journal
https://read.qxmd.com/read/36925265/hyaluronic-acid-modified-curcumin-copper-complex-nano-delivery-system-for-rapid-healing-of-bacterial-prostatitis
#1
JOURNAL ARTICLE
Yanyao Gao, Kailai Liu, Yuchen Zhang, Zhenye Sun, Bin Song, Yong Wang, Bo Zhang, Xi Chen, Datao Hu, Jinpeng Wen, He Wang, Ke Wang, Lei Wang
Bacterial prostatitis is a bacterial infection of the prostate gland presenting with lower quadrant abdominal pain, urination disorders and poor fertility. In recent years, reports have emerged on the significantly reduced efficacy of fluoroquinolone drugs attributed to multiple drug-resistant bacteria, emphasizing the need for new drugs. In this study, we designed a targeting drug delivery system via curcumin copper complex grafted with hyaluronic acid. Subsequently, the prepared system was characterized using FT-IR, XRD, SEM, XPS and 1 H NMR methods...
June 15, 2023: Carbohydrate Polymers
https://read.qxmd.com/read/36925264/chitin-nanofibrils-modulate-mechanical-response-in-tympanic-membrane-replacements
#2
JOURNAL ARTICLE
Shivesh Anand, Bahareh Azimi, Mónica Lucena, Claudio Ricci, Mariarita Candito, Lorenzo Zavagna, Laura Astolfi, Maria-Beatrice Coltelli, Andrea Lazzeri, Stefano Berrettini, Lorenzo Moroni, Serena Danti, Carlos Mota
The tympanic membrane (TM), is a thin tissue lying at the intersection of the outer and the middle ear. TM perforations caused by traumas and infections often result in a conductive hearing loss. Tissue engineering has emerged as a promising approach for reconstructing the damaged TM by replicating the native material characteristics. In this regard, chitin nanofibrils (CN), a polysaccharide-derived nanomaterial, is known to exhibit excellent biocompatibility, immunomodulation and antimicrobial activity, thereby imparting essential qualities for an optimal TM regeneration...
June 15, 2023: Carbohydrate Polymers
https://read.qxmd.com/read/36925263/production-of-highly-branched-%C3%AE-limit-dextrins-with-enhanced-slow-digestibility-by-various-glycogen-branching-enzymes
#3
JOURNAL ARTICLE
Ye-Eun Shim, Young-Bo Song, Sang-Ho Yoo, Byung-Hoo Lee
α-Limit dextrins (α-LDx) are slowly digestible carbohydrates that attenuate postprandial glycemic response and trigger the secretion of satiety-related hormones. In this study, more highly branched α-LDx were enzymatically synthesized to enhance the slowly digestible property by various origins of glycogen branching enzyme (GBE), which catalyzes the transglycosylation to form α-1,6 branching points after cleaving α-1,4 linkages. Results showed that the proportion of branched α-LDx in starch molecules increased around 2...
June 15, 2023: Carbohydrate Polymers
https://read.qxmd.com/read/36925262/a-comparative-study-on-inclusion-complex-formation-between-formononetin-and-%C3%AE-cyclodextrin-derivatives-through-multiscale-classical-and-umbrella-sampling-simulations
#4
JOURNAL ARTICLE
Vijay Kumar Bhardwaj, Rituraj Purohit
Formononetin, a naturally occurring isoflavone exhibits a wide range of therapeutic applications including antioxidant, anti-tumor, antiviral, anti-diabetic and neuroprotective activities. However, the low hydro-solubility of formononetin has limited its prospective use in cosmetic, neutraceutical and pharmaceutical industries. Cyclodextrins (CDs), especially β-CD and its derivatives have emerged as promising agents to improve the water solubility of poorly hydrosoluble compounds by the formation of inclusion complexes...
June 15, 2023: Carbohydrate Polymers
https://read.qxmd.com/read/36925261/enzymatic-formation-of-cyclic-maltooligosaccharides-for-the-application-of-quercetin-inclusion-complex
#5
JOURNAL ARTICLE
Ye-Rim Lee, Hyun-Mo Jeong, Ji-Soo Kim, Eun-A Kim, Eun-Hyeong Lee, Jae-Hoon Shim
To improve the applicability of quercetin (QCT), we produced a QCT and cycloamylose (CA-QCT) inclusion complex based on the cyclization activity of cyclodextrin glucanotransferase (CGTase; EC 2.4.1.19). The encapsulated QCT was purified using recycling preparative high-performance liquid chromatography, and its formation was analyzed using matrix-assisted laser desorption/ionization-time of flight mass spectrometry. The water solubility of CA-QCT was 55,000-fold higher than that of QCT. CA-QCT had 97 % stability for one week at pH 8 in a 4 °C water bath...
