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Asian Pacific Journal of Allergy and Immunology

Xueting Liu, Yuhuan Wen, De Wang, Zhongqiu Zhao, Joseph Jeffry, Liping Zeng, Zehong Zou, Huifang Chen, Ailin Tao
BACKGROUND: Staphylococcal enterotoxin A (SEA) is a well-known superantigen and stimulates human peripheral blood mononuclear cells (PBMCs) involving in the pathogenesis of inflammatory disorders and cancer. OBJECTIVE: To better understand the biological activities of SEA and the possible intracellular mechanisms by which SEA plays its roles in conditions like staphylococcal inflammatory and/or autoimmune disorders and immunotherapy. METHODS: Recombinant SEA (rSEA) was expressed in a prokaryotic expression system and its effects on the cytokine and chemokine production was examined by Enzyme-linked Immunospot (ELISpot) Assay and ELISA analysis...
January 13, 2019: Asian Pacific Journal of Allergy and Immunology
Lefèvre Sébastien, Moumane Laurianne, Jacquenet Sandrine, Beaudouin Etienne
Fish roe is an extremely rare cause of anaphylaxis and although its consumption has increased in recent years. We described the case of a 59-year-old man, who experienced an anaphylactic reaction after consuming caviar. Skin prick-test were performed with Beluga caviar, salmon caviar, cod, salmon, hen egg yolk and egg white, ovalbumin, ovomucoid, shrimp and mold. Only SPT to Beluga caviar was positive. The absence of sensitization to fish and hen egg was confirmed by undetectable specific IgEs to cod, parvalbumin (Gad c 1 and Cyp c 1), egg yolk and egg white, ovalbumin and ovomucoid...
January 13, 2019: Asian Pacific Journal of Allergy and Immunology
Areerat Kunanopparat, Nattiya Hirankarn, Jiraphorn Issara-Amphorn, Pisit Tangkijvanich, Anapat Sanpavat
BACKGROUND: Notch signaling has been linked to many cancers. However, there is still limited information about the expression and role of the Notch ligand in hepatocellular carcinoma (HCC). OBJECTIVE: To investigate the expression of JAG1 and DLL4 in HCC tissues. METHODS: One hundred and forty-five HCC tissues in paraffin block since 2009 to 2016 at King Chulalongkorn Memorial hospital were assayed for JAG1 and DLL4 by immunohistochemistry...
January 13, 2019: Asian Pacific Journal of Allergy and Immunology
Apichaya Khlaiphuengsin, Natthaya Chuaypen, Nattiya Hirankarn, Anchalee Avihingsanon, Megan Crane, Sharon R Lewin, Pisit Tangkijvanich
BACKGROUND: B-cell activating factor (BAFF), an essential cytokine for B lymphocytes activation, has been implicated in the pathogenesis of chronic viral hepatitis. However, the role of BAFF in patients with chronic hepatitis B (CHB) undergoing antiviral therapy is unknown. METHODS: Patients with HBeAg-positive CHB treated with 48-week pegylated interferon (PEG-IFN; n = 42), who had stored plasma samples during treatment were recruited. Serial plasma levels of BAFF and C-X-C motif chemokine 10 (CXCL10) during therapy were measured...
January 13, 2019: Asian Pacific Journal of Allergy and Immunology
Teerapong Rattananukrom, Pranee Svetvilas, Kumutnart Chanprapaph
Urticarial vasculitis (UV) is a rare form of cutaneous leukocytoclastic vasculitis with persistent urticarial lesions. UV may be severe and refractory to standard treatment including antihistamines, anti-inflammatories, antimalarials, corticosteroids and immunosuppressants. Omalizumab, an anti-IgE antibody, is approved for chronic spontaneous urticaria. However, its benefit for UV remains controversial. We report, herein, three patients with normocomplementemic UV and angioedema. All patients were diagnosed with chronic urticaria preceding the presentation of painful urticarial plaques...
January 13, 2019: Asian Pacific Journal of Allergy and Immunology
Eakachai Prompetchara, Chutitorn Ketloy, Stephen J Thomas, Kiat Ruxrungtham
The first licensed dengue vaccine, CYD-TDV (Dengvaxia®), has received regulatory approval in a number of countries. However, this vaccine has some limitations. Its efficacy against DENV2 was consistently lower than other serotypes. Protective efficacy also depended on prior dengue sero-status of the vaccinees. Lower efficacy was observed in children with < 9 years old and dengue-na?ve individuals. More importantly, risk of hospitalization and severe dengue was increased in the youngest vaccine recipients (2-5 years) compared to controls...
