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Amy S Babiuch, Atsuro Uchida, Natalia Figueiredo, Ming Hu, Mehnaz Khan, Sunil K Srivastava, Rishi P Singh, Aleksandra Rachitskaya, Peter K Kaiser, Jamie L Reese, Justis P Ehlers
PURPOSE: To compare optical coherence tomography angiography (OCTA) review strategies for optimizing choroidal neovascularization (CNV) detection. METHODS: Eyes with CNV in the differential diagnosis were imaged with the Avanti RTVue XR HD (Optovue, Fremont, CA). Three modalities of review for CNV presence were used in each case: a single report generated using automated segmentation within Avanti software; a continuous slab descent video OCTA export; and a manual segmentation approach using cross-sectional OCT with decorrelation signal overlay...
February 11, 2019: Retina
Alexander Barash, Toco Y P Chui, Patricia Garcia, Richard B Rosen
PURPOSE: Intravitreal injections acutely and temporarily increase intraocular pressure (IOP), and this may have cumulative long-term effects including an increased risk for glaucoma surgery. This study was designed to measure retinal perfusion density changes on optical coherence tomography (OCT) angiography and OCT thickness alterations associated with acutely increased IOP after intravitreal injections. METHODS: Retrospective observational clinical study of 40 eyes (39 patients) with various retinopathies from October 2016 to June 2017 at a tertiary care retina clinic in NYC...
February 11, 2019: Retina
Ali M Allahdina, Katherine G Chen, Jason A Alvarez, Wai T Wong, Emily Y Chew, Catherine A Cukras
PURPOSE: To characterize functional and structural changes in hydroxychloroquine (HCQ) retinal toxicity after drug cessation. METHODS: Twenty-two patients (91% female; mean age 58.7 ± 11.4 years; mean duration of HCQ treatment 161.1 ± 90 months; mean dose 5.9 ± 1.9 mg/kg) with detected HCQ retinopathy were monitored for 6 months to 82 months after HCQ cessation with multimodal imaging including spectral domain optical coherence tomography and fundus autofluorescence imaging at 488 nm (standard) and 787 nm (near-infrared autofluorescence)...
February 5, 2019: Retina
Tom Buelens, Jeannette Ossewaarde-van Norel, Joke H de Boer, Isabelle Nubourgh, Gérald Glibert, Prochore Kamgang Semeu, Jean-François Fils, Laure Caspers, Laurence Postelmans, François Willermain
PURPOSE: To evaluate the effect of tumor necrosis factor (TNF) inhibitor therapy on ocular relapses in patients with Susac syndrome. METHODS: Multicenter retrospective cohort study of patients diagnosed with Susac syndrome according to classical clinical criteria. We evaluated the disease activity before and after introduction of anti-TNF therapy and its value as a steroid-sparing agent. RESULTS: Five patients were included. All were initially treated with a combination of corticosteroids and classical immunosuppressive drugs...
January 29, 2019: Retina
Gilad Rabina, Nur Azem, Dana Barequet, Adiel Barak, Anat Loewenstein, Shulamit Schwartz
PURPOSE: To evaluate the influence of silicone oil (SO) tamponade on retinal layers thickness and visual acuity in patients who underwent pars plana vitrectomy for rhegmatogenous retinal detachment. METHODS: This is a retrospective case series of consecutive patients who underwent pars plana vitrectomy for rhegmatogenous retinal detachment with SO tamponade. Visual acuity and central macular thickness were measured with SO and at least a month after SO removal (SOR)...
January 29, 2019: Retina
Alyssa C Bonnell, Dimosthenis Mantopoulos, Howard F Fine, Sumit P Shah, H Matthew Wheatley, Jonathan L Prenner
PURPOSE: To report the 1-year outcomes of a novel surgical technique for the fixation of a CZ70BD intraocular lens with Gore-Tex suture using cow-hitch knots. METHODS: A retrospective chart review of 15 patients (13 men and 2 women) who underwent fixation of a posterior chamber intraocular lens with Gore-Tex suture was performed. Short- and long-term outcomes data were collected 1 month and 1 year after surgery, respectively. RESULTS: Fourteen of the 15 patients met inclusion criteria and were included in the analysis...
