journal
https://read.qxmd.com/read/36961622/surgical-management-of-glioma-grade-4-technical-update-from-the-neuro-oncology-section-of-the-italian-society-of-neurosurgery-sinch%C3%A2-a-systematic-review
#1
REVIEW
Tamara Ius, Giovanni Sabatino, Pier Paolo Panciani, Marco Maria Fontanella, Roberta Rudà, Antonella Castellano, Giuseppe Maria Vincenzo Barbagallo, Francesco Belotti, Riccardo Boccaletti, Giuseppe Catapano, Gabriele Costantino, Alessandro Della Puppa, Francesco Di Meco, Filippo Gagliardi, Diego Garbossa, Antonino Francesco Germanò, Maurizio Iacoangeli, Pietro Mortini, Alessandro Olivi, Federico Pessina, Fabrizio Pignotti, Giampietro Pinna, Antonino Raco, Francesco Sala, Francesco Signorelli, Silvio Sarubbo, Miran Skrap, Giannantonio Spena, Teresa Somma, Carmelo Sturiale, Filippo Flavio Angileri, Vincenzo Esposito
PURPOSE: The extent of resection (EOR) is an independent prognostic factor for overall survival (OS) in adult patients with Glioma Grade 4 (GG4). The aim of the neuro-oncology section of the Italian Society of Neurosurgery (SINch®) was to provide a general overview of the current trends and technical tools to reach this goal. METHODS: A systematic review was performed. The results were divided and ordered, by an expert team of surgeons, to assess the Class of Evidence (CE) and Strength of Recommendation (SR) of perioperative drugs management, imaging, surgery, intraoperative imaging, estimation of EOR, surgery at tumor progression and surgery in elderly patients...
March 24, 2023: Journal of Neuro-oncology
https://read.qxmd.com/read/36951945/radiotherapy-for-atypical-teratoid-rhabdoid-tumor-atrt-on-the-pediatric-proton-photon-consortium-registry-ppcr
#2
JOURNAL ARTICLE
Andrew Roehrig, Daniel J Indelicato, Arnold C Paulino, Ralph Ermoian, William Hartsell, John Perentesis, Christine Hill-Kayser, Jae Y Lee, Nadia N Laack, Victor Mangona, Iain MacEwan, Bree R Eaton, Sara Gallotto, Benjamin V M Bajaj, Paul D Aridgides, Torunn I Yock
PURPOSE: Atypical teratoid/rhabdoid tumors (ATRT) of the central nervous system (CNS) are rare tumors with a poor prognosis and variable use of either focal or craniospinal (CSI) radiotherapy (RT). Outcomes on the prospective Pediatric Proton/Photon Consortium Registry (PPCR) were evaluated according to RT delivered. METHODS: Pediatric patients receiving RT were prospectively enrolled on PPCR to collect initial patient, disease, and treatment factors as well as provide follow-up for patient outcomes...
March 23, 2023: Journal of Neuro-oncology
https://read.qxmd.com/read/36940053/cognitive-issues-in-patients-with-idh-mutant-gliomas-from-neuroscience-to-clinical-neuropsychology
#3
REVIEW
Michael W Parsons, David S Sabsevitz
PURPOSE: The understanding of cognitive symptoms in patients with IDH-Mutant gliomas (IDH-Mut) is rapidly developing. In this article, we summarize the neuroscientific knowledge base regarding the influence of IDH-Mut tumors and their treatment on cognition and provide guidance regarding the management of these symptoms in patients. METHODS: We performed a review of peer reviewed publications relevant to IDH-Mut glioma and cognitive outcomes and provide an overview of the literature as well as a case example to clarify management strategies...
March 20, 2023: Journal of Neuro-oncology
https://read.qxmd.com/read/36940052/poor-karnofsky-performance-status-is-not-a-contraindication-for-neurosurgical-resection-in-patients-with-lung-cancer-brain-metastases-a-multicenter-retrospective-psm-iptw-cohort-study
#4
JOURNAL ARTICLE
Lun Liang, Liangbao Wen, Shixing Qin, Zhenqiang He, Jie Lu, Run Cui, Xiaobing Jiang, Hongrong Hu, Sheng Zhong, Chang Li, Chengwei Yu, Yuang Xie, Zhenning Wang, Hao Duan, Yonggao Mou
BACKGOUND: Neurosurgical resection is a standard local treatment for lung cancer brain metastases (BMs). This study aims to investigate whether neurosurgical resection provides survival benefit in lung cancer BMs with poor KPS. MATERIALS AND METHODS: This multicenter retrospective study included 386 lung cancer BMs with pretreatment KPS ≤ 70 among a total of 1177 lung cancer BMs treated at three centers from August 2010 to July 2021. Data analysis was performed from July to September 2022...
