journal
https://read.qxmd.com/read/38874340/usnic-acid-alleviates-inflammatory-responses-and-induces-apoptotic-signaling-through-inhibiting-nf-%C3%A4-b-expressions-in-human-oral-carcinoma-cells
#1
JOURNAL ARTICLE
Theerthu Azhamuthu, Suresh Kathiresan, Ilanchitchenni Senkuttuvan, Nihal Ahamed Abulkalam Asath, Pugazhendhi Ravichandran, Rajeswari Vasu
Usnic acid (UA) is a unique bioactive substance in lichen with potential anticancer properties. Recently, we have reported that UA can reduce 7,12-dimethylbenz[a] anthracene-induced oral carcinogenesis by inhibiting oxidative stress, inflammation, and cell proliferation in a male golden Syrian hamster in vivo model. The present study aims to explore the relevant mechanism of cell death induced by UA on human oral carcinoma (KB) cell line in an in vitro model. We found that UA can induce apoptosis (cell death) in KB cells by decreasing cell viability, increasing the production of reactive oxygen species (ROS), depolarizing mitochondrial membrane potential (MMP) levels, causing nuclear fragmentation, altering apoptotic morphology, and causing excessive DNA damage...
June 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38874324/dopamine-receptor-agonist-cabergoline-promotes-immunogenic-phenotype-in-human-monocyte-derived-dendritic-cells
#2
JOURNAL ARTICLE
Bahar Naseri, Javad Masoumi, Samin Abdolzadeh, Saba Abedimanesh, Elham Baghbani, Amirhossein Hatami-Sadr, Javad Ahmadian Heris, Dariush Shanehbandi, Morteza Akbari, Somayeh Vaysi, Nazila Alizadeh, Behzad Baradaran
Dendritic cells (DCs) are known as antigen-presenting cells that are capable of regulating immune responses. DCs and T cells can interact mutually to induce antigen-specific T-cell responses. Cabergoline, which is a dopamine (DA) receptor agonist, seems to implement anti-inflammatory properties in the immune system, and therefore in the present study the impact of a DA receptor agonist cabergoline on the monocyte-derived DCs (moDCs) was assessed. Immature moDCs were treated with lipopolysaccharide to produce mature DCs (mDCs)...
June 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38863255/effects-of-metformin-on-cancers-in-experimental-and-clinical-studies-focusing-on-autophagy-and-ampk-mtor-signaling-pathways
#3
REVIEW
Mohammad Yasin Zamanian, Maryam Golmohammadi, Alexey Yumashev, Ahmed Hjazi, Mariam Alaa Toama, Mervat Ahmed AbdRabou, Anita Gehlot, Enas R Alwaily, Niyousha Shirsalimi, Pankaj Kumar Yadav, Gervason Moriasi
Metformin (MET) is a preferred drug for the treatment of type 2 diabetes mellitus. Recent studies show that apart from its blood glucose-lowering effects, it also inhibits the development of various tumours, by inducing autophagy. Various studies have confirmed the inhibitory effects of MET on cancer cell lines' propagation, migration, and invasion. The objective of the study was to comprehensively review the potential of MET as an anticancer agent, particularly focusing on its ability to induce autophagy and inhibit the development and progression of various tumors...
