Sondos M Flieh, Antje Hebestreit, Hermann Pohlabeln, María L Miguel-Berges, Esther M González-Gil, Paola Russo, Dénes Molnár, Kathleen Wijnant, Lauren Lissner, Stefanie Do, Tonia Solea, Toomas Veidebaum, Luis A Moreno
This study aims to investigate the influence of psychosomatic and emotional status on food portion sizes (PSs) consumption from high energy-dense food groups in European children and adolescents. We hypothesized that psychosomatic and emotional status would have a significant association with the PS selection of energy-dense food. The study included 7355 children aged between 2 and 9.9 years at baseline (T0) (48.8% females); 3869 after 2 years (T1) (48.2% females), and 2971 (51.8% females) after 6 years of follow-up (T3)...
May 26, 2024: Nutrition Research
Chan Yoon Park, Sunhye Shin
Although vitamin C is one of the most important antioxidants, its effect on muscle quality is not fully understood. Therefore, we hypothesized that low dietary vitamin C intake is associated with low muscle strength. To test the hypothesis, a single 24-h dietary recall and handgrip strength test of 10,883 younger adults 19-64 y and 3,961 older adults ≥65 y from the seventh Korea National Health and Examination Survey (KNHANES VII 2016-2018) was analyzed by multivariable linear and logistic regression models, and low muscle strength was defined as handgrip strength <28 kg for men and <18 kg for women...
May 25, 2024: Nutrition Research
Emilia Zawieja, Natalia Drabińska, Henryk Jeleń, Artur Szwengiel, Krzysztof Durkalec-Michalski, Agata Chmurzynska
Betaine supplementation is used by athletes, but its mechanism of action is still not fully understood. We hypothesized that betaine supplementation would increase betaine concentration and alter amino acid profiles in relation to MTHFR genotype and dose in physically active males. The study followed a randomized placebo-controlled cross-over design. Blood samples were collected before and after each supplementation period. Serum was analyzed for amino acid profile, homocysteine, betaine, choline, and trimethylamine N-oxide (TMAO) concentrations...
May 23, 2024: Nutrition Research
Berenice Rivera-Paredez, Anna D Argoty-Pantoja, Rafael Velázquez-Cruz, Jorge Salmerón, Aida Jiménez-Corona, Clicerio González-Villalpando, Martin Lajous, Juan Tamayo, Andrés Catzin-Kuhlmann, Robert Nelson, Ricardo Correa-Rotter, Edgar Denova-Gutiérrez
We hypothesized that higher scores on the dietary inflammatory index (DII) would be associated with a lower glomerular filtration rate (GFR). This cross-sectional study included 2098 participants from Mexican Teachers Cohort Study, the Health Workers Cohort Study, and the Comitán Study belonging to the RenMex consortium. Energy-adjusted DII scores were estimated using a semi-quantitative food frequency questionnaire (FFQ). eGFR was estimated by the CKD Epidemiology Collaboration equation. Quantile regression models and ordered regression models were estimated to assess the associations of interest...
May 23, 2024: Nutrition Research
Levin G Dotimas, Babajide Ojo, Amritpal Kaur, Sanmi Alake, Madison Dixon, Guadalupe Davila-El Rassi, John A Ice, Jiangchao Zhao, Sam R Emerson, Brenda J Smith, Edralin A Lucas
Wheat germ (WG), a by-product of flour milling, is rich in bioactive substances that may help improve health complications associated with increased adiposity. This study investigated the effects of WG on gut health, metabolic, and inflammatory markers in adults classified as overweight. We hypothesized that WG, because of its many bioactive components, would improve gut health and metabolic, and inflammatory markers in overweight adults. Forty adults (18-45 years old) and with a body mass index between 25 and 30 kg/m2 participated in this single-blinded randomized controlled pilot study...
May 4, 2024: Nutrition Research
Julia Silva E Oliveira, Júnia Maria Geraldo Gomes, Jorge de Assis Costa, Leandro Licursi de Oliveira, Rita de Cássia Gonçalves Alfenas
The effect of calcium (Ca) on glycation markers is unknown. We hypothesized that increased Ca intake from skimmed milk associated with an energy-restricted diet intake will reduce glycation markers. This reduction will be associated with a greater improvement in markers of metabolic control in adults with type 2 diabetes, overweight, and low habitual Ca intake (<600 mg/d). In this secondary data analysis based on a crossover clinical trial, 14 adults were allocated into 2 groups: high calcium (shake containing 700 mg Ca/day) or low calcium (shake with 6...
May 2, 2024: Nutrition Research
Filipe M Ribeiro, Maycon Anderson, Samuel Aguiar, Elza Gabriela, Bernardo Petriz, Octavio L Franco
Gut peptides play a role in signaling appetite control in the hypothalamus. Limited knowledge exists regarding the release of these peptides in individuals with obesity before and during external stimuli. We hypothesize that the expression of gut peptides is different in the fasting and postprandial states in the scenario of obesity. PubMed/MEDLINE, Scopus, and Science Direct electronic databases were searched. The meta-analysis was performed using Review Manager Software. Randomized controlled trials that measured gut peptides in both obese and lean subjects were included in the analysis...
