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Trends in Biotechnology | Page 2

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https://read.qxmd.com/read/31182244/crispr-mediated-gene-editing-scientific-and-ethical-issues
#21
LETTER
Jarrod Bailey
There remains substantial evidence to warrant great concern over the poor efficiency and specificity of clustered regularly interspaced short palindromic repeats (CRISPR)-mediated genetic modification (GM), despite relatively minor improvements compared to other GM methods. These issues cause persistent, adverse, ethical, and scientific consequences for GM animals, which may never be sufficiently resolvable.
June 7, 2019: Trends in Biotechnology
https://read.qxmd.com/read/31174882/new-prospects-for-modified-algae-in-heavy-metal-adsorption
#22
REVIEW
Sze Yin Cheng, Pau-Loke Show, Beng Fye Lau, Jo-Shu Chang, Tau Chuan Ling
Heavy metal pollution is one of the most pervasive environmental problems globally. Novel finely tuned algae have been proposed as a means to improve the efficacy and selectivity of heavy metal biosorption. This article reviews current research on selective algal heavy metal adsorption and critically discusses the performance of novel biosorbents. We emphasize emerging state-of-the-art techniques that customize algae for enhanced performance and selectivity, particularly molecular and chemical extraction techniques as well as nanoparticle (NP) synthesis approaches...
June 4, 2019: Trends in Biotechnology
https://read.qxmd.com/read/31174881/paradigm-shift-in-algal-h-2-production-bypassing-competitive-processes
#23
Szilvia Z Tóth, Iftach Yacoby
Hydrogen is a promising energy carrier, but producing it sustainably remains a challenge. Green algae can produce hydrogen photosynthetically using their efficient but oxygen-sensitive hydrogenases. Recent strategies aiming to bypass competing processes provide a promising route for scaling up algal hydrogen production.
June 4, 2019: Trends in Biotechnology
https://read.qxmd.com/read/31171377/antimicrobial-inks-the-anti-infective-applications-of-bioprinted-bacterial-polysaccharides
#24
Ronan R McCarthy, Muhammad Wajid Ullah, Eujin Pei, Guang Yang
Bioprinting is a rapidly emerging technology with the potential to transform the biomedical sector. Here, we discuss how a range of bacterial polysaccharides with antibiofilm and antibacterial activity could be used to augment current bioink formulations to improve their biocompatibility and tackle the spread of antibiotic-resistant infections.
June 3, 2019: Trends in Biotechnology
https://read.qxmd.com/read/31160055/thermodynamic-activity-based-solvent-design-for-bioreactions
#25
Anton Wangler, Christoph Held, Gabriele Sadowski
To improve the kinetics of enzyme-catalyzed reactions, cosolvents are commonly added to reaction mixtures. The search for a good cosolvent is still empirical and experimentally based. We discuss a thermodynamic activity-based approach that improves biocatalytic processes by predicting cosolvent influences on Michaelis constants, ultimately reducing time and cost.
May 31, 2019: Trends in Biotechnology
https://read.qxmd.com/read/31153633/translating-biofabrication-to-the-market
#26
Pedro F Costa
Biofabrication holds great potential to revolutionize important industries in the health, food, and textile sectors, but its translation to market is still challenging. I analyze the current state of innovation and commercialization in biofabrication and try to assess its limitations, strengths, and future progress.
May 29, 2019: Trends in Biotechnology
https://read.qxmd.com/read/31151764/designing-biobased-recyclable-polymers-for-plastics
#27
REVIEW
Rajni Hatti-Kaul, Lars J Nilsson, Baozhong Zhang, Nicola Rehnberg, Stefan Lundmark
Several concurrent developments are shaping the future of plastics. A transition to a sustainable plastics system requires not only a shift to fossil-free feedstock and energy to produce the carbon-neutral building blocks for polymers used in plastics, but also a rational design of the polymers with both desired material properties for functionality and features facilitating their recyclability. Biotechnology has an important role in producing polymer building blocks from renewable feedstocks, and also shows potential for recycling of polymers...
May 28, 2019: Trends in Biotechnology
https://read.qxmd.com/read/31153632/crispr-cas-multiplexed-biosensing-a-challenge-or-an-insurmountable-obstacle
#28
LETTER
Yi Li, Linyang Liu, Guozhen Liu
Performing multiplex detection is still an elusive goal for molecular diagnostics. CRISPR/Cas-based biosensing has demonstrated potential for multiplex detection. Instead of being an insurmountable obstacle, CRISPR/Cas multiplexed biosensing is a realistic challenge with some recent successful applications. Strategic considerations are required to fully explore its potential in multiplex diagnostics.