June 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38863227/ameliorative-potential-of-rosmarinic-acid-in-a-rat-model-of-polycystic-ovary-syndrome-targeting-mcp-1-and-vegf-a-histological-immunohistochemical-and-biochemical-study
#4
JOURNAL ARTICLE
Amany Mohamed Shalaby, Rania H Shalaby, Amira Mostafa Elshamy, Sulaiman Mohammed Alnasser, Mohammed Alorini, Fatima A Jaber, Mohamed Ali Alabiad, Ahmed Baker A Alshaikh, Shaimaa Mohamed Abdelfattah Hassan, Seham Ahmed Mohammed Abdel Aziz, Mohamed A Safa, Mahmoud Ramadan Elkholy
Polycystic ovary syndrome (PCOS) is a multidisciplinary endocrinopathy that affects women of reproductive age. It is characterized by menstrual complications, hyperandrogenism, insulin resistance, and cardiovascular issues. The current research investigated the efficacy of rosmarinic acid in letrozole-induced PCOS in adult female rats as well as the potential underlying molecular mechanisms. Forty female rats were divided into the control group, the rosmarinic acid group (50 mg/kg per orally, po) for 21 days, PCOS group; PCOS was induced by administration of letrozole (1 mg/kg po) for 21 days, and rosmarinic acid-PCOS group, received rosmarinic acid after PCOS induction...
June 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38856033/improvement-of-current-immunotherapies-with-engineered-oncolytic-viruses-that-target-cancer-stem-cells
#5
REVIEW
Alborz Soroush, Reza Shahhosseini, Nima Ghavamikia, Ahmed Hjazi, Shahrzad Roudaki, Mahdi KhalatbariLimaki, Mahtab Mirbolouk, SeyedAbbas Pakmehr, Parvin Karimi
The heterogeneity of the solid tumor microenvironment (TME) impairs the therapeutic efficacy of standard therapies and also reduces the infiltration of antitumor immune cells, all of which lead to tumor progression and invasion. In addition, self-renewing cancer stem cells (CSCs) support tumor dormancy, drug resistance, and recurrence, all of which might pose challenges to the eradication of malignant tumor masses with current therapies. Natural forms of oncolytic viruses (OVs) or engineered OVs are known for their potential to directly target and kill tumor cells or indirectly eradicate tumor cells by involving antitumor immune responses, including enhancement of infiltrating antitumor immune cells, induction of immunogenic cell death, and reprogramming of cold TME to an immune-sensitive hot state...
June 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38853469/ring-finger-protein-216-loss-of-function-induces-white-matter-hyperintensities-by-inhibiting-oligodendroglia-proliferation
#6
JOURNAL ARTICLE
Wenqing Xu, Keliang Chen, Yiwen Yuan, Min Guo, Qiang Dong, Mei Cui
White matter hyperintensities (WMHs) refer to a group of diseases with numerous etiologies while oligodendrocytes remain the centerpiece in the pathogenesis of WMHs. Ring Finger Protein 216 (RNF216) encodes a ubiquitin ligase, and its mutation begets WMHs, ataxia, and cognitive decline in patients. Yet no study has revealed the function of RNF216 in oligodendroglia and WHIs before. In this study, we summarized the phenotypes of RNF216-mutation cases and explored the normal distribution of RNF216 in distinct brain regions and neuronal cells by bioinformatic analysis...
June 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38850132/human-umbilical-cord-mesenchymal-stem-cells-alleviate-fatty-liver-ischemia-reperfusion-injury-by-activating-autophagy-through-upregulation-of-ifn%C3%AE
#7
JOURNAL ARTICLE
Chenhao Xu, Xixi Fang, Bei Lu, Yisu Song, Wenzhi Shu, Zhengyang Lu, Renyi Su, Ze Xiang, Xiao Xu, Xuyong Wei
Liver ischemia-reperfusion injury (IRI) is an important factor affecting the prognosis of liver transplantation, and extended criteria donors (e.g., steatosis donor livers) are considered to be more sensitive to ischemia-reperfusion injury in liver transplantation. Currently, the application of human umbilical cord mesenchymal stem cells (hMSCs) has great promise in the treatment of various injuries in the liver. This study aimed to investigate the therapeutic role and mechanism of hMSCs in fatty liver IRI...
