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World Journal of Urology

Sara Jasionowska, Oliver Brunckhorst, Rowland W Rees, Asif Muneer, Kamran Ahmed
PURPOSE: Redo-urethroplasty is a challenge for any genitourethral surgeon, with a number of techniques previously described. This systematic review aims to identify the surgical techniques described in the literature and evaluate the evidence for their effectiveness in managing recurrent urethral strictures. MATERIALS AND METHODS: A systematic review of the MEDLINE and EMBASE databases from 1945 to July 2018 was performed and the urethroplasty procedures were classified according to the site and surgical technique...
March 15, 2019: World Journal of Urology
Ivo G Schoots, Monique J Roobol
BACKGROUND AND PURPOSE: Individualized risk-adapted algorithms in prostate cancer (PCa) diagnosis using predictive prebiopsy variables in addition to prostate-specific antigen value may result in a considerable reduction of unnecessary systematic biopsies. Multi-parametric magnetic resonance imaging (mpMRI) has emerged as a secondary prediction tool that can further improve the detection of clinically significant prostate cancer (csPCa). This review explores the performance of new MRI risk models for indicating a biopsy for prostate cancer diagnosis...
March 13, 2019: World Journal of Urology
Guoliang Yang, Lianhua Zhang, Mengyao Liu, Qiang Liu, Xuehui Duan, Juanjie Bo
PURPOSE: Macrophages are a major cell type that can infiltrate solid tumors and exhibit distinct phenotypes in different tumor microenvironments. This study investigates the prognostic value of tumor-infiltrated CD163+ macrophages in patients with T1 high-grade (T1HG) bladder cancer. METHODS: CD163+ macrophages were assessed by immunohistochemistry in 94 T1HG bladder cancer samples. Kaplan-Meier analyses and Cox proportional hazards' regression models were applied to evaluate recurrence-free survival, progression-free survival and disease-specific survival...
March 13, 2019: World Journal of Urology
Farzaneh Sharifiaghdas
PURPOSE: This study evaluated sacral neuromodulation's effectiveness for managing refractory neuropathic lower urinary tract dysfunction in children and adolescents. METHODS: Twenty-five children and adolescents underwent peripheral nerve evaluation test phase of sacral neuromodulation at our center. Thirteen (seven boys and six girls) cases suffered from neuropathic lower urinary tract dysfunction refractory to the maximum medical treatment. The test was done with temporary wire in all patients...
March 12, 2019: World Journal of Urology
R Christopher Doiron, Daniel A Shoskes, J Curtis Nickel
INTRODUCTION: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), commonly encountered in urologic practice, carries with it a stigma of poor understanding, ineffective treatment, and significant financial and quality of life burden. MATERIALS AND METHODS: This clinically practical review is based on the authors' personal clinical experience in interpretation and application of currently available evidence. RESULTS: Significant progress has been made in terms of classification and evaluation of the disease, leading to encouraging improvements in treatment outcomes...
March 12, 2019: World Journal of Urology
Sung Jin Kim, Jongpill Lee, Dong Hyeon An, Chang-Hoo Park, Ju Hyun Lim, Han Gwun Kim, Jong Yeon Park
PURPOSE: To compare the pain control efficacies of the pelvic plexus block (PPB), periprostatic nerve block (PNB), and controls during a 14-core basal and apical core prostate biopsy. METHODS: This randomized controlled study, performed between January 2015 and January 2016, included patients with an abnormal serum prostate-specific antigen (PSA > 3 ng/mL) level or a palpable nodule on digital rectal examination. The enrolled patients were randomized into three groups: Group 1, intrarectal local anesthesia (IRLA, 10 mL of 2% lidocaine jelly) and PPB with 3...
