journal
https://read.qxmd.com/read/38527848/development-and-validation-of-a-nomogram-for-prognosis-prediction-in-patients-with-synchronous-primary-thyroid-and-breast-cancer-based-on-seer-database
#1
JOURNAL ARTICLE
Miao Huo, Jianfei Zhang, Minna Hou, Jianhui Li, Ning Bai, Ruifen Xu, Jiao Guo
This study aimed to develop prognostic prediction models for patients diagnosed with synchronous thyroid and breast cancer (TBC). Utilizing the SEER database, key predictive factors were identified, including T stage of thyroid cancer, T stage of breast cancer, M stage of breast cancer, patient age, thyroid cancer surgery type, and isotope therapy. A nomogram predicting 5-year and 10-year survival rates was constructed and validated, exhibiting strong performance (C-statistic: 0.79 in the development cohort (95% CI: 0...
March 25, 2024: Cancer Investigation
https://read.qxmd.com/read/38501256/impacts-of-perioperative-comprehensive-nursing-intervention-on-postoperative-urinary-incontinence-and-quality-of-life-of-patients-undergoing-laparoscopic-radical-prostatectomy
#2
JOURNAL ARTICLE
Lulu Xin, Jinjin Guo
To evaluate the impact of perioperative comprehensive nursing intervention on postoperative urinary incontinence, various aspects of patient well-being were assessed. The comprehensive group, that received the nursing intervention, demonstrated significant improvements in self-care skills, health knowledge level, self-care responsibility, and self-concept compared to the standard group. The findings indicate that perioperative comprehensive nursing intervention has a remarkable effect on patients undergoing laparoscopic radical prostatectomy...
March 19, 2024: Cancer Investigation
https://read.qxmd.com/read/38486424/targeting-egfr-and-vegfr-2-kinases-with-nanoparticles-a-computational-approach-for-cancer-therapy-advancement
#3
JOURNAL ARTICLE
Ibrahim Khater, Aaya Nassar
The study investigates titanium and zinc nanoparticles as inhibitors for the epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor-2 (VEGFR-2), pivotal regulators of cell processes. VEGFR-2 activation fuels tumor angiogenesis in cancer cells, sustaining malignant tissue expansion. Molecular docking analysis illustrates the nanoparticles' binding to the active sites, inhibiting the phosphorylation of key proteins in downstream signaling. This inhibition offers a promising therapeutic approach to impede cancer-related signaling, potentially slowing down aberrant protein cascades controlled by EGFR and VEGFR-2...
March 14, 2024: Cancer Investigation
https://read.qxmd.com/read/38486421/retrospective-analyses-of-pd-l1-lag-3-tim-3-ox40l-expressions-and-msi-status-in-gastroenteropancreatic-neuroendocrine-neoplasms
#4
JOURNAL ARTICLE
Fatih Gürler, Selin Aktürk Esen, Bediz Kurt İnci, Osman Sütçüoğlu, Gökhan Uçar, Orhun Akdoğan, Doğan Uncu, Nesrin Turhan, Nalan Akyürek, Nuriye Özdemir, Ahmet Özet, Ozan Yazıcı
We investigated expressions of PD-L1, LAG-3, TIM-3, and OX40L as immune checkpoint proteins, and MSI (repetitive short-DNA-sequences due to defective DNA-repair system) status were analyzed with immunohistochemistry from tissue blocks. Of 83 patients, PD-L1 expression was observed in 18.1% (n = 15) of the patients. None of the patients exhibited LAG-3 expression. TIM-3 expression was 4.9% (n = 4), OX40L was 22.9% (n = 19), and 8.4% (n = 7) of the patients had MSI tumor...
March 14, 2024: Cancer Investigation
https://read.qxmd.com/read/38404236/a-review-on-emerging-techniques-for-diagnosis-of-colorectal-cancer
#5
REVIEW
Shruthi Nagainallur Ravichandran, Diptimayee Das, Erica Katriel Dayananda, Amit Dey, Antara Banerjee, Alexander Sun-Zhang, Hong Zhang, Xiao-Feng Sun, Surajit Pathak
Common detection methods in practice for diagnosing colorectal cancer (CRC) are painful and invasive leading to less participation of individuals for CRC diagnosis. Whereas, improved or enhanced imaging systems and other minimally invasive techniques with shorter detection times deliver greater detail and less discomfort in individuals. Thus, this review is a summary of the diagnostic tests, ranging from the simple potential use in developing a flexible CRC treatment to the patient's potential benefits in receiving less invasive procedures and the advanced treatments that might provide a better assessment for the diagnosis of CRC and reduce the mortality related to CRC...
