journal
https://read.qxmd.com/read/38230618/blood-pressure-and-variability-responses-to-the-down-titration-of-antihypertensive-drugs
#21
JOURNAL ARTICLE
Byung Sik Kim, Yonggu Lee, Jeong-Hun Shin, Ran Heo, Hyun-Jin Kim, Jinho Shin
OBJECTIVES: Several recent guidelines have proposed the gradual reduction of antihypertensive drugs for patients with well controlled blood pressure (BP). However, no studies have examined alterations in BP variability (BPV) during the down-titration of antihypertensives. This study aims to investigate changes in home BPV during the down-titration of antihypertensives. METHODS: We analyzed 83 hypertensive patients who underwent down-titration of antihypertensives and had available home BP data during the down-titration...
January 17, 2024: Journal of Hypertension
https://read.qxmd.com/read/38230616/dietary-patterns-associated-with-hypertension-among-stroke-free-indigenous-africans-insights-from-the-stroke-investigative-research-and-educational-network-study
#22
JOURNAL ARTICLE
Akinkunmi Paul Okekunle, Osahon Jeffery Asowata, Onoja Matthew Akpa, Adekunle Gregory Fakunle, Ifeoluwa Bodunde, Morenikeji Komolafe, Oyedunni Arulogun, Fred Stephen Sarfo, Reginald Obiako, Godwin Osaigbovo, Godwin Ogbole, Abiodun Bello, Sunday Adeniyi, Benedict Calys-Tagoe, Lambert Appiah, Carolyn Jenkins, Olalekan Oyinloye, Hamisu Dambatta, Olayemi Balogun, Arti Singh, Abimbola Olalere, Yaw Mensah, Okechukwu S Ogah, Philip Ibinaiye, Oladimeji Adebayo, Olayinka Adebajo, Philip Adebayo, Ijezie Chukwuonye, Rufus Akinyemi, Bruce Ovbiagele, Mayowa Owolabi
BACKGROUND: The dietary factors associated with the high burden of hypertension among indigenous Africans remain poorly understood. We assessed the relationship between dietary patterns and hypertension among indigenous Africans. METHOD: In this study, 1550 participants with hypertension matched (for age: ± 5 years, sex and ethnicity) with 1550 participants without hypertension were identified from the stroke-free population in the Stroke Investigative Research and Educational Network study in Ghana and Nigeria...
January 17, 2024: Journal of Hypertension
https://read.qxmd.com/read/38230624/associations-between-lipid-lowering-drugs-and-pregnancy-and-perinatal-outcomes-a-mendelian-randomization-study
#23
JOURNAL ARTICLE
Runfang Wang, Jing Zhao, Li Li, Yan Huo
INTRODUCTION: Mounting evidence has indicated that maternal dyslipidemia is associated with adverse obstetric outcomes, and the actions of lipid-lowering drugs in pregnant women remain controversial. Hence, this study aimed to appraise the causal relationship of lipid-lowering drugs [hydroxymethylglutaryl-coenzyme reductase (HMGCR) inhibitors, PCSK9 inhibitors, and NPC1L1 inhibitors] with pregnancy and perinatal outcomes using drug-targeting Mendelian randomization analysis. METHODS: As a proxy for lipid-lowering drug exposure, two genetic instruments were used: genetic variants within or near the gene linked to low-density lipoprotein cholesterol (LDL-C) and the expression of quantitative trait loci of the drug target gene...
January 16, 2024: Journal of Hypertension
https://read.qxmd.com/read/38230619/blood-pressure-lowering-for-kidney-transplant-recipients-systematic-review-with-network-meta-analysis
#24
JOURNAL ARTICLE
Patrizia Natale, Suetonia C Palmer, Allison Jaure, Valeria Saglimbene, Andrea Iannone, Amanda Sluiter, Jonathan Craig, Giovanni F M Strippoli
OBJECTIVE: Hypertension affects 50-90% of kidney transplant recipients and is associated with cardiovascular disease and graft loss. We aimed to evaluate the comparative benefits and harms of blood pressure lowering agents in people with a functioning kidney transplant. METHODS: We conducted a systematic review with network meta-analysis of randomized controlled trials (RCTs). We searched MEDLINE, Embase, and CENTRAL through to October 2023. RCTs evaluating blood pressure lowering agents administered for at least 2 weeks in people with a functioning kidney transplant with and without preexisting hypertension were eligible...
