Zeling Guo, Yu Meng, Shang Zhou, Jiangting Li, Xinyu Li, Rongrong Feng, Yulan Zou, Wenchao Liao, Weiting Wu, Mingjing Xu, Xiangfu Zeng, Weidong Zhao, Haijian Zhong
Hepatocellular carcinoma (HCC) is a highly prevalent cancer with a significant impact on human health. Curcumin, a natural compound, induces cytoskeletal changes in liver cancer cells and modifies the distribution of lipids, proteins, and polysaccharides on plasma membranes, affecting their mechanical and electrical properties. In this study, we used nanomechanical indentation techniques and Kelvin probe force microscopy (KPFM) based on atomic force microscopy (AFM) to investigate the changes in surface nanomechanical and electrical properties of nuclear and cytoplasmic regions of HepG2 cells in response to increasing curcumin concentrations...
March 13, 2024: Journal of Pharmaceutical and Biomedical Analysis