journal
https://read.qxmd.com/read/38008487/high-throughput-intact-glycopeptide-quantification-strategy-with-targeted-ms-htigqs-target-reveals-site-specific-igg-n-glycopeptides-as-biomarkers-for-hepatic-disorder-diagnosis-and-staging
#1
JOURNAL ARTICLE
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Liver disease is one of the leading causes of global mortality, and identifying biomarkers for diagnosing the progression of liver diseases is crucial for improving its outcomes. Targeted mass spectrometry technology is a powerful tool with unique advantages for verifying biomarker candidates and clinical applications. It is particularly useful in validating protein biomarkers with post-translational modifications, eliminating the need for site-specific antibodies. Especially, targeted mass spectrometry technique is particularly critical for translation of glycoproteins into clinical applications as there are no site-specific antibodies for N-glycosylation...
February 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38008486/corrigendum-to-salecan-confers-anti-inflammatory-effects-in-liver-injury-via-regulating-gut-microbiota-and-its-metabolites-carbohydrate-polymers-2023-120418
#2
Yanjun Liu, Panpan Li, Wenjie Pan, Juan Zhao, Chen Guang Olnood, Yuanfa Liu, Yong-Jiang Xu
No abstract text is available yet for this article.
February 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38008485/treatment-and-mechanism-for-hot-melting-starch-by-reducing-the-molecular-chain-winding-and-crystallinity
#3
JOURNAL ARTICLE
Shen Wang, Yanhui Li, Jingxian Zhang, Jia Man, Yanyan Nie, Maocheng Ji, Heyu Chen, Fangyi Li, Chuanwei Zhang
Unlike thermoplastic petroleum-based materials, starch-based materials rely on aqueous systems but are incapable of hot melting, resulting in low processing efficiency and limited large-scale industrial applications. In this study, the combination of α-amylase liquefaction and urea plasticization was used for the first time to obtain enzymatic thermoplastic starch (ETPS) for hot melting by changing the molecular chain of starch. ETPS showed an apparent hot melting phenomenon when heated below 200 °C...
February 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38008484/triple-physical-cross-linking-cellulose-nanofibers-based-poly-ionic-liquid-hydrogel-as-wearable-multifunctional-sensors
#4
JOURNAL ARTICLE
Dong Fu, Yang Xie, Lili Zhou, Lili Zhang, Ting Zheng, Jun Shen
A novel triple physical cross-linking poly(ionic liquid) hydrogel, composed of poly(acrylamide-co-dodecyl methacrylate-co-1-vinyl-3-methyluracil-imidazolium chloride)/cellulose nanofibers-Ca2+ (PADV/CNFs-Ca2+ ), was synthesized through micellar-copolymerization followed by a solvent-soaked procedure. The synergistic interactions in polymer network (i.e. the hydrophobic association of dodecyl methacrylate moiety in surfactant micelles, the hydrogen bondings between imidazolium monomer segments and other monomer segments in polymers, and the ionic coordination between Ca2+ and -COO- on cellulose nanofibers surface) endowed the hydrogel with excellent mechanical properties, including high strength (754 kPa of tensile strength and 1905 kPa of compressive strength), outstanding stretchability (1963 %), elastic modulus (56...
February 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38008483/chitin-based-pulps-structure-property-relationships-and-environmental-sustainability
#5
JOURNAL ARTICLE
Luiz G Greca, Ainara Azpiazu, Guillermo Reyes, Orlando J Rojas, Blaise L Tardy, Erlantz Lizundia
The deconstruction and valorization of chitinous biomass from crustaceans is a promising route for sustainable bioproduct development alternative to petroleum-based materials. However, chitin nanocrystal and chitin nanofibril isolation from crustacean shells is often subjected to extensive processing, compromising their environmental and cost sustainability. To address the sustainability challenge that chitin valorization presents, herein we introduce a mild fibrillation route to generate "chitin pulp"; where a careful control of the macro- and micro-fibrillated chitin with protein and mineral components yields tailored properties...