January 16, 2024: Journal of Hypertension
https://read.qxmd.com/read/38230615/comparison-of-cuff-inflation-and-cuff-deflation-brachial-sphygmomanometry-with-intra-arterial-blood-pressure-as-reference
#25
JOURNAL ARTICLE
Branko G Celler, Andy Yong, Imants Rubenis, Mark Butlin, Ahmadreza Argha, Rajan Rehan, Alberto Avolio
Conventional sphygmomanometry with cuff deflation is used to calibrate all noninvasive BP (NIBP) instruments and the International Standard makes no mention of calibrating methods specifically for NIBP instruments, which estimate systolic and diastolic pressure during cuff inflation rather than cuff deflation. There is however increasing interest in inflation-based NIBP (iNIBP) instruments on the basis of shorter measurement time, reduction in maximal inflation pressure and improvement in patient comfort and outcomes...
January 16, 2024: Journal of Hypertension
https://read.qxmd.com/read/38230614/prediction-of-preeclampsia-from-retinal-fundus-images-via-deep-learning-in-singleton-pregnancies-a-prospective-cohort-study
#26
JOURNAL ARTICLE
Tianfan Zhou, Shengyi Gu, Feixue Shao, Ping Li, Yuelin Wu, Jianhao Xiong, Bin Wang, Chenchen Zhou, Peng Gao, Xiaolin Hua
INTRODUCTION: Early prediction of preeclampsia (PE) is of universal importance in controlling the disease process. Our study aimed to assess the feasibility of using retinal fundus images to predict PE via deep learning in singleton pregnancies. METHODS: This prospective cohort study was conducted at Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine. Eligible participants included singleton pregnancies who presented for prenatal visits before 14 weeks of gestation from September 1, 2020, to February 1, 2022...
January 16, 2024: Journal of Hypertension
https://read.qxmd.com/read/38230603/inverse-association-between-obesity-and-aortic-pressure-augmentation-is-attenuated-in-women-the-wakuya-study
#27
JOURNAL ARTICLE
Kaname Tagawa, Yusuke Tsuru, Katsumi Yokoi, Takanori Aonuma, Junichiro Hashimoto
OBJECTIVE: Pressure wave reflection predicts cardiovascular events in the general population. Obesity is negatively associated with pressure wave reflection. Muscular arterial diameter (responsible for pressure wave reflection) increases with obesity, and obesity-dependent dilation of muscular arteries is attenuated in women compared with men. We investigated the sex differences in the cross-sectional relationship between obesity and pressure wave reflection in a general population cohort...
January 16, 2024: Journal of Hypertension
https://read.qxmd.com/read/38230612/high-dietary-salt-intake-attenuates-nitric-oxide-mediated-endothelium-dependent-vasodilation-and-increases-oxidative-stress-in-pregnancy
#28
JOURNAL ARTICLE
Martina Vulin, Andrijana Muller, Ines Drenjančević, Petar Šušnjara, Zrinka Mihaljević, Ana Stupin
OBJECTIVE: This study aimed to investigate the impact of dietary salt intake during normal pregnancy on maternal microvascular and macrovascular endothelium-dependent reactivity and oxidative stress level. MATERIALS AND METHODS: In this cross-sectional study, based on their 24-h urinary sodium excretion, pregnant women (37-40 weeks of gestation) were divided into three groups: normal salt (<5.75 g/day, N = 12), high salt (5.75-10.25 g/day, N = 36), and very high salt (VHS;>10...
January 15, 2024: Journal of Hypertension
https://read.qxmd.com/read/38230602/salt-sensitivity-risk-derived-from-nocturnal-dipping-and-24-h-heart-rate-predicts-long-term-blood-pressure-reduction-following-renal-denervation
#29
JOURNAL ARTICLE
Gianni Sesa-Ashton, Revathy Carnagarin, Janis M Nolde, Ida Muente, Rebecca Lee, Vaughan G Macefield, Tye Dawood, Yusuke Sata, Elisabeth A Lambert, Gavin W Lambert, Antony Walton, Marcio G Kiuchi, Murray D Esler, Markus P Schlaich
BACKGROUND: Renal denervation (RDN) has been consistently shown in recent sham-controlled clinical trials to reduce blood pressure (BP). Salt sensitivity is a critical factor in hypertension pathogenesis, but cumbersome to assess by gold-standard methodology. Twenty-four-hour average heart rate (HR) and mean arterial pressure (MAP) dipping, taken by ambulatory blood pressure monitoring (ABPM), stratifies patients into high, moderate, and low salt sensitivity index (SSI) risk categories...
