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JOURNAL ARTICLE
Rithwick Rajagopal, Janet B McGill
PURPOSE: Novel therapies for diabetes have potent effects on glycemic control, obesity and cardiovascular risk reduction but some, including the popular drug semaglutide, have also been implicated in worsening of diabetic retinopathy (DR). Given the ubiquity of these new agents, understanding the risks to vision is important. Here we review the data for several newly available agents in terms of systemic efficacy and retinal safety. METHODS: Literature review. RESULTS: Novel antihyperglycemic treatments include incretin mimetics and enhancers, sodium-glucose cotransporter inhibitors, long-acting insulins, and insulin delivery systems...
August 14, 2024: Retina
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JOURNAL ARTICLE
Ji Hye Lee, Joo-Young Kim, Bo-Een Hwang, Joo-Young Kim, Rae-Young Kim, Mirinae Kim, Young-Gun Park, Young-Hoon Park
PURPOSE: To assess the longitudinal surgical outcomes of macular telangiectasia type 2 macular hole (MacTel-MH) and compare them with those of idiopathic MH. METHODS: This retrospective, single-tertiary center study included patients who underwent MH surgery between January 2015 and September 2023. Patients with characteristic optical coherence tomography (OCT) findings of MacTel in both eyes or those who underwent fluorescence angiography were classified as having MacTel MH...
August 14, 2024: Retina
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JOURNAL ARTICLE
Junhong Chen, Jiwei Tao, Yun Zhang
PURPOSE: To compare the anatomical and functional outcomes of the inverted flap technique versus conventional internal limited membrane (ILM) peeling in large idiopathic full-thickness macular holes (FTMHs) smaller than 650 µm. METHODS: Retrospective comparative study. Patients with large idiopathic MHs smaller than 650 µm who underwent either the inverted flap technique (IFT) or ILM peeling were investigated. The main outcomes included the MH closure rate, recovery rates of the external limiting membrane (ELM) and ellipsoid zone (EZ) and best-corrected visual acuity (BCVA) at 1, 3, and 6 months postoperatively...
August 14, 2024: Retina
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JOURNAL ARTICLE
Swathi Kaliki, Vijitha S Vempuluru, Komal Rajendra Bakal, Samten Dorji, Vishakha Tanna, Charlotte N Shields, Samuel J Fallon, Vishal Raval, Alia Ahmad, Asma Mushtaq, Mahvish Hussain, Yacoub A Yousef, Mona Mohammad, Soma Rani Roy, Fahmida Huque, Ushakova Tatiana, Serov Yuri, Polyakov Vladimir, Sandro Casavilca Zambrano, Sandra Alarcón-León, Cinthya Valdiviezo-Zapata, Maria Vargas-Martorellet, Cynthia Gutierrez-Chira, Mario Buitrago, Joana Sánchez Ortiz, Rosdali Diaz-Coronado, Devjyoti Tripathy, Suryasnata Rath, Gaurav Patil, Jesse L Berry, Sarah Pike, Brianne Brown, Mika Tanabe, Shahar Frenkel, Maya Eiger-Moscovich, Jacob Pe'er, Carol L Shields, Ralph C Eagle, Andrea Laiton, Ana Maria Velasco, Katherine Vega, Joseph DeSimone, Kavya Madhuri Bejjanki, Anasua Ganguly Kapoor, Anusha Venkataraman, Victoria Bryant, M Ashwin Reddy, Mandeep S Sagoo, G Baker Hubbard, Corrina P Azarcon, Thomas A Olson, Hans Grossniklaus, Olivia Rolfe, Sandra E Staffieri, Roderick O'Day, Anu A Mathew, James E Elder, John D McKenzie, Ido Didi Fabian, Rachel Shemesh, Vicktoria Vishnevskia-Dai, Mohammed Hasnat Ali, Saumya Jakati, Dilip K Mishra, Vijay Anand Reddy Palkonda
PURPOSE: To evaluate high-risk histopathological features (HRHF) following primary enucleation of eyes with retinoblastoma (RB) and assess the patient outcomes across continents. METHODS: Retrospective study of 1426 primarily enucleated RB eyes from five continents. RESULTS: Of all, 923 (65%) were from Asia (AS), 27 (2%) from Australia (AUS), 120 (8%) from Europe (EUR), 162 (11%) from North America (NA), and 194 (14%) from South America (SA)...
August 14, 2024: Retina
#25
JOURNAL ARTICLE
Zigan Zhou, Zhong Lin, Binghua Guo, Chen Yang, Xingyi Wu, Bi Sun, Yuhao Liu, Ronghan Wu
PURPOSE: Summarizing the causes of retinal arterial microaneurysm (RAM) combined with branch retinal artery occlusion (BRAO). METHODS: The case reports of RAM combined with BRAO were searched in PubMed, Web of Science, and CNKI databases before May 1, 2024. A total of 9 participants from 9 case reports were included to analyze factors leading to complications. RESULTS: The reasons for this complication are as follows: complications during photocoagulation therapy...
