journal
MENU ▼
Read by QxMD icon Read
search

Hepatology: Official Journal of the American Association for the Study of Liver Diseases

journal
https://read.qxmd.com/read/30779450/deliberations-more-than-a-cut-off-hbsag-value-for-nuc-cessation-authors-reply
#1
LETTER
Jiaye Liu, Tao Li, Li Zhang, Aiqiang Xu
We read the comments by Jeng WJ, et al. with great interest and would like to clarify a few issues raised on our systematic review.(1) We didn't include the study of Wang CC AJG 2016 and Tseng CH J Formos Med Assoc 2018 for unavailable relapse data in the setting of different HBsAg levels at the end of treatment (EOT). We also excluded the study of Hsu YC CGH 2016 because only minimum entecavir treatment time was emphasized without consideration of consolidation therapy after achieving HBeAg seroconversion or undetectable HBV DNA when patients discontinued entecavir...
February 19, 2019: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/30779442/no-baclofen-for-alcohol-use-disorders-even-more-when-liver-disease-is-serious
#2
LETTER
Alain Braillon, Florian Naudet
Caputo and colleagues wrongly promoted baclofen for patients with end-stage alcoholic liver disease.(1) First, there is no reason to use it. A recent Cochrane review found a negative benefit harm:ratio of baclofen. This precludes any off-label use. This article is protected by copyright. All rights reserved.
February 19, 2019: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/30779441/predicting-postoperative-liver-dysfunction-based-on-blood-derived-microrna-signatures
#3
Patrick Starlinger, Hubert Hackl, David Pereyra, Susanna Skalicky, Elisabeth Geiger, Michaela Finsterbusch, Dietmar Tamandl, Christine Brostjan, Thomas Grünberger, Matthias Hackl, Alice Assinger
There is an urgent need for an easily assessable preoperative test to predict postoperative liver function recovery and thereby determine the optimal time point of liver resection, specifically as current markers are often expensive, time consuming and invasive. Emerging evidence suggests that microRNA (miRNA) signatures represent potent diagnostic, prognostic and treatment response biomarkers for several diseases. Using next-generation sequencing as an unbiased systematic approach 554 miRNAs were detected in preoperative plasma of 21 patients suffering from postoperative liver dysfunction (LD) after liver resection and 27 matched controls...
February 19, 2019: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/30779440/are-there-upper-limits-in-tumor-burden-for-down-staging-of-hcc-to-liver-transplant-analysis-of-the-all-comers-protocol
#4
Jasmine Sinha, Neil Mehta, Jennifer L Dodge, Eduard Poltavskiy, John Roberts, Francis Yao
Patients with hepatocellular carcinoma (HCC) within University of California, San Francisco down-staging (UCSF-DS) criteria (1 lesion >5cm and <8cm; 2-3 lesions each <5cm or 4-5 lesions each <3cm with total tumor diameter <8cm) who achieved successful down-staging (DS) to Milan criteria had similar outcomes after liver transplant (LT) compared to HCC initially meeting Milan criteria. Nevertheless, little is known about the outcome of DS in patients with initial tumor burden exceeding UCSF-DS criteria, defined as "all-comers" (AC)...
February 19, 2019: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/30779439/reply-to-lte-hep-19-0174
#5
LETTER
Fabio Caputo, Marco Domenicali, Mauro Bernardi
We thank dr Braillon and dr Naudet for their interest in our review article (1). Based on their comments, several aspects need to be clarified and pointed out. First, we addressed a specific patient population presenting alcohol use disorder (AUD) and alcohol-induced chronic liver disease (ALD) in an advanced stage. This article is protected by copyright. All rights reserved.
February 19, 2019: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/30779368/the-intestinal-microbiome-plasma-metabolome-and-liver-transcriptome-a-conspiracy-driving-hepatic-steatosis
#6
Wajahat Z Mehal, Rohit Loomba
With chronic overnutrition the storage of triglyceride in numerous cells including hepatocytes seems inevitable, and can be explained by well recognized pathways of lipid metabolism. This seemingly obvious association between chronic overnutrition and hepatocyte steatosis appears to be regulated by an unnervingly complex set of pathways that are not traditionally thought of as metabolic regulators. The study of regulation of steatosis is traditionally approached by hypothesis driven manner which examine the role of an individual molecules and pathways...