January 11, 2024: Journal of Hypertension
https://read.qxmd.com/read/38230626/accurate-detection-of-korotkoff-sounds-reveals-large-discrepancy-between-intra-arterial-systolic-pressure-and-simultaneous-noninvasive-measurement-of-blood-pressure-with-brachial-cuff-sphygmomanometry
#30
JOURNAL ARTICLE
Branko G Celler, Andy Yong, Imants Rubenis, Mark Butlin, Ahmadreza Argha, Rajan Rehan, Alberto Avolio
Cardiovascular disease is the number 1 cause of death globally, with elevated blood pressure (BP) being the single largest risk factor. Hence, BP is an important physiological parameter used as an indicator of cardiovascular health. Noninvasive cuff-based automated monitoring is now the dominant method for BP measurement and irrespective of whether the oscillometric or the auscultatory method is used, all are calibrated according to the Universal Standard (ISO 81060-2:2019), which requires two trained operators to listen to Korotkoff K1 sounds for SBP and K4/K5 sounds for DBP...
January 9, 2024: Journal of Hypertension
https://read.qxmd.com/read/38230613/association-between-anxiety-and-elevated-blood-pressure-in-adolescent-patients-a-single-center-cross-sectional-study
#31
JOURNAL ARTICLE
Yaritzy Astudillo, Sara Kibrom, Tanya Pereira, Sonia Solomon, Sankaran Krishnan, Dmitry Samsonov
OBJECTIVE: Although anxiety is known to be associated with elevated blood pressure and hypertension in adults, this has not been studied in children. The aim of this study was to determine the association between anxiety and elevated blood pressures in adolescents. METHODS: Adolescents, aged 12-18 years old, referred to the nephrology clinic were eligible to participate. Elevated blood pressure was defined as either SBP or DBP measurement above the 95th percentile for age, height, and sex...
January 9, 2024: Journal of Hypertension
https://read.qxmd.com/read/38230609/renalase-mediates-macrophage-to-fibroblast-crosstalk-to-attenuate-pressure-overload-induced-pathological-myocardial-fibrosis
#32
JOURNAL ARTICLE
Ru Fu, Nana You, Ruixuan Li, Xiexiong Zhao, Yihui Li, Xiaogang Li, Weihong Jiang
A potential antifibrotic mechanism in pathological myocardial remodeling is the recruitment of beneficial functional subpopulations of macrophages or the transformation of their phenotype. Macrophages are required to activate molecular cascades that regulate fibroblast behavior. Identifying mediators that activate the antifibrotic macrophage phenotype is tantamount to identifying the button that retards pathological remodeling of the myocardium; however, relevant studies are inadequate. Circulating renalase (RNLS) is mainly of renal origin, and cardiac myocytes also secrete it autonomously...
January 4, 2024: Journal of Hypertension
https://read.qxmd.com/read/38230605/effect-of-12-week-high-intensity-interval-training-on-hemodynamic-variables-at-rest-and-during-exercise-in-patients-with-obstructive-sleep-apnoea
#33
JOURNAL ARTICLE
Ozeas Lins-Filho, Antonio H Germano-Soares, José Lucas Porto Aguiar, José Ricardo Vieira de Almedia, Elton Carlos Felinto, Maria Julia Lyra, Danielle Batista Leite, Luciano Ferreira Drager, Breno Quintella Farah, Rodrigo Pinto Pedrosa
This study aimed to investigate the impact of 12 weeks of high-intensity interval training (HIIT) on hemodynamic variables at rest and during exercise in patients with obstructive sleep apnoea. Twenty-six obese adults with moderate-to-severe OSA (AHI = 42 ± 22.9 e/h) were randomly assigned to HIIT or a control group. Sleep parameters, ambulatorial, aortic, and during-exercise SBP and DBP were assessed at baseline and after 12 weeks. Generalized estimated equations assessed differences between groups over time...
January 4, 2024: Journal of Hypertension
https://read.qxmd.com/read/38164966/comparing-the-severity-of-second-preeclampsia-with-first-preeclampsia-a-multicenter-retrospective-longitudinal-cohort-study
#34
JOURNAL ARTICLE
Lizi Zhang, Shilei Bi, Jingjin Gong, Xinghe Wang, Jingying Liang, Shifeng Gu, Minglian Su, Weiwei Wang, Manna Sun, Jingsi Chen, Weitan Zheng, Junwei Wu, Zhijian Wang, Jianmeng Liu, Hong-Tian Li, Dunjin Chen, Lili Du
OBJECTIVE: Compare the clinical severity of second preeclampsia with the first preeclampsia. METHODS: This retrospective longitudinal cohort study was conducted in three teaching hospitals in Guangzhou, where there were a total of 296 405 deliveries between 2010 and 2021. Two consecutive singleton deliveries complicated with preeclampsia were included. Clinical features, laboratory results within 1 week before delivery, and maternal and neonatal outcomes of both deliveries were collected...