August 14, 2024: Retina
#26
JOURNAL ARTICLE
Rajani P Brandsen, Bart J Biemond, Gulsum Z Nasim, Erfan Nur, Reinier O Schlingemann, Roselie M H Diederen
PURPOSE: To evaluate macular abnormalities in sickle cell disease (SCD) with OCT-Angiography (OCTA) and to determine associations with sickle cell retinopathy (SCR) and clinical and laboratory characteristics. METHODS: Complete ophthalmic examination was performed in consecutive SCD patients (HbSS, HbSC, HbSβ0 or HbSβ+ genotype), including fundoscopy and macular SD-OCT/OCTA scans. SCR stage was based on fundoscopic examination (without fluorescein angiography) instead of the Goldberg classification, since fluorescein angiography was only used in case of tentative diagnosis...
August 13, 2024: Retina
#27
JOURNAL ARTICLE
Pei-Liang Wu, Chia-Pang Shih, Yu-Shu Huang, Hung-Chi Chen, Yi-Jen Hsueh, Chia-Wen Lee, Ming-Chou Chiang, Reyin Lien, Chien-Chung Lee, Shih-Ming Chu, Hung-Da Chou, Laura Liu, Kuan-Jen Chen, Yih-Shiou Huang, Chi-Chun Lai, Wei-Chi Wu
PURPOSE: Determine whether intravitreal injection of bevacizumab (IVB) exerts long-term effects on neurodevelopmental outcomes in children with retinopathy of prematurity (ROP) when reaching the age of 8 years. METHODS: We enrolled 277 children. Patients were stratified into the groups full-term, preterm without ROP, ROP without treatment, or ROP with treatment, based on gestational age (GA) and ROP status. Children under GA of 37 weeks were considered premature...
August 12, 2024: Retina
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JOURNAL ARTICLE
Kai Zhu, Yonghao Gu, Xiaojun Li, Enliang Zhou, Qin He, Qihong Gu
PURPOSE: The goal of the study is to introduce a modified technique for the removal of subretinal fluid during scntleral buckling (SB) to treat rhegmatogenous retinal detachment (RRD). METHODS: This case series study was comprised of 18 cases of RRD patients suffering from a novel automated aspiration of subretinal fluid method during SB. The cases took place from July 2023 to November 2023 at the First Affiliated Hospital of USTC. Preoperative and intraoperative situations were evaluated, and spectral-domain optical coherence (SDOCT) and scanning laser ophthalmoscopy were used to observe the absorption of SRF in the early postoperative period...
August 9, 2024: Retina
#29
JOURNAL ARTICLE
Rita Serra, Yasmine Serrar, Thibaud Mathis, Antonio Pinna, Laurent Kodjikian
No abstract text is available yet for this article.
August 9, 2024: Retina
#30
JOURNAL ARTICLE
Alessandro Feo, David Sarraf
No abstract text is available yet for this article.
August 9, 2024: Retina
#31
JOURNAL ARTICLE
Nir Gomel, Rossella D'Aloisio, Aya Wattad, Rodolfo Mastropasqua, Federico Formenti, Anat Loewenstein, Matias Iglicki, Dinah Zur
PURPOSE: The approach to managing patients with retinal vein occlusion (RVO) and cystoid macular edema (CME) with good initial visual acuity (VA) better than 6/12 has not been investigated. This study aimed to evaluate functional and anatomical outcomes of intravitreal treatment and observation in patients with CME due to RVO, who presented with good initial VA. Methods: Multicenter retrospective cohort study. Seventy-nine eyes of 79 patients with CME secondary to RVO and initial VA better than 6/12, either treated with anti-VEGF therapy or observed...
August 9, 2024: Retina
#32
JOURNAL ARTICLE
Clara Valor Suárez, Jonathan Than, Ye Ling, Jean-Yves Guillemaut, David M Frohlich, Tom H Williamson
PURPOSE: To determine the validity, accuracy and acceptability of the Image Warping Test (IWT), a novel test for the measurement of visual distortion in the central visual field. METHODS: 25 volunteers with metamorphopsia secondary to vitreoretinal pathology were recruited at a tertiary referral center. All subjects underwent ophthalmological examination and measurement of metamorphopsia via Amsler grid, Morphision, M-CHARTS and the IWT. Construct validity was determined through assessment of the association between symptoms, pathology, visual acuity, established metamorphopsia test results and IWT results...
August 9, 2024: Retina
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JOURNAL ARTICLE
Richard F Spaide
PURPOSE: This study aimed to characterize and quantify the precursor lesions of geographic atrophy (GA) in eyes with age-related macular degeneration (AMD). METHODS: A retrospective study of eyes with a minimum 6-month follow-up prior to developing GA. Evaluations included color and autofluorescence imaging, along with spectral domain optical coherence tomography, employing definitions from the Consensus of Atrophy Meeting Group and Consensus on Neovascular Age-Related Macular Degeneration Nomenclature Study Group...