February 26, 2024: Cancer Investigation
https://read.qxmd.com/read/38390854/ngs-based-tissue-blood-tmb-comparison-and-blood-tmb-monitoring-in-stage-iii-non-small-cell-lung-cancer-treated-with-concurrent-chemoradiotherapy
#6
JOURNAL ARTICLE
Luxi Ye, Xiao Chu, Jianjiao Ni, Li Chu, Xi Yang, Zhengfei Zhu
In this study, we analyzed the blood-based TMB (b-TMB) and its dynamic changes in patients with locally advanced non-small cell lung cancer (LA-NSCLC) who received concurrent chemoradiotherapy. Baseline tissue and blood TMB from 15 patients showed a strong positive correlation (Pearson correlation = 0.937), and nearly all mutations were markedly reduced in the later course of treatment, indicating a treatment-related response. This study suggests that in patients with LA-NSCLC, b-TMB is a reliable biomarker, and its dynamic monitoring can help distinguish patients who might benefit most from the consolidated immunotherapy...
February 23, 2024: Cancer Investigation
https://read.qxmd.com/read/38390837/immune-cell-infiltration-types-as-biomarkers-for-the-recurrence-diagnosis-and-prognosis-of-bladder-cancer
#7
JOURNAL ARTICLE
Hongwei Xu, Dapeng Sun, Dahong Zhou, Shiheng Sun
This study aimed to investigate the role of infiltrating immune cell types in diagnosing and predicting bladder cancer recurrence. This study mainly applied some algorithms, including Estimate the Proportion of Immune and Cancer Cells (EPIC), support vector machine-recursive feature elimination (SVM-RFE), random forest out-of-bag (RF-OOB) and least absolute shrinkage and selection operator (LASSO)-Cox regression analysis. We found six immune infiltrating cell types significantly associated with recurrence prognosis and two independent clinical prognostic factors...
February 23, 2024: Cancer Investigation
https://read.qxmd.com/read/38385429/randomized-double-blind-placebo-controlled-clinical-trial-of-concurrent-use-of-crocin-during-chemoradiation-for-esophageal-squamous-cell-carcinoma
#8
JOURNAL ARTICLE
Nima Ebrahimi, Seyed Alireza Javadinia, Roham Salek, Azar Fanipakdel, Samaneh Sepahi, Mansoureh Dehghani, Niloufar Valizadeh, Seyed Ahmad Mohajeri
Crocin is the major active carotenoid of saffron (Crocus sativus L.). Its pluripotent effects have led to a growing body of literature investigating its antitumor properties as well as its diverse potentials for mood stabilization, normal tissue protection, and inflammation reduction; However, there is a gap in clinical trials testing this substance in cancer patients. In this randomized, double-blind, placebo-controlled clinical trial, patients with newly diagnosed esophageal squamous cell carcinoma were randomly assigned to either 30 mg/day of crocin or placebo, prescribed during the neoadjuvant chemo-radiotherapy...
February 22, 2024: Cancer Investigation
https://read.qxmd.com/read/38345052/microvessel-density-mvd-in-patients-with-osteosarcoma-a-systematic-review-and-meta-analysis
#9
REVIEW
Konstantinos Perivoliotis, Panagiotis Ntellas, Katerina Dadouli, Athina A Samara, Sotirios Sotiriou, Maria Ioannou, Konstantinos Tepetes
A meta-analysis was designed and conducted to estimate the effect of tumoral microvessel density (MVD) on the survival of patients with osteosarcoma. There was no difference between high and low MVD regarding the overall (OS) and disease-free (DFS) survival. Low MVD tumors displayed a lower DFS at the third year of follow-up. Although primary metastases did not affect the mean MVD measurements, tumors with a good chemotherapy response had a higher MVD value. Although no significant differences between tumoral MVD, OS and DFS were found, good adjuvant therapy responders had a significant higher vascularization pattern...
