Min Zeng, Joanna K Hodges, Avinash Pokala, Mona Khalafi, Geoffrey Y Sasaki, Jillian Pierson, Sisi Cao, Guy Brock, Zhongtang Yu, Jiangjiang Zhu, Yael Vodovotz, Richard S Bruno
Anti-inflammatory activities of catechin-rich green tea extract (GTE) in obese rodents protect against metabolic endotoxemia by decreasing intestinal permeability and absorption of gut-derived endotoxin. However, translation to human health has not been established. We hypothesized that GTE would reduce endotoxemia by decreasing gut permeability and intestinal and systemic inflammation in persons with metabolic syndrome (MetS) compared with healthy persons. A randomized, double-blind, placebo-controlled, crossover trial in healthy adults (n = 19, 34 ± 2 years) and adults with MetS (n = 21, 40 ± 3 years) examined 4-week administration of a decaffeinated GTE confection (890 mg/d total catechins) on serum endotoxin, intestinal permeability, gut and systemic inflammation, and cardiometabolic parameters...
February 5, 2024: Nutrition Research