Paul R Mueller, Alexandra J Kershner, Brooke I Breitrick, Katharina N Keller, Rebecca L Radtke, Ruchita J Patel, Kylie Gierach, Jon Arvedson, Georgette E Moyle-Heyrman, Debra A Pearson
BACKGROUND: Ovarian cancer is one of the deadliest cancers in women. Improved preventative, diagnostic, and therapeutic strategies are needed. Certain dietary patterns and nutrients such as vitamin D and omega-3 fatty acids are associated with reduced cancer risk, but their effects on ovarian cancer remain to be fully elucidated, and their combined effects have not been explored. AIM: To determine the individual and combined effects of the active vitamin D metabolite, calcitriol, and the omega-3 fatty acid, docosahexaenoic acid, on cell growth, and the abundance of the vitamin D receptor (VDR), proteins that modulate cell cycle progression, and apoptotic markers...
September 20, 2023: Nutrition and Health