January 13, 2019: Asian Pacific Journal of Allergy and Immunology
Chalerat Direkwattanachai, Chalermthai Aksilp, Pantipa Chatchatee, Orathai Jirapongsananuruk, Haruthai Kamalaporn, Wasu Kamchaisatian, Sorasak Lochindarat, Lina Ngamtrakulpanit, Orapan Poachanukoon, Muthita Trakultivakorn, Jamaree Teeratakulpisarn, Kanokporn Udomittipong, Mukda Vangveeravong, Jitladda Deerojanawong
BACKGROUND: Acute asthmatic exacerbation in children causes economic burdens both directly and indirectly. The GINA guideline does mention the use of inhaled or oral corticosteroids in the treatment of asthmatic exacerbation, it provides little practical guidance on the use of nebulized corticosteroid. OBJECTIVE: To review and recommend the practical considerations in the use of nebulized corticosteroid in children with acute asthmatic exacerbation. METHODS: This consensus was developed by a group of expert pediatricians in respiratory and allergy fields in Thailand...
January 13, 2019: Asian Pacific Journal of Allergy and Immunology
Gil Myeong Seong, Jaechun Lee, Changhwan Kim
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) are a major cause of drug-induced hypersensitivity, called "NSAID hypersensitivity". A confirmative diagnosis is necessary for ensuring drug safety and finding alternative drugs. No reliable test other than direct challenge is diagnostic. An intravenous (IV) aspirin challenge has rarely been tried. OBJECTIVE: To assess the safety and efficacy of the aspirin IV provocation test. METHODS: A retrospective and descriptive study in a hospital...
January 13, 2019: Asian Pacific Journal of Allergy and Immunology
Chaicharn Pothirat, Warawut Chaiwong, Atikun Limsukon, Nittaya Phetsuk, Nonglak Chetsadaphan, Woranoot Choomuang, Chalerm Liwsrisakun
BACKGROUND: Inhaler devices are a keystone in the management of asthma during the maintenance phase of treatment. OBJECTIVE: To evaluate techniques for using inhaler devices in asthma patients. METHODS: A prospective cross-sectional study was conducted to assess patient compliance with correct techniques for using inhaler devices across three regimens: pressurized metered-dose inhaler (pMDI), Accuhaler®, and Turbuhaler®. The compliance of patients with essential steps for correct device usage in the case of each regimen was recorded...
January 13, 2019: Asian Pacific Journal of Allergy and Immunology
Apichaya Khlaiphuengsin, Natthaya Chuaypen, Nutcha Pinjaroen, Boonchoo Sirichindakul, Nattiya Hirankarn, Pisit Tangkijvanich
BACKGROUND: B-cell activating factor (BAFF), an important cytokine for B lymphocyte activation, has been shown to be increased in chronic hepatitis B virus (HBV) infection. OBJECTIVES: This study aimed at evaluating clinical correlation and prognostic role of plasma BAFF and related polymorphisms in patients with HBV-related hepatocellular carcinoma (HCC). METHODS: Plasma BAFF levels were measured from 100 healthy controls and 490 patients with chronic HBV infection (200 with HCC and 290 without HCC)...
January 13, 2019: Asian Pacific Journal of Allergy and Immunology
Kanokporn Udomittipong, Jurairut Triwatanawong, Akarin Nimmannit, Chulaluk Komoltri
BACKGROUND: Forced oscillation technique (FOT) requires minimal patient cooperation and is particularly useful in young children. Bronchodilator test is a valuable tool for wheezy and asthmatic patients. The cut-off value for bronchodilator response by FOT in healthy Thai children has not been reported. OBJECTIVE: To determine the cut-off values for positive bronchodilator response in healthy Thai preschool children using pseudorandom FOT. METHODS: FOT was used to measure respiratory function at baseline and after 400 mcg MDI salbutamol in healthy Thai children aged 3-6 years...
January 13, 2019: Asian Pacific Journal of Allergy and Immunology
Leila Ksouri, Yahia Mouloud, Nancy Dumais
BACKGROUND: Immediate hypersensitivity reactions to beta-lactams are IgE-mediated and constitute the most common adverse reactions to antibiotics mediated by a specific immunologic mechanism. OBJECTIVE: We investigated the association between four functional polymorphisms of IL13 (R130Q variant) and IL4RA (I50V, S478P and Q551R variants) genes and susceptibility to immediate allergic reactions to beta-lactams in the Algerian population. METHODS: We determined these gene variants in 199 patients and 99 healthy controls from Algeria...
December 9, 2018: Asian Pacific Journal of Allergy and Immunology
Motohiko Suzuki, Makoto Yokota, Shinya Ozaki, Yoshihisa Nakamura
BACKGROUND: We previously reported that dendritic cells (DCs) transfected with CD40 siRNA and pulsed by ovalbumin (OVA) (CD40-silenced OVA DCs) inhibited allergic responses through facilitation of regulatory T cells (Tregs). However, to our knowledge, no prior study has examined allergen-specific therapy by administration of siRNA-induced Tregs for the control of allergy. OBJECTIVE: We aimed to investigate the effect of Tregs induced in vitro on allergic responses and symptoms in vivo...
