Qian-Han Xiao, Ze-Zhi Li, Li Ren, Shu-Yao Wang, Xiao-Qiang Li, Hong-Xin Bai, Rui-Zhi Qiao, Na Tang, Wen-Juan Liu, Jing-Mei Wang, Guang-Yuan Ma, Dian-Chao Dong, Ke-Han Wu, Wei Cao
Aldolase A (ALDOA) promotes hepatocellular carcinoma (HCC) growth and is a potential therapeutic target. A previous study found an α-D-glucan (α-D-(1,6)-Glcp-α-D-(1,4)-Glcp, 10.0:1.0), named HDPS-4II, that could specifically inhibit ALDOA but its activity was not high enough. In this study, the derivatives of α-D-glucan binding to ALDOA were optimized using molecular docking, and its sulfated modification demonstrated the highest affinity with ALDOA among sulfated, carboxylated, and aminated derivatives...
February 1, 2024: Carbohydrate Polymers