journal
https://read.qxmd.com/read/37699529/interpersonal-needs-mental-pain-and-hopelessness-in-psychiatric-inpatients-with-suicidal-ideation
#21
JOURNAL ARTICLE
Isabella Berardelli, Elena Rogante, Salvatore Sarubbi, Maria Anna Trocchia, Ludovica Longhini, Denise Erbuto, Marco Innamorati, Maurizio Pompili
INTRODUCTION: Suicide is a leading cause of death worldwide and models may help the understanding of the phenomenon and ultimately reduce its burden through effective suicide prevention strategies. The Interpersonal Theory of Suicide and Shneidman's Model have tried to describe different unmet needs related to suicidal ideation. The study aims to assess the association between thwarted belongingness, perceived burdensomeness, and suicidal ideation in a sample of psychiatric inpatients and the mediating role of hopelessness and mental pain in this association...
September 12, 2023: Pharmacopsychiatry
https://read.qxmd.com/read/37678394/longitudinal-digital-mood-charting-in-bipolar-disorder-experiences-with-chronorecord-over-20-years
#22
JOURNAL ARTICLE
Michael Bauer, Tasha Glenn, Martin Alda, Paul Grof, Rita Bauer, Ulrich W Ebner-Priemer, Stefan Ehrlich, Andrea Pfennig, Maximilian Pilhatsch, Natalie Rasgon, Peter C Whybrow
INTRODUCTION: Longitudinal study is an essential methodology for understanding disease trajectories, treatment effects, symptom changes, and long-term outcomes of affective disorders. Daily self-charting of mood and other illness-related variables is a commonly recommended intervention. With the widespread acceptance of home computers in the early 2000s, automated tools were developed for patient mood charting, such as ChronoRecord, a software validated by patients with bipolar disorder...
September 2023: Pharmacopsychiatry
https://read.qxmd.com/read/37647941/correction-lithium-therapy-in-old-age-recommendations-from-a-delphi-survey
#23
JOURNAL ARTICLE
Julia Christl, Bruno Müller-Oerlinghausen, Michael Bauer, Daniel Kamp, Fabian Fußer, Jens Benninghoff, Rosa A Fehrenbach, Christian Lange-Asschenfeldt, Michael Rapp, Bernd Ibach, Rainer Schaub, Axel Wollmer, Timm Strotmann-Tack, Michael Hüll, Susanne Biermann, Katharina Roscher, Bernd Meissnest, Alexander Menges, Bernd Weigel, Dorothee Maliszewski-Makowka, Christian Mauerer, Martin Schaefer, Beate Joachimsmeier, Sarah Kayser, Lars Christian Rump, Tillmann Supprian
No abstract text is available yet for this article.
August 30, 2023: Pharmacopsychiatry
https://read.qxmd.com/read/37643732/challenges-and-ethical-considerations-to-successfully-implement-artificial-intelligence-in-clinical-medicine-and-neuroscience-a-narrative-review
#24
JOURNAL ARTICLE
Scott Monteith, Tasha Glenn, John R Geddes, Eric D Achtyes, Peter C Whybrow, Michael Bauer
This narrative review discusses how the safe and effective use of clinical artificial intelligence (AI) prediction tools requires recognition of the importance of human intelligence. Human intelligence, creativity, situational awareness, and professional knowledge, are required for successful implementation. The implementation of clinical AI prediction tools may change the workflow in medical practice resulting in new challenges and safety implications. Human understanding of how a clinical AI prediction tool performs in routine and exceptional situations is fundamental to successful implementation...
August 29, 2023: Pharmacopsychiatry
https://read.qxmd.com/read/37643731/does-lidocaine-shorten-seizure-duration-in-electroconvulsive-therapy
#25
JOURNAL ARTICLE
Jose López-Ilundain, Alejandro Ballesteros Prados, Ángela S Rosero Enriquez, Mónica Enguita-Germán, Estefania Uriarte Rosquil, Jose López Gil, Ana Marmol Fábrega, Estitxu Martinez de Zabarte Moraza, Alex R Maughan, Javier Yoldi-Murillo
BACKGROUND: Electroconvulsive therapy (ECT) is an effective short-term treatment for schizophrenia and depression, amongst other disorders. Lidocaine is typically added to reduce pain from intravenous propofol injection. However, depending on the dose used in the ECT setting, it can shorten seizure duration. The aim of this study was to investigate the effect of lidocaine dose on seizure duration. METHODS: This retrospective, naturalistic cohort study included 169 patients treated with ECT...