February 19, 2019: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/30773711/depression-an-overlooked-villain-in-autoimmune-hepatitis
#7
LETTER
Maciej K Janik, Ewa Wunsch, Joanna Raszeja-Wyszomirska, Marcin Krawczyk, Piotr Milkiewicz
We read with great interest the recent article by Wong et al. on the impact of autoimmune hepatitis (AIH) on health-related quality of life (HRQoL).(1) So far, this issue has been vastly neglected in patients with AIH. Our particular attention has been drawn to data on mood disturbance, particularly depression. This problem is of great importance in patients with AIH, as depression is one of the key factors responsible for nonadherence to therapy, which increases the risk of relapse and disease progression...
February 17, 2019: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/30773663/repair-or-prevent-what-is-the-real-impact-of-normothermic-machine-perfusion-in-liver-transplantation
#8
LETTER
A Schlegel, P Dutkowski
We read with great interest the paper by Jassem et al(1), which provides detailed gene expression profiles of human livers during normothermic machine perfusion (NMP), compared to conventional cold storage. Authors should be congratulated to this extensive analysis, which shows for the first time transcriptional changes during any form of reperfusion under normothermic conditions(1). However, we would like to add a few critical comments. This article is protected by copyright. All rights reserved.
February 17, 2019: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/30767249/the-yield-and-safety-of-screening-colonoscopy-in-patients-evaluated-for-liver-transplantation
#9
Rosalie C Oey, Laurelle van Tilburg, Nicole S Erler, Herold J Metselaar, Manon C W Spaander, Henk R van Buuren, Robert A de Man
Colorectal cancer screening with colonoscopy is commonly used in candidate patients for liver transplantation. We initiated this study to define the risk-benefit ratio of performing screening colonoscopy in this population. A retrospective observational study of all consecutive patients undergoing colonoscopy during pre-liver transplantation screening between 2004-2017 was conducted. Endoscopic and pathological findings and clinical events potentially related to the colonoscopy in the 30 days after the procedure were registered and compared with a 30 days in-patient control time frame...
February 14, 2019: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/30762896/tissue-repair-in-the-mouse-liver-following-acute-carbon-tetrachloride-depends-on-injury-induced-wnt-%C3%AE-catenin-signaling
#10
Ludan Zhao, Yinhua Jin, Katie Donahue, Margaret Tsui, Matt Fish, Catriona Y Logan, Bruce Wang, Roel Nusse
In the liver, Wnt/β-catenin signaling is involved in regulating zonation and hepatocyte proliferation during homeostasis. We have examined Wnt gene expression and signaling after injury and we show by in situ hybridization that Wnts are activated by acute carbon tetrachloride (CCl4 ) toxicity. Following injury, peri-injury hepatocytes become Wnt-responsive, expressing the Wnt target gene Axin2. Lineage tracing of peri-injury Axin2+ hepatocytes shows that during recovery, the injured parenchyma becomes repopulated and repaired by Axin2+ descendants...
February 14, 2019: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/30762895/lusutrombopag-for-the-treatment-of-thrombocytopenia-in-patients-with-chronic-liver-disease-undergoing-invasive-procedures-l-plus-2
#11
Markus Peck-Radosavljevic, Krzysztof Simon, Angelo Iacobellis, Tarek Hassanein, Zeid Kayali, Albert Tran, Mihaly Makara, Ziv Ben Ari, Marius Braun, Paul Mitrut, Sheng-Shun Yang, Meral Akdogan, Mario Pirisi, Ajay Duggal, Toshimitsu Ochiai, Tomoko Motomiya, Takeshi Kano, Tsutae Nagata, Nezam Afdhal
Thrombocytopenia may be associated with increased bleeding risk impacting timing and outcome of invasive procedures in patients with chronic liver disease (CLD). Lusutrombopag, a small-molecule, thrombopoietin (TPO) receptor agonist, was evaluated as a treatment to raise platelet counts (PC) in patients with thrombocytopenia and CLD undergoing invasive procedures. L-PLUS 2 was a global, phase 3, randomized, double-blind, placebo-controlled study. Adults with CLD and baseline PC <50 × 109 /L were randomized to receive once-daily lusutrombopag 3 mg or placebo ≤7 days prior to an invasive procedure scheduled 2-7 days after the last dose...