March 20, 2023: Journal of Neuro-oncology
https://read.qxmd.com/read/36933053/social-media-and-the-journal-of-neuro-oncology
#5
LETTER
Kathryn Kearns, Matthew J Shepard, Jason P Sheehan
No abstract text is available yet for this article.
March 18, 2023: Journal of Neuro-oncology
https://read.qxmd.com/read/36932228/calcified-spinal-meningiomas-a-systematic-review-of-clinical-characteristics-treatment-strategies-and-outcomes
#6
REVIEW
Darsh S Shah, Raghuram V Reddy, Yücel Doğruel, Mohamed Z Asfour, Ahmad Pour-Rashidi, Ali S Haider, Mayur Sharma, Salah G Aoun, Giuseppe E Umana, Paolo Palmisciano
BACKGROUND: Calcified meningiomas involving the spine are rare but can pose significant surgical challenges. We systematically reviewed the literature on calcified spinal meningiomas. METHODS: PubMed, EMBASE, Web-of-Science, and Scopus databases were searched to include studies reporting clinical data of patients with calcified spinal meningioma. Included articles were analyzed for symptoms, imaging, spine level of the tumor, tumor location relative to the spinal cord, calcification status, treatment regimen, recurrence, progression-free survival, and outcomes...
March 17, 2023: Journal of Neuro-oncology
https://read.qxmd.com/read/36928699/interstitial-photodynamic-therapy-for-newly-diagnosed-glioblastoma
#7
JOURNAL ARTICLE
Stefanie Quach, Christoph Schwartz, Maximilian Aumiller, Marco Foglar, Michael Schmutzer, Sophie Katzendobler, Mohamed El Fahim, Robert Forbrig, Katja Bochmann, Rupert Egensperger, Ronald Sroka, Herbert Stepp, Adrian Rühm, Niklas Thon
PURPOSE: Innovative, efficient treatments are desperately needed for people with glioblastoma (GBM). METHODS: Sixteen patients (median age 65.8 years) with newly diagnosed, small-sized, not safely resectable supratentorial GBM underwent interstitial photodynamic therapy (iPDT) as upfront eradicating local therapy followed by standard chemoradiation. 5-aminolevulinic acid (5-ALA) induced protoporphyrin IX was used as the photosensitizer. The tumors were irradiated with light at 635 nm wavelength via stereotactically implanted cylindrical diffuser fibers...
March 16, 2023: Journal of Neuro-oncology
https://read.qxmd.com/read/36928698/mortality-trends-in-primary-malignant-brain-and-central-nervous-system-tumors-vary-by-histopathology-age-race-and-sex
#8
JOURNAL ARTICLE
Marisa Thierheimer, Gino Cioffi, Kristin A Waite, Carol Kruchko, Quinn T Ostrom, Jill S Barnholtz-Sloan
PURPOSE: Primary malignant brain and other central nervous system tumors are rare cancers that have shown rising mortality rates in recent years. To elucidate potential factors involved in this rising death rate, we examined mortality trends for primary malignant BT in the United States stratified by histopathology groupings, age, race, and sex. METHODS: Mortality rates for demographic factors within primary malignant BT were generated using the National Center for Health Statistics' National Vital Statistics Systems data from 2004 to 2018...
March 16, 2023: Journal of Neuro-oncology
https://read.qxmd.com/read/36920679/medulloblastoma-in-adults-evaluation-of-the-dutch-society-for-neuro-oncology-treatment-protocol
#9
JOURNAL ARTICLE
L Bleeker, M C M Kouwenhoven, I de Heer, B I Lissenberg-Witte, A H Gijsbers, H J Dubbink, J M Kros, J M M Gijtenbeek, E Kurt, C C D van der Rijt, A T Swaak-Kragten, F Y de Vos, H L van der Weide, P J French, M J van den Bent, P Wesseling, J E C Bromberg
PURPOSE: Medulloblastoma is a rare tumor in adults. The objective of this nationwide, multicenter study was to evaluate the toxicity and efficacy of the Dutch treatment protocol for adult medulloblastoma patients. METHODS: Adult medulloblastoma patients diagnosed between 2010 and 2018 were identified in the Dutch rare tumors registry or nationwide pathology database. Patients with intention to treat according to the national treatment protocol were included. Risk stratification was performed based on residual disease, histological subtype and extent of disease...