December 9, 2018: Asian Pacific Journal of Allergy and Immunology
Nanae Kimura, Hiromichi Takeshita, Tatsuya Kai, Yasushi Inoue, Masutaka Furue
Schnitzler's syndrome is an acquired autoinflammatory disease characterized by chronic urticarial rash and monoclonal gammopathy (predominantly IgM type). A 75-year-old Japanese woman complained of high fever and non-pruritic urticarial rash appearing almost every day for 3 years. Her abnormal laboratory data included leukocytosis and neutrophilia with elevated erythrocyte sedimentation rate and C-reactive protein level. Hyperglobulinemia of IgA and IgM was also noted. Histological analysis revealed perivascular and interstitial neutrophilic infiltration without any signs of vasculitis...
December 9, 2018: Asian Pacific Journal of Allergy and Immunology
Sasawan Chinratanapisit, Narissara Suratannon, Punchama Pacharn, Paskorn Sritipsukho, Pakit Vichyanond
BACKGROUND: Allergic rhinitis (AR) is a disease with a high global disease burden and significant morbidity and expense. Risk factors are not well understood. OBJECTIVE: The objective of our project is to study the prevalence and risk factors of AR in children living in the Bangkok area. METHODS: A cross-sectional, multi-center survey using new GAN core questionnaires on current AR and risk factors was completed by 3,074 parents of children aged 6-7 years and by 3,217 children aged 13-14 years, directly...
December 9, 2018: Asian Pacific Journal of Allergy and Immunology
Yang Shen, Ji-Hong Zeng, Su-Ling Hong, Hou-Yong Kang
BACKGROUND: Allergic rhinitis (AR) and asthma are the most common inflammatory diseases of the airways. The relationship between asthma and AR is widely and clinically recognised. The concept "one airway, one disease" has been gradually accepted. However, in China, we could not find any systematic review and meta-analysis on the prevalence of AR with asthma and asthma with AR. OBJECTIVE: The aim of this research was to carry out a meta-analysis on the results of all conducted studies to present valid information about the co-occurrence rate of AR with asthma and asthma with AR in China...
December 9, 2018: Asian Pacific Journal of Allergy and Immunology
Pinyapa Mukdjindapa, Wiparat Manuyakorn, Potjanee Kiewngam, Cherapat Sasisakulporn, Pisut Pongchaikul, Wasu Kamchaisatian, Suwat Benjaponpitak
BACKGROUND: The reference values of Forced Oscillation Technique (FOT) parameters of the inspiratory and expiratory phase for preschool children have not yet been established. OBJECTIVE: To evaluate FOT measures in Thai healthy preschool children. METHODS: Preschool children, aged 3-6 years, were screened. Children who were positive for the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire for asthma, positive family history of allergic diseases, recent lower respiratory tract infections, and environmental tobacco smoke were excluded...
December 9, 2018: Asian Pacific Journal of Allergy and Immunology
Kittiyaporn Sansila, Peem Eiamprapai, Ratree Sawangjit
BACKGROUND: Nasal saline irrigation has been reported to be effective as an adjunctive therapy for allergic rhinitis (AR), but concerns about adverse events, supply problems, and high costs have limited its widespread clinical use. Aqueous 1.8% sodium chloride solution prepared by patients using drinking water (1.8% self-prepared hypertonic nasal saline irrigation; 1.8% SPHNSI) could solve some of these problems, but its clinical efficacy and safety need to be determined. OBJECTIVE: We aimed to compare the efficacy and safety of 1...
December 9, 2018: Asian Pacific Journal of Allergy and Immunology
Artitaya Yatsomboon, Rasana W Sermswan, Surasakdi Wongratanacheewin
BACKGROUND: Septicemic melioidosis caused by Burkholderia pseudomallei is a serious cause of morbidity and mortality. An effective, rapid and simple diagnostic method is required for detection of B. pseudomallei infection. OBJECTIVE: To develop immunomagnetic beads (IMB) coupled with ELISA (IMB-ELISA) for detection of B. pseudomallei in blood samples of patients with suspected melioidosis. METHODS: For separation of B. pseudomallei from buffer, blood samples and hemoculture, 200 nm immunomagnetic beads (IMBs) coated with 4B11 monoclonal antibody (4B11-IMBs) against exopolysaccharide antigens were used...
December 9, 2018: Asian Pacific Journal of Allergy and Immunology
Meng-Che Lu, Shyh-Dar Shyur, Lee-Wen Lee, Timothy Hsu
Generalised morphea (GM) is a subtype of localised scleroderma that usually manifests with bilateral involvement. Unilateral generalised morphea (UGM) is a rare variant of GM. This is a case report of a Taiwanese girl with UGM over the left side of her body. She presented with hyperpigmentation, tightness, and skin atrophy over the left extremities and trunk. Mild range of motion (ROM) limitation over the left knee was also noted. At the clinic, the patient was given oral prednisolone, oral methotrexate (MTX), and oral D-penicillamine...
December 9, 2018: Asian Pacific Journal of Allergy and Immunology
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