Journals Journal of Experimental & Clin...

Journal of Experimental & Clinical Cancer Research : CR
Fei Xu, Wen-Qiang Cui, Ying Wei, Jie Cui, Jian Qiu, Ling-Li Hu, Wei-Yi Gong, Jing-Cheng Dong, Bao-Jun Liu
No abstract text is available yet for this article.
March 23, 2023: Journal of Experimental & Clinical Cancer Research: CR
Claudia De Vitis, Anna Martina Battaglia, Matteo Pallocca, Gianluca Santamaria, Maria Chiara Mimmi, Alessandro Sacco, Francesca De Nicola, Marco Gaspari, Valentina Salvati, Francesca Ascenzi, Sara Bruschini, Antonella Esposito, Giulia Ricci, Eleonora Sperandio, Alice Massacci, Licia Elvira Prestagiacomo, Andrea Vecchione, Alberto Ricci, Salvatore Sciacchitano, Gerardo Salerno, Deborah French, Ilenia Aversa, Cristina Cereda, Maurizio Fanciulli, Ferdinando Chiaradonna, Egle Solito, Giovanni Cuda, Francesco Costanzo, Gennaro Ciliberto, Rita Mancini, Flavia Biamonte
BACKGROUND: Metastases are the major cause of cancer-related morbidity and mortality. By the time cancer cells detach from their primary site to eventually spread to distant sites, they need to acquire the ability to survive in non-adherent conditions and to proliferate within a new microenvironment in spite of stressing conditions that may severely constrain the metastatic process. In this study, we gained insight into the molecular mechanisms allowing cancer cells to survive and proliferate in an anchorage-independent manner, regardless of both tumor-intrinsic variables and nutrient culture conditions...
March 22, 2023: Journal of Experimental & Clinical Cancer Research: CR
Yuan Dong, Qiu Jin, Minghao Sun, Da Qi, Huinan Qu, Xinqi Wang, Chengshi Quan
BACKGROUND: As a breast cancer suppressor gene, CLDN6 overexpression was found to inhibit breast cancer metastasis in our previous studies, but the specific mechanism remains unclear. This study aimed to clarify the role and mechanism of CLDN6 in inhibiting breast cancer metastasis. METHODS: Western blot, immunofluorescence and transmission electron microscopy were performed to detect autophagy. Wound healing, transwell assays and lung metastasis mouse models were used to examine breast cancer metastasis...
March 20, 2023: Journal of Experimental & Clinical Cancer Research: CR
Adriana Amaro, Francesco Reggiani, Daniela Fenoglio, Rosaria Gangemi, Anna Tosi, Alessia Parodi, Barbara Banelli, Valentina Rigo, Luca Mastracci, Federica Grillo, Alessandra Cereghetti, Aizhan Tastanova, Adhideb Ghosh, Fabio Sallustio, Laura Emionite, Antonio Daga, Tiziana Altosole, Gilberto Filaci, Antonio Rosato, Mitchell Levesque, Michele Maio, Ulrich Pfeffer, Michela Croce
BACKGROUND: The combination of Programmed Cell Death 1 (PD-1) and Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) blockade has dramatically improved the overall survival rate for malignant melanoma. Immune checkpoint blockers (ICBs) limit the tumor's immune escape yet only for approximately a third of all tumors and, in most cases, for a limited amount of time. Several approaches to overcome resistance to ICBs are being investigated among which the addition of epigenetic drugs that are expected to act on both immune and tumor cells...
March 18, 2023: Journal of Experimental & Clinical Cancer Research: CR
Shengchao Xu, Chengke Luo, Dikang Chen, Lu Tang, Quan Cheng, Ling Chen, Zhixiong Liu
BACKGROUND: Tumor treating fields (TTF) is the latest treatment for GBM. Circular RNA (circRNA) has been demonstrated to play critical roles in tumorigenesis. However, the molecular mechanism of TTF remained largely unknown and the role of circRNA in TTF was not reported. The aim of this study was to elucidate the role and mechanism of circMMD in TTF treatment of GBM. METHODS: Divergent primer was designed to verify the existence of circMMD in GBM cells. The prognostic role of circMMD was explored in glioma specimens...