February 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38008482/phosphorylated-cellulose-nanocrystals-optimizing-production-by-decoupling-hydrolysis-and-surface-modification
#6
JOURNAL ARTICLE
Anita Etale, Amaka J Onyianta, Jean-Charles Eloi, Jemma Rowlandson, Stephen J Eichhorn
Urea and phosphoric acid are essential for the isolation of phosphorylated cellulose nanocrystals (CNCs). Besides limiting dissolution of nanocrystals, urea facilitates the swelling of fibres thus increasing access for the phosphorylating agent. The aim of this study was to determine optimal conditions for isolation of highly charged phosphorylated CNCs. Using a design of experiments approach, seventeen experiments in which reaction time, urea, and acid concentrations were varied, were conducted. A two-step process was used, in which CNCs were first isolated by treatment in phosphoric acid, and then treated with metaphosphoric acid, and urea...
February 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38008481/in-process-epimerisation-of-alginates-from-saccharina-latissima-alaria-esculenta-and-laminaria-hyperborea
#7
JOURNAL ARTICLE
Katharina Nøkling-Eide, Finn Lillelund Aachmann, Anne Tøndervik, Øystein Arlov, Håvard Sletta
Alginates are valued in many industries, due to their versatile properties. These polysaccharides originate from brown algae (Phaeophyceae) and some bacteria of the Azotobacter and Pseudomonas genera, consisting of 1 → 4 linked β-d-mannuronic acid (M), and its C5-epimer α-l-guluronic acid (G). Several applications rely on a high G-content, which confers good gelling properties. Because of its high natural G-content (FG  = 0.60-0.75), the alginate from Laminaria hyperborea (LH) has sustained a thriving industry in Norway...
February 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38008480/tailoring-the-surface-charges-of-iron-crosslinked-dextran-nanogels-towards-improved-tumor-associated-macrophage-targeting
#8
JOURNAL ARTICLE
Hong Deng, Xue Yang, Huimin Wang, Menghan Gao, Yiyi Zhang, Runmeng Liu, Haiyan Xu, Weiqi Zhang
Tumor-associated macrophages (TAMs) have emerged as therapeutic interests in cancer nanomedicine because TAMs play a pivotal role in the immune microenvironment of solid tumors. Dextran and its derived nanocarriers are among the most promising nanomaterials for TAM targeting due to their intrinsic affinities towards macrophages. Various dextran-based nanomaterials have been developed to image TAMs. However, the effects of physiochemical properties especially for surface charges of dextran nanomaterials on TAM-targeting efficacy were ambiguous in literature...
February 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38008479/nanohybrid-dual-network-chitosan-based-hydrogels-synthesis-characterization-quicken-infected-wound-healing-by-angiogenesis-and-immune-microenvironment-regulation
#9
JOURNAL ARTICLE
Yifan Liu, Fengxin Zhao, Tao Song, Ming Tang, Luoqiang Tian, Tinghan He, Dongxiao Li, Yumei Xiao, Xingdong Zhang
Infectious wounds are difficult to heal because of vascular damage and immune imbalance. The multi-functional hydrogel dressing can regulate vascular regeneration and immune microenvironment through continuous supply of bioactive ingredients to the wound site, which can effectively accelerate the healing speed of infected wounds. In this work, a multifunctional dual-network hydrogel (QCMOD) with good injectability, stability, self-healing and adhesion was designed by combining methacrylic anhydride-modified quaternized chitosan (QCM) with oxidized dextran (OD) via Schiff base reaction and photo-crosslinked polymerization...
February 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38008478/does-pervasive-interconnected-network-of-cellulose-nanocrystals-in-nanocomposite-membranes-address-simultaneous-mechanical-strength-water-permeability-salt-rejection-improvement
#10
JOURNAL ARTICLE
Elham Ostadi, Naser Mohammadi
In this research work, we investigated the effect of two cellulose nanocrystal (CNC)-related parameters, namely aspect ratio and loading content on the mechanical and desalination performance of a cellulose diacetate (CDA) model membrane system. Dispersion of high aspect ratio (HAR) CNCs in the CDA resulted in different types of nanoassembly, represented by evaluating the mechanical efficacy coefficient (CFE ), viscoelastic responses and separation performance of the nanocomposite membranes. Accordingly, 0...
