journal
https://read.qxmd.com/read/38602622/tissue-biopsy-before-resection-in-glioblastoma-is-there-an-opportunity-to-improve-outcomes-with-liquid-biopsies-and-pre-operative-stereotactic-radiosurgery
#1
LETTER
Jason P Sheehan, Daniel M Trifiletti, Eric J Lehrer
No abstract text is available yet for this article.
April 11, 2024: Journal of Neuro-oncology
https://read.qxmd.com/read/38598089/correction-to-focused-ultrasound-combined-with-radiotherapy-for-malignant-brain-tumor-a-preclinical-and-clinical-study
#2
Ko-Ting Chen, Chiung-Yin Huang, Ping-Ching Pai, Wen-Chi Yang, Chen-Kan Tseng, Hong-Chieh Tsai, Jui-Chin Li, Chi-Cheng Chuang, Peng-Wei Hsu, Cheng-Chi Lee, Cheng-Hong Toh, Hao-Li Liu, Kuo-Chen Wei
No abstract text is available yet for this article.
April 10, 2024: Journal of Neuro-oncology
https://read.qxmd.com/read/38598088/gamma-knife-radiosurgery-for-clival-metastasis-case-series-and-systematic-review
#3
JOURNAL ARTICLE
Sakibul Huq, Regan M Shanahan, Samuel Adida, Othman Bin-Alamer, Hussam Abou-Al-Shaar, Ajay Niranjan, Constantinos G Hadjipanayis, L Dade Lunsford
PURPOSE: Clival metastatic cancer is rare and has limited literature to guide management. We describe management of clival metastasis with Gamma Knife radiosurgery (GKRS). We augment our findings with a systematic review of all forms of radiation therapy for clival metastasis. METHODS: Records of 14 patients with clival metastasis who underwent GKRS at the University of Pittsburgh Medical Center from 2002 to 2023 were reviewed. Treatment parameters and clinical outcomes were assessed...
April 10, 2024: Journal of Neuro-oncology
https://read.qxmd.com/read/38598087/profile-of-mirnas-in-small-extracellular-vesicles-released-from-glioblastoma-cells-treated-by-boron-neutron-capture-therapy
#4
JOURNAL ARTICLE
Natsuko Kondo, Tadatoshi Kinouchi, Manabu Natsumeda, Juntaro Matsuzaki, Eishu Hirata, Yoshinori Sakurai, Masayasu Okada, Minoru Suzuki
PURPOSE: Boron neutron capture therapy (BNCT) is a tumor cell-selective particle-radiation therapy. In BNCT, administered p-boronophenylalanine (BPA) is selectively taken up by tumor cells, and the tumor is irradiated with thermal neutrons. High-LET α-particles and recoil 7 Li, which have a path length of 5-9 μm, are generated by the capture reaction between 10 B and thermal neutrons and selectively kill tumor cells that have uptaken 10 B. Although BNCT has prolonged the survival time of malignant glioma patients, recurrences are still to be resolved...
April 10, 2024: Journal of Neuro-oncology
https://read.qxmd.com/read/38587609/assessment-of-multimodal-treatment-options-in-recurrent-and-persistent-acromegaly-a-systematic-review-and-meta-analysis
#5
REVIEW
Seyed Farzad Maroufi, Manijeh Assar, MirHojjat Khorasanizadeh, Fatemeh Mahdavi Sabet, Mohammadmahdi Sabahi, Rocco Dabecco, Badih Adada, Gabriel Zada, Hamid Borghei-Razavi
PURPOSE: In patients with acromegaly, secondary treatment options in cases of hormonal non-remission or tumor progression include repeat transsphenoidal surgery (TSS), radiation-based treatment (RT), or medical therapy (MT). In this study, we aim to evaluate the clinical effectiveness of various second-line treatment options for acromegaly. METHODS: Using the PRISMA guideline, a systematic review was performed by searching MEDLINE (PubMed), Web of Science, Scopus, and Cochrane electronic bibliographic databases from conception to the end of 2022...
April 8, 2024: Journal of Neuro-oncology
https://read.qxmd.com/read/38568377/intraoperative-magnetic-resonance-imaging-in-glioma-surgery-a-single-center-experience
#6
JOURNAL ARTICLE
Leyla Mirzayeva, Murat Uçar, Ahmet Memduh Kaymaz, Esra Temel
PURPOSE: To investigate the effect of intraoperative magnetic resonance imaging (Io MRI) on overall and progression-free survival (OS and PFS), on the extent of resection (EOR) in patients with glioma, and impact of the radiological diagnosis on the decision to continue the surgery when a residual mass was detected on Io MRI. METHODS: The study comprised 153 glioma patients who received surgical treatment between 2013 and 2023. One-hundred twenty-five of them had Io MRI guidance during surgery...