August 2019: Trends in Biotechnology
https://read.qxmd.com/read/31103070/factoring-ecological-societal-and-economic-considerations-into-inoculant-development
#29
LETTER
Terrence H Bell, Laura M Kaminsky, Beth K Gugino, John E Carlson, Rondy J Malik, Kevin L Hockett, Ryan V Trexler
There are many paths toward effective microbial inoculants for agriculture. Considering what is practical for the present day technological and farming landscape should not limit our creativity in developing innovative technologies. However, factors including production costs, practicality of implementation, and technology adoption by farmers will drive the success of new management approaches.
June 2019: Trends in Biotechnology
https://read.qxmd.com/read/31103069/field-specific-microbial-consortia-are-feasible-a-response-to-kaminsky-et-al
#30
LETTER
Ashutosh Awasthi
Kaminsky et al. (Trends Biotechnol. 2019:37;140-151) discuss the conflicts in developing microbial inoculants for agriculture. The authors affirm that microbial inoculants should perform across a wide range of environments but rule out the feasibility of personalized inoculants for individual fields. Here, I propose customized microbial consortia for specific field environments.
June 2019: Trends in Biotechnology
https://read.qxmd.com/read/31130309/plant-bacterial-degradation-of-polyaromatic-hydrocarbons-in-the-rhizosphere
#31
Olga Turkovskaya, Anna Muratova
Studies of polycyclic aromatic hydrocarbon (PAH)-degrading bacteria and plant root exudate enzymes from contaminated rhizospheres suggest that pollutant rhizodegradation involves the joint work of bacteria and plants. Plant-microbial associations with coupled metabolic capabilities that completely degrade PAHs while avoiding the formation of dangerous intermediates are biotechnologically promising.
May 23, 2019: Trends in Biotechnology
https://read.qxmd.com/read/31130308/advances-in-microfluidic-blood-brain-barrier-bbb-models
#32
REVIEW
Arianna Oddo, Bo Peng, Ziqiu Tong, Yingkai Wei, Wing Yin Tong, Helmut Thissen, Nicolas Hans Voelcker
Therapeutic options for neurological disorders currently remain limited. The intrinsic complexity of the brain architecture prevents potential therapeutics from reaching their cerebral target, thus limiting their efficacy. Recent advances in microfluidic technology and organ-on-chip systems have enabled the development of a new generation of in vitro platforms that can recapitulate complex in vivo microenvironments and physiological responses. In this context, microfluidic-based in vitro models of the blood-brain barrier (BBB) are of particular interest as they provide an innovative approach for conducting research related to the brain, including modeling of neurodegenerative diseases and high-throughput drug screening...
May 23, 2019: Trends in Biotechnology
https://read.qxmd.com/read/31109738/oligonucleotide-analogs-and-mimics-for-sensing-macromolecular-biocompounds
#33
REVIEW
Katarzyna Bartold, Agnieszka Pietrzyk-Le, Francis D'Souza, Wlodzimierz Kutner
Living organisms create life-sustaining macromolecular biocompounds including biopolymers. Artificial polymers can selectively recognize biocompounds and are more resistant to harsh physical, chemical, and physiological conditions than biopolymers are. Due to recognition at a molecular level, molecularly imprinted polymers (MIPs) provide powerful tools to correlate structure with biological functionality and are often used to build next-generation chemosensors. We envision an increasing emergence of nucleic acid analogs (NAAs) or biorelevant monomers built into nature-mimicking polymers...
May 17, 2019: Trends in Biotechnology
https://read.qxmd.com/read/31104858/recent-advances-in-biosensors-for-detecting-cancer-derived-exosomes
#34
REVIEW
Nan Cheng, Dan Du, Xinxian Wang, Dong Liu, Wentao Xu, Yunbo Luo, Yuehe Lin
Early detection and effective treatments are two of the greatest challenges in the fight against cancer. Cancer-derived exosomes are attractive biomarkers for the early diagnosis and therapeutic response evaluation of cancer. Here, we review recent advances in biosensors for the detection of cancer-derived exosomes. We discuss the potential exosomal biomarkers of various cancers, which can be applied as indicative targets in the design of biosensors. We further describe the fabrication of exosome detection biosensors with respect to biological recognition strategies and signal transduction techniques, which involve integrated scientific and technological aspects of analytical chemistry and nanotechnology...