May 2, 2024: Nutrition Research
Ying Tang, Ting-Chun Lin, Hong Yang, Yanjiao Zhou, Lindiwe Sibeko, Zhenhua Liu
The influence of gut microbiota on gut health is well-documented, but it remains obscure for extraintestinal diseases such as breast cancer. Moreover, it is entirely unknown how gut dysbiosis during early life contributes to breast tumorigenesis later in life. In this study, we hypothesized that a high-fat diet during early life leads to alterations in the gut microbiome and is associated with disruptions in the mammary microenvironment. Female C57BL/6 mice were fed a low-fat diet (10% kcal fat) or a high-fat diet (HF, 60% kcal fat) for 8 weeks from the age of 4 to 12 weeks, which is equivalent to human childhood and adolescence...
April 30, 2024: Nutrition Research
Felix Twum, Logan Cowan, Lili Yu, Evans Afriyie-Gyawu, Jian Zhang
The relationship between folate and diabetes remains inconclusive, possibly because of folate measured differentially between studies. Interference from mandatory folic acid fortification (FAF) has also been blamed. With both folate intake and circulating concentration measured, we assessed the relationship between folate and the risk of diabetes death in a hypertensive cohort established before FAF. We hypothesized that the association between folate and diabetes death is measurement dependent. We analyzed the data of 3133 hypertensive adults aged ≥19 years who participated in the Third National Health and Nutrition Examination Survey (1991-1994) and were followed up through December 31, 2010...
April 30, 2024: Nutrition Research
Sofía Alfaro-González, Miriam Garrido-Miguel, Rubén Fernández-Rodríguez, Arthur Eumann Mesas, Elisabeth Bravo-Esteban, Purificación López-Muñoz, Eva Rodríguez-Gutiérrez, Vicente Martínez-Vizcaíno
The objective was to assess the association of the overall score and different items of the Mediterranean Diet Adherence Screener (MEDAS) questionnaire with academic achievement in Spanish university students. We hypothesized that university students with greater adherence to the Mediterranean Diet (MedDiet) would have better academic achievement. A cross-sectional study was performed involving 266 first-year students from the University of Castilla-La Mancha, Spain, during the 2017-2018 academic year. Adherence to the Mediterranean diet was evaluated with the 14-item MEDAS questionnaire...
April 23, 2024: Nutrition Research
Ece Koc Yildirim, Mehmet Kaya, Asude Gulce Guler, Edasu Yildirim, Yalcin Alper Ozturan, Aaron Aykut Uner
Hypertension, characterized by persistent and uncontrolled high blood pressure, is one of the most common significant causes of mortality worldwide. Lifestyle modifications such as exercise and antioxidant intake have showed beneficial effects on hypertensive conditions. Adropin and endothelin-1 (ET-1) have important vasoregulatory functions in the endothelium. However, the underlying mechanisms linking exercise- and/or antioxidant intake-mediated improvement of hypertension are not fully understood. In this study, it was hypothesized that swimming exercise and pomegranate juice (PJ) (as an antioxidant) administration might have protective effects on hypertension development and possible involvements of serum adropin and ET-1...
April 19, 2024: Nutrition Research
Henrique Souza-Tavares, Daiana Araujo Santana-Oliveira, Isabela Macedo Lopes Vasques-Monteiro, Flavia Maria Silva-Veiga, Carlos Alberto Mandarim-de-Lacerda, Vanessa Souza-Mello
Metabolic dysfunction-associated steatotic liver disease (MASLD) has attracted increasing attention from the scientific community because of its severe but silent progression and the lack of specific treatment. Glucolipotoxicity triggers endoplasmic reticulum (ER) stress with decreased beta-oxidation and enhanced lipogenesis, promoting the onset of MASLD, whereas regular physical exercise can prevent MASLD by preserving ER and mitochondrial function. Thus, the hypothesis of this study was that high-intensity interval training (HIIT) could prevent the development of MASLD in high-fat (HF)-fed C57BL/6J mice by maintaining insulin sensitivity, preventing ER stress, and promoting beta-oxidation...
April 16, 2024: Nutrition Research
Xuqian Zhang, Wanting Yang, Gaoyue Guo, Wetian Liu, Chao Sun
Emerging evidence expands on a close connection between trace elements and muscular abnormalities, mostly focusing on sarcopenia. We hypothesized an association between concentrations of serum trace elements and myosteatosis, given that myosteatosis has a more pronounced clinical implication relative to sarcopenia, but there is a paucity of data in patients with cirrhosis. Consecutive patients were hospitalized for cirrhosis-associated complications. Serum trace elements (zinc, copper, manganese [Mn], magnesium, calcium, and iron) were measured by inductively coupled plasma mass spectrometry...