March 12, 2019: World Journal of Urology
Roger Li, Janet E Baack Kukreja, Mohamed A Seif, Firas G Petros, Matthew T Campbell, Justin V Nguyen, Graciela M Nogueras González, Ashish M Kamat, Louis L Pisters, Colin P Dinney, Neema Navai
PURPOSE: To describe our institutional experience with cytoreductive/consolidative radical cystectomy (CCRC) for metastatic urothelial carcinoma (UC) and to investigate clinicopathologic features predicting prolonged cancer specific survival (CSS) following CCRC. METHODS: We performed IRB-approved review of our cystectomy database, and identified 43 patients with metastatic UC who underwent CCRC. Baseline demographics, chemotherapy regimen, clinicopathologic features, and perioperative complications were collected...
March 12, 2019: World Journal of Urology
Antonino Battaglia, Gaëtan Devos, Karel Decaestecker, Manuel Witters, Lisa Moris, Thomas Van den Broeck, Charlien Berghen, Wouter Everaerts, Maarten Albersen, Arman Tsaturyan, Gert De Meerleer, Hein Van Poppel, Karolien Goffin, Piet Ost, Lorenzo Tosco, Steven Joniau
OBJECTIVES: Metastasis direct therapy (MDT) is a common practice in different fields of oncology. However, there is a lack of data on surgical MDT in visceral/skeletal oligometastatic prostate cancer (PCa). We aimed to assess the role of surgical excision of visceral and skeletal PCa recurrence. METHODS: Seventeen PCa patients experienced metachronous visceral or skeletal oligometastatic recurrence following maximal local treatment. Oligometastatic recurrence was defined as 1-3 lesions, detected with the best imaging technique available at the time of diagnosis...
March 12, 2019: World Journal of Urology
Luca Triggiani, Rosario Mazzola, Stefano Maria Magrini, Gianluca Ingrosso, Paolo Borghetti, Fabio Trippa, Andrea Lancia, Beatrice Detti, Giulio Francolini, Fabio Matrone, Roberto Bortolus, Giuseppe Fanetti, Ernesto Maranzano, Francesco Pasqualetti, Fabiola Paiar, Marco Lorenzo Bonù, Alessandro Magli, Alessio Bruni, Ercole Mazzeo, Ciro Franzese, Marta Scorsetti, Filippo Alongi, Barbara Alicja Jereczek-Fossa, Piet Ost, Michela Buglione
PURPOSE: Herein, we report the clinical outcomes of a multicenter study evaluating the role of SBRT in a cohort of patients affected by oligoprogressive castration-resistant prostate cancer (CRPC). MATERIALS AND METHODS: This is a retrospective multicenter observational study including eleven centers. Inclusion criteria of the current study were: (a) Karnofsky performance status > 80, (b) histologically proven diagnosis of PC, (c) 1-5 oligoprogressive metastases, defined as progressive disease at bone or nodes levels (detected by means of choline PET/CT or CT plus bone scan) during ADT, (d) serum testosterone level under 50 ng/ml during ADT, (e) controlled primary tumor, (f) patients treated with SBRT with a dose of at least 5 Gy per fraction to a biologically effective dose (BED) of at least 80 Gy using an alpha-to-beta ratio of 3 Gy, (g) at least 6 months of follow-up post-SBRT...
March 11, 2019: World Journal of Urology
Guan Hee Tan, Gregory Nason, Khaled Ajib, Dixon Teck Sing Woon, Jaime Herrera-Caceres, Omar Alhunaidi, Nathan Perlis
PURPOSE: Prostate cancer is the second commonest cancer among men. In the large European Randomized Study of Screening for Prostate Cancer (ERSPC) trial, prostate-specific antigen (PSA) screening has been shown to substantially reduce prostate cancer mortality. However, PSA screening is known to lead to more unnecessary prostate biopsies and over-diagnosis of clinically insignificant cancer. Therefore, it is imperative that smarter screening methods be developed to overcome the weaknesses of PSA screening...
March 11, 2019: World Journal of Urology
Ishan Aditya, Ethan D Grober, Yonah Krakowsky
INTRODUCTION: Peyronie's disease (PD) and testosterone deficiency (TD) impact men at the same stage of life and can ultimately contribute to erectile dysfunction. There is speculation that low levels of testosterone (T) may predispose men to penile fibrosis; however, there is no published, up-to-date review summarizing the current evidence. Therefore, we conducted a narrative review of the literature exploring the relationship between PD and TD. METHODS: A comprehensive systematic search of existing literature of five online databases from June 1990 to June 2018 examining the relationship between PD and TD was conducted...
