David L Caudell, Gregory O Dugan, Galina Babitzki, Christine Schubert, Annamaria Braendli-Baiocco, Ken Wasserman, Gonzalo Acona, Martin Stern, Alexandre Passioukov, J Mark Cline, Jehad Charo
The cell surface molecule CD40 is a member of the tumor necrosis factor receptor superfamily and is broadly expressed by immune cells including B cells, dendritic cells (DC), and monocytes, as well as other normal cells and some malignant cellsCD40 is constitutively expressed on antigen-presenting cells (APCs) and ligation promotes functional maturation leading to an increase in antigen presentation, cytokine production, and a subsequent increase in the activation of antigen specific T cells. It is postulated that CD40 agonists can mediate both T-cell-dependent and T-cell-independent immune mechanisms of tumor regression in mice and patients...
February 19, 2024: Journal of Leukocyte Biology