February 14, 2019: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/30762891/reply-to-hep-17-1319
#12
LETTER
Anna S Lok
We are disappointed that the Cochrane Group remains unconvinced that sustained virologic response (SVR) is a validated surrogate outcome and that direct-acting antiviral agents (DAAs) have been demonstrated to improve clinical as well as patient-reported outcomes in patients with chronic hepatitis C. Since our commentary in 2017, there have been many more studies supporting the benefits of SVR and DAA therapies, including a decline in patients added to the waiting list for liver transplantation for hepatitis C...
February 14, 2019: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/30762890/soluble-fibers-improve-metabolic-syndrome-but-may-cause-liver-disease-and-hepatocellular-carcinoma
#13
Wen Wen, Robert F Schwabe
Nearly 25% of the world's population is suffering from non-alcoholic fatty liver disease (NAFLD), which is closely associated with obesity and type 2 diabetes. NAFLD may progress to the development of non-alcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma (HCC). With efficient medical therapies lacking, modifications of life style and diet are considered the best options for the prevention and treatment of NAFLD. For the latter, it is thought that besides reducing fat, sugar and caloric intake, increasing fiber may exert beneficial effects on NAFLD, e...
February 14, 2019: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/30762889/hip-fracture-risk-in-patients-with-cirrhosis-does-diabetes-mellitus-matter
#14
LETTER
Mindie H Nguyen
In this article, Dr. Lai discusses the risk of hip fractures in persons with cirrhosis and when diabetes is present, the risk for hip fracture is 2.5 times greater (9.72 vs. 22.3 per 1000 person-years). [1] We agree with the author that the presence of cirrhosis carries risk for many other comorbidities to include bone fractures. [2] In addition, the presence of diabetes in the presence of liver disease is known to hasten liver disease progression so when both are present the risk of having more severe comorbidities would also likely increase...
February 14, 2019: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/30761561/hip-fracture-risk-in-patients-with-cirrhosis-does-diabetes-mellitus-matter
#15
LETTER
Shih-Wei Lai, Cheng-Li Lin
Insurance reimbursement claims data used in this study were available for public access. Patient identification numbers were scrambled to ensure confidentiality. Patient informed consent was not required. This study was approved by the Research Ethics Committee of China Medical University and Hospital in Taiwan (CMUH-104-REC2-115). This article is protected by copyright. All rights reserved.
February 14, 2019: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/30748020/hepatic-irf6-alleviates-liver-steatosis-and-metabolic-disorder-by-transcriptionally-suppressing-ppar%C3%AE
#16
Jingjing Tong, Cui-Juan Han, Jia Zhen Zhang, Wen-Zhi He, Guo-Jun Zhao, Xu Cheng, Lei Zhang, Ke-Qiong Deng, Ye Liu, Hui-Fen Fan, Song Tian, Jingjing Cai, Zan Huang, Zhi-Gang She, Peng Zhang, Hongliang Li
Nonalcoholic fatty liver disease (NAFLD) has become a worldwide epidemic. A large and growing unmet therapeutic need has inspired numerous studies in the field. Integrating the published genomic data available in the Gene Expression Omnibus with NAFLD samples from rodents, we discovered that interferon regulatory factor 6 (IRF6) is significantly suppressed in high-fat diet (HFD)-induced fatty liver. In the current study, we identified IRF6 in hepatocytes as a protective factor in liver steatosis. During HFD challenge, hepatic Irf6 was suppressed by promoter hypermethylation...