June 15, 2023: Carbohydrate Polymers
https://read.qxmd.com/read/36925260/targeted-release-of-soybean-peptide-from-cmc-pva-hydrogels-in-simulated-intestinal-fluid-and-their-pharmacokinetics
#6
JOURNAL ARTICLE
Jun Ye, Luying Liu, Wu Lan, Jian Xiong
Carboxymethyl cellulose (CMC)/polyvinyl alcohol (PVA) hydrogels loaded with soybean peptide (SPE) were fabricated via a freeze-thaw method. These hydrogels conquer barriers in simulated gastric fluid (SGF), and then release SPE in simulated intestinal fluid (SIF). The results of in vitro SPE release from these hydrogels showed that in SGF only a little of the SPE released, but in SIF the SPE was completely released. The released SPE had scavenging rates for DPPH and ABTS free radicals of 41.68 and 31.43 %...
June 15, 2023: Carbohydrate Polymers
https://read.qxmd.com/read/36925259/carbon-black-and-chitin-nanofibers-for-green-tyres-preparation-and-property-evaluation
#7
JOURNAL ARTICLE
Mariya Mathew, C D Midhun Dominic, K V Neenu, P M Sabura Begum, P Dileep, T G Ajith Kumar, Akshay Alax Sabu, Dhiraj Nagane, Jyotishkumar Parameswaranpillai, Michael Badawi
This research highlights the synergistic use of carbon black (CB) and chitin nanofibers (CHNFs) for developing green tyres for the first time. The CHNFs (12-30 nm) were prepared from chitin powder with the help of steam explosion and mild oxalic acid hydrolysis. The CHNFs were uniformly dispersed in natural rubber (NR) latex, dried, and mixed with CB in a two-roll mill to form NR/CB/CHNF composites. The NR/CB/CHNF composite at 1 phr CHNF loading exhibited tensile and tear strengths that were about 47 and 160 % greater than the NR-Neat, respectively...
June 15, 2023: Carbohydrate Polymers
https://read.qxmd.com/read/36925258/a-seminal-perspective-on-the-role-of-chondroitin-sulfate-in-biomineralization
#8
JOURNAL ARTICLE
Jia-Xin Hao, Qian-Qian Wan, Zhao Mu, Jun-Ting Gu, Wei-Wei Yu, Wen Qin, Yu-Tao Li, Chen-Yu Wang, Yu-Xuan Ma, Kai Jiao, Franklin Tay, Lina Niu
Chondroitin sulfate (CS) is an important extracellular matrix component of mineralized tissues. It participates in biomineralization, osteoblast differentiation and promotes bone tissue repair in vitro. However, the mechanism in which CS functions is unclear. Accordingly, an in-depth investigation of how CS participates in mineralization was conducted in the present study. Chondroitin sulfate was found to directly induce intrafibrillar mineralization of the collagen matrix. The mineralization outcome was dependent on whether CS remained free in the extracellular matrix or bound to core proteins; mineralization only occurred when CS existed in a free state...
June 15, 2023: Carbohydrate Polymers
https://read.qxmd.com/read/36925257/effects-of-lactobacillus-fermentation-on-eucheuma-spinosum-polysaccharides-characterization-and-mast-cell-membrane-stabilizing-activity
#9
JOURNAL ARTICLE
Jun Zhang, Qingmei Liu, Fudie Gu, Yan Liu, Yu Zhou, Yan Li, Huiying Chen, Hong Liu, Anfeng Xiao, Guangming Liu
Eucheuma polysaccharides have varieties of biological activities. However, it is accompanied by problems like large molecular weight, high viscosity, and low utilization. Here, we first prepared fermented Eucheuma spinosum polysaccharides (F-ESP) by Lactobacillus fermentation, compared with low-temperature freeze-thaw ESP (L-ESP) prepared by the freeze-thaw method, explored the composition and structural characteristics of F-ESP and L-ESP, and evaluation of the ability of different samples to inhibit mast cell degranulation using classical mast cell model...
June 15, 2023: Carbohydrate Polymers
https://read.qxmd.com/read/36925256/dual-electro-and-magneto-induced-bending-actuators-of-magnetite-loaded-agarose-ionogels
#10
JOURNAL ARTICLE
Kornkanok Rotjanasuworapong, Wanchai Lerdwijitjarud, Anuvat Sirivat
Magnetic ionogels are a new kind of gel composites which combine the elastic properties from the swollen gel matrix and the magnetic properties from a magnetic filler. The dual electro-magneto-responsive agarose ionogels (AG IGels) were fabricated by a solution casting method using 1-butyl-3-methylimidazolium chloride [Bmim][Cl] as the ionic liquid solvent, and embedded with magnetite nanoparticles (Fe3 O4 NPs). The addition of Fe3 O4 NPs induced the high bending responses under applied electric and magnetic fields via the electronic polarization and magnetic interaction...