February 12, 2024: Cancer Investigation
https://read.qxmd.com/read/38317281/covid-19-outbreak-impact-on-cancer-multidisciplinary-team-meetings-a%C3%A2-multicenter-french-experience
#10
JOURNAL ARTICLE
Wafa Bouleftour, Amandine Mondiere-Wichurski, Pierre Fournel, Quentin Reboul
Multidisciplinary team meeting (MDT) became a standard of care in cancer management. The COVID-19 epidemic induced unprecedented pressure on the health system. The impact of this health crisis on MDTs held within a regional French health structures was analyzed. A decrease in the total number of records discussed in hematological, digestive, thoracic, gynecological and genitourinary MDTs was observed following the 1st wave of the COVID-19 pandemic. This decrease was generally maintained during the 2nd and 3rd wave...
February 5, 2024: Cancer Investigation
https://read.qxmd.com/read/38314786/gain-of-chromosome-5q-predicts-a-favorable-prognosis-in-localized-renal-cell-carcinoma
#11
JOURNAL ARTICLE
Cedric Lebacle, Aydin Pooli, Brian Shuch, Nagesh Rao, Karim Chamie, Nils Kroeger, Izak Faiena, Sandy Liu, Erika L Wood, Arie Belldegrun, Alexandra Drakaki, Allan J Pantuck
Approximately 65% of renal cell carcinomas (RCC) are diagnosed at a localized stage. We investigated the chromosome 5q gain impact on disease-free survival (DFS) in RCC patients. Overall, 676 patients with stages 1-2 RCC and having cytogenetic analysis were included. Gain of 5q was observed in 108 patients, more frequently in clear cell (ccRCC) than non-clear cell tumors. Gain of 5q is likely an independent prognostic factor since the concerned patients had a decreased recurrence risk in stages 1-2 RCC, confirmed in multivariable analysis...
February 5, 2024: Cancer Investigation
https://read.qxmd.com/read/38303557/the-nature-origin-and-evolution-of-life-part-v-bringing-it-together-concepts-constraints-and-closure
#12
EDITORIAL
Gary H Lyman, Christopher H Lyman, Nicole M Kuderer
No abstract text is available yet for this article.
February 1, 2024: Cancer Investigation
https://read.qxmd.com/read/38299573/comorbidity-in-small-cell-lung-cancer-prognostic-impacts-of-hypertension-coronary-artery-disease-diabetes-mellitus-and-chronic-obstructive-pulmonary-disease
#13
JOURNAL ARTICLE
Faruk Tas, Akin Ozturk, Kayhan Erturk
Comorbidity, the most important components of which are hypertension/coronary artery disease (HTN/CAD), diabetes mellitus (DM), and chronic obstructive pulmonary disease (COPD), is frequently encountered in small cell lung cancer (SCLC) patients. We aimed to assess the possible impacts of these major comorbidities on the prognoses of SCLC patients. A total of 378 SCLC patients were analyzed retrospectively. We did not ascertain the effect of comorbidity on survival in SCLC patients in general; and similarly, the presence of HTN/CAD and COPD did not adversely affect the outcome...
February 1, 2024: Cancer Investigation
https://read.qxmd.com/read/38186047/human-mycobiota-and-its-role-in-cancer-progression-diagnostics-and-therapeutics-a-link-lesser-known
#14
REVIEW
Souvik Roy, Dhrisaj Ray, Ishani Laha, Lopamudra Choudhury
Although not as well studied as the bacterial component of the human microbiota, the commensal fungi or mycobiota play important roles in maintaining our health by augmenting our immune system. This mycobiota is also associated with various fatal diseases like opportunistic mycoses, and even cancer, with different cancers having respective type-specific mycobiota. The different fungal species which comprise these different intratumoral mycobiota play important roles in cancer progression. The aim of this review paper is to decipher the association between mycobiota and cancer, and shed light on new avenues in cancer diagnosis, and the development of new anti-cancer therapeutics...
January 7, 2024: Cancer Investigation
https://read.qxmd.com/read/38175037/the-nature-origin-and-evolution-of-life-part-iv-cellular-differentiation-and-the-emergence-of-multicellular-life
#15
EDITORIAL
Gary H Lyman, Christopher H Lyman, Nicole M Kuderer
No abstract text is available yet for this article.