June 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38845544/curcumin-loaded-nanoparticles-effectively-prevent-t-4-induced-oxidative-stress-in-rat-heart
#8
JOURNAL ARTICLE
Pallavi Mishra, Dipak Kumar Sahoo, Chandana Mohanty, Luna Samanta
In this study, we report the cardioprotective effect of the glycerol monooleate (GMO) based nanocurcumin in both in vitro and in vivo conditions under a hyperthyroid state. The heart is one of the primary target organs sensitive to the action of thyroid hormone, and slight variations in the thyroid hormone serum concentrations result in measurable changes in cardiac performance. Hyperthyroidism-induced hypermetabolism is associated with oxidative stress and is an important mechanism responsible for the progression of heart failure...
June 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38845083/peripheral-blood-mononuclear-cells-show-markers-of-mitochondrial-dysfunction-in-rheumatoid-arthritis
#9
JOURNAL ARTICLE
Anahita Abbasifard, Ghasem Solgi, Iraj Khodadadi, Amin Doosti-Irani, Heidar Tayebinia, Alireza Fazaeli
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease. Metabolic and mitochondrial dysregulation are critical causal factors in the pathogenesis and progression of RA. Mitochondrial dysfunction include abnormal energy metabolism, and excessive production of reactive oxygen species (ROS). This study aimed to investigate the adenosine triphosphate (ATP), mitochondrial membrane potential (ΔΨm), ROS, and mRNA expression level of ROMO1 (as ROS modulator) and OMA1 (as regulator mitochondrial dynamics) of peripheral blood mononuclear cells (PBMC) in RA patients...
June 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38822669/periostin-regulates-lysyl-oxidase-through-erk1-2-mapk-dependent-serum-response-factor-in-activated-cardiac-fibroblasts
#10
JOURNAL ARTICLE
Sruthi Radhakrishnan, Sachin J Shenoy, Indraja Devidasan, Binchu V Shaji, Sarayu Gopal, Sreekanth Sreekumaran, Abhilash Sp, Divya M Sivaraman, Neethu Mohan
Collagen crosslinking, mediated by lysyl oxidase, is an adaptive mechanism of the cardiac repair process initiated by cardiac fibroblasts postmyocardial injury. However, excessive crosslinking leads to cardiac wall stiffening, which impairs the contractile properties of the left ventricle and leads to heart failure. In this study, we investigated the role of periostin, a matricellular protein, in the regulation of lysyl oxidase in cardiac fibroblasts in response to angiotensin II and TGFβ1. Our results indicated that periostin silencing abolished the angiotensin II and TGFβ1-mediated upregulation of lysyl oxidase...
June 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38817105/oncostatin-m-suppresses-bone-morphogenetic-protein-4-induced-osteoprotegerin-synthesis-in-mc3t3-e1-osteoblast-like-cells-p70-s6-kinase-attenuation
#11
JOURNAL ARTICLE
Tomoyuki Hioki, Junko Tachi, Rie Matsushima-Nishiwaki, Hiroki Iida, Osamu Kozawa, Haruhiko Tokuda
Evidence is accumulating that osteal macrophages, in addition to bone-resorbing osteoclasts and bone-forming osteoblasts, participate vitally in bone remodeling process. Oncostatin M (OSM), an inflammatory cytokine belonging to interleukin-6 superfamily, is recognized as an essential factor secreted by osteal macrophages to orchestrate bone remodeling. Osteoprotegerin (OPG) produced by osteoblasts regulates osteoclastogenesis. We have reported that bone morphogenetic protein-4 (BMP-4) stimulates OPG synthesis in MC3T3-E1 osteoblast-like cells, and that SMAD1/5/8(9), p38 mitogen-activated protein kinase (MAPK), and p70 S6 kinase are involved in the OPG synthesis...
