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JOURNAL ARTICLE
Qin-Yu Cai, Zhuo-Hang Li, Bei-Ning Deng, Xin Luo, Xia Lan, Ya Chen, Li-Fang Liang, Chen-Yang Liu, Tai-Hang Liu, Ying-Xiong Wang, Lan Wang
BACKGROUND AND AIMS: Intrahepatic cholestasis of pregnancy (ICP) is a special liver disease during pregnancy, characterized by abnormal bile acid metabolism. However, there is no consensus on how to group women with ICP based on the time of diagnosis worldwide. This study aimed to adopt a new grouping model of women with ICP, and the time from diagnosis to delivery was defined as the monitoring period. METHODS: This retrospective real-world data study was conducted across multiple centers and included 3172 women with ICP...
September 22, 2023: Journal of Hypertension
#2
JOURNAL ARTICLE
Artjom Schott, Alexander Kluttig, Rafael Mikolajczyk, Anne Großkopf, Karin Halina Greiser, Karl Werdan, Daniel Sedding, Sebastian Nuding
OBJECTIVES: The subendocardial viability ratio (SEVR) reflects the balance of myocardial oxygen supply and demand. Low SEVR indicates a reduced subendocardial perfusion and has been shown to predict mortality in patients with kidney disease and diabetes. The aim of this study is to investigate the association of SEVR and mortality in the elderly population. METHODS: We analysed data from the CARdiovascular disease, Living and Ageing in Halle (CARLA) study. SEVR was estimated noninvasively by radial artery tonometry and brachial blood pressure measurement...
September 21, 2023: Journal of Hypertension
#3
JOURNAL ARTICLE
Mubarak M A Osman, Edward Mullins, Hana Kleprlikova, Ian B Wilkinson, Christoph Lees
OBJECTIVE: Prepregnancy optimization of cardiovascular function may reduce the risk of pre-eclampsia. We aimed to assess the feasibility and effect of preconception cardiovascular monitoring, exercise, and beetroot juice on cardiovascular parameters in women planning to conceive. DESIGN AND METHOD: Prospective single-site, open-label, randomized controlled trial. Thirty-two women, aged 18-45 years, were allocated into one of four arms (1 : 1 : 1 : 1): exercise, beetroot juice, exercise plus beetroot juice and no intervention for 12 weeks...
September 20, 2023: Journal of Hypertension
#4
JOURNAL ARTICLE
Jacques R Snyman, Luiz Aparecido Bortolotto, Luca Degli Esposti, Pathiyil Balagopalan Jayagopal, Alexandra O Konradi, Valentina Perrone, Claudio Borghi
OBJECTIVES: This analysis compared adherence, cardiovascular (CV) events and all-cause mortality incidence, and healthcare costs among hypertensive patients treated with perindopril (PER)/indapamide (IND)/amlodipine (AML) in single-pill combination (SPC) vs. multiple-pill combination, in a real-world setting in Italy. METHODS: In this observational retrospective analysis of Italian administrative databases, adult patients treated with PER/IND/AML between 2010 and 2020 were divided into two cohorts: single-pill vs...
September 20, 2023: Journal of Hypertension
#5
JOURNAL ARTICLE
Robertson T Dutra, Isabela M Bensenor, Alessandra C Goulart, Alexandre C Pereira, Paulo A Lotufo, Itamar S Santos
BACKGROUND: High blood pressure (BP) increases carotid intima-media thickness (CIMT). On the other hand, it is not clear whether the vascular abnormalities reflected in high CIMT may predict incident hypertension. The present study aims to investigate the association between CIMT and incident hypertension after 4 years of follow-up in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), a multiethnic sample of middle-aged adults from six Brazilian cities. METHODS: We analyzed data from 6682 ELSA-Brasil participants (aged 35-74) without hypertension and with complete CIMT data at baseline...
