Zhi-Qin Xu, Xiu-Zhen Li, Rong Zhu, Rui Ge, Hui Wei, Hong-Wei Shi, Zhe Wang, Cuan Yang, Ya-Wen Yang, Xue-Juan Lu, Ai-Dong Chen, Guo-Qing Zhu, Xiao Tan
OBJECTIVE: Proliferation and migration of vascular smooth muscle cells (VSMCs) contribute to vascular remodeling. Asprosin, a newly discovered protein hormone, is involved in metabolic diseases. Little is known about the roles of asprosin in cardiovascular diseases. This study focused on the role and mechanism of asprosin on VSMC proliferation and migration, and vascular remodeling in a rat model of hypertension. METHODS AND RESULTS: VSMCs were obtained from the aortic media of 8-week-old male Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR)...
April 23, 2024: Journal of Hypertension
Breno Q Farah, Claudia L M Forjaz, Jamie M O'Driscoll, Philip J Millar, Marcelo S Oliveira, Rafael Fecchio, Helcio Kanegusuku, Julio C S Sousa, Marilia A Correia, Raphael M Ritti-Dias
OBJECTIVE: Isometric handgrip training (IHT) has been shown to reduce blood pressure (BP) in hypertensive patients. However, factors that predict responsiveness to IHT are largely unknown. The aim of this study was to investigate the patient characteristics associated with the antihypertensive response to IHT using a recommended statistical approach for evaluating interindividual responses. METHODS: Data from four randomized controlled trials were joined, totaling 81 patients undergoing IHT (48...
April 23, 2024: Journal of Hypertension
Motohiko Adomi, Thomas F McElrath, Sonia Hernández-Díaz, Seanna M Vine, Krista F Huybrechts
BACKGROUND: Although the clinical importance of preeclampsia is widely recognized, few treatment options are available for prevention. TNF-α inhibitors have been hypothesized to potentially prevent the disease. We aimed to examine whether exposure to TNF-α inhibitors during pregnancy reduces the risk of preeclampsia. METHODS: We conducted a population-based pregnancy cohort study using nationwide samples of publicly (Medicaid data, 2000-2018) and commercially (MarketScan Research Database, 2003-2020) insured pregnant women linked to their liveborn infants...
April 22, 2024: Journal of Hypertension
Jinhang Che, Jin Tong, Xue Kuang, Caiyin Zheng, Na He, Zengzhang Liu
BACKGROUND: Asymptomatic hyperuricemia (HUA) and normouricemic gout are common in clinic but recommendations for them in hypertension management are absent. The present study aims to simultaneously evaluate the effect of HUA and gout on long-term mortality in hypertension. METHODS: Individuals from 2007-2018 National Health and Nutrition Examination Survey were enrolled. Hazard ratios and 95% confidence intervals (CIs) were calculated with the aid of the Cox proportional-hazards model...
April 16, 2024: Journal of Hypertension
Alun D Hughes, George Davey Smith, Laura D Howe, Deborah Lawlor, Siana Jones, Chloe M Park, Nish Chaturvedi
OBJECTIVES: Blood pressure (BP) is the leading global cause of mortality, and its prevalence is increasing in children and adolescents. Aortic BP is lower than brachial BP in adults. We aimed to assess the extent of this difference and its impact on the diagnosis of hypertension among adolescents. METHODS: We used data from 3850 participants from a UK cohort of births in the early 1990s in the Southwest of England, who attended their ∼17-year follow-up and had valid measures of brachial and aortic BP at that clinic [mean (SD) age 17...
April 16, 2024: Journal of Hypertension
Eduard Shantsila, D Gareth Beevers, Gregory Y H Lip
Originally, the beta-blockers were equally ranked alongside the other antihypertensive drug classes. Things changed when two major long-term randomized controlled trials, ASCOT-BPLA and LIFE showed that the patients receiving the beta-blockers based regimes suffered 25-30% more strokes than those receiving a calcium channel blocker based regime or an angiotensin receptor blocker based regime. The inferiority of the beta-blockers at stroke prevention was not due to differences in blood pressure control during the follow-up period in both trials...
April 15, 2024: Journal of Hypertension
Andrew S P Sharp, Alice Sanderson, Neil Hansell, Katie Reddish, Paul Miller, Joe Moss, Roland E Schmieder, Rachael McCool
This systematic review and meta-analysis was conducted to assess the randomized controlled trial (RCT) evidence available for renal denervation (RDN) in uncontrolled arterial hypertension. Twenty-five RCTs met the eligibility criteria for the systematic review, and 16 RCTs were included in the meta-analysis. The results of the random effects meta-analysis estimated a mean difference of -8.5 mmHg [95% confidence interval (CI) -13.5 to -3.6] for office SBP, -3.6 mmHg (95% CI -5.2 to -2.0) for 24 h SBP and -3...