January 4, 2024: Cancer Investigation
https://read.qxmd.com/read/38224061/efficacy-of-adjuvant-first-generation-tkis-versus-chemotherapy-in-patients-with-completely-resected-egfr-mutant-non-small-cell-lung-cancer-a-meta-analysis
#16
REVIEW
Bin Shen, Dongping Wu, Jianjiang Liu, Yang Yang
BACKGROUND: The use of adjuvant first-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKIs) in patients with resected EGFR-mutant non-small cell lung cancer (NSCLC) remains controversial. Therefore, we performed a systematic review with meta-analysis to investigate the overall survival (OS) in patients with resected NSCLC. METHODS: Relevant studies were identified from the PubMed and EMBASE databases, and pooled hazard risks were obtained by random-effects models...
January 2024: Cancer Investigation
https://read.qxmd.com/read/38149612/impact-of-the-multidisciplinary-cancer-team-on-the-diagnostic-and-therapeutic-care-pathway-of-early-breast-cancer-patients-and-perception-of-team-members-the-experience-of-a-cancer-centre-in-italy
#17
JOURNAL ARTICLE
Aml Capobianco, G Gallucci, L Lapadula, G Dinardo, G La Torre, N Sisti, L G Sisti
Literature on the role of multidisciplinary team (MDT) in cancer is still controversial. We aimed to investigate MDT impact on a panel of indicators in breast cancer care in a single-center retrospective study performed in a Cancer Reference Center in Italy. We analysed the diagnostic and therapeutic care pathway (DTCP) of 266 early breast cancer patients managed by our MDT during 2019-2020.Process indicators reflecting the change of the diagnostic and therapeutic care pathways occurred after the MDT discussion were computed...
December 27, 2023: Cancer Investigation
https://read.qxmd.com/read/38055319/single-nucleotide-polymorphisms-associated-with-prostate-cancer-progression-a-systematic-review
#18
JOURNAL ARTICLE
Daniel Felipe Mendivelso González, Santiago Andrés Sánchez Villalobos, Andrea Estefanía Ramos, Wendy Johana Montero Ovalle, Martha Lucía Serrano López
BACKGROUND: New biomarkers of progression in patients with prostate cancer (PCa) are needed to improve their classification and clinical management. This systematic review investigated the relationship between single nucleotide polymorphisms (SNPs) and PCa progression. METHODS: A keyword search was performed in Pubmed, EMBASE, Scopus, Web of Science, and Cochrane for publications between 2007 and 2022. We included articles with adjusted and significant associations, a median follow-up greater than or equal to 24 months, patients taken to radical prostatectomy (RP) as a first therapeutic option, and results presented based on biochemical recurrence (BCR)...
December 6, 2023: Cancer Investigation
https://read.qxmd.com/read/37962276/assessment-of-swallowing-function-in-patients-with-head-and-neck-squamous-cell-carcinoma-in-high-vs-low-dose-cisplatin
#19
JOURNAL ARTICLE
Amber Veldman, Annika van Oosbree, Madisyn Braun, Aarabhi Gurumoorthy, William C Spanos, Steven Powell
Cisplatin-based therapies are standard-of-care for advanced-stage head and neck squamous cell carcinoma (HNSCC). Treatment regimens include 3 weeks of high-dose bolus cisplatin or 6-7 weeks of low-dose weekly cisplatin, both with concurrent radiation. The effects of cisplatin dosage on swallowing function warrant further study. A 237-patient cohort treated for HNSCC at a single center were studied retrospectively. Gastrostomy tube dependence served as the primary endpoint. Secondary endpoints included weight changes, esophageal stricture, and lymphedema...
December 2023: Cancer Investigation
https://read.qxmd.com/read/37997757/genomic-alterations-of-signaling-and-dna-damage-repair-pathways-in-non-muscle-invasive-bladder-cancer
#20
JOURNAL ARTICLE
Serdar Celik, Tekincan Aktas, Ozde Gokbayrak, Aylin Erol, Kutsal Yorukoglu, Batuhan Yilmaz, Hilmi Sari, Zekiye Altun, Mehmet Ugur Mungan, Ilhan Celebi, Guven Aslan, Safiye Aktas
The aim of the study was to demonstrate the most common genetic alterations and evaluate possible targets involving PIK3/AKT/mTOR signaling and DNA damage repair (DDR) pathways for personalized treatment in patients with NMIBC. Alterations of these pathways were observed in 89.5% and 100% of patients, respectively. Among them, BARD1 was more frequently altered in low/intermediate-risk cases, but PARP4 was more frequently affected in intermediate/high-risk patients. The possible target feasibility of BARD1 and PARP4 alterations should be evaluated for personalized treatment using PARP-inhibitors in NMIBC...
November 24, 2023: Cancer Investigation
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