April 3, 2024: Journal of Neuro-oncology
https://read.qxmd.com/read/38563856/comparative-analysis-of-the-spatial-distribution-of-brain-metastases-across-several-primary-cancers-using-machine-learning-and-deep-learning-models
#7
JOURNAL ARTICLE
Saeedeh Mahmoodifar, Dhiraj J Pangal, Josh Neman, Gabriel Zada, Jeremy Mason, Bodour Salhia, Tehila Kaisman-Elbaz, Selcuk Peker, Yavuz Samanci, Andréanne Hamel, David Mathieu, Manjul Tripathi, Jason Sheehan, Stylianos Pikis, Georgios Mantziaris, Paul K Newton
OBJECTIVE: Brain metastases (BM) are associated with poor prognosis and increased mortality rates, making them a significant clinical challenge. Studying BMs can aid in improving early detection and monitoring. Systematic comparisons of anatomical distributions of BM from different primary cancers, however, remain largely unavailable. METHODS: To test the hypothesis that anatomical BM distributions differ based on primary cancer type, we analyze the spatial coordinates of BMs for five different primary cancer types along principal component (PC) axes...
April 2, 2024: Journal of Neuro-oncology
https://read.qxmd.com/read/38563855/sex-differences-in-adverse-events-in-medicare-individuals%C3%A2-%C3%A2-%C3%A2-66-years-of-age-post-glioblastoma-treatment
#8
JOURNAL ARTICLE
Mantas Dmukauskas, Gino Cioffi, Kristin A Waite, Andrew E Sloan, Corey Neff, Mackenzie Price, Quinn T Ostrom, Jill S Barnholtz-Sloan
PURPOSE: Glioblastoma (GB) is the most common primary malignant brain tumor with the highest incidence occurring in older adults with a median age at diagnosis of 64 years old. While treatment often improves survival it brings toxicities and adverse events (AE). Here we identify sex differences in treatment patterns and AE in individuals ≥ 66 years at diagnosis with GB. METHODS: Using the SEER-Medicare dataset sex differences in adverse events were assessed using multivariable logistic regression performed to calculate the male/female odds ratio (M/F OR) and 95% confidence intervals [95% CI] of experiencing an AE adjusted for demographic variables and Elixhauser comorbidity score...
April 2, 2024: Journal of Neuro-oncology
https://read.qxmd.com/read/38563854/perioperative-psychological-distress-in-patients-with-intracranial-tumors-a-single-center-study
#9
JOURNAL ARTICLE
Michael-Karl Fehrenbach, Florian Wilhelmy, Tim Wende, Erdem Güresir, Johannes Kasper
PURPOSE: Distress Thermometer (DT) was adopted to evaluate distress in neuro-oncology on a scale from 1 to 10. DT values above 4 indicate major distress and should initiate psycho(onco)logical co-therapy. However, data about peri-operative distress is scarce. Hence, we evaluated peri-operative distress levels in a neurosurgical patient cohort with various intracranial tumors using the DT. METHODS: We conducted a retrospective study including inpatients with brain tumors who underwent surgery in our department between October 2015 and December 2019...
April 2, 2024: Journal of Neuro-oncology
https://read.qxmd.com/read/38563853/elevating-the-findings-by-substituting-in-isarcoprm
#10
LETTER
Ahmad Jasem Abdulsalam, Murat Kara, Levent Özçakar
No abstract text is available yet for this article.
April 2, 2024: Journal of Neuro-oncology
https://read.qxmd.com/read/38563852/pediatric-neurosurgical-medulloblastoma-outcomes-in-la-paz-bolivia-how-a-lower-middle-income-country-lmic-institution-in-south-america-compares-to-the-united-states
#11
JOURNAL ARTICLE
Victor M Lu, Jorge Daniel Brun, Toba N Niazi, Jorge David Brun
BACKGROUND: How pediatric medulloblastoma patients fare in Lower Middle-Income Country (LMICs) in South America is not well understood. Correspondingly, the aim of this study was to summarize the pediatric neurosurgical experience of an institution in La Paz, and compare outcomes to that of a generalized High Income Country (HIC) United States (US) experience. METHODS: A retrospective review of all pediatric neurosurgical medulloblastoma patients at the Children's Hospital of La Paz, Bolivia (Hospital del Niño "Dr...