January 24, 2019: Retina
Sagar B Patel, Nikitha K Reddy, Yu-Guang He
PURPOSE: To report toxic posterior segment syndrome after dropless cataract surgery using locally compounded triamcinolone-moxifloxacin. METHODS: A retrospective case review of 7 patients presenting with a decrease in visual acuity after dropless cataract surgery. RESULTS: All patients experienced significant reductions in best-corrected visual acuity of the postoperative eye ranging from 20/40 to count finger at 4 feet (average best-corrected visual acuity 20/220) immediately after surgery...
January 24, 2019: Retina
Yan He, Ling Zhang, Fang Wang, Meidong Zhu, Yi Wang, Yong Liu
PURPOSE: To compare the impact of surgical timing on anatomical and functional outcomes of vitrectomy for open-globe injury. METHODS: Fifty-three patients were entered into this prospective open-label study, with 26 patients randomized into early surgery group (vitrectomy conducted within 4 days) and 27 into delayed surgery group (vitrectomy performed between 10-14 days after injury). Six-month data were available for 46 patients and 7 were lost to follow-up. The main outcome measures were incidence of traumatic proliferative vitreoretinopathy assessed intraoperatively and postoperatively, reattachment of retina, eye enucleation, improvement of the best-corrected visual acuity, and complications...
January 24, 2019: Retina
Cláudia Farinha, Torcato Santos, Ana Rita Santos, Marta Lopes, Dalila Alves, Rufino Silva, José Cunha-Vaz
PURPOSE: To test optical coherence tomography leakage in the identification and quantification of choroidal neovascularization-related fluid, its change after anti-vascular endothelial growth factor therapy in neovascular age-related macular degeneration eyes and its relation to functional outcome. METHODS: Prospective analysis of a cohort of neovascular age-related macular degeneration cases treated with 2.0-mg intravitreal aflibercept. Eyes included were analyzed before, 1-week, and 1-month after one injection...
January 24, 2019: Retina
Alexandra Mouallem-Beziere, Rocio Blanco-Garavito, Florence Richard, Alexandra Miere, Camille Jung, Jean-Michel Rozet, Eric H Souied
PURPOSE: We hypothesized that severe forms of neovascular age-related macular degeneration (AMD) such as large pigment epithelial detachments poorly responding to anti-vascular endothelial growth factor therapy might present a distinct genotype compared with overall series of neovascular AMD. METHODS: This is a multicenter genetic association study. Sixty-eight patients presenting pigment epithelial detachments resistant to ranibizumab (issued from ARI2 study, register number NCT02157077 on clinicaltrials...
January 23, 2019: Retina
Paul S Boeke, Michael M Altaweel
No abstract text is available yet for this article.
January 23, 2019: Retina
Silvia Méndez-Martínez, Pilar Calvo, Oscar Ruiz-Moreno, Nieves Pardiñas Barón, Jesús Leciñena Bueno, María Del Rocío Gil Ruiz, Luis Pablo
PURPOSE: Mitogen-activates protein kinase (MAPK) inhibitors, particularly MEK inhibitors, have shifted the treatment paradigm for metastatic BRAF-mutant cutaneous melanoma; however, oncologists, ophthalmologists, and patients have noticed different toxicities of variable importance. This review aims to provide an update of the ocular adverse events (OAEs), especially retinal toxicity, associated with the use of MEK inhibitors. METHODS: We conducted a scientific literature search using the PubMed database up to July 2018 with the terms "MEK inhibitors" with a "review" filter and "MEK inhibitors" with a "clinical trials" filter...
January 23, 2019: Retina
Vivek Pravin Dave, Avinash Pathengay, Imoro Zeba Braimah, Bhavik Panchal, Savitri Sharma, Rajeev Reddy Pappuru, Annie Mathai, Mudit Tyagi, Raja Narayanan, Subhadra Jalali, Taraprasad Das
PURPOSE: To report the clinical presentation and management outcome of patients with endophthalmitis caused by Enterococcus species and to report the susceptibility profile of the isolates. METHODS: Twenty-nine cases with culture-proven Enterococcus endophthalmitis from January 2005 to May 2018 underwent vitrectomy/vitreous biopsy, intravitreal antibiotic with or without additional procedures. The undiluted vitreous was subjected to microbiologic evaluation. A favorable anatomical outcome was defined as preservation of the globe, absence of hypotony, attached retina, and absence of active inflammation at the last visit...