June 15, 2023: Carbohydrate Polymers
https://read.qxmd.com/read/36925255/effects-of-natural-starch-phosphate-monoester-content-on-the-multi-scale-structures-of-potato-starches
#11
JOURNAL ARTICLE
Li Ding, Wenxin Liang, Jianzhou Qu, Staffan Persson, Xingxun Liu, Klaus Herburger, Jacob Judas Kain Kirkensgaard, Bekzod Khakimov, Kasper Enemark-Rasmussen, Andreas Blennow, Yuyue Zhong
No abstract text is available yet for this article.
June 15, 2023: Carbohydrate Polymers
https://read.qxmd.com/read/36925254/evolution-of-the-free-volume-during-water-desorption-in-thermoplastic-starch-citric-acid-films-in-situ-positron-annihilation-studies
#12
JOURNAL ARTICLE
Santiago Estevez-Areco, Carlos Macchi, Lucas Guz, Silvia Goyanes, Alberto Somoza
The effect of citric acid (CA) concentration and water content on the free hole volume of thermoplastic cassava starch films (TPS) was studied. To this aim, continuous in situ positron annihilation lifetime spectroscopy measurements were performed at fixed moisture content and during water desorption. The results show that the increase in CA concentration leads to wider free hole volume distributions with lower mean values. During water desorption, the mean values and width of such distributions systematically decrease with the exposure time, and the evolution of the hole volumes was well-described using the Kohlrausch-Williams-Watts function...
June 15, 2023: Carbohydrate Polymers
https://read.qxmd.com/read/36925253/human-milk-whey-glycoprotein-n-glycans-varied-greatly-among-different-maternal-secretor-status
#13
JOURNAL ARTICLE
Xiaoqin Wang, Wenqing Li, Zhenhua Li, Tianjiao Han, Jinqiao Rong, Jiangbo Fan, Linjuan Huang, Yu Lu, Zhongfu Wang
Human milk glycans are complex carbohydrates, which play a pivotal role in infant health and neonatal development. Maternal secretor status is known to affect free oligosaccharides in milk. Here, the milk N-glycome of secretor (Se+) and nonsecretor (Se-) individuals was qualitatively and quantitatively analyzed by hydrophilic interaction chromatography-electrospray ionization-tandem mass spectrometry. The total glycosylation, fucosylation, and sialylation of N-glycans was three times higher in the Se+ group compared to the Se- group (p < 0...
June 15, 2023: Carbohydrate Polymers
https://read.qxmd.com/read/36925252/decoupling-hydrolysis-and-oxidation-of-cellulose-in-permanent-paper-aged-under-atmospheric-conditions
#14
JOURNAL ARTICLE
Caroline Vibert, Bruno Fayolle, Denise Ricard, Anne-Laurence Dupont
In order to investigate a synergetic role of water and oxygen in the degradation of permanent paper in archiving climate, accelerated ageing in three different conditions was conducted: humid air, humid nitrogen and dry air. This allowed to decouple acid-catalysed hydrolysis versus oxidation of cellulose. After ensuring the reliability of the ageing experiment, the degradation state of the paper was assessed. Various techniques (size exclusion chromatography, pH extraction, alkaline reserve, paper colour and water content) were used...
June 15, 2023: Carbohydrate Polymers
https://read.qxmd.com/read/36925251/bimetallic-auag-aupd-and-agpd-nanoparticles-supported-on-cellulose-based-hydrogel-for-reusable-catalysis
#15
JOURNAL ARTICLE
Xiong Liu, Fangfei Liu
Biopolymer-derived hydrogels with low-cost and sustainable features have been considered as fascinating supported materials for metal nanoparticles. Cellulose, as the most abundant biopolymer, is a renewable raw material to prepare biopolymer-derived hydrogels for catalysis. Here, a cellulose-based hydrogel is designed to load bimetallic (AuAg, AuPd and AgPd) nanoparticles. 4-Nitrophenol reduction and Suzuki-Miyaura coupling reactions are selected to evaluate and compare the catalytic performance of the resulting bimetallic nanoparticle-loaded cellulose-based composite hydrogels...