September 19, 2023: Journal of Hypertension
#6
JOURNAL ARTICLE
Xi Yuan, Xiyao Liu, Fangyu Zhu, Biao Huang, Li Lin, Jiayu Huang, Li Wen, Mark D Kilby, Philip N Baker, Yong Fu, Weiwei Wu, Hongbo Qi, Jing Tang, Chao Tong
OBJECTIVE: Syncytiotrophoblasts form via mononuclear cytotrophoblast fusion during placentation and play a critical role in maternal-fetal communication. Impaired syncytialization inevitably leads to pregnancy-associated complications, including preeclampsia. Endoplasmic reticulum stress (ERS) is reportedly linked with preeclampsia, but little is known about its association with syncytialization. High temperature requirement factor A4 (HtrA4), a placental-specific protease, is responsible for protein quality control and placental syncytialization...
September 19, 2023: Journal of Hypertension
#7
JOURNAL ARTICLE
Hiroki Ohara, Fumihiko Takeuchi, Norihiro Kato, Toru Nabika
BACKGROUND: The stroke-prone spontaneously hypertensive rat (SHRSP) is a genetic model for cerebral stroke. Although a recent study on a congenic SHRSP suggested that a nonsense mutation in stromal interaction molecule 1 (Stim1) encoding a major component of store-operated Ca2+ entry was a causal variant for stroke in SHRSP, this was not conclusive because the congenic region including Stim1 in that rat was too wide. On the other hand, we demonstrated that the Wistar-Kyoto (WKY)-derived congenic fragment adjacent to Stim1 exacerbated stroke susceptibility in a congenic SHRSP called SPwch1...
September 15, 2023: Journal of Hypertension
#8
JOURNAL ARTICLE
Eduard Shantsila, Alena Shantsila, Nefyn Williams, Gregory Y H Lip, Paramjit S Gill
OBJECTIVES: Hypertension is the key modifiable cardiovascular risk factor but is underdiagnosed, and its scale in South Asian and African-Caribbean communities is unknown. Left ventricular hypertrophy (LVH) is a measure of target organ damage in uncontrolled hypertension. The study assesses LVH prevalence in South Asian and African-Caribbean communities and its impact on mortality. METHOD: This study is based on the large prospective UK community Ethnic-Echocardiographic Heart of England Screening Study (E-ECHOES, age ≥45 years)...
September 15, 2023: Journal of Hypertension
#9
JOURNAL ARTICLE
Elisa Gherbesi, Andrea Faggiano, Carla Sala, Stefano Carugo, Guido Grassi, Marijana Tadic, Cesare Cuspidi
AIM: Gender-based evidence on the association between serum uric acid (SUA) and left ventricular hypertrophy (LVH), as assessed by echocardiography, is still based on single studies. Thus, we performed a systematic meta-analysis of echocardiographic studies in order to provide an updated and comprehensive information on this issue. METHODS: The PubMed, OVID-MEDLINE, and Cochrane library databases were analyzed to search English-language articles published from the inception up to March 31, 2023...
September 15, 2023: Journal of Hypertension
#10
JOURNAL ARTICLE
Demosthenes Panagiotakos, Christina Antza, Vasileios Kotsis
OBJECTIVE: The aim of this work was to systematically review the level of evidence based on prospective cohort studies investigating the role of 24-h ambulatory blood pressure measurement (ABPM) and home blood pressure measurement (HBPM) on cardiovascular disease (CVD) risk prediction. METHODS: Eight studies were included in the meta-analysis. The Der Simonian and Laird's random-effects model with standard error adjustment using the Knapp-Hartung method was used...
September 14, 2023: Journal of Hypertension
#11
JOURNAL ARTICLE
Felix Götzinger, Mathias Hohl, Lucas Lauder, Dominic Millenaar, Michael Kunz, Markus R Meyer, Christian Ukena, Catharina M Lerche, Peter A Philipsen, Jörg Reichrath, Michael Böhm, Felix Mahfoud
BACKGROUND AND AIMS: Pharmocovigillance reports, associating hydrochlorothiazide (HCT) with skin cancer, resulted in a significant decrease of HCT prescriptions for hypertension and heart failure. Whether HCT exhibits phototoxic properties thereby causing skin cancer remains unknown. This study aimed to examine the photosensitizing, phototoxic and carcinogenic potential of HCT in a randomized, placebo-controlled, double-blinded trial in vivo and also in vitro. METHODS: The trial assigned 30 healthy, normotensive adult volunteers in a 2:1 ratio to either HCT 25 mg/day or placebo for 15 days...