February 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38008477/dual-thermoresponsive-polysaccharide-derivative-water-system-partially-substituted-amylose-butylcarbamate-in-water
#11
JOURNAL ARTICLE
Yuma Nakata, Shinichi Kitamura, Ken Terao
Partially substituted amylose n-butylcarbamate (ABC) samples were synthesized with weight-average molar mass Mw ranging between 40 kg mol-1 and 220 kg mol-1 with different degree of substitution DS. When DS was between 0.17 and 0.33, the ABC samples were soluble in water. Furthermore, both LCST and UCST type phase separations were observed for the ABC samples in water when DS is >0.26. The closed-loop phase diagrams for the dual thermoresponsive ABC samples in water were constructed by turbidity measurement...
February 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38008476/exploitation-of-function-groups-in-cellulose-materials-for-lithium-ion-batteries-applications
#12
REVIEW
Yuanyuan Xia, Xinping Li, Jingshun Zhuang, Wenliang Wang, Syed Comail Abbas, Chenglong Fu, Hui Zhang, Ting Chen, Yue Yuan, Xingjin Zhao, Yonghao Ni
Cellulose, an abundant and eco-friendly polymer, is a promising raw material to be used for preparing energy storage devices such as lithium-ion batteries (LIBs). Despite the significance of cellulose functional groups in LIBs components, their structure-properties-application relationship remains largely unexplored. This article thoroughly reviews the current research status on cellulose-based materials for LIBs components, with a specific focus on the impact of functional groups in cellulose-based separators...
February 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38008475/hyaluronan-arginine-enhanced-and-dynamic-interaction-emerges-from-distinctive-molecular-signature-due-to-electrostatics-and-side-chain-specificity
#13
JOURNAL ARTICLE
Miguel Riopedre-Fernandez, Denys Biriukov, Martin Dračínský, Hector Martinez-Seara
Hyaluronan is a natural carbohydrate polymer with a negative charge that fosters gel-like conditions crucial for its cellular functions and industrial applications. As a recognized ligand for proteins, understanding their mutual interactions provides solid ground to tune hyaluronan's gel properties using biocompatible peptides. This work employs NMR and molecular dynamics simulations to identify molecular motifs relevant to hyaluronan-peptide interactions using arginine, lysine, and glycine oligopeptides. Arginine-rich peptides exhibit the strongest binding to hyaluronan according to chemical shift perturbation measurements, followed distantly by the similarly charged lysine...
February 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38008474/a-scientometric-analysis-and-recent-advances-of-emerging-chitosan-based-biomaterials-as-potential-catalyst-for-biodiesel-production-a-review
#14
JOURNAL ARTICLE
S Prabakaran, K J Rupesh, Itha Sai Keeriti, S Sudalai, G Pragadeeswara Venkatamani, A Arumugam
Chitosan is a widely available polymer with a reasonably high abundance, as well as a sustainable, biodegradable, and biocompatible material with different functional groups that are used in a wide range of operations. Chitosan is frequently employed in widespread applications such as environmental remediation, adsorption, catalysts, and drug formulation. The goal of this review is to discuss the potential applications of chitosan and its chemically modified solids as a catalyst in biodiesel production. The existing manuscripts are integrated based on the nature of materials used as chitosan and its modifications...
February 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38008473/%C3%AE-glucan-derivatives-as-selective-blockers-of-aldolase-a-computer-aided-structure-optimization-and-the-effects-on-hcc
#15
JOURNAL ARTICLE
Qian-Han Xiao, Ze-Zhi Li, Li Ren, Shu-Yao Wang, Xiao-Qiang Li, Hong-Xin Bai, Rui-Zhi Qiao, Na Tang, Wen-Juan Liu, Jing-Mei Wang, Guang-Yuan Ma, Dian-Chao Dong, Ke-Han Wu, Wei Cao
Aldolase A (ALDOA) promotes hepatocellular carcinoma (HCC) growth and is a potential therapeutic target. A previous study found an α-D-glucan (α-D-(1,6)-Glcp-α-D-(1,4)-Glcp, 10.0:1.0), named HDPS-4II, that could specifically inhibit ALDOA but its activity was not high enough. In this study, the derivatives of α-D-glucan binding to ALDOA were optimized using molecular docking, and its sulfated modification demonstrated the highest affinity with ALDOA among sulfated, carboxylated, and aminated derivatives...