June 15, 2023: Carbohydrate Polymers
https://read.qxmd.com/read/36925250/lbp1c-2-from-lycium-barbarum-alleviated-age-related-bone-loss-by-targeting-bmpria-bmprii-noggin
#16
JOURNAL ARTICLE
Chuanxin Sun, Xia Chen, Shangpo Yang, Can Jin, Kan Ding, Chang Chen
Age-related bone loss is unavoidable and effective safe drugs are in great need. The fruit of Lycium barbarum was recorded to strengthen bones in the "Ben Cao Gang Mu (Compendium of Materia Medica)". However, there lacks scientific explanation. Herein, we investigated L. barbarum water extract (LBE), L. barbarum polysaccharides (LBP) and the homogeneous polysaccharide LBP1C-2 on the bone loss in adult mouse, aging mouse and ovariectomized mouse models. LBE, LBP and LBP1C-2 all markedly increased bone mass and bone strength in these models and promoted osteoblast proliferation, differentiation and ossification...
June 15, 2023: Carbohydrate Polymers
https://read.qxmd.com/read/36925249/dialdehyde-xanthan-gum-and-curcumin-synergistically-crosslinked-bioprosthetic-valve-leaflets-with-anti-thrombotic-anti-inflammatory-and-anti-calcification-properties
#17
JOURNAL ARTICLE
Mengyue Hu, Xu Peng, Shubin Shi, Chang Wan, Can Cheng, Xixun Yu
Currently commercial glutaraldehyde (GA)-crosslinked bioprosthetic valve leaflets (BVLs) suffer from thromboembolic complications, calcification, and limited durability, which are the major stumbling block to wider clinical application of BVLs. Thus, developing new-style BVLs will be an urgent need to enhance the durability of BVLs and alleviate thromboembolic complications. In this study, a quick and effective collaborative strategy of the double crosslinking agents (oxidized polysaccharide and natural active crosslinking agent) was reported to realize enhanced mechanical, and structural stability, excellent hemocompatibility and anti-calcification properties of BVLs...
June 15, 2023: Carbohydrate Polymers
https://read.qxmd.com/read/36925248/facile-fabrication-of-self-healing-injectable-and-antimicrobial-cationic-guar-gum-hydrogel-dressings-driven-by-hydrogen-bonds
#18
JOURNAL ARTICLE
Yan Wang, Mingrui Yang, Zheng Zhao
Developing self-healing polysaccharide hydrogels offers a promising strategy for the healing of full-thickness skin wounds. However, the green and facile fabrication of self-healing polysaccharide hydrogel dressings is challenging. Herein, a novel hydrogen-bonded polysaccharide hydrogel consisting only of cationic guar gum (CG) and CuCl2 was developed by simply mixing CG and Cu2+ solution. A strong enough intermolecular hydrogen bonding could be formed between ipsilateral hydroxyl groups to induce rapid gelation...
June 15, 2023: Carbohydrate Polymers
https://read.qxmd.com/read/36925247/injectable-nano-composite-hydrogels-based-on-hyaluronic-acid-chitosan-derivatives-for-simultaneous-photothermal-chemo-therapy-of-cancer-with-anti-inflammatory-capacity
#19
JOURNAL ARTICLE
Liduo Rong, Yao Liu, Yu Fan, Jing Xiao, Yanhong Su, Ligong Lu, Shaojun Peng, Weizhong Yuan, Meixiao Zhan
Nowadays, the photothermal therapy (PTT) has received widespread attention and research by rapidly killing tumors with local high temperature. However, due to the irregular edges of tumor and the blurred boundary between normal and necrotic tissues, the desirable treatment cannot be achieved by the single PTT, and excessive heat will cause serious inflammation in local tissues. Herein, an injectable composite hydrogel is prepared by the oxidized hyaluronic acid (OHA) and hydroxypropyl chitosan (HPCS) via the imine bonds, which is employed as the delivery substrate for functional substances...
June 15, 2023: Carbohydrate Polymers
https://read.qxmd.com/read/36925246/tuning-interfacial-microstructure-of-alginate-based-amphiphile-by-dynamic-bonding-for-stabilizing-pickering-emulsion
#20
JOURNAL ARTICLE
Shuntian Huang, Zhaojun Wang, Qichang Zhou, Shujuan Yang, Riting Huang, Keyang Mai, Wenqi Qin, Junhao Huang, Gaobo Yu, Yuhong Feng, Jiacheng Li
Polysaccharide-based soft colloidal particles mediated by the dynamic bonding-engineered interfacial self-assembly can regulate the properties of oil-water interfacial films, availing the stability of emulsions under a wide pH range. The amphiphilic phenylboronic alginate soft colloidal particles (Alg-PBA) were designed to stabilize pH-responsive Pickering emulsions (PEs). Combining stability analysis with quartz crystal microbalance and dissipation monitoring (QCM-D), the microstructure and viscoelasticity of Alg-PBA at the oil-water interface were determined...
June 15, 2023: Carbohydrate Polymers
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