Retina

PURPOSE: To determine the longitudinal changes in the morphologic features of dome-shaped macula (DSMs) in highly myopic eyes. METHODS: Patients with a DSM and high myopia (spherical equivalent <-8 diopters [D] or axial length ≥26.5 mm) were retrospectively studied. The medical records, optical coherence tomographic (OCT) images, and ultra-widefield OCT images were analyzed. RESULTS: A total of 113 eyes of 82 patients were studied with a mean follow-up of 122...

PURPOSE: To investigate the predictors of macular chorioretinal atrophy (CRA), consisting of patchy atrophy (PA) at the macula and choroidal neovascularization (CNV)-related macular atrophy (CNV-MA), during treatment with either ranibizumab or aflibercept for myopic CNV (mCNV) and its impact on visual outcomes. METHODS: This retrospective study included 82 eyes with treatment-naïve mCNV who were treated with pro re nata injections of either ranibizumab or aflibercept...

PURPOSE: To investigate the possible correlation factors of choroidal thickness in ABCA4-related retinopathy. METHODS: A total of 66 patients were included in the cohort. It is a retrospective, cross-sectional laboratory investigation. The patients were tested using whole exon sequencing (WES) and ophthalmic exams, including slip lamp exams, best corrected visual acuity (BCVA), spectral-domain optical coherence tomography (SD-OCT), fundus photo (FP), and fundus autofluorescence (FAF)...

PURPOSE: To study visual function, retinal layer thickness changes and tangential displacement after Pars Plana Vitrectomy (PPV) for EpiRetinal Membrane (ERM). METHODS: Retrospective series of patients undergoing PPV for ERM, with 6-month follow-up including best-corrected visual acuity (BCVA), Optical Coherence Tomography (OCT), M-charts, ERM grading, and InfraRed fundus photo at time 0 (T0, pre-op) at month 1 (T1), 3 (T3), 6 (T6) post-op (±1 week). Retinal layer thickness and tangential (en-face) retinal displacement between successive times for the entire retinal surface and the central horizontal and vertical meridian were also measured...

PURPOSE: To evaluate the status of the posterior vitreous hyaloid on presenting optical coherence tomography (OCT) images of the macula and its relationship to clinical characteristics, treatment patterns, and outcomes in eyes with central retinal vein occlusion (CRVO). METHODS: This is a retrospective longitudinal cohort study of consecutive patients with acute, treatment-naïve CRVO diagnosed between 2009-2021 who had at least 12 months of follow-up. Clinical characteristics, treatment patterns, and outcomes were analyzed between eyes stratified based on presence or absence of a complete posterior vitreous detachment (PVD) on OCT at presentation...

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PURPOSE: RPGR-associated X-linked retinitis pigmentosa (RPGR-XLRP) is a rare and severe form of retinitis pigmentosa (RP) resulting in progressive visual impairment; however, disease progression data are limited. A systematic literature review was conducted to assess available data on disease progression in RPGR-XLRP. METHODS: PubMed, EMBASE, and select congress abstracts were evaluated through June 2022. Eligible studies included results specific to RPGR-XLRP or populations with ≥80% of RP patients carrying disease-causing RPGR variants...

PURPOSE: To determine the prevalence and rate of persistence over two years of various-sized hypertransmission defects (hyperTDs) in eyes with intermediate age-related macular degeneration (iAMD). METHODS: Retrospective analysis of optical coherence tomography (OCT) data from consecutive iAMD patients. Choroidal en face OCT images were evaluated for the presence and number of hyperTDs of three different sizes based on greatest linear dimension (small, 63-124 µm; medium, 125-249 µm; large, ≥250 µm) at baseline and at 2-years follow-up...

PURPOSE: In this article, submacular autologous neurosensory retinal transplantation technique is presented in patients with large macular hole (MH) accompanying retinal detachment (RD). METHODS: In the surgical procedure, 23-G pars plana vitrectomy (PPV) and peripheral vitrectomy were carried out. An autologous neurosensory retinal patch, which should be larger than the diameter of the MH, was released from a suitable quadrant. The retinal patch was grasped with 23 Gauge micro forceps and then passed through the MH and placed under the macula...

PURPOSE: To describe and evaluate demographics, clinical features, prognostic factors, rate of success of surgery, incidence and visual outcomes in patients with a late recurrence of rhegmatogenous retinal detachment(RRD) over a 10-year period at a large tertiary referral eye centre. METHODS: A retrospective, observational case-series of patients with late recurrence of retinal detachment, defined as redetachment after at least 6 months of total reattachment in non-PVR RRD, after vitrectomy(PPV) surgery with gas tamponade...

