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Annual Review of Immunology

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https://read.qxmd.com/read/30726153/tissue-resident-t-cells-and-other-resident-leukocytes
#1
David Masopust, Andrew G Soerens
Resident memory T (Trm) cells stably occupy tissues and cannot be sampled in superficial venous blood. Trm cells are heterogeneous but collectively constitute the most abundant memory T cell subset. Trm cells form an integral part of the immune sensing network, monitor for local perturbations in homeostasis throughout the body, participate in protection from infection and cancer, and likely promote autoimmunity, allergy, and inflammatory diseases and impede successful transplantation. Thus Trm cells are major candidates for therapeutic manipulation...
June 2, 2019: Annual Review of Immunology
https://read.qxmd.com/read/30699000/using-t-cell-receptor-repertoires-to-understand-the-principles-of-adaptive-immune-recognition
#2
Philip Bradley, Paul G Thomas
Adaptive immune recognition is mediated by antigen receptors on B and T cells generated by somatic recombination during lineage development. The high level of diversity resulting from this process posed technical limitations that previously limited the comprehensive analysis of adaptive immune recognition. Advances over the last ten years have produced data and approaches allowing insights into how T cells develop, evolutionary signatures of recombination and selection, and the features of T cell receptors that mediate epitope-specific binding and T cell activation...
January 30, 2019: Annual Review of Immunology
https://read.qxmd.com/read/30698999/crispr-based-tools-in-immunity
#3
Dimitre R Simeonov, Alexander Marson
CRISPR technology has opened a new era of genome interrogation and genome engineering. Discovered in bacteria, where it protects against bacteriophage by cleaving foreign nucleic acid sequences, the CRISPR system has been repurposed as an adaptable tool for genome editing and multiple other applications. CRISPR's ease of use, precision, and versatility have led to its widespread adoption, accelerating biomedical research and discovery in human cells and model organisms. Here we review CRISPR-based tools and discuss how they are being applied to decode the genetic circuits that control immune function in health and disease...
January 30, 2019: Annual Review of Immunology
https://read.qxmd.com/read/30676822/cd8-t-cell-exhaustion-during-chronic-viral-infection-and-cancer
#4
Laura M McLane, Mohamed S Abdel-Hakeem, E John Wherry
Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression, metabolic dysregulation, poor memory recall and homeostatic self-renewal, and distinct transcriptional and epigenetic programs. The ability to reinvigorate Tex cells through inhibitory receptor blockade, such as αPD-1, highlights the therapeutic potential of targeting this population...
January 24, 2019: Annual Review of Immunology
https://read.qxmd.com/read/30676821/purine-release-metabolism-and-signaling-in-the-inflammatory-response
#5
Joel Linden, Friedrich Koch-Nolte, Gerhard Dahl
ATP, NAD+ , and nucleic acids are abundant purines that, in addition to having critical intracellular functions, have evolved extracellular roles as danger signals released in response to cell lysis, apoptosis, degranulation, or membrane pore formation. In general ATP and NAD+ have excitatory and adenosine has anti-inflammatory effects on immune cells. This review focuses on recent advances in our understanding of purine release mechanisms, ectoenzymes that metabolize purines (CD38, CD39, CD73, ENPP1, and ENPP2/autotaxin), and signaling by key P2 purinergic receptors (P2X7, P2Y2, and P2Y12)...
January 24, 2019: Annual Review of Immunology
https://read.qxmd.com/read/30673536/double-stranded-rna-sensors-and-modulators-in-innate-immunity
#6
Sun Hur
Detection of double-stranded RNAs (dsRNAs) is a central mechanism of innate immune defense in many organisms. We here discuss several families of dsRNA-binding proteins involved in mammalian antiviral innate immunity. These include RIG-I-like receptors, protein kinase R, oligoadenylate synthases, adenosine deaminases acting on RNA, RNA interference systems, and other proteins containing dsRNA-binding domains and helicase domains. Studies suggest that their functions are highly interdependent and that their interdependence could offer keys to understanding the complex regulatory mechanisms for cellular dsRNA homeostasis and antiviral immunity...
January 23, 2019: Annual Review of Immunology
https://read.qxmd.com/read/30673535/disease-tolerance-as-an-inherent-component-of-immunity
#7
Rui Martins, Ana Rita Carlos, Faouzi Braza, Jessica A Thompson, Patricia Bastos-Amador, Susana Ramos, Miguel P Soares
Pathogenic organisms exert a negative impact on host health, revealed by the clinical signs of infectious diseases. Immunity limits the severity of infectious diseases through resistance mechanisms that sense and target pathogens for containment, killing, or expulsion. These resistance mechanisms are viewed as the prevailing function of immunity. Under pathophysiologic conditions, however, immunity arises in response to infections that carry health and fitness costs to the host. Therefore, additional defense mechanisms are required to limit these costs, before immunity becomes operational as well as thereafter to avoid immunopathology...