March 17, 2023: Journal of Experimental & Clinical Cancer Research: CR
Ana Belén Díaz Méndez, Andrea Sacconi, Elisa Tremante, Valentina Lulli, Valentina Caprara, Laura Rosanò, Frauke Goeman, Mariantonia Carosi, Marta Di Giuliani, Giulia Vari, Antonio Silvani, Bianca Pollo, Carlo Garufi, Sara Ramponi, Giorgia Simonetti, Emilio Ciusani, Chiara Mandoj, Stefano Scalera, Veronica Villani, Agnese Po, Elisabetta Ferretti, Giulia Regazzo, Maria Giulia Rizzo
BACKGROUND: Altered microRNA profiles have been observed not only in tumour tissues but also in biofluids, where they circulate in a stable form thus representing interesting biomarker candidates. This study aimed to identify a microRNA signature as a non-invasive biomarker and to investigate its impact on glioma biology. METHODS: MicroRNAs were selected using a global expression profile in preoperative serum samples from 37 glioma patients. Comparison between serum samples from age and gender-matched controls was performed by using the droplet digital PCR...
March 17, 2023: Journal of Experimental & Clinical Cancer Research: CR
Yueqin Sun, Weitao Shen, Shulu Hu, Qiong Lyu, Qiongyao Wang, Ting Wei, Weiliang Zhu, Jian Zhang
BACKGROUND: Small cell lung cancer (SCLC) is the most aggressive subtype of lung cancer. Although most patients are initially sensitive to first-line combination chemotherapy with cisplatin and etoposide, chemotherapy drug resistance easily develops and quickly leads to tumour progression. Therefore, understanding the mechanisms of chemotherapy drug resistance and how to reverse it is key to improving the prognosis of patients with SCLC. Moreover, N6-methyladenosine (m6A) is the most abundant mRNA modification and is catalysed by the methyltransferase complex, in which methyltransferase-like 3 (METTL3) is the sole catalytic subunit...
March 17, 2023: Journal of Experimental & Clinical Cancer Research: CR
Jun Zheng, Xijing Yan, Tongyu Lu, Wen Song, Yang Li, Jinliang Liang, Jiebin Zhang, Jianye Cai, Xin Sui, Jiaqi Xiao, Haitian Chen, Guihua Chen, Qi Zhang, Yubin Liu, Yang Yang, Kanghong Zheng, Zihao Pan
BACKGROUND: The Warburg effect is well-established to be essential for tumor progression and accounts for the poor clinical outcomes of hepatocellular carcinoma (HCC) patients. An increasing body of literature suggests that circular RNAs (circRNAs) are important regulators for HCC. However, few circRNAs involved in the Warburg effect of HCC have hitherto been investigated. Herein, we aimed to explore the contribution of circFOXK2 to glucose metabolism reprogramming in HCC. METHODS: In the present study, different primers were designed to identify 14 circRNAs originating from the FOXK2 gene, and their differential expression between HCC and adjacent liver tissues was screened...
March 15, 2023: Journal of Experimental & Clinical Cancer Research: CR
Yiwen Zhang, Lu Lu, Feifeng Song, Xiaozhou Zou, Yujia Liu, Xiaowei Zheng, Jinjun Qian, Chunyan Gu, Ping Huang, Ye Yang
Non-protein target drugs, especially RNA-based gene therapies for treating hereditary diseases, have been recognized worldwide. As cancer is an insurmountable challenge, no miracle drug is currently available. With the advancements in the field of biopharmaceuticals, research on cancer therapy has gradually focused on non-protein target-targeted drugs, especially RNA therapeutics, including oligonucleotide drugs and mRNA vaccines. This review mainly summarizes the clinical research progress in RNA therapeutics and highlights that appropriate target selection and optimized delivery vehicles are key factors in increasing the effectiveness of cancer treatment in vivo...