August 29, 2023: Pharmacopsychiatry
https://read.qxmd.com/read/37604167/valproic-acid-induced-thrombocytopenia-in-an-elderly-man-with-schizoaffective-disorder-a-case-report
#26
JOURNAL ARTICLE
Yun Tien
No abstract text is available yet for this article.
August 21, 2023: Pharmacopsychiatry
https://read.qxmd.com/read/37506738/effects-of-early-clozapine-treatment-on-remission-rates-in-acute-schizophrenia-the-early-trial-protocol-of-a-randomized-controlled-multicentric-trial
#27
Elias Wagner, Wolfgang Strube, Thomas Görlitz, Aslihan Aksar, Ingrid Bauer, Mattia Campana, Joanna Moussiopoulou, Alexander Hapfelmeier, Petra Wagner, Silvia Egert-Schwender, Robert Bittner, Kathrin Eckstein, Igor Nenadić, Tilo Kircher, Berthold Langguth, Eva Meisenzahl, Martin Lambert, Sigrid Neff, Berend Malchow, Peter Falkai, Dusan Hirjak, Kent-Tjorben Böttcher, Andreas Meyer-Lindenberg, Christiane Blankenstein, Stefan Leucht, Alkomiet Hasan
BACKGROUND: Quick symptomatic remission after the onset of psychotic symptoms is critical in schizophrenia treatment, determining the subsequent disease course and recovery. In this context, only every second patient with acute schizophrenia achieves symptomatic remission within three months of initiating antipsychotic treatment. The potential indication extension of clozapine-the most effective antipsychotic-to be introduced at an earlier stage (before treatment-resistance) is supported by several lines of evidence, but respective clinical trials are lacking...
July 28, 2023: Pharmacopsychiatry
https://read.qxmd.com/read/37506737/lithium-therapy-in-old-age-recommendations-from-a-delphi-survey
#28
JOURNAL ARTICLE
Julia Christl, Bruno Müller-Oerlinghausen, Michael Bauer, Daniel Kamp, Fabian Fußer, Jens Benninghoff, Rosa A Fehrenbach, Christian Lange-Asschenfeldt, Michael Rapp, Bernd Ibach, Rainer Schaub, Axel Wollmer, Timm Strotmann-Tack, Michael Hüll, Susanne Biermann, Katharina Roscher, Bernd Meissnest, Alexander Menges, Bernd Weigel, Dorothee Maliszewski-Makowka, Christian Mauerer, Martin Schaefer, Beate Joachimsmeier, Sarah Kayser, Lars Christian Rump, Tillmann Supprian
INTRODUCTION: While lithium (Li) has been well established for the treatment of bipolar disorder, geriatric patients require special attention when it comes to issues of drug safety. Declining renal function, amongst other medical conditions, and polypharmacy may pose increased risks. Only a few previous studies have addressed the management of Li in geriatric patients. METHODS: Twenty-four German medical experts on geriatric medicine and Li treatment participated in a Delphi survey, consisting of two rounds of questionnaires and a final formulation of treatment recommendations...
July 28, 2023: Pharmacopsychiatry
https://read.qxmd.com/read/37437578/revisiting-the-world-s-strictest-covid-19-lockdown-formidable-mental-health-challenges
#29
JOURNAL ARTICLE
Beier Guan, Ruihua Li, Chuanning Huang, Jiang Du, Min Zhao, Shuyan Liu
INTRODUCTION: Many nations have implemented lockdowns to prevent and minimize the spread of infections in healthcare settings. However, the impact of lockdown duration on mental health remains controversial. METHODS: We conducted a retrospective study using online questionnaires to assess the mental health status of the general population during the Shanghai lockdown period from March to May 2022. The mental health of the participants was evaluated by the 12-item General Health Questionnaire (GHQ-12), in which a cut-off score of 12 or more indicated psychological distress...