April 2, 2024: Journal of Neuro-oncology
https://read.qxmd.com/read/38563851/real-world-cost-effectiveness-analysis-tumor-treating-fields-for-newly-diagnosed-glioblastoma-in-china
#12
JOURNAL ARTICLE
Yuliang Xiang, Yingyao Chen, Zian Xu, Shanyan Zhou, Zhiyong Qin, Lingchao Chen, Dunming Xiao, Shimeng Liu
BACKGROUND: Glioblastoma (GBM) stands as the most aggressive and prevalent primary brain malignancy. Tumor Treating Fields (TTFields), an innovative therapy complementing chemotherapy for GBM treatment, which can significantly enhance overall survival, disease progression-free survival, and patient's quality of life. However, there is a dearth of health economics evaluation on TTFields therapy both domestically and internationally. OBJECTIVE: The study aims to assess the cost-effectiveness of TTFields + temozolomide (TMZ) in comparison to TMZ alone for newly diagnosed GBM patients...
April 2, 2024: Journal of Neuro-oncology
https://read.qxmd.com/read/38563850/repurposing-mebendazole-against-triple-negative-breast-cancer-cns-metastasis
#13
JOURNAL ARTICLE
Adrian J Rodrigues, Sophia B Chernikova, Yuelong Wang, Thy T H Trinh, David E Solow-Cordero, Ludmila Alexandrova, Kerriann M Casey, Elizabeth Alli, Abhishek Aggarwal, Tyler Quill, Ashley K Koegel, Brian J Feldman, James M Ford, Melanie Hayden-Gephart
PURPOSE: Triple-negative breast cancer (TNBC) often metastasizes to the central nervous system (CNS) and has the highest propensity among breast cancer subtypes to develop leptomeningeal disease (LMD). LMD is a spread of cancer into leptomeningeal space that speeds up the disease progression and severely aggravates the prognosis. LMD has limited treatment options. We sought to test whether the common anti-helminthic drug mebendazole (MBZ) may be effective against murine TNBC LMD. METHODS: A small-molecule screen involving TNBC cell lines identified benzimidazoles as potential therapeutic agents for further study...
April 2, 2024: Journal of Neuro-oncology
https://read.qxmd.com/read/38561565/maximal-cardiopulmonary-exercise-testing-in-glioblastoma-patients-undergoing-chemotherapy-assessment-of-feasibility-safety-and-physical-fitness-status
#14
JOURNAL ARTICLE
Johanna Jost, Klaus Völker, Ralf Brandt, Walter Stummer, Steffi Urbschat, Ralf Ketter, Dorothee Wiewrodt, Rainer Wiewrodt
PURPOSE: Maximal cardiopulmonary exercise testing (max. CPET) provides the most accurate measurement of cardiorespiratory fitness. However, glioblastoma (GBM) patients often undergo less intensive tests, e.g., 6-min walk test or self-rating scales. This study aims to demonstrate feasibility and safety of max. CPET in GBM patients, concurrently evaluating their physical fitness status. METHODS: Newly diagnosed GBM patients undergoing adjuvant chemotherapy were offered participation in an exercise program...
April 1, 2024: Journal of Neuro-oncology
https://read.qxmd.com/read/38557927/loss-of-methylthioadenosine-phosphorylase-immunoreactivity-correlates-with-poor-prognosis-and-elevated-uptake-of-11-c-methionine-in-idh-mutant-astrocytoma
#15
JOURNAL ARTICLE
Toshihiro Yamamura, Kaoru Tamura, Daisuke Kobayashi, Motoki Inaji, Yuka Toyama, Hiroaki Wakimoto, Juri Kiyokawa, Shoko Hara, Yoji Tanaka, Tadashi Nariai, Kazuhide Shimizu, Kenji Ishii, Taketoshi Maehara
PURPOSE: The proximate localization of MTAP, which encodes methylthioadenosine phosphorylase, and CDKN2A/B on Chromosome 9q21 has allowed the loss of MTAP expression as a surrogate for homozygous deletion of CDKN2A/B. This study aimed to determine whether MTAP status correlates with clinical outcomes and 11 C-methionine uptake in astrocytomas with IDH mutations. METHODS: We conducted immunohistochemistry for MTAP in 30 patients with astrocytoma, IDH-mutant who underwent 11 C-methionine positron emission tomography scans prior to surgical resection...
April 1, 2024: Journal of Neuro-oncology
https://read.qxmd.com/read/38557926/machine-learning-based-pathomics-signature-of-histology-slides-as-a-novel-prognostic-indicator-in-primary-central-nervous-system-lymphoma
#16
JOURNAL ARTICLE
Ling Duan, Yongqi He, Wenhui Guo, Yanru Du, Shuo Yin, Shoubo Yang, Gehong Dong, Wenbin Li, Feng Chen
PURPOSE: To develop and validate a pathomics signature for predicting the outcomes of Primary Central Nervous System Lymphoma (PCNSL). METHODS: In this study, 132 whole-slide images (WSIs) of 114 patients with PCNSL were enrolled. Quantitative features of hematoxylin and eosin (H&E) stained slides were extracted using CellProfiler. A pathomics signature was established and validated. Cox regression analysis, receiver operating characteristic (ROC) curves, Calibration, decision curve analysis (DCA), and net reclassification improvement (NRI) were performed to assess the significance and performance...