February 12, 2019: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/30746731/the-renaissance-of-cholemic-nephropathy-a-likely-underestimated-cause-of-renal-dysfunction-in-liver-disease
#17
EDITORIAL
Mattias Mandorfer, Manfred Hecking
In this issue of Hepatology, Bräsen and Mederacke et al (1) present an analysis of all kidney biopsies performed at the gastroenterology and hepatology department at Hannover Medical School over a 16-year period. The authors identified 79 patients with both liver disease and impaired renal function, 57% of whom had acute kidney injury (AKI) or AKI overlapping chronic kidney disease (CKD), while 43% had CKD, as defined by the recently updated European clinical practice guidelines. Interestingly, 8 patients were diagnosed with cholemic nephropathy (CN), who all presented as AKI...
February 11, 2019: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/30737831/axin1-deletion-induced-hepatocarcinogenesis-requires-intact-%C3%AE-catenin-but-not-notch-cascade-in-mice
#18
Yu Qiao, Jingxiao Wang, Eylul Karagoz, Binyong Liang, Xinhua Song, Runze Shang, Katja Evert, Meng Xu, Li Che, Matthias Evert, Diego F Calvisi, Junyan Tao, Bruce Wang, Satdarshan P Monga, Xin Chen
Inactivating mutations of AXIN1, a negative regulator of the Wnt/β-Catenin cascade, are among the common genetic events in human hepatocellular carcinoma (HCC), affecting around 10% of cases. In the present manuscript, we sought to define the genetic crosstalk between Axin1 mutants and Wnt/β-catenin as well as Notch signaling cascades along hepatocarcinogenesis. We discovered that c-MET activation and AXIN1 mutations occur concomitantly in ~3 to 5% of human HCC samples. Subsequently, we generated a murine HCC model via CRISPR/Cas9 based gene deletion of Axin1 (sgAxin1) in combination with transposon-based expression of c-Met in the mouse liver (c-Met/sgAxin1)...
February 8, 2019: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/30737815/bezafibrate-improves-globe-and-uk-pbc-scores-and-long-term-outcomes-in-patients-with-primary-biliary-cholangitis
#19
Akira Honda, Atsushi Tanaka, Tetsuji Kaneko, Atsumasa Komori, Masanori Abe, Mie Inao, Tadashi Namisaki, Naoaki Hashimoto, Kazuhito Kawata, Atsushi Takahashi, Masashi Ninomiya, Jong-Hon Kang, Mie Arakawa, Satoshi Yamagiwa, Satoru Joshita, Takeji Umemura, Ken Sato, Akira Kaneko, Kentaro Kikuchi, Jun Itakura, Takako Nomura, Keisuke Kakisaka, Hideki Fujii, Norifumi Kawada, Yasuhiro Takikawa, Tsutomu Masaki, Hiromasa Ohira, Satoshi Mochida, Hitoshi Yoshiji, Satoshi Iimuro, Yasushi Matsuzaki, Hajime Takikawa
In Japan, bezafibrate (BF) is a second-line agent for primary biliary cholangitis (PBC) that is refractory to ursodeoxycholic acid (UDCA) treatment. From a retrospective cohort (n=873) from the Japan PBC Study Group, we enrolled 118 patients who had received UDCA monotherapy for ≥1 year followed by combination therapy with UDCA+BF for ≥1 year. GLOBE and UK-PBC scores after UDCA monotherapy (that is, immediately before UDCA+BF combination therapy) were compared with those after 1 year of UDCA+BF combination therapy...
February 8, 2019: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/30737812/carbon-tetrachloride-ccl-4-induced-classical-liver-cirrhosis-model-revisiting-the-mode-of-action
#20
LETTER
Priyankar Dey
I read with interest the study by Munoz et. al. (1) that showed CCl4 -associated intestinal dysbiosis and altered immune phenotype. Although no hepatic parameters were reported, ileal-centric data collectively showed that CCl4 oral-gavage induce intestinal pro-inflammatory phenotype and gut-barrier dysfunction in association with a bloom of endotoxin-rich gram-negative bacteria. These data are consistent with the gut-associated etiology of progressive liver-disease and metabolic anomalies that centers on gut dysbiosis and loss of barrier function, allowing gut-to-hepatic endotoxin translocation through portal circulation...
February 8, 2019: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
journal
journal
28566
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"