January 23, 2019: Annual Review of Immunology
https://read.qxmd.com/read/30649989/fine-tuning-cytokine-signals
#8
Jian-Xin Lin, Warren J Leonard
Cytokines are secreted or otherwise released polypeptide factors that exert autocrine and/or paracrine actions, with most cytokines acting in the immune and/or hematopoietic system. They are typically pleiotropic, controlling development, cell growth, survival, and/or differentiation. Correspondingly, cytokines are clinically important, and augmenting or attenuating cytokine signals can have deleterious or therapeutic effects. Besides physiological fine-tuning of cytokine signals, altering the nature or potency of the signal can be important in pathophysiological responses and can also provide novel therapeutic approaches...
January 16, 2019: Annual Review of Immunology
https://read.qxmd.com/read/30649988/the-myeloid-cell-compartment-cell-by-cell
#9
Kevin Bassler, Jonas Schulte-Schrepping, Stefanie Warnat-Herresthal, Anna C Aschenbrenner, Joachim L Schultze
Myeloid cells are a major cellular compartment of the immune system comprising monocytes, dendritic cells, tissue macrophages, and granulocytes. Models of cellular ontogeny, activation, differentiation, and tissue-specific functions of myeloid cells have been revisited during the last years with surprising results; for example, most tissue macrophages are yolk sac derived, monocytes and macrophages follow a multidimensional model of activation, and tissue signals have a significant impact on the functionality of all these cells...
January 16, 2019: Annual Review of Immunology
https://read.qxmd.com/read/30633609/self-awareness-nucleic-acid-driven-inflammation-and-the-type-i-interferonopathies
#10
Carolina Uggenti, Alice Lepelley, Yanick J Crow
Recognition of foreign nucleic acids is the primary mechanism by which a type I interferon-mediated antiviral response is triggered. Given that human cells are replete with DNA and RNA, this evolutionary strategy poses an inherent biological challenge, i.e., the fundamental requirement to reliably differentiate self-nucleic acids from nonself nucleic acids. We suggest that the group of Mendelian inborn errors of immunity referred to as the type I interferonopathies relate to a breakdown of self/nonself discrimination, with the associated mutant genotypes involving molecules playing direct or indirect roles in nucleic acid signaling...
January 11, 2019: Annual Review of Immunology
https://read.qxmd.com/read/30576253/origin-organization-dynamics-and-function-of-actin-and-actomyosin-networks-at-the-t-cell-immunological-synapse
#11
John A Hammer, Jia Wang, Mezida Saeed, Antonio Pedrosa
The engagement of aTcell with an antigen-presenting cell (APC) or activating surface results in the formation within the T cell of several distinct actin and actomyosin networks. These networks reside largely within a narrow zone immediately under the T cell's plasma membrane at its site of contact with the APC or activating surface, i.e., at the immunological synapse. Here we review the origin, organization, dynamics, and function of these synapse-associated actin and actomyosin networks. Importantly, recent insights into the nature of these actin-based cytoskeletal structures were made possible in several cases by advances in light microscopy...
December 21, 2018: Annual Review of Immunology
https://read.qxmd.com/read/30566366/the-antibody-response-to-plasmodium-falciparum-cues-for-vaccine-design-and-the-discovery-of-receptor-based-antibodies
#12
Joshua Tan, Luca Piccoli, Antonio Lanzavecchia
Plasmodium falciparum remains a serious public health problem and a continuous challenge for the immune system due to the complexity and diversity of the pathogen. Recent advances from several laboratories in the characterization of the antibody response to the parasite have led to the identification of critical targets for protection and revealed a new mechanism of diversification based on the insertion of host receptors into immunoglobulin genes, leading to the production of receptor-based antibodies. These advances have opened new possibilities for vaccine design and passive antibody therapies to provide sterilizing immunity and control blood-stage parasites...
December 19, 2018: Annual Review of Immunology
https://read.qxmd.com/read/30550719/cancer-neoantigens
#13
Ton N Schumacher, Wouter Scheper, Pia Kvistborg
Malignant transformation of cells depends on accumulation of DNA damage. Over the past years we have learned that the T cell-based immune system frequently responds to the neoantigens that arise as a consequence of this DNA damage. Furthermore, recognition of neoantigens appears an important driver of the clinical activity of both T cell checkpoint blockade and adoptive T cell therapy as cancer immunotherapies. Here we review the evidence for the relevance of cancer neoantigens in tumor control and the biological properties of these antigens...