March 14, 2023: Journal of Experimental & Clinical Cancer Research: CR
Jun Li, Tao Huang, Jun Hua, Qiong Wang, Yang Su, Ping Chen, Scott Bidlingmaier, Allan Li, Zhongqiu Xie, Anil P Bidkar, Sui Shen, Weibin Shi, Youngho Seo, Robert R Flavell, Daniel Gioeli, Robert Dreicer, Hui Li, Bin Liu, Jiang He
We recently identified CD46 as a novel prostate cancer cell surface antigen that shows lineage independent expression in both adenocarcinoma and small cell neuroendocrine subtypes of metastatic castration resistant prostate cancer (mCRPC), discovered an internalizing human monoclonal antibody YS5 that binds to a tumor selective CD46 epitope, and developed a microtubule inhibitor-based antibody drug conjugate that is in a multi-center phase I trial for mCRPC (NCT03575819). Here we report the development of a novel CD46-targeted alpha therapy based on YS5...
March 11, 2023: Journal of Experimental & Clinical Cancer Research: CR
Zixian Huang, Xi Rui, Chen Yi, Yongju Chen, Rui Chen, Yancan Liang, Yan Wang, Weicheng Yao, Xiaoding Xu, Zhiquan Huang
BACKGROUND: EGFR is an important signal involved in tumor growth that can induce tumor metastasis and drug resistance. Exploring targets for effective EGFR regulation is an important topic in current research and drug development. Inhibiting EGFR can effectively inhibit the progression and lymph node metastasis of oral squamous cell carcinoma (OSCC) because OSCC is a type of cancer with high EGFR expression. However, the problem of EGFR drug resistance is particularly prominent, and identifying a new target for EGFR regulation could reveal an effective strategy...
March 11, 2023: Journal of Experimental & Clinical Cancer Research: CR
Shiming Tan, Yiqing Yang, Wenjuan Yang, Yaqian Han, Lisheng Huang, Ruiqian Yang, Zifan Hu, Yi Tao, Lin Liu, Yun Li, Linda Oyang, Jinguan Lin, Qiu Peng, Xianjie Jiang, Xuemeng Xu, Longzheng Xia, Mingjing Peng, Nayiyuan Wu, Yanyan Tang, Deliang Cao, Qianjin Liao, Yujuan Zhou
Metabolic reprogramming is one of the hallmarks of cancer. As nutrients are scarce in the tumor microenvironment (TME), tumor cells adopt multiple metabolic adaptations to meet their growth requirements. Metabolic reprogramming is not only present in tumor cells, but exosomal cargos mediates intercellular communication between tumor cells and non-tumor cells in the TME, inducing metabolic remodeling to create an outpost of microvascular enrichment and immune escape. Here, we highlight the composition and characteristics of TME, meanwhile summarize the components of exosomal cargos and their corresponding sorting mode...
March 10, 2023: Journal of Experimental & Clinical Cancer Research: CR
Hongtao Liu, Qing Zhang, Yinsen Song, Yibin Hao, Yunxia Cui, Xin Zhang, Xueying Zhang, Yue Qin, Guangzhao Zhu, Feng Wang, Jinghan Dang, Shanshan Ma, Yanting Zhang, Wenna Guo, Shenglei Li, Fangxia Guan, Tianli Fan
No abstract text is available yet for this article.
March 9, 2023: Journal of Experimental & Clinical Cancer Research: CR
Hui Jun Lim, Lizhe Zhuang, Rebecca C Fitzgerald
Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome attributed to germline CDH1 mutations that carries a high risk for early onset DGC. HDGC raises a significant health issue due to its high penetrance and mortality unless diagnosed early. The definitive treatment is to undergo prophylactic total gastrectomy which is associated with significant morbidity., highlighting the urgent need for alternative treatment methods. However, there is limited literature examining potential therapeutic strategies building on emerging insights into the molecular basis of progressive lesions in the context of HDGC...
March 4, 2023: Journal of Experimental & Clinical Cancer Research: CR
Joyce Y Buikhuisen, Patricia M Gomez Barila, Kate Cameron, Saskia J E Suijkerbuijk, Cor Lieftink, Simone di Franco, Ana Krotenberg Garcia, Rebeca Uceda Castro, Kristiaan J Lenos, Lisanne E Nijman, Arezo Torang, Ciro Longobardi, Joan H de Jong, Daniëlle Dekker, Giorgio Stassi, Louis Vermeulen, Roderick L Beijersbergen, Jacco van Rheenen, Stephan Huveneers, Jan Paul Medema
BACKGROUND: Colorectal cancer (CRC) can be divided into four consensus molecular subtypes (CMS), each with distinct biological features. CMS4 is associated with epithelial-mesenchymal transition and stromal infiltration (Guinney et al., Nat Med 21:1350-6, 2015; Linnekamp et al., Cell Death Differ 25:616-33, 2018), whereas clinically it is characterized by lower responses to adjuvant therapy, higher incidence of metastatic spreading and hence dismal prognosis (Buikhuisen et al., Oncogenesis 9:66, 2020)...
