Shivesh Anand, Bahareh Azimi, Mónica Lucena, Claudio Ricci, Mariarita Candito, Lorenzo Zavagna, Laura Astolfi, Maria-Beatrice Coltelli, Andrea Lazzeri, Stefano Berrettini, Lorenzo Moroni, Serena Danti, Carlos Mota
The tympanic membrane (TM), is a thin tissue lying at the intersection of the outer and the middle ear. TM perforations caused by traumas and infections often result in a conductive hearing loss. Tissue engineering has emerged as a promising approach for reconstructing the damaged TM by replicating the native material characteristics. In this regard, chitin nanofibrils (CN), a polysaccharide-derived nanomaterial, is known to exhibit excellent biocompatibility, immunomodulation and antimicrobial activity, thereby imparting essential qualities for an optimal TM regeneration...
June 15, 2023: Carbohydrate Polymers