December 14, 2018: Annual Review of Immunology
https://read.qxmd.com/read/30526160/emerging-cellular-therapies-for-cancer
#14
Sonia Guedan, Marco Ruella, Carl H June
Genetically engineered T cells are powerful new medicines, offering hope for curative responses in patients with cancer. Chimeric antigen receptor (CAR) T cells were recently approved by the US Food and Drug Administration and are poised to enter the practice of medicine for leukemia and lymphoma, demonstrating that engineered immune cells can serve as a powerful new class of cancer therapeutics. The emergence of synthetic biology approaches for cellular engineering provides a broadly expanded set of tools for programming immune cells for enhanced function...
December 10, 2018: Annual Review of Immunology
https://read.qxmd.com/read/30485751/the-platelet-napoleon-complex-small-cells-but-big-immune-regulatory-functions
#15
Craig N Morrell, Daphne N Pariser, Zachary T Hilt, Denisse Vega Ocasio
Platelets have dual physiologic roles as both cellular mediators of thrombosis and immune modulatory cells. Historically, the thrombotic function of platelets has received significant research and clinical attention, but emerging research indicates that the immune regulatory roles of platelets may be just as important. We now know that in addition to their role in the acute thrombotic event at the time of myocardial infarction, platelets initiate and accelerate inflammatory processes that are part of the pathogenesis of atherosclerosis and myocardial infarction expansion...
November 28, 2018: Annual Review of Immunology
https://read.qxmd.com/read/30379595/neuro-immune-cell-units-a-new-paradigm-in-physiology
#16
Cristina Godinho-Silva, Filipa Cardoso, Henrique Veiga-Fernandes
The interplay between the immune and nervous systems has been acknowledged in the past, but only more recent studies have started to unravel the cellular and molecular players of such interactions. Mounting evidence indicates that environmental signals are sensed by discrete neuro-immune cell units (NICUs), which represent defined anatomical locations in which immune and neuronal cells colocalize and functionally interact to steer tissue physiology and protection. These units have now been described in multiple tissues throughout the body, including lymphoid organs, adipose tissue, and mucosal barriers...
October 31, 2018: Annual Review of Immunology
https://read.qxmd.com/read/30379594/sixty-years-of-discovery
#17
David Baltimore
Each of us is a story. Mine is a story of doing science for 60 years, and I am honored to be asked to tell it. Even though this autobiography was written for the Annual Review of Immunology, I have chosen to describe my whole career in science because the segment that was immunology is so intertwined with all else I was doing. This article is an elongation and modification of a talk I gave at my 80th birthday celebration at Caltech on March 23, 2018. Expected final online publication date for the Annual Review of Immunology Volume 37 is April 26, 2019...
October 31, 2018: Annual Review of Immunology
https://read.qxmd.com/read/30379593/tuft-cells-systemically-dispersed-sensory-epithelia-integrating-immune-and-neural-circuitry
#18
Claire E O'Leary, Christoph Schneider, Richard M Locksley
Tuft cells-rare solitary chemosensory cells in mucosal epithelia-are undergoing intense scientific scrutiny fueled by recent discovery of unsuspected connections to type 2 immunity. These cells constitute a conduit by which ligands from the external space are sensed via taste-like signaling pathways to generate outputs unique among epithelial cells: the cytokine IL-25, eicosanoids associated with allergic immunity, and the neurotransmitter acetylcholine. The classic type II taste cell transcription factor POU2F3 is lineage defining, suggesting a conceptualization of these cells as widely distributed environmental sensors with effector functions interfacing type 2 immunity and neural circuits...
October 31, 2018: Annual Review of Immunology
https://read.qxmd.com/read/29677479/rig-i-and-other-rna-sensors-in-antiviral-immunity
#19
Kwan T Chow, Michael Gale, Yueh-Ming Loo
Pattern recognition receptors (PRRs) survey intra- and extracellular spaces for pathogen-associated molecular patterns (PAMPs) within microbial products of infection. Recognition and binding to cognate PAMP ligand by specific PRRs initiates signaling cascades that culminate in a coordinated intracellular innate immune response designed to control infection. In particular, our immune system has evolved specialized PRRs to discriminate viral nucleic acid from host. These are critical sensors of viral RNA to trigger innate immunity in the vertebrate host...
April 26, 2018: Annual Review of Immunology
https://read.qxmd.com/read/29677478/unfinished-business-evolution-of-the-mhc-and-the-adaptive-immune-system-of-jawed-vertebrates
#20
Jim Kaufman
The major histocompatibility complex (MHC) is a large genetic region with many genes, including the highly polymorphic classical class I and II genes that play crucial roles in adaptive as well as innate immune responses. The organization of the MHC varies enormously among jawed vertebrates, but class I and II genes have not been found in other animals. How did the MHC arise, and are there underlying principles that can help us to understand the evolution of the MHC? This review considers what it means to be an MHC and the potential importance of genome-wide duplication, gene linkage, and gene coevolution for the emergence and evolution of an adaptive immune system...
April 26, 2018: Annual Review of Immunology
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