June 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38816947/the-therapeutic-potential-of-isosakuranetin-against-perfluorooctane-sulfonate-instigated-cardiac-toxicity-via-modulating-nrf-2-keap-1-pathway-inflammatory-apoptotic-and-histological-profile
#12
JOURNAL ARTICLE
Muhammad Umar Ijaz, Humna Shahid, Muhammad Faisal Hayat, Hammad Ahmad Khan, Khalid A Al-Ghanim, Mian Nadeem Riaz
Perfluorooctane sulfonate (PFOS) is a pervasive organic toxicant that damages body organs, including heart. Isosakuranetin (ISN) is a plant-based flavonoid that exhibits a broad range of pharmacological potentials. The current investigation was conducted to evaluate the potential role of ISN to counteract PFOS-induced cardiac damage in rats. Twenty-four albino rats (Rattus norvegicus) were distributed into four groups, including control, PFOS (10 mg/kg) intoxicated, PFOS + ISN (10 mg/kg + 20 mg/kg) treated, and ISN (20 mg/kg) alone supplemented group...
June 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38812287/curcumin-and-its-nano-formulations-combined-with-exercise-from-molecular-mechanisms-to-clinic
#13
REVIEW
Qian Liu, Chengyu Wang, Xinyan Guo, Qiankun Du, Maryam Keshavarzi
Curcumin is a strong substance derived from turmeric, a popular spice, renowned for its antioxidant and anti-inflammatory abilities. The study delved deeply into a thorough examination of various sources to evaluate the impact of both regular curcumin and nano-formulated curcumin on elements that impact physical performance, including muscular strain, discomfort, swelling, and oxidative tension. While engaging in exercise, the body experiences a rise in reactive oxygen species and inflammation. As a result, it is important to ensure a proper balance between internal and external sources of antioxidants to maintain stability in the skeletal muscle...
June 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38812104/biological-role-of-mitochondrial-tlr4-mediated-nf-%C3%AE%C2%BAb-signaling-pathway-in-central-nervous-system-injury
#14
REVIEW
Zhuochao Wu, Ying Song, Ying Wang, Hua Zhou, Lingling Chen, Yunyun Zhan, Ting Li, Guomin Xie, Hao Wu
Previous studies suggested that central nervous system injury is often accompanied by the activation of Toll-like receptor 4/NF-κB pathway, which leads to the upregulation of proapoptotic gene expression, causes mitochondrial oxidative stress, and further aggravates the inflammatory response to induce cell apoptosis. Subsequent studies have shown that NF-κB and IκBα can directly act on mitochondria. Therefore, elucidation of the specific mechanisms of NF-κB and IκBα in mitochondria may help to discover new therapeutic targets for central nervous system injury...
June 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38807490/synthesis-characterization-and-evaluation-of-the-anticancer-properties-of-ph-responsive-carvacrol-zinc-oxide-quantum-dots-on-breast-cancer-cell-line-mda-mb-231
#15
JOURNAL ARTICLE
Manoj Kumar Srinivasan, Briska Jifrina Premnath, Ramya Parimelazhagan, Nalini Namasivayam
Since most solid tumors have a low pH value, a pH-responsive drug delivery system may offer a broad method for tumor-targeting treatment. The present study is used to analyze the anticancer activity of carvacrol-zinc oxide quantum dots (CVC-ZnO QDs) against breast cancer cells (MDA-MB-231). CVC-ZnO QDs demonstrate pH responsive and are specifically released within the acidic pH tumor microenvironment. This property enables targeted drug delivery exclusively to cancer cells while minimizing the impact on normal cells...
June 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38807466/controlled-cell-proliferation-and-immortalization-of-human-dental-pulp-stem-cells-with-a-doxycycline-inducible-expression-system
#16
JOURNAL ARTICLE
Ai Orimoto, William N Addison, Shinichi Mochizuki, Wataru Ariyoshi, Kentaro Ono, Chiaki Kitamura, Tohru Kiyono, Tomokazu Fukuda
Human dental pulp stem cells are a potentially useful resource for cell-based therapies and tissue repair in dental and medical applications. However, the primary culture of isolated dental pulp stem cells has notably been limited. A major requirement of an ideal human dental pulp stem cell culture system is the preservation of efficient proliferation and innate stemness over prolonged passaging, while also ensuring ease of handling through standard, user-friendly culture methods. In this study, we have engineered a novel human dental pulp stem cell line, distinguished by the constitutive expression of telomerase reverse transcriptase (TERT), and the conditional expression of the R24C mutant cyclin-dependent kinase 4 (CDK4R24C ) and Cyclin D1...