January 3, 2024: Journal of Hypertension
https://read.qxmd.com/read/38164947/prognostic-value-of-home-versus-ambulatory-blood-pressure-monitoring-a-systematic-review-and-meta-analysis-of-outcome-studies
#35
JOURNAL ARTICLE
Anastasios Kollias, Konstantinos G Kyriakoulis, Aikaterini Komnianou, Panagiota Stathopoulou, George S Stergiou
OBJECTIVES: Ambulatory (ABP) and self-home blood pressure (HBP) measurements are known to be superior to office blood pressure (OBP) measurements in predicting cardiovascular events. Whether ABP has superior prognostic ability than HBP, or the reverse, has not been adequately investigated. METHODS: A systematic literature search was conducted to identify outcome studies investigating HBP and ABP in the same population. A meta-analysis was conducted to calculate the pooled measure of risk regarding the primary endpoint of each study for each method...
January 3, 2024: Journal of Hypertension
https://read.qxmd.com/read/38441188/exaggerated-blood-pressure-response-to-standing-a-still-underinvestigated-issue
#36
JOURNAL ARTICLE
Paolo Palatini
No abstract text is available yet for this article.
April 1, 2024: Journal of Hypertension
https://read.qxmd.com/read/38441187/angiotensin-converting-enzyme-inhibitors-statins-and-the-polypill-in-cardiovascular-diseases-prevention-ignorance-is-bliss-or-not
#37
JOURNAL ARTICLE
Francesco Natale, Paolo Golino, Giovanni Cimmino
The polypill strategy, which combines several medicines that simultaneously control different risk factors/diseases in a single pill, is one of the approaches used in cardiovascular therapy. In different guidelines, this one-pill combination therapy is suggested as first-line step in disease management. Because the cardiovascular diseases (CVD) pandemia, prevention is essential. The approaches that could improve adherence are of great importance to achieve health, social and economical benefits. However, direct or indirect experience of adverse drug reaction is often the reason for discontinuation, with serious fatal and non-fatal consequences especially for a polypill...
April 1, 2024: Journal of Hypertension
https://read.qxmd.com/read/38441186/short-duration-dynamic-power-training-with-elastic-bands-combined-with-endurance-training-a-promising-approach-to-hypertension-management-in-older-adults
#38
RANDOMIZED CONTROLLED TRIAL
Bruno Bavaresco Gambassi, Luiz Filipe Costa Chaves, Thiago Matheus da Silva Sousa, Maria Jacqueline Silva Ribeiro, Thiago Antonio Souza, Paulo Adriano Schwingel
Previous studies have investigated the effects of different combined training programs involving traditional resistance training and aerobic exercise on hemodynamic parameters and arterial stiffness in older adults. However, little is known about the impact of power training combined with endurance training on these variables in hypertensive older adults. Therefore, this study aimed to investigate the effects of dynamic power training with elastic bands combined with endurance training on arterial stiffness and hemodynamic parameters in hypertensive older adults...
April 1, 2024: Journal of Hypertension
https://read.qxmd.com/read/38441185/concurrent-exercise-training-potentiates-the-effects-of-angiotensin-converting-enzyme-inhibitor-on-regulatory-systems-of-blood-pressure-control-in-ovariectomized-hypertensive-rats
#39
JOURNAL ARTICLE
Maycon Junior Ferreira, Danielle da Silva Dias, Gabriel do Carmo Silva, Amanda Aparecida de Araujo, Marina Rascio Henriques Dutra, Nathalia Bernardes, Maria-Cláudia Irigoyen, Kátia De Angelis
OBJECTIVE: Enalapril has shown satisfactory potential in controlling increased and sustained blood pressure (BP). However, multiple dysregulated mechanisms that interact with each other and are involved in the pathophysiology of arterial hypertension may not be affected, contributing to the remaining cardiovascular risk. Using an exercise training protocol, we investigated whether adding both approaches to arterial hypertension management could promote higher modulation of regulatory mechanisms of BP in postmenopausal rats...
April 1, 2024: Journal of Hypertension
https://read.qxmd.com/read/38441184/differences-in-the-impact-of-newly-diagnosed-type-2-diabetes-on-cardiovascular-mortality-between-normotensive-and-hypertensive-individuals
#40
JOURNAL ARTICLE
Nobuo Sasaki, Ryo Maeda, Ryoji Ozono, Kenichi Yoshimura, Yukiko Nakano, Yukihito Higashi
OBJECTIVE: We investigated the interrelationship between hyperglycemia and hypertension on cardiovascular mortality in the middle-aged and elderly people. METHODS: In this retrospective cohort study that used data from the Hiroshima Study on Glucose Metabolism and Cardiovascular Diseases, we included 16,564 participants without cardiovascular disease (mean age: 65.8 years; 6179 normoglycemic people, 3017 people with newly diagnosed type 2 diabetes, and 7368 people with prediabetes per the 75-g oral glucose tolerance test)...
April 1, 2024: Journal of Hypertension
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