March 11, 2019: World Journal of Urology
Aaron Brant, Marcus Daniels, Meera R Chappidi, Gregory A Joice, Nikolai A Sopko, Andres Matoso, Trinity J Bivalacqua, Max Kates
PURPOSE: Non-muscle-invasive bladder cancer involving the prostatic urethra is associated with pathologic upstaging and shorter survival. We investigated the survival impact of prostatic urethral involvement in non-muscle-invasive patients who are not upstaged at cystectomy. METHODS: From 2000 to 2016, 177 male patients underwent cystectomy for high-risk non-muscle-invasive bladder cancer and remained pT1, pTis, or pTa, and N0 on final pathology; 63 (35.6%) patients had prostatic urethral involvement and 114 (64...
March 8, 2019: World Journal of Urology
Tiffany Daly
PURPOSE: Although the clinical significance of a diagnosis of prostate cancer for some men is debated, for many men it leads to significant morbidity and mortality. Radical treatment of clinically localized prostate cancer has been shown to improve survival in men with intermediate or high-risk disease. There is no high level evidence to support the superiority of radical prostatectomy, with or without adjuvant or salvage external beam radiotherapy in comparison to definitive radiotherapy with or without androgen deprivation, and the choice should be individualized...
March 8, 2019: World Journal of Urology
Jinhai Fan, Kaijie Wu, Pu Zhang, Dalin He
PURPOSE: To describe a green-laser marking technique to assist partial cystectomy, which allows accurate identification of tumour margins, and provide our initial experience with ten patients. METHODS: Between January 2014 and February 2018, ten patients suspected with muscle-invasive bladder cancer and request of bladder-preserving treatment were selected. In each case, bilateral pelvic lymphadenectomy was performed before green-laser assisted laparoscopic partial cystectomy...
March 6, 2019: World Journal of Urology
Zachary Klaassen, Christopher J D Wallis, Luke T Lavallée, Philippe D Violette
PURPOSE: To describe a patient and procedure specific approach to selecting Venous thromboembolism (VTE) prophylaxis for men who undergo radical prostatectomy. METHODS: We performed a literature search and narrative review of VTE after radical prostatectomy. We describe the current paradigm of perioperative thromboprophylaxis and underlying rationale. Relevant findings from the European Association of Urology thromboprophylaxis guidelines are interpreted and summarized...
March 6, 2019: World Journal of Urology
Marko Babjuk
No abstract text is available yet for this article.
March 5, 2019: World Journal of Urology
Hua Liang, Tao Yang, Kaijie Wu, Dalin He, Jinhai Fan
PURPOSE: The T1 substage, according to the relationship between muscularis mucosae (MM) and tumors, is a promising prognostic factor for T1 bladder cancer. However, the identification rate of MM is low in specimens, and it is, therefore, not widely used in clinical practice. In this study, we investigated whether en bloc resection of non-muscle invasive bladder cancer (NMIBC) could improve the identification of muscularis mucosae (MM), which may further accurate identification of the T1 substage...
March 4, 2019: World Journal of Urology
Sophie Knipper, David Pröwrock, Zhe Tian, Hans Heinzer, Derya Tilki, Pierre Karakiewicz, Markus Graefen
PURPOSE: Accurate life expectancy prediction is essential in decision-making concerning treatment of clinically localized prostate cancer (PCa). Nomogram predictions are more precise and reproducible than clinician's estimations. The most accurate nomogram addressing 10-year life expectancy in PCa patients has not been externally validated to date. Therefore, we aimed to evaluate the performance of this nomogram in a contemporary external cohort. PATIENTS AND METHODS: For this, we enrolled all consecutive patients, who underwent radical prostatectomy at a single institution between 2005 and 2007...
March 4, 2019: World Journal of Urology
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