Rudimentary innate immune "memory" states such as training, tolerance, and exhaustion develop based on the nature, strength, and duration of immune challenge, thereby enabling dynamic transcriptional reprogramming to alter present and future cell behavior...
February 1, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38298146/cxcl17-is-a-proinflammatory-chemokine-and-promotes-neutrophil-trafficking
#57
JOURNAL ARTICLE
Emily Lowry, Rani C Chellappa, Brigith Penaranda, Kirti V Sawant, Maki Wakamiya, Roberto P Garofalo, Krishna Rajarathnam
CXCL17, a novel member of the CXC chemokine class, has been implicated in several human pathologies, but its role in mediating immune response is not well understood. Characteristic features of immune response include resident macrophages orchestrating successive and structured recruitment of neutrophils and monocytes to the insult site. Here, we show that Cxcl17 knockout (KO) mice, compared to the littermate wildtype (WT) control, were significantly impaired in peritoneal neutrophil recruitment post-lipopolysaccharide (LPS) challenge...
January 31, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38289835/upregulated-selenoprotein-i-during-lps-induced-b-cell-activation-promotes-lipidomic-changes-and-is-required-for-effective-differentiation-into-igm-secreting-plasma-b-cells
#58
JOURNAL ARTICLE
Chi Ma, FuKun W Hoffmann, Ashley E Shay, Imhoi Koo, Kathy A Green, William R Green, Peter R Hoffmann
The mechanisms driving metabolic reprogramming during B cell activation are unclear, particularly roles for enzymatic pathways involved in lipid remodeling. We found that murine B cell activation with lipopolysaccharide (LPS) led to a 1.6-fold increase in total lipids that included higher levels of phosphatidylethanolamine (PE) and plasmenyl PE. Selenoprotein I (SELENOI) is an[62] ethanolamine phospholipid transferase involved in the synthesis of both PE and plasmenyl PE, and SELENOI expression was also upregulated during activation...
January 30, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38289832/ythdc1-inhibits-osteoclast-differentiation-to-alleviate-osteoporosis-by-enhancing-ptpn6-mrna-stability-in-an-m6a-hur-dependent-manner
#59
JOURNAL ARTICLE
Meijie Zhang, Jiaxin Guan, Simiao Yu, Yimeng Zhang, Luyang Cheng, Yina Zhang
YTH domain containing 1 (YTHDC1) has been confirmed to mediate osteoporosis (OP) progression by regulating osteogenic differentiation. However, whether YTHDC1 mediates osteoclast differentiation and its molecular mechanism remain unclear. Quantitative real-time PCR and western blot analysis were performed to detect the levels of YTHDC1, protein tyrosine phosphatase non-receptor type 6 (PTPN6), nuclear factor of activated T cells 1 (NFATc1), tartrate-resistant acid phosphatase (TRAP), runt-related transcription factor 2 (RUNX2), alkalinephosphatase (ALP) human antigen R (HUR)...
January 30, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38289826/ally-adversary-or-arbitrator-the-context-dependent-role-of-eosinophils-in-vaccination-for-respiratory-viruses-and-subsequent-breakthrough-infections
#60
JOURNAL ARTICLE
Lauren A Chang, Michael Schotsaert
Eosinophils are a critical type of immune cell and central players in Type 2 immunity. Existing literature suggests that eosinophils also can play a role in host antiviral responses, typically Type 1 immune events, against multiple respiratory viruses, both directly through release of antiviral mediators and indirectly through activation of other effector cell types. One way to prime host immune responses towards effective antiviral responses is through vaccination, where typically a Type 1-skewed immunity is desirable in the context of intracellular pathogens like respiratory viruses...
January 30, 2024: Journal of Leukocyte Biology
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