April 15, 2024: Journal of Hypertension
Costas Thomopoulos, Jana Brguljan Hitij, Tine De Backer, Eugenia Gkaliagkousi, Reinhold Kreutz, Marilucy Lopez-Sublet, Maria Marketou, Anastasia S Mihailidou, Agnieszka Olszanecka, Antoinette Pechère-Bertschi, Mariana Paula Pérez, Alexandre Persu, Federica Piani, Thenral Socrates, Katarzyna Stolarz-Skrzypek, Renata Cífková
Hypertensive disorders in pregnancy (HDP), remain the leading cause of adverse maternal, fetal, and neonatal outcomes. Epidemiological factors, comorbidities, assisted reproduction techniques, placental disorders, and genetic predisposition determine the burden of the disease. The pathophysiological substrate and the clinical presentation of HDP are multifarious. The latter and the lack of well designed clinical trials in the field explain the absence of consensus on disease management among relevant international societies...
April 12, 2024: Journal of Hypertension
Alice Palermiti, Marco Pappaccogli, Franco Rabbia, Antonio D'Avolio, Franco Veglio
Drug allergy and intolerance are increasingly recognized as significant public health concerns, leading to adverse reactions in patients undergoing pharmacological treatments. Multiple drug intolerance syndrome (MDIS), characterized by adverse reactions to at least three different drug classes without a clear immunological mechanism, poses a substantial challenge, particularly in hypertensive patients. Despite its link to suboptimal adherence and uncontrolled blood pressure, MDIS in the context of hypertension remains insufficiently explored...
April 12, 2024: Journal of Hypertension
Anat Sason, Miriam Adelson, Dahlia Leshno, Shaul Schreiber, Einat Peles
BACKGROUND: Patients in methadone maintenance treatment (MMT) may develop age-related medical problems, but hypertension (HTN) proportion and its occurrence during MMT have not been studied yet. We aimed to evaluate changes in blood pressure (BP) during MMT and characterize current HTN. METHODS: Of all 1098 ever admitted MMT patients, those with ≥2 BP follow-up measures were included (n = 516), of them all current patients (N = 245) tested for HTN (systolic BP ≥140 mmHg or diastolic BP ≥90 were detected twice (one week apart) were considered as affected with HTN...
April 11, 2024: Journal of Hypertension
Konstantinos G Kyriakoulis, Anastasios Kollias, Grzegorz Bilo, Davide Soranna, Chang-Yuan Liu, Martino F Pengo, Antonella Zambon, Wei Zhang, Antonios Destounis, Ji-Guang Wang, George S Stergiou, Gianfranco Parati
OBJECTIVES: Blood pressure (BP) variability (BPV) can be assessed using office (OBP), home (HBP), or ambulatory BP (ABP) measurements. This analysis investigated the association and agreement between OBP, HBP, and ABP measurements for BPV assessment at baseline and 10 weeks after initiating antihypertensive drug therapy. METHODS: Untreated hypertensive patients with elevated BPV were randomized to receive an angiotensin-converting enzyme inhibitor (ramipril) or a calcium channel blocker (nifedipine GITS) in a 10-week, open-label, blinded-end point study...
April 5, 2024: Journal of Hypertension
Thomas Keiser, Sarah Katz, Shannon M Robson, Jody L Greaney, Sean Healy, Susan K Malone, Vahid Farrahi, Freda Patterson
The purpose of this review is to synthesize results from studies examining the association between time-of-day for eating, exercise, and sleep with blood pressure (BP) in adults with elevated BP or hypertension. Six databases were searched for relevant publications from which 789 were identified. Ten studies met inclusion criteria. Four studies examined time-of-day for eating, five examined time-of-day for exercise, and one examined time-of-day for sleep and their associations with BP. Results suggested that later time-of-day for eating (n = 2/4) and later sleep mid-point (n = 1/1) were significantly related to higher BP in multivariable models, whereas morning (n = 3/5) and evening (n = 4/5) exercise were associated with significantly lower BP...
April 3, 2024: Journal of Hypertension
Emmanouil Mavrogeorgis, Margarita Kondyli, Harald Mischak, Antonia Vlahou, Justyna Siwy, Peter Rossing, Archie Campbell, Carina M C Mels, Christian Delles, Jan A Staessen, Agnieszka Latosinska, Alexandre Persu
OBJECTIVES: Hypertension is a common condition worldwide; however, its underlying mechanisms remain largely unknown. This study aimed to identify urinary peptides associated with hypertension to further explore the relevant molecular pathophysiology. METHODS: Peptidome data from 2876 individuals without end-organ damage were retrieved from the Human Urinary Proteome Database: general population (discovery) or type 2 diabetic (validation) cohorts. Participants were divided based on systolic blood pressure (SBP) and diastolic BP (DBP) into hypertensive (SBP ≥140 mmHg and/or DBP ≥90 mmHg) and normotensive (SBP <120 mmHg and DBP <80 mmHg, without antihypertensive treatment) groups...
March 29, 2024: Journal of Hypertension
Olga Berillo, Kevin Comeau, Antoine Caillon, Séverine Leclerc, Brandon G Shokoples, Ahmad U M Mahmoud, Gregor Andelfinger, Pierre Paradis, Ernesto L Schiffrin
OBJECTIVES: γδ T-lymphocytes play a role in angiotensin II (AngII)-induced hypertension, vascular injury and T-cell infiltration in perivascular adipose tissue (PVAT) in mice. Mesenteric arteries of hypertensive mice and subcutaneous arteries from obese humans present similar remodeling. We hypothesized that γδ T-cell subtypes in mesenteric vessels with PVAT (MV/PVAT) from hypertensive mice and subcutaneous adipose tissue (SAT) from obese humans, who are prone to develop hypertension, would be similar...