July 2023: Pharmacopsychiatry
https://read.qxmd.com/read/37253382/establishing-core-symptoms-of-acute-serotonin-reuptake-inhibitor-withdrawal-results-from-an-international-survey-of-online-peer-support-communities
#30
JOURNAL ARTICLE
Bryan Shapiro, Eric Kramer, Dina Khoury, Adrian Preda
BACKGROUND: Serotonin reuptake inhibitor (SRI) antidepressants are commonly associated with withdrawal reactions. The Discontinuation Emergent Signs and Symptoms (DESS) checklist has been considered the gold standard research and screening tool for SRI withdrawal but has several limitations, including its length, lack of specificity, and omission of baseline symptom and symptom severity scores, making it impractical for use in clinical or research settings. We investigated the prevalence and severity of common SRI withdrawal symptoms to determine whether a very small subset of symptoms can capture most occurrences of SRI withdrawal...
July 2023: Pharmacopsychiatry
https://read.qxmd.com/read/37116539/effects-of-anesthesia-changes-during-maintenance-ect-a-longitudinal-comparison-of-seizure-quality-under-anesthesia-using-propofol-esketamine-versus-methohexital
#31
JOURNAL ARTICLE
Isabel Methfessel, David Zilles-Wegner, Nils Kunze-Szikszay, Michael Belz
INTRODUCTION: The effectiveness of ECT relies on the induction of a generalized cerebral seizure. Among others, seizure quality (SQ) is potentially influenced by the anesthetic drug used. Commonly used anesthetics comprise barbiturates, etomidate, propofol, and esketamine, with different characteristics and impacts on seizure parameters. So far, no studies have compared the influence of methohexital vs. a combination of propofol/esketamine on established SQ parameters. METHODS: This retrospective longitudinal study compared eight established SQ parameters (PSI, ASEI, MSC, midictal amplitude, motor and electroencephalography (EEG) seizure duration, concordance, PHR) before and after the change from propofol/esketamine to methohexital in 34 patients under maintenance ECT...
July 2023: Pharmacopsychiatry
https://read.qxmd.com/read/37285910/high-prescribing-and-state-level-variation-in-z-drug-use-among-medicare-patients
#32
JOURNAL ARTICLE
Kaitlin E Anderson, Rachel I Gifeisman, James L Basting, Donovan J Harris, Antonica R Rajan, Kenneth L McCall, Brian J Piper
BACKGROUND: Z-drugs are nonbenzodiazepine hypnotics used for sleep initiation and maintenance; these drugs increase the risk of fall-related injuries in older adults. The American Geriatrics Society's Beers criteria classifies Z-drugs as high-risk and strongly recommends avoiding prescribing Z-drugs to older adults due to adverse effects. The study objectives were to determine the prevalence of Z-drug prescribing among Medicare Part D patients and identify state or specialty-dependent prescribing differences...
June 7, 2023: Pharmacopsychiatry
https://read.qxmd.com/read/37220781/gabaergic-effects-of-etifoxine-and-alprazolam-assessed-by-double-pulse-tms
#33
JOURNAL ARTICLE
Marco Riebel, Benedikt von Pappenheim, Carolina Kanig, Caroline Nothdurfter, Thomas C Wetter, Rainer Rupprecht, Jens Schwarzbach
INTRODUCTION: There is a need for novel anxiolytics with improved side effect profiles compared to benzodiazepines. A promising candidate with alternative pharmacodynamics is the translocator protein ligand, etifoxine. METHODS: To get further insight into its mechanisms of action and side effects compared to the benzodiazepine alprazolam, we performed a double-blind, placebo-controlled, repeated-measures study in 36 healthy male subjects. Participants were examined for trait anxiety and side effects and underwent repeated transcranial magnetic stimulation (TMS) assessments, including motor evoked potentials (MEP), short intracortical inhibition (SICI), intracortical facilitation (ICF), and cortical silent period (CSP)...