February 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38008472/structural-elucidation-of-an-active-polysaccharide-from-radix-puerariae-lobatae-and-its-protection-against-acute-alcoholic-liver-disease
#16
JOURNAL ARTICLE
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Radix Pueraria lobata can be used as medicine and food, whose polysaccharide is one of the main bioactive ingredients. To explore the effect and mechanism of Pueraria lobata polysaccharide, a homogeneous and novel water-soluble polysaccharide (PLP1) was successfully isolated and purified from P. lobata by column chromatography in the current study. Structure analysis revealed that PLP1 (Mw  = 10.43 kDa) was constituted of the residues including (1 → 4)-α-d-glucose and (1 → 4, 6)-α-d-glucose, which were linked together at a ratio of 5:1 and represented the main glycosidic units...
February 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38008471/corrigendum-to-mussel-inspired-polysaccharide-based-sponges-for-hemostasis-and-bacteria-infected-wound-healing-carbohydrate-polymers-295-2022-119868
#17
Wen Sun, Changjun Mu, Xu Zhang, Hengchong Shi, Qiuyan Yan, Shifang Luan
No abstract text is available yet for this article.
February 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38008470/tunability-of-pickering-particle-features-of-whey-protein-isolate-via-remodeling-partial-unfolding-during-ultrasonication-assisted-complexation-with-chitosan-chitooligosaccharide
#18
JOURNAL ARTICLE
Hongmei Yu, Yuanrong Zheng, Changyu Zhou, Lianliang Liu, Libin Wang, Jinxuan Cao, Yangyin Sun, Jun He, Daodong Pan, Zhendong Cai, Qiang Xia
The potential of ultrasonication-driven molecular self-assembly of whey protein isolate (WPI) with chitosan (CS)/chitooligosaccharide (COS) to stabilize Pickering emulsions was examined, based on CS/COS ligands-induced partial unfolding in remodeling the Pickering particles features. Multi-spectral analysis suggested obvious changes in conformational structures of WPI due to interaction with CS/COS, with significantly higher unfolding degrees of WPI induced by COS. Non-covalent interactions were identified as the major forces for WPI-CS/COS conjugates...
February 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38008469/immuno-modulation-of-tumor-and-tumor-draining-lymph-nodes-through-enhanced-immunogenic-chemotherapy-by-nano-complexed-hyaluronic-acid-polyvinyl-alcohol-microneedle
#19
JOURNAL ARTICLE
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Certain chemo-drugs could induce immunogenic cell death (ICD) activating T cell antitumor immunity while trigger indoleamine-2,3-dioxygenase (IDO) upregulation suppressing immune responses. Moreover, to achieve therapeutic efficacies on both primary tumors and tumor draining lymph nodes (TDLNs) in the meantime is still a big challenge. In this study, transfersomes functionalized with a tumor targeting, cell penetrating peptide tLyp1 (CGNKRTR) was developed to co-encapsulate doxorubicin (DOX, ICD inducer) and 1MT (IDO inhibitor)...
February 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/37985122/transparent-regenerated-cellulose-film-containing-azobenzene-group-with-reversible-stimulus-discoloration-property
#20
JOURNAL ARTICLE
Ming Li, Gongwen Liu, Shuang Liu, Xialian Xiao, Yun Bai, Yali Li, Xingxing Li, Yibao Li
The cellulose film, exhibiting color alterations in response to external stimuli, presents itself as a promising functional material. In this study, a universal dissolution-regeneration technique was employed to manufacture a transparent, regenerated cellulose film, characterized by its reversible multi-stimulus discoloration property. This functional cellulose film, endowed with both photochromic and acid-chromic attributes, was synthesized through the introduction of a cellulose-grafted azobenzene derivative into the cellulose solution...
January 15, 2024: Carbohydrate Polymers
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