March 27, 2024: Journal of Hypertension
Peder Af Geijerstam, Karin Rådholm, Lena Jonasson, Tomas L Lindahl, Jan Engvall, Fredrik H Nyström, Joakim Alfredsson
BACKGROUND: Soluble P-selectin (sP-selectin) and high-sensitivity C-reactive protein (hsCRP) have previously been associated with hypertension, but the relation with out-of-office blood pressure (BP) and coronary artery calcification score is unknown. We aimed to examine the relationship between sP-selectin, hsCRP and home BP, as well as coronary artery calcification score and carotid artery plaques. METHODS: In the Swedish CArdioPulmonary bioImage Study (SCAPIS), 5057 randomly selected participants were evaluated with office and home BP using the semi-automatic Omron M10-IT device...
March 19, 2024: Journal of Hypertension
De-Wei An, Yu-Ling Yu, Azusa Hara, Dries S Martens, Wen-Yi Yang, Yi-Bang Cheng, Qi-Fang Huang, Kei Asayama, Katarzyna Stolarz-Skrzypek, Marek Rajzer, Peter Verhamme, Tim S Nawrot, Yan Li, Jan A Staessen
OBJECTIVES: We undertook time-stratified analyses of the National Health and Nutrition Examination Survey in the US to assess time trends (1999-2020) in the associations of blood lead (BL) with blood pressure, mortality, the BL-associated population attributable fraction (PAF). METHODS: Vital status of participants, 20-79 years old at enrolment, was ascertained via the National Death Index. Regressions, mediation analyses and PAF were multivariable adjusted and standardized to 2020 US Census data...
March 15, 2024: Journal of Hypertension
Jialing Lin, Juliana de Oliveira Costa, Sallie-Anne Pearson, Nicholas A Buckley, David Brieger, Aletta E Schutte, Andrea L Schaffer, Michael O Falster
BACKGROUND: Adherence to antihypertensives is key for blood pressure control. Most people with hypertension have several comorbidities and require multiple medicines, leading to complex care pathways. Strategies for coordinating medicine use can improve adherence, but cumulative benefits of multiple strategies are unknown. METHODS: Using dispensing claims for a 10% sample of eligible Australians, we identified adult users of antihypertensives during July 2018-June 2019 who experienced polypharmacy (≥5 unique medicines)...
March 14, 2024: Journal of Hypertension
Branko G Celler, Andy Yong, Imants Rubenis, Mark Butlin, Ahmadreza Argha, Rajan Rehan, Alberto Avolio
There is little quantitative clinical data available to support blood pressure measurement accuracy during cuff inflation. In this study of 35 male and 5 female lightly anaesthetized subjects aged 64.1 ± 9.6 years, we evaluate and compare the performance of both the oscillometric ratio and gradient methods during cuff deflation and cuff inflation with reference to intra-arterial measurements. We show that the oscillometric waveform envelopes (OWE), which are key to both methods, exhibit significant variability in both shape and smoothness leading to at least 15% error in the determination of mean pressure (MP)...
March 14, 2024: Journal of Hypertension
Yiqian Zhang, Qiufen Sun, Canqing Yu, Dianjianyi Sun, Yuanjie Pang, Pei Pei, Huaidong Du, Ling Yang, Yiping Chen, Xiaoming Yang, Xiaofang Chen, Junshi Chen, Zhengming Chen, Liming Li, Jun Lv
OBJECTIVE: How traditional cardiovascular disease (CVD) risk factors are related to long-term blood pressure change (BPC) or trajectories remain unclear. We aimed to examine the independent associations of these factors with 15-year BPC and trajectories in Chinese adults. METHODS: We included 15 985 participants who had attended three surveys, including 2004-2008 baseline survey, and 2013-2014 and 2020-2021 resurveys, over 15 years in the China Kadoorie Biobank (CKB)...
March 14, 2024: Journal of Hypertension
Zhiyan Wang, Wenjie Li, Chao Jiang, Jue Wang, Chang Hua, Yangyang Tang, Hao Zhang, Xinru Liu, Yufeng Wang, Mingyang Gao, Qiang Lv, Jianzeng Dong, Changsheng Ma, Xin Du
BACKGROUND: Blood pressure variability (BPV) is a risk factor for poor kidney function independent of blood pressure (BP) in chronic kidney disease (CKD). Little is known about the association between kidney function decline and BPV in hypertensive patients without CKD. METHODS: A post-hoc analysis of the Systolic Blood Pressure Intervention Trial (SPRINT) was performed. BPV was measured as standard deviation (SD) and average real variability (ARV). Cox proportional hazard models were employed to explore the relationship between BPV and incident CKD and albuminuria...
March 11, 2024: Journal of Hypertension
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