August 9, 2024: Retina
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JOURNAL ARTICLE
João Heitor Marques, Inês Morais, João Coelho, Milton Severo, Maria João Menéres, João Melo Beirão
PURPOSE: To describe a series of patients with hereditary transthyretin amyloidosis (ATTRv) with vitreous amyloid and to study the efficacy and safety of pars plana vitrectomy (PPV) for its treatment. METHODS: Retrospective study of 266 patients with ATTRv due to Val30Met mutation submitted to PPV for vitreous amyloid, with a minimum 3-month follow-up. Indications for surgery were disabling myodesopsia or 2 lines loss in visual acuity. Only the first operated eye was considered for analysis...
August 9, 2024: Retina
#35
JOURNAL ARTICLE
Aurora Pecaku, Ahmed El-Sehemy, Isabela Martins Melo, Sue Ellen Demian, Michael Andreoli, Arun Ramachandran, Rajeev H Muni
PURPOSE: To describe a novel positioning maneuver for patients with rhegmatogenous retinal detachment (RRD) following pneumatic retinopexy(PnR). METHODS: Single-center prospective case series of primary RRDs referred to St. Michael's Hospital, Toronto, Canada, between 2021 and 2023. All patients underwent PnR. Baseline ultra-widefield fundus imaging and repeat imaging 10 minutes after the gas injection was performed. After PnR, patients were instructed to perform the mini-steamroll maneuver which consists of a face-down position for ten minutes followed by positioning to the retinal break...
August 9, 2024: Retina
#36
JOURNAL ARTICLE
Jianfeng Long, Haoyu Li, Liwei Zhang, Xinyue Sun, Shaohua Liu, Hanhan Peng, Baihua Chen
PURPOSE: Complications such as explosive choroidal hemorrhage, residual cortex, and capsule rupture often occur during intraocular surgery combined with penetrating keratoplasty (PKP) due to poor maintenance of the anterior chamber. To address these challenges, we have innovatively utilized a sterile polyethylene instrument cover to temporarily reconstruct the anterior chamber. METHODS: In this report, we describe a technique where a 'temporary corneal patch' was created from a sterile instrument cover, using a trephine to ensure a diameter approximately 1-2 mm wider than the corneal bed or perforation...
August 8, 2024: Retina
#37
JOURNAL ARTICLE
Matteo Mario Carlà, Alessandra Scampoli, Lorenzo Governatori, Giulia Grieco, Tomaso Caporossi
PURPOSE: We aimed to introduce a novel visualization technique of en-face scans during epiretinal membrane (ERM) peeling, by using the in-built picture-in-picture (PIP) modality of the Alcon Ngenuity 3D System, connected to a smartphone. METHODS: Prospective mono-centric interventional analysis on 20 patients undergoing vitrectomy and peeling for idiopathic ERMs. RTVue XR Avanti device was used perform a 6 × 6 mm optical coherence tomography angiography (OCTA)...
August 8, 2024: Retina
#38
JOURNAL ARTICLE
Soichiro Yamamoto, Yuta Taniguchi, Yohei Kuroki, Hidenori Nagahama, Shin Tanaka, Kazuaki Kadonosono, Fumihito Arai, Hiroshi Enaida
PURPOSE: To construct a quantitative evaluation system for hand tremor during internal limiting membrane (ILM) peeling and investigate changes in hand tremor attributable to the use of the customized passive surgical support robot. METHODS: This analytical and experimental study developed a hand tremor evaluation system that synchronizes three elements: surgical microscope images, an artificial eye module with a force sensor to simulate ILM peeling, and microforceps with an inertial measurement unit...
August 8, 2024: Retina
#39
JOURNAL ARTICLE
Kushal U Agrawal, Abhishek Das, Prema Subramanyam, Parag K Shah, Venkatapathy Narendran
No abstract text is available yet for this article.
August 6, 2024: Retina
#40
JOURNAL ARTICLE
Elodie Bousquet, Neda Abraham, Rania Estawro, Simanta Khadka, Shilo Voichanski, Mostafa Mafi, Adrian Au, Ahmad Santina, SriniVas Sadda, David Sarraf
PURPOSE: To describe and study hyporeflective sub retinal pigment epithelium (RPE) spaces in large drusen and drusenoid pigment epithelial detachment prior to collapse. METHOD: Retrospective longitudinal study which enrolled patients with large and very large drusen due to intermediate age-related macular degeneration (AMD). The following optical coherence tomography (OCT) parameters were assessed: Drusen size (maximum width and height), OCT biomarkers of RPE atrophy, presence of intraretinal and subretinal fluid (IRF, SRF), acquired vitelliform lesion and sub RPE regions of hyporeflectivity within the PED compartment...
August 6, 2024: Retina
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