April 1, 2024: Journal of Neuro-oncology
https://read.qxmd.com/read/38551747/hypofractionated-re-irradiation-with-bevacizumab-for-relapsed-chemorefractory-glioblastoma-after-prior-high-dose-radiotherapy-a-feasible-option-for-patients-with-large-volume-relapse
#17
JOURNAL ARTICLE
Elissa Tong, Patrick Horsley, Helen Wheeler, Matthew Wong, Venkatesha Venkatesha, Joseph Chan, Marina Kastelan, Michael Back
PURPOSE: There remains no standard of care for patients with recurrent and chemorefractory glioblastoma. Re-irradiation (reRT) provides an additional management option. However, published series predominantly focus on small reRT volumes utilizing stereotactic hypofractionated regimens. Concerns regarding toxicity have limited utilisation of reRT for larger recurrences, however this may be mitigated with use of bevacizumab (BEV). METHODS AND MATERIALS: A prospective database of patients managed with the EORTC-NCIC (Stupp) protocol 60 Gy chemoradiotherapy protocol for glioblastoma between 2007 and 2021 was reviewed for those patients receiving reRT for chemorefractory relapse...
March 29, 2024: Journal of Neuro-oncology
https://read.qxmd.com/read/38539006/a-new-updated-prognostic-index-for-patients-with-brain-metastases-bms-treated-with-palliative-whole-brain-radiotherapy-wbrt-in-the-era-of-precision-oncology-metasncore-project
#18
JOURNAL ARTICLE
Pablo Flores-Paco, Alicia Vargas-Aliaga, María Geraldina Guevara, Ignacio Lopera, Lucía Rodríguez Ruiz, María López-Herrero, Juan Adrián Camús, Javier López-González, Elizabeth Inga-Saavedra, Marina Montero, Isidoro Barneto, Mª Auxiliadora Gómez-España, Estela Ruiz, Marta Ruza, Ana Armenta, Amalia Palacios, Juan R De La Haba-Rodríguez, Enrique Aranda
INTRODUCTION: Palliative WBRT is the main treatment for multiple BMs. Recent studies report no benefit in survival after WBRT compared to palliative supportive care in patients (pts) with poor prognosis. A new era of systemic treatment strategies based on targeted therapies are improving the prognosis of patients with BMs. The purpose of this study is to develop a prognostic score in palliative pts with BMs who undergo WBRT in this new setting. METHODS: 239 pts with BMs who received palliative WBRT between 2013-2022 in our center were analyzed retrospectively...
March 27, 2024: Journal of Neuro-oncology
https://read.qxmd.com/read/38530549/a-systematic-review-of-extraneural-meningioma-metastasis-timing-evolution-and-outlook
#19
REVIEW
Gina Watanabe, Kurtis Young, Erin Rauber, Mohammad Faizan Khan, Reannon Suzuki, Robert Riestenberg, Giuseppe E Umana, Paolo Palmisciano
PURPOSE: Extraneural meningioma metastasis is a rare occurrence and may pose a clinical challenge due to its unclear prognosis. In this systematic review, we analyze patient demographics, clinical characteristics, management strategies, and outcomes. METHODS: PubMed, EMBASE, Scopus, Cochrane, and Web of Science databases were searched from inception to February 23, 2024 for cases of metastatic meningioma according to PRISMA guidelines. Descriptive statistics, Mann-Whitney U test, Fisher's exact tests, Kaplan-Meier curves, and log-rank tests were used for selected analyses...
March 26, 2024: Journal of Neuro-oncology
https://read.qxmd.com/read/38526757/utility-of-molecular-markers-in-predicting-local-control-specific-to-lung-cancer-spine-metastases-treated-with-stereotactic-body-radiotherapy
#20
JOURNAL ARTICLE
Dana Shor, Alexander V Louie, Kang Liang Zeng, Ines B Menjak, Eshetu G Atenafu, Chia-Lin Tseng, Jay Detsky, Jeremie Larouche, Beibei Zhang, Hany Soliman, Sten Myrehaug, Pejman Maralani, David M Hwang, Arjun Sahgal, Hanbo Chen
BACKGROUND AND PURPOSE: We report outcomes following spine stereotactic body radiotherapy (SBRT) in metastatic non-small cell lung cancer (NSCLC) and the significance of programmed death-ligand 1 (PD-L1) status, epidermal growth factor receptor (EGFR) mutation and timing of immune check point inhibitors (ICI) on local failure (LF). MATERIALS AND METHODS: 165 patients and 389 spinal segments were retrospectively reviewed from 2009 to 2021. Baseline patient characteristics, treatment and outcomes were abstracted...
March 25, 2024: Journal of Neuro-oncology
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