March 15, 2023: Journal of Neuro-oncology
https://read.qxmd.com/read/36920678/comparable-safety-profile-between-neuro-oncology-procedures-involving-stereotactic-needle-biopsy-snb-followed-by-laser-interstitial-thermal-therapy-litt-and-litt-alone-procedures
#10
JOURNAL ARTICLE
Mayur Sharma, Truong H Do, Elise F Palzer, Jared D Huling, Clark C Chen
INTRODUCTION: Tissue diagnosis through stereotactic needle biopsy (SNB) is often needed prior to laser interstitial thermal therapy (LITT). Whether these procedures should be performed in the same surgery or in separate settings remain unclear. As a first step to address this question, we assess safety profile of procedures involving LITT alone versus SNB + LITT. METHODS: Using International Classification of Disease (ICD) codes, we queried the National Readmissions Database (NRD, 2010-2018) for malignant brain tumor patients who underwent either (1) LITT alone or (2) elective LITT in combination with SNB (SNB + LITT)...
March 15, 2023: Journal of Neuro-oncology
https://read.qxmd.com/read/36914878/hypofractionated-stereotactic-radiosurgery-hsrs-as-a-salvage-treatment-for-brain-metastases-failing-prior-stereotactic-radiosurgery-srs
#11
JOURNAL ARTICLE
Michael Yan, Minha Lee, Sten Myrehaug, Chia-Lin Tseng, Jay Detsky, Hanbo Chen, Sunit Das, Collins Yeboah, Nir Lipsman, Leodante Da Costa, Lori Holden, Chinthaka Heyn, Pejman Maralani, Mark Ruschin, Arjun Sahgal, Hany Soliman
INTRODUCTION: Various treatment options exist to salvage stereotactic radiosurgery (SRS) failures for brain metastases, including repeat SRS and hypofractionated SRS (HSRS). Our objective was to report outcomes specific to salvage HSRS for brain metastases that failed prior HSRS/SRS. METHODS: Patients treated with HSRS to salvage local failures (LF) following initial HSRS/SRS, between July 2010 and April 2020, were retrospectively reviewed. The primary outcomes were the rates of LF, radiation necrosis (RN), and symptomatic radiation necrosis (SRN)...
March 13, 2023: Journal of Neuro-oncology
https://read.qxmd.com/read/36913047/occurrence-of-non-central-nervous-system-cancers-during-postoperative-follow-up-of-patients-who-underwent-surgery-for-a-who-grade-ii-glioma-implications-for-therapeutic-management
#12
JOURNAL ARTICLE
Hugues Duffau
PURPOSE: Survival is currently prolonged in WHO grade II glioma (GIIG). Although exceptionally described, long-term survivors may develop second primary cancers outside the central nervous system (CNS). Here, a consecutive series explored the association between non-CNS cancers (nCNSc) and GIIG in patients who underwent glioma resection. METHODS: Inclusion criteria were adult patients operated for a GIIG who experienced nCNSc following cerebral surgery. RESULTS: Nineteen patients developed nCNSc after GIIG removal (median time 7...
March 13, 2023: Journal of Neuro-oncology
https://read.qxmd.com/read/36913046/demographic-variations-and-time-to-initiation-of-adjunct-treatment-following-surgical-resection-of-anaplastic-astrocytoma-in-the-united-states-a-national-cancer-database-analysis
#13
JOURNAL ARTICLE
Mayur Sharma, Grant W McKenzie, Jeremy Gaskins, Mehran Yusuf, Shiao Woo, Akshitkumar M Mistry, Brian J Williams
BACKGROUND AND AIMS: The aim of this study was to analyze the trends, demographic differences in the type and time to initiation (TTI) of adjunct treatment AT following surgery for anaplastic astrocytoma (AA). MATERIAL AND METHODS: The National Cancer Database (NCDB) was queried for patients diagnosed with AA from 2004 to 2016. Cox proportional hazards and modeling was used to determine factors influencing survival, including the impact of time to initiation (TTI) of adjuvant therapy...
March 13, 2023: Journal of Neuro-oncology
https://read.qxmd.com/read/36897466/when-clinician-becomes-caregiver-perspectives-from-the-other-side
#14
LETTER
Jason Sheehan
No abstract text is available yet for this article.
March 10, 2023: Journal of Neuro-oncology
https://read.qxmd.com/read/36894719/using-the-deformity-index-of-vital-structures-to-predict-outcome-of-patients-with-large-vestibular-schwannomas-after-gamma-knife-radiosurgery
#15
JOURNAL ARTICLE
Hao-Chun Chang, Weir Chiang You, Chiung-Chyi Shen, Ying Ju Chen, Ming-His Sun, Meei-Ling Sheu, Liang-Yi Pan, Jason Sheehan, Kuo-Chih Su, Hung-Chuan Pan
PURPOSE: Microsurgery is the mainstay of treatment for large vestibular schwannomas (VS), but the benefits of radiosurgery remain incompletely defined. Here, we aim to use automated volumetric analysis software to quantify the degree of brain stem deformity to predict long-term outcomes of patients with large VS following GKRS. METHODS: Between 2003 and 2020, 39 patients with large VS (volume > 8 cc) undergoing GKRS with a margin dose of 10-12 Gy were analyzed...