March 3, 2023: Journal of Experimental & Clinical Cancer Research: CR
Lola E Navas, Elena Blanco-Alcaina, Elisa Suarez-Martinez, Eva M Verdugo-Sivianes, Asuncion Espinosa-Sanchez, Laura Sanchez-Diaz, Eduardo Dominguez-Medina, Ceres Fernandez-Rozadilla, Angel Carracedo, Lindsay E Wu, Amancio Carnero
Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of tumors that affect different anatomical locations. Despite this heterogeneity, HNSCC treatment depends on the anatomical location, TNM stage and resectability of the tumor. Classical chemotherapy is based on platinum-derived drugs (cisplatin, carboplatin and oxaliplatin), taxanes (docetaxel, paclitaxel) and 5-fluorouracil1 . Despite advances in HNSCC treatment, the rate of tumor recurrence and patient mortality remain high. Therefore, the search for new prognostic identifiers and treatments targeting therapy-resistant tumor cells is vital...
March 3, 2023: Journal of Experimental & Clinical Cancer Research: CR
Guizhi Jia, Yan Wang, Chengjie Lin, Shihui Lai, Hongliang Dai, Zhiqian Wang, Luo Dai, Huizhao Su, Yanjie Song, Naiwen Zhang, Yukuan Feng, Bo Tang
No abstract text is available yet for this article.
March 2, 2023: Journal of Experimental & Clinical Cancer Research: CR
Yujing Bi, Qiuli Yang, Zhengchao Li, Yuexin Wang, Yufei Wang, Anna Jia, Zhiyuan Pan, Ruifu Yang, Guangwei Liu
BACKGROUND: Although the role and mechanism of neutrophils in tumors have been widely studied, the precise effects of aryl hydrocarbon receptor nuclear translocator (ARNT) on neutrophils remain unclear. In this study, we investigated the roles of ARNT in the function of CD11b+ Gr1+ neutrophils in colitis-associated colorectal cancer. METHODS: Wild-type (WT), ARNT myeloid-specific deficient mice and a colitis-associated colorectal cancer mouse model were used in this study...
March 1, 2023: Journal of Experimental & Clinical Cancer Research: CR
Jian-Xin Cui, Xian-Hui Xu, Tao He, Jia-Jia Liu, Tian-Yu Xie, Wen Tian, Jun-Yan Liu
BACKGROUND: Natural killer (NK) cells play a major role in body's fighting against various types of cancers. Their infiltration in the tumor microenvironment (TME) of gastric cancer (GC) are significantly decreased, which has been reported as a robust prognostic marker. However, the causes leading to NK cells loss in GC TME remains poorly understood. METHODS: We constructed a non-contact co-culturing system and humanized xenograft tumor mice model to detect the influence of GC microenvironment on NK-92 or primary human NK cells viability by flow cytometry...
March 1, 2023: Journal of Experimental & Clinical Cancer Research: CR
Xinghua Sui, Chunxia Chen, Xiuman Zhou, Xueyan Wen, Chao Shi, Guanyu Chen, Juan Liu, Zhuoying He, Yongjie Yao, Yin Li, Yanfeng Gao
BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is a common gastrointestinal malignancy with poor patient prognosis. Current treatment for ESCC, including immunotherapy, is only beneficial for a small subset of patients. Better characterization of the tumor microenvironment (TME) and the development of novel therapeutic targets are urgently needed. METHODS: In the present study, we hypothesized that integration of single-cell transcriptomic sequencing and large microarray sequencing of ESCC biopsies would reveal the key cell subtypes and therapeutic targets that determine the prognostic and tumorigenesis of ESCC...
February 27, 2023: Journal of Experimental & Clinical Cancer Research: CR
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