May 23, 2023: Pharmacopsychiatry
https://read.qxmd.com/read/37187180/-not-available
#34
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
May 2023: Pharmacopsychiatry
https://read.qxmd.com/read/37187179/-not-available
#35
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
May 2023: Pharmacopsychiatry
https://read.qxmd.com/read/37187178/the-role-of-mood-stabilizers-in-children-and-adolescents-with-anorexia-nervosa-a-1-year-follow-up-propensity-score-matched-study
#36
JOURNAL ARTICLE
Jacopo Pruccoli, Antonia Parmeggiani
BACKGROUND: The existing literature on the use of mood stabilizers (MS) in children and adolescents with anorexia nervosa (AN) is limited, for the most part, to small case studies. METHODS: This was an observational, naturalistic, propensity score-matched study. Subjects treated and not-treated with MS were compared by being matched via propensity score on age, sex, concurrent atypical antipsychotics, and concurrent antidepressants. General and AN-specific psychopathology was assessed with Symptom Check List-90-R, Beck Depression Inventory-II, Eating Disorders Inventory-3, and Body Uneasiness Test-A...
May 2023: Pharmacopsychiatry
https://read.qxmd.com/read/37187177/human-derived-dermal-fibroblasts-as-in-vitro-research-tool-to-study-circadian-rhythmicity-in-psychiatric-disorders
#37
JOURNAL ARTICLE
Denise Palm, Adriana Uzoni, Golo Kronenberg, Johannes Thome, Frank Faltraco
A number of psychiatric disorders are defined by persistent or recurrent sleep-wake disturbances alongside disruptions in circadian rhythm and altered clock gene expression. Circadian rhythms are present not only in the hypothalamic suprachiasmatic nucleus but also in peripheral tissues. In this respect, cultures of human derived dermal fibroblasts may serve as a promising new tool to investigate cellular and molecular mechanisms underlying the pathophysiology of mental illness. In this article, we discuss the advantages of fibroblast cultures to study psychiatric disease...
May 2023: Pharmacopsychiatry
https://read.qxmd.com/read/37187176/the-role-of-circadian-rhythmicity-and-clock-genes-in-psychiatry
#38
EDITORIAL
Denise Palm, Johannes Thome
Circadian rhythms are biological oscillations, that perpetuate themselves even in the absence of "zeitgebers" (external time cues), with a period of approximately 24 hours. The master pacemaker is the suprachiasmatic nucleus (SCN) of the hypothalamus. The SCN is entrained by environmental factors, particularly light, to the 24-hour light-dark cycle by the Earth's rotation. Peripheral circadian oscillators, located in multiple cell types and tissues, are controlled by signals arising from the SCN and from the environment, particularly food intake, hormonal signals and body-temperature fluctuations...
May 2023: Pharmacopsychiatry
https://read.qxmd.com/read/36944330/low-escitalopram-concentrations-in-patients-with-depression-predict-treatment-failure-a-naturalistic-retrospective-study
#39
JOURNAL ARTICLE
Xenia M Hart, Friederike Amann, Jonas Brand, Luzie Eichentopf, Gerhard Gründer
INTRODUCTION: Cross sectional therapeutic drug monitoring (TDM) data mining introduces new opportunities for the investigation of medication treatment effects to find optimal therapeutic windows. Medication discontinuation has been proven useful as an objective surrogate marker to assess treatment failure. This study aimed to investigate the treatment effects of escitalopram and pharmacokinetic influences on blood levels using retrospectively assessed data from a TDM database. METHODS: Data was collected from 134 patients longitudinally treated with escitalopram for whom TDM was requested to guide drug therapy...
March 2023: Pharmacopsychiatry
https://read.qxmd.com/read/36944329/dna-methylation-of-pomc-and-nr3c1-1f-and-its-implication-in-major-depressive-disorder-and-electroconvulsive-therapy
#40
JOURNAL ARTICLE
Hannah B Maier, Nicole Moschny, Franziska Eberle, Kirsten Jahn, Thorsten Folsche, Rasmus Schülke, Stefan Bleich, Helge Frieling, Alexandra Neyazi
INTRODUCTION: Precision medicine in psychiatry is still in its infancy. To establish patient-tailored treatment, adequate indicators predicting treatment response are required. Electroconvulsive therapy (ECT) is considered one of the most effective options for pharmacoresistant major depressive disorder (MDD), yet remission rates were reported to be below 50%. METHODS: Since epigenetics of the stress response system seem to play a role in MDD, we analyzed the DNA methylation (DNAm) of genes encoding the glucocorticoid receptor ( NR3C1 ) and proopiomelanocortin ( POMC ) through Sanger Sequencing...
March 2023: Pharmacopsychiatry
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