March 9, 2023: Journal of Neuro-oncology
https://read.qxmd.com/read/36894718/radiosurgery-outcomes-in-infratentorial-juvenile-pilocytic-astrocytomas
#16
JOURNAL ARTICLE
Zhishuo Wei, Matthew Pease, Lilly W Tang, Hansen Deng, Regan Shanahan, Andrew Faramand, Ajay Niranjan, L Dade Lunsford
PURPOSE: To assess survival and neurological outcomes for patients who underwent primary or salvage stereotactic radiosurgery (SRS) for infratentorial juvenile pilocytic astrocytomas (JPA). METHODS: Between 1987 and 2022, 44 patients underwent SRS for infratentorial JPA. Twelve patients underwent primary SRS and 32 patients underwent salvage SRS. The median patient age at SRS was 11.6 years (range, 2-84 years). Prior to SRS, 32 patients had symptomatic neurological deficits, with ataxia as the most common symptom in 16 patients...
March 9, 2023: Journal of Neuro-oncology
https://read.qxmd.com/read/36890398/pediatric-central-nervous-system-tumor-survivor-and-caregiver-experiences-with-multidisciplinary-telehealth
#17
JOURNAL ARTICLE
Chantel Cacciotti, Isaac S Chua, Jennifer Cuadra, Nicole J Ullrich, Tabitha M Cooney
PURPOSE: Telehealth use to facilitate cancer survivorship care is accelerating; however, patient satisfaction and barriers to facilitation have not been studied amongst pediatric central nervous system (CNS) tumor survivors. We assessed the telehealth experiences of survivors and caregivers in the Pediatric Neuro-Oncology Outcomes Clinic at Dana-Farber/ Boston Children's Hospital. METHODS: Cross-sectional study of completed surveys among patients and caregivers with ≥ 1 telehealth multidisciplinary survivorship appointment from January 2021 through March 2022...
March 8, 2023: Journal of Neuro-oncology
https://read.qxmd.com/read/36884201/feasibility-of-a-virtual-reality-intervention-targeting-distress-and-anxiety-symptoms-in-patients-with-primary-brain-tumors-interim-analysis-of-a-phase-2-clinical-trial
#18
JOURNAL ARTICLE
Amanda L King, Kayla N Roche, Heather E Leeper, Elizabeth Vera, Tito Mendoza, Kelly Mentges, Alvina A Acquaye-Mallory, Kendra A Adegbesan, Lisa Boris, Eric Burton, Anna Choi, Ewa Grajkowska, Tricia Kunst, Jason Levine, Nicole Lollo, Hope Miller, Marissa Panzer, Marta Penas-Prado, Valentina Pillai, Lily Polskin, Jennifer Reyes, Solmaz Sahebjam, Macy L Stockdill, Brett J Theeler, Jing Wu, Mark R Gilbert, Terri S Armstrong
PURPOSE: Cancer patients experience distress and anxiety when undergoing imaging studies to monitor disease status, yet these symptoms are not always appropriately identified or well-managed. This interim analysis of a phase 2 clinical trial explored feasibility and acceptability of a virtual reality relaxation (VR) intervention for primary brain tumor (PBT) patients at the time of clinical evaluation. METHODS: English speaking, adult PBT patients with previous reports of distress and upcoming neuroimaging were recruited between March of 2021 and March 2022...
March 8, 2023: Journal of Neuro-oncology
https://read.qxmd.com/read/36884200/systematic-review-of-the-management-of-brain-metastases-from-hormone-receptor-positive-breast-cancer
#19
REVIEW
Shirley Jusino, Camilo E Fadul, Patrick Dillon
INTRODUCTION: Brain metastases are a common cause of morbidity and mortality in patients with breast cancer. Local central nervous system (CNS) directed therapies are usually the first line treatment for breast cancer brain metastases (BCBM), but those must be followed by systemic therapies to achieve long-term benefit. Systemic therapy for hormone receptor (HR+ ) breast cancer has evolved in the last 10 years, but their role when brain metastases occur is uncertain. METHODS: We performed a systematic review of the literature focused on management of HR+ BCBM by searching Medline/PubMed, EBSCO, and Cochrane databases...
March 8, 2023: Journal of Neuro-oncology
https://read.qxmd.com/read/36877383/glioma-inadvertently-treated-with-preoperative-stereotactic-radiosurgery-focusing-on-safety
#20
LETTER
Daniel M Trifiletti, Tobi Akinyelu, Stuart H Burri, Andjie Jeudy, Alfredo Quinones-Hinojosa, Roshan S Prabhu
No abstract text is available yet for this article.
March 6, 2023: Journal of Neuro-oncology
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