September 14, 2023: Journal of Hypertension
#12
JOURNAL ARTICLE
Benjamin Gavish, Allan Gottschalk, Charles W Hogue, Jochen Steppan
OBJECTIVES: The lower limit of autoregulation (LLA) of cerebral blood flow was previously shown to vary directly with the Ambulatory Arterial Stiffness Index (AASI) redefined as 1-regression slope of DBP-versus-SBP readings invasively measured from the radial artery before the bypass. We aimed expanding the predictive capacity of the LLA with AASI by combining it with additional predictors and provide new indications whether mean arterial pressure (MAP) is above/below the LLA. DESIGN AND METHOD: In 181 patients undergoing cardiac surgery, mean (SD) age 71 (8) years), we identified from the demographic, preoperative and intraoperative characteristics independent and statistically significant 'single predictors' of the LLA (including AASI)...
September 14, 2023: Journal of Hypertension
#13
JOURNAL ARTICLE
Fadi J Charchar, Priscilla R Prestes, Charlotte Mills, Siew Mooi Ching, Dinesh Neupane, Francine Z Marques, James E Sharman, Liffert Vogt, Louise M Burrell, Lyudmila Korostovtseva, Manja Zec, Mansi Patil, Martin G Schultz, Matthew P Wallen, Nicolás F Renna, Sheikh Mohammed Shariful Islam, Swapnil Hiremath, Tshewang Gyeltshen, Yook-Chin Chia, Abhinav Gupta, Aletta E Schutte, Britt Klein, Claudio Borghi, Colette J Browning, Marta Czesnikiewicz-Guzik, Hae-Young Lee, Hiroshi Itoh, Katsuyuki Miura, Mattias Brunström, Norm R C Campbell, Olutope Arinola Akinnibossun, Praveen Veerabhadrappa, Richard D Wainford, Ruan Kruger, Shane A Thomas, Takahiro Komori, Udaya Ralapanawa, Véronique A Cornelissen, Vikas Kapil, Yan Li, Yuqing Zhang, Tazeen H Jafar, Nadia Khan, Bryan Williams, George Stergiou, Maciej Tomaszewski
Hypertension, defined as persistently elevated systolic blood pressure (SBP) >140 mmHg and/or diastolic blood pressure (DBP) at least 90 mmHg (International Society of Hypertension guidelines), affects over 1.5 billion people worldwide. Hypertension is associated with increased risk of cardiovascular disease (CVD) events (e.g. coronary heart disease, heart failure and stroke) and death. An international panel of experts convened by the International Society of Hypertension College of Experts compiled lifestyle management recommendations as first-line strategy to prevent and control hypertension in adulthood...
September 13, 2023: Journal of Hypertension
#14
JOURNAL ARTICLE
Giulia Rivasi, Ludovica Ceolin, Giada Turrin, Virginia Tortu', Maria Flora D'Andria, Giuseppe Dario Testa, Sara Montali, Francesco Tonarelli, Enrico Brunetti, Mario Bo, Roman Romero-Ortuno, Enrico Mossello, Andrea Ungar
OBJECTIVES: To date, few studies have investigated frailty in hypertensive individuals. This study aimed at identifying the prevalence of frailty in a sample of hypertensive older outpatients using six different identification tools. Clinical correlates of frailty and agreement between different frailty definitions were also investigated. METHODS: The HYPER-FRAIL pilot study recruited hypertensive patients aged at least 75 years from two geriatric outpatient clinics of Careggi Hospital, Florence, Italy...
September 13, 2023: Journal of Hypertension
#15
JOURNAL ARTICLE
Anja G Bos-Roubos, Ellen Wingbermühle, Mareike Giesen, Rogier Kersseboom, Laura C G De Graaff, Jos I M Egger
This case report aims to alert physicians to neuropsychological features and chromosomal variants that may underly resistant hypertension. We present a 35-year-old female patient with hypertensive crisis (BP 260/160 mmHg), initially treated with a combination of calcium antagonists, beta blockers, diuretics and angiotensin-converting enzyme (ACE)-inhibitors, though with little improvement. Cushing's syndrome, Conn's syndrome, and glucocorticoid receptor deficiency were ruled out. Multidisciplinary examination of medical history and (hetero)anamneses including psychosocial factors revealed mild dysmorphic body features, developmental delay, early diagnosis of autism spectrum disorder, a history of being bullied at school, little peer contact, learning disabilities, and special education...