PURPOSE: To perform an unsupervised machine learning clustering of patients with punctate inner choroidopathy (PIC) and provide new insights into the significance of pachychoroid disease features in PIC eyes. METHODS: Retrospective multicenter study, including 102 eyes from 82 patients diagnosed with PIC. Demographics, clinical data, and multimodal imaging (MMI), including fundus photography, optical coherence tomography (OCT), and indocyanine green angiography (ICGA), were collected...

PRECIS: Analysis of 50 patients with sarcoid granuloma of the choroid/ciliary body revealed granulomas with yellow color (41,82%) and irregular vermiform margins (46,92%). Imaging features included clear subretinal fluid (6,12%), dirty subretinal fluid (14,28%), and cystoid macular edema (1,2%).Systemic sarcoidosis was detected during ophthalmic care (4,8%) or diagnosed after presentation (3,6%). PURPOSE: To describe the clinical and imaging features of sarcoid granuloma of the choroid and ciliary body...

PURPOSE: To investigate the characteristics and natural history of treatment-naïve non-exudative polypoidal choroidal vasculopathy (PCV) and to determine biomarkers predicting exudative conversion. METHODS: Patients diagnosed with non-exudative PCV based on indocyanine green angiography (ICGA) and optical coherence tomography (OCT) were included. Incidence of exudative conversion in non-exudative PCV patients and cumulative estimates for overall risk were assessed...

PURPOSE: To determine the efficacy of secondary salvage intravenous chemotherapy (IVC) for refractory/recurrent retinoblastoma (RB). METHODS: Retrospective, nonrandomized interventional case series of 41 eyes of 33 patients with RB. RESULTS: Of the 33 patients, mean age at the time of commencement of salvage IVC was 5 years (median, 5 years; range, 2 to 8 years). At presentation, RB in 41 eyes of 33 patients were classified by the International Classification of Retinoblastoma as Group B (n=7, 17%), Group C (n=3, 7%), Group D (n=16, 39%) and Group E (n=15, 37%)...

PURPOSE: To determine the utility of Ultra-widefield (UWF) imaging in detecting pathologic peripheral retinal tears and holes. METHODS: This was a retrospective, observational study. One-hundred and ninety-eight eyes of 198 patients diagnosed with acute posterior vitreous detachment were included. Eyes were divided into two groups: 89 eyes with peripheral retinal holes and tears treated with laser retinopexy (treatment group) and 109 control eyes. Patients underwent UWF imaging and indirect ophthalmoscopy with scleral depression...

PURPOSE: To summarize the current evidence regarding the therapeutic effect of using autologous platelet concentrate (APC) in vitrectomy for macular hole (MH). METHODS: The PubMed, Web of Science, Embase, etc. databases were searched according to the PROSPERO Protocol (CRD42022366202). Controlled trials comparing whether APC was used in the vitrectomy of MH were included. The primary outcome was the closure rate of MH and postoperative best-corrected visual acuity (BCVA), and the secondary outcome was the incidence of different types of complications...

PURPOSE: The objective of this research is to explore how psoriasis is linked to the occurrence of retinal vein occlusion (RVO) in diabetic population. METHODS: This was a retrospective, nationwide, population-based cohort study that examined medical records from January 2009 to December 2012. The study focused on patients ≥ 20 years of age who had been diagnosed with type 2 diabetes mellitus (DM). We compared the incidence rate of RVO between a group of patients with psoriasis and a group of patients without psoriasis until December 2018 in all subjects...

PURPOSE: To describe the incidence, features, and clinical outcomes of photodynamic therapy (PDT)-induced acute exudative maculopathy (PAEM) in circumscribed choroidal hemangioma (CCH). METHODS: Prospective series of 10 patients that underwent standard-fluence PDT for CCH. Best-corrected visual acuity (BCVA) in the Early Treatment Diabetic Retinopathy Score and swept-source optical coherence tomography (SS-OCT) were performed before, 3 days and 1 month after. Central retinal thickness (CRT), CCH retinal thickness and subretinal fluid (SRF) were measured...

PURPOSE: Our study describes the racial/ethnic composition and the broad health status/severity of disease of the cohorts of Diabetic Retinopathy Clinical Research (DRCR) clinical trials and compares the rates of non-completion of the trial to the first data report (lost to follow up (LTFU)). METHODS: This study is a retrospective cohort study of participants in Diabetic Retinopathy Clinical Research (DRCR) Retina Network clinical trials that met our inclusion criteria...

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