April 16, 2024: Nutrition Research
Ruiting Zhu, Yangyang Lei, Saikun Wang, Jingyi Zhang, Mengjiao Lv, Ruixue Jiang, Jinjian Zhou, Tianshu Li, Lirong Guo
Plantago is rich in soluble fiber, known for its beneficial health effects. Given this, we hypothesized that Plantago consumption might positively influence blood lipid in adults. Researchers have conducted numerous randomized controlled trials (RCTs), revealing the impacts of Plantago consumption on various blood lipid parameters. However, findings regarding specific blood lipid parameters have shown variability. This study aimed to comprehensively assess the effect of Plantago consumption on blood lipid parameters...
April 3, 2024: Nutrition Research
Nicole K Reeder, Jennifer C Reneker
The primary objective of this study was to examine the association between food security status and metabolic syndrome (MetS) using a nationally representative dataset. We hypothesized that food insecurity would be associated with an increased odds of having MetS. This was a cross-sectional analysis of data from the 2005-2006 to 2015-2016 National Health and Nutrition Examination Survey data collection cycles. Food security was measured using the US Food Security Survey Module. Presence of MetS was determined using the National Cholesterol Education Program Adult Treatment Panel III criteria...
April 1, 2024: Nutrition Research
Natalie M Zahr
Deficiency for thiamine (vitamin B1 ), traditionally assessed via the activity of the thiamine-dependent enzyme erythrocyte transketolase, has been reported in individuals with alcohol use disorder (AUD) and in people with HIV; concentrations of the metabolically active diphosphate form, however, have yet to be reported in HIV cohorts and results in AUD are equivocal. In this cross-sectional study, samples from 170 AUD, 130 HIV, and 100 healthy control individuals were analyzed to test the hypothesis that AUD and HIV groups relative to healthy controls would show low whole blood thiamine diphosphate (TDP) concentrations related to peripheral neuropathy...
March 30, 2024: Nutrition Research
Cheng Zhang, Ke Li, Shu-Ning Xu, Jia-Kui Zhang, Ming-Hui Ma, Ying Liu
The study focuses on the association between serum carotenoids and cancer-related death. Using data from the National Health and Nutrition Examination Survey (2001-2006 and 2017-2018), the study encompasses 10,277 participants older than age 20 years, with recorded baseline characteristics and serum carotenoid concentrations (including α-carotene, trans-β-carotene, cis-β-carotene, β-cryptoxanthin, trans-lycopene, and lutein/zeaxanthin). We hypothesized that serum carotenoid concentrations were negatively associated with cancer-related death...
March 30, 2024: Nutrition Research
Avinash Pokala, Jana Kraft, Victoria M Taormina, Marie-Caroline Michalski, Cécile Vors, Moises Torres-Gonzalez, Richard S Bruno
Bovine dairy milk is a nutrient-rich matrix, but consumption of full-fat dairy food varieties has been claimed historically to be associated with poorer cardiometabolic health, a notion often attributed to the saturated fat content. However, continued investigation that includes observational studies and randomized controlled trials (RCTs) provide evidence that favorably supports full-fat dairy foods and their bioactive components on cardiometabolic health. This review addresses this controversy by examining the evidence surrounding full-fat dairy foods and their implications for human health...
March 21, 2024: Nutrition Research
Lenycia de Cassya Lopes Neri, Monica Guglielmetti, Simona Fiorini, Ludovica Pasca, Martina Paola Zanaboni, Valentina de Giorgis, Anna Tagliabue, Cinzia Ferraris
Treatment adherence, defined as the degree to which the patient actively follows the plan of care, is very difficult for subjects undergoing ketogenic dietary therapies (KDTs). This is a relevant issue because adherence to dietary therapies is considered 1 of the primary determinants of the treatment's success. This paper aimed to review the literature evidence about KDT adherence according to age and diagnosis of patients. Performed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses method, this systematic review included clinical trials and observational studies...
March 21, 2024: Nutrition Research
Tori A Holthaus, Shelby A Keye, Shreya Verma, Corinne N Cannavale, Nicholas A Burd, Hannah D Holscher, Naiman A Khan
The Mediterranean-Dietary Approaches to Stop Hypertension (DASH) Intervention for Neurodegenerative Delay (MIND) dietary pattern is associated with reduced cognitive decline and dementia risk. However, the nutrient features that distinguish the MIND from other patterns are unknown. We investigated the relationship between accordance to the MIND pattern and carotenoid intake (phytonutrients hypothesized to confer neuroprotection) relative to the Mediterranean, DASH, and Healthy Eating Index (HEI-2020). We hypothesized that MIND diet accordance would be a stronger predictor of carotenoid intake relative to other diet indices...
March 21, 2024: Nutrition Research
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