January 23, 2019: Retina
Shin Yamane, Maiko Maruyama-Inoue, Kazuaki Kadonosono
No abstract text is available yet for this article.
January 22, 2019: Retina
Jesse J Jung, Michael H Chen, Yue Shi, Marco Nassisi, Kenneth Marion, Srinivas R Sadda, Quan V Hoang
PURPOSE: To demonstrate the effect of averaging multiple en face optical coherence tomography angiography images on the correlation between retinal microvasculature quantitative metrics and best-corrected visual acuity (BCVA) in eyes with retinal vein occlusion. METHODS: A cross-sectional cohort with unilateral retinal vein occlusion was imaged in both eyes. Five 3 mm × 3-mm spectral domain optical coherence tomography angiography images were averaged, and quantitative parameters from averaged versus single images were correlated with logMAR BCVA...
January 22, 2019: Retina
Giuseppe Giannaccare, Marco Pellegrini, Stefano Sebastiani, Federico Bernabei, Fabiana Moscardelli, Claudio Iovino, Pietro E Napoli, Emilio Campos
PURPOSE: To evaluate choroidal structural changes occurring over time in geographic atrophy (GA) secondary to age-related macular degeneration using choroidal vascularity index (CVI). METHODS: Enhanced-depth imaging optical coherence tomography scans of 34 patients with GA and 32 control subjects were retrospectively analyzed. Data were collected at baseline and after a mean follow-up of 18.3 ± 8.3 months. Choroidal images were binarized using the ImageJ software, and the luminal area and stromal area were segmented...
January 22, 2019: Retina
Devesh Kumawat, Pradeep Venkatesh, Anand S Brar, Pranita Sahay, Vinod Kumar, Parijat Chandra, Rohan Chawla
PURPOSE: To study the etiology, clinical features, management options, and visual prognosis in various types of atypical macular holes (MHs). METHODS: A review of the literature was performed, which focused on the etiopathogenesis of atypical or secondary MHs, their differentiating clinical features, management strategies, and varied clinical outcomes. Idiopathic or age-related, myopic, and traumatic MHs were excluded. RESULTS: Atypical or secondary MHs arise out of concurrent ocular pathologies (dystrophy, degeneration, or infections) and laser/surgery...
January 16, 2019: Retina
Edward H Wood, Peter H Tang, Irina De la Huerta, Edward Korot, Stephanie Muscat, Daniel A Palanker, George A Williams
PURPOSE: To review and discuss current innovations and future implications of promising biotechnology and biomedical offerings in the field of retina. We focus on therapies that have already emerged as clinical offerings or are poised to do so. METHODS: Literature review and commentary focusing on stem cell therapies, gene-based therapies, optogenetic therapies, and retinal prosthetic devices. RESULTS: The technologies discussed herein are some of the more recent promising biotechnology and biomedical developments within the field of retina...
January 16, 2019: Retina
(no author information available yet)
No abstract text is available yet for this article.
January 14, 2019: Retina
Shinichiro Doi, Shuhei Kimura, Yuki Morizane, Mio M Hosokawa, Yusuke Shiode, Masayuki Hirano, Shinji Toshima, Kosuke Takahashi, Mika Hosogi, Atsushi Fujiwara, Toshio Okanouchi, Yasushi Inoue, Fumio Shiraga
PURPOSE: To investigate the clinical course of submacular hemorrhage associated with ruptured retinal arterial macroaneurysm using swept-source optical coherence tomography. METHODS: This study included 23 eyes of 23 consecutive patients diagnosed with submacular hemorrhage associated with ruptured retinal arterial macroaneurysm. Cases underwent displacement of submacular hemorrhage (vitrectomy + subretinal injection of tissue plasminogen activator + air tamponade) and were followed up for 6 months after surgery...
January 14, 2019: Retina
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