June 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38807444/an-exploratory-study-on-the-effect-of-kynurenine-metabolites-on-send-2-endothelioma-cells
#17
JOURNAL ARTICLE
Danielle Sandra Nkandeu, Anna Margaretha Joubert, June Cheptoo Serem, Priyesh Bipath, Yvette Nkondo Hlophe
Cancer is the second leading cause of mortality worldwide. The development of anticancer therapy plays a crucial role in mitigating tumour progression and metastasis. Epithelioid hemangioendothelioma is a very rare cancer, however, with a high systemic involvement. Kynurenine metabolites which include l-kynurenine, 3-hydroxykynurenine, 3-hydroxyanthranilic acid and quinolinic acid have been shown to inhibit T-cell proliferation resulting in a decrease in cell growth of natural killer cells and T cells...
June 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38783647/4-meta-mma-tbb-resin-containing-nano-hydroxyapatite-induces-the-healing-of-periodontal-tissue-repair-in-perforations-at-the-pulp-chamber-floor
#18
JOURNAL ARTICLE
Hideki Sugii, Shinichiro Yoshida, Mhd Safwan Albougha, Sayuri Hamano, Daigaku Hasegawa, Tomohiro Itoyama, Junko Obata, Hiroshi Kaneko, Fumiko Minowa, Atsushi Tomokiyo, Hidefumi Maeda
We aimed to evaluate the materials based on 4-methacryloxyethyl trimellitate anhydride/methyl methacrylate tri-n-butylborane (Super-bond [SB]) and nano hydroxyapatite (naHAp) for the repair of perforation at pulp chamber floor (PPF) in vitro and in vivo models. SB and naHAp were mixed in the mass ratio of 10% or 30% to produce naHAp/SB. Human periodontal ligament stem cells (HPDLSCs) were cultured on resin discs of SB or naHAp/SB to analyze the effects of naHAp/SB on cell adhesion, proliferation, and cementoblastic differentiation...
June 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38783623/hybrid-machine-learning-based-breast-cancer-segmentation-framework-using-ultrasound-images-with-optimal-weighted-features
#19
JOURNAL ARTICLE
Sudharsana Vijayan, Radhika Panneerselvam, Thundi Valappil Roshini
One of the most dangerous conditions in clinical practice is breast cancer because it affects the entire life of women in recent days. Nevertheless, the existing techniques for diagnosing breast cancer are complicated, expensive, and inaccurate. Many trans-disciplinary and computerized systems are recently created to prevent human errors in both quantification and diagnosis. Ultrasonography is a crucial imaging technique for cancer detection. Therefore, it is essential to develop a system that enables the healthcare sector to rapidly and effectively detect breast cancer...
June 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38778584/mutant-p53-reactivators-protect-breast-cancer-cells-from-ferroptosis
#20
JOURNAL ARTICLE
Dewmi Sandaru Rathnayake, Samkeliso Dlamini, Kadry Elkalawozgy, L M Viranga Tillekeratne, William R Taylor
Ferroptosis is a novel nonapoptotic form of cell death characterized by iron-dependent reactive oxygen species-mediated lipid peroxidation. In several different cell systems, the tumor suppressor p53 can enhance sensitivity to ferroptotic inducers. At least half of all human cancers show loss of function of p53. Furthermore, many of those tumors express mutant forms of p53 that has lost its wild-type function. Several groups have designed small molecules that can reactivate the wild-type function of these missense p53 mutants...
June 2024: Cell Biochemistry and Function
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