May 16, 2019: Trends in Biotechnology
https://read.qxmd.com/read/31103352/-living-inks-for-3d-bioprinting
#35
Leo Hsu, Xiaocheng Jiang
A critical aspect in bioprinting is the formulation of bioactive inks. A recent breakthrough in bioink design (Qian et al. Nano Lett. 2019; https://doi.org/10.1021/acs.nanolett.9b00066) enables the direct writing of catalytically active microorganisms with unprecedented cell loading, tunable structural properties, and long-term activity. This strategy will create possibilities for bottom-up design and integration of functional living systems.
May 15, 2019: Trends in Biotechnology
https://read.qxmd.com/read/31078316/crispr-cas-powered-multiplexed-biosensing
#36
LETTER
Richard Bruch, Gerald A Urban, Can Dincer
Multiplexed CRISPR/Cas biosensing offers various possibilities for diagnosing different diseases by analyzing many analytes from one single specimen. However, in this relatively new field, nearly no multiplexing approaches exist, as many challenges need to be addressed. We discuss the reasons behind it and possible strategies to push the multiplexing level.
May 8, 2019: Trends in Biotechnology
https://read.qxmd.com/read/31076248/microchannels-in-development-survival-and-vascularisation-of-tissue-analogues-for-regenerative-medicine
#37
REVIEW
Khoon S Lim, Marissa Baptista, Shahana Moon, Tim B F Woodfield, Jelena Rnjak-Kovacina
Microchannels are simple, perfusable architectural features engineered into biomaterials to promote mass transport of solutes to cells, effective cell seeding and compartmentalisation for tissue engineering applications, control over spatiotemporal distribution of molecules and ligands, and survival, integration, and vascularisation of engineered tissue analogues in vivo. Advances in biofabrication have led to better control over microchannel fabrication in 3D scaffolds, enabling sophisticated designs that drive the development of complex tissue structures...
May 7, 2019: Trends in Biotechnology
https://read.qxmd.com/read/31072609/wearable-devices-for-single-cell-sensing-and-transfection
#38
REVIEW
Lingqian Chang, Yu-Chieh Wang, Faheem Ershad, Ruiguo Yang, Cunjiang Yu, Yubo Fan
Wearable healthcare devices are mainly used for biosensing and transdermal delivery. Recent advances in wearable biosensors allow for long-term and real-time monitoring of physiological conditions at a cellular resolution. Transdermal drug delivery systems have been further scaled down, enabling wide selections of cargo, from natural molecules (e.g., insulin and glucose) to bioengineered molecules (e.g., nanoparticles). Some emerging nanopatches show promise for precise single-cell gene transfection in vivo and have advantages over conventional tools in terms of delivery efficiency, safety, and controllability of delivered dose...
May 6, 2019: Trends in Biotechnology
https://read.qxmd.com/read/31054854/grand-research-challenges-for-sustainable-industrial-biotechnology
#39
REVIEW
Adrie J J Straathof, S Aljoscha Wahl, Kirsten R Benjamin, Ralf Takors, Nick Wierckx, Henk J Noorman
Future manufacturing will focus on new, improved products as well as on new and enhanced production methods. Recent biotechnological and scientific advances, such as CRISPR/Cas and various omic technologies, pave the way to exciting novel biotechnological research, development, and commercialization of new sustainable products. Rigorous mathematical descriptions of microbial cells and consortia thereof will enable deeper biological understanding and lead to powerful in silico cellular models. Biological engineering, namely model-based design together with synthetic biology, will accelerate the construction of robust and high-performing microorganisms...
May 1, 2019: Trends in Biotechnology
https://read.qxmd.com/read/30497871/biofilms-in-chronic-wounds-pathogenesis-and-diagnosis
#40
REVIEW
Yuan-Kun Wu, Nai-Chen Cheng, Chao-Min Cheng
Chronic non-healing wounds have become a major worldwide healthcare burden. The impact of biofilms on chronic wound infection is well established. Despite increasing understanding of the underlying mechanism of biofilm formation in chronic wounds, current strategies for biofilm diagnosis in chronic wounds are still far from ideal. In this review, we briefly summarize the mechanism of biofilm formation and focus on current diagnostic approaches of chronic wound biofilms based on morphology, microbiology, and molecular assays...
May 2019: Trends in Biotechnology
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