September 13, 2023: Journal of Hypertension
#16
JOURNAL ARTICLE
Yumeng Shi, Wei Zhou
BACKGROUND AND AIMS: Research reports on the relationship between systemic immune-inflammation index (SII) and hypertension are limited. We aim to evaluate the possible relationship between SII and hypertension. METHODS AND RESULTS: We conducted a cross-sectional analysis of adults from the National Nutrition and Health Database from 2017 to 2020. In this study, 13 742 participants were included. The exposure variable in this study was the systemic inflammatory state as defined by SII and an outcome was hypertension...
September 13, 2023: Journal of Hypertension
#17
JOURNAL ARTICLE
Sawako Goto, Yutaka Yoshida, Michihiro Hosojima, Shoji Kuwahara, Hideyuki Kabasawa, Hiroyuki Aoki, Tomomichi Iida, Ryuhei Sawada, Daisuke Ugamura, Yuta Yoshizawa, Kazuya Takemoto, Koichi Komochi, Ryota Kobayashi, Ryohei Kaseda, Eishin Yaoita, Satoru Nagatoishi, Ichiei Narita, Kouhei Tsumoto, Akihiko Saito
BACKGROUND: Kidney angiotensin (Ang) II is produced mainly from liver-derived, glomerular-filtered angiotensinogen (AGT). Podocyte injury has been reported to increase the kidney Ang II content and induce Na+ retention depending on the function of megalin, a proximal tubular endocytosis receptor. However, how megalin regulates the renal content and action of Ang II remains elusive. METHODS: We used a mass spectrometry-based, parallel reaction-monitoring assay to quantitate Ang II in plasma, urine, and kidney homogenate of kidney-specific conditional megalin knockout (MegKO) and control (Ctl) mice...
September 8, 2023: Journal of Hypertension
#18
JOURNAL ARTICLE
Guoqing Ma, Junqi Li, Jiawen Xie, Yunfeng Li, Kun Xu, Yafang He, Jiaomei Yang, Huaidong Du, Xin Liu
BACKGROUND: Wide brachial pulse pressure (PP) has been associated with cardiovascular events, while its population distribution and association with body composition were poorly characterized in large populations. METHODS: We evaluated the age and sex distributions of PP and its associations with body composition using baseline data from the China Kadoorie Biobank. A total of 434 200 participants without diagnosed hypertension were included in the analysis...
September 7, 2023: Journal of Hypertension
#19
JOURNAL ARTICLE
Xiyan Zhang, Yonglin Zhou, Jie Yang, Yan Wang, Yao Xiang, Hongxia Ma, Wei Lu
OBJECTIVES: The primary objective of this study is to examine the secular trends in blood pressure levels from 2012 to 2022 in eastern China. Additionally, to compare two standards [International Blood Pressure Reference for Children and Adolescents (ICBP) and the National Blood Pressure Reference for Chinese Han Children and Adolescents (CCBP)], we calculate the 95th percentile of blood pressure levels for students in developed regions (ECCBP). Secondly, the study aims to investigate potential contributors to elevated blood pressure, including sex, age, behaviors, and mental health...
September 6, 2023: Journal of Hypertension
#20
JOURNAL ARTICLE
Li Feng, Zhenyao Ye, Chen Mo, Jingtao Wang, Song Liu, Si Gao, Hongjie Ke, Travis A Canida, Yezhi Pan, Marleen M J van Greevenbroek, Alfons J H M Houben, Kai Wang, Kathryn S Hatch, Yizhou Ma, David K Y Lei, Chixiang Chen, Braxton D Mitchell, L Elliot Hong, Peter Kochunov, Shuo Chen, Tianzhou Ma
BACKGROUND: Elevated blood pressure (BP) is a modifiable risk factor associated with cognitive impairment and cerebrovascular diseases. However, the causal effect of BP on white matter brain aging remains unclear. METHODS: In this study, we focused on N = 228 473 individuals of European ancestry who had genotype data and clinical BP measurements available (103 929 men and 124 544 women, mean age = 56.49, including 16 901 participants with neuroimaging data available) collected from UK Biobank (UKB)...
September 6, 2023: Journal of Hypertension
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