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Journals Hepatology : Official Journal ...

Hepatology : Official Journal of the American Association for the Study of Liver Diseases

https://read.qxmd.com/read/38607809/an-artificial-intelligence-generated-model-predicts-90-day-survival-in-alcohol-associated-hepatitis-a-global-cohort-study
#1
JOURNAL ARTICLE
Winston Dunn, Yanming Li, Ashwani K Singal, Douglas A Simonetto, Luis A Díaz, Francisco Idalsoaga, Gustavo Ayares, Jorge Arnold, María Ayala-Valverde, Diego Perez, Jaime Gomez, Rodrigo Escarate, Eduardo Fuentes-López, Carolina Ramirez-Cadiz, Dalia Morales-Arraez, Wei Zhang, Steve Qian, Joseph C Ahn, Seth Buryska, Heer Mehta, Nicholas Dunn, Muhammad Waleed, Horia Stefanescu, Andreea Bumbu, Adelina Horhat, Bashar Attar, Rohit Agrawal, Joaquín Cabezas, Victor Echavaría, Berta Cuyàs, Maria Poca, German Soriano, Shiv K Sarin, Rakhi Maiwall, Prasun K Jalal, Fátima Higuera-de-la-Tijera, Anand V Kulkarni, P Nagaraja Rao, Patricia Guerra-Salazar, Lubomir Skladaný, Natália Kubánek, Veronica Prado, Ana Clemente-Sanchez, Diego Rincon, Tehseen Haider, Kristina R Chacko, Gustavo A Romero, Florencia D Pollarsky, Juan C Restrepo, Luis G Toro, Pamela Yaquich, Manuel Mendizabal, Maria L Garrido, Sebastián Marciano, Melisa Dirchwolf, Victor Vargas, César Jiménez, David Hudson, Guadalupe García-Tsao, Guillermo Ortiz, Juan G Abraldes, Patrick S Kamath, Marco Arrese, Vijay H Shah, Ramon Bataller, Juan P Arab
BACKGROUND AIMS: Alcohol-associated hepatitis (AH) poses significant short-term mortality. Existing prognostic models lack precision for 90-day mortality. Utilizing artificial intelligence (AI) in a global cohort, we sought to derive and validate an enhanced prognostic model. APPROACH AND RESULTS: The Global AlcHep initiative, a retrospective study across 23 centers in 12 countries, enrolled AH patients per NIAAA criteria. Centers were partitioned into derivation (11 centers, 860 patients) and validation cohorts (12 centers, 859 patients)...
April 12, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38607785/-reply-chronic-hepatitis-b-baseline-viral-load-and-on-treatment-liver-cancer-risk-a-multinational-cohort-study-of-hbeag-positive-patients
#2
JOURNAL ARTICLE
Won-Mook Choi, Young-Suk Lim
No abstract text is available yet for this article.
April 12, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38607742/reply-endoscopy-for-potential-variceal-bleeding-within-12-hours-not-so-fast
#3
JOURNAL ARTICLE
Guadalupe Garcia-Tsao, David E Kaplan
No abstract text is available yet for this article.
April 12, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38607725/alcohol-associated-liver-cancer
#4
JOURNAL ARTICLE
Yaojie Fu, Luca Maccioni, Xin Wei Wang, Tim F Greten, Bin Gao
Heavy alcohol intake induces a wide spectrum of liver diseases ranging from steatosis, steatohepatitis, cirrhosis, and hepatocellular carcinoma (HCC). Although alcohol consumption is a well-known risk factor for the development, morbidity, and mortality of HCC globally, alcohol-associated HCC (A-HCC) is poorly characterized compared to viral hepatitis-associated HCC. Most A-HCCs develop post alcohol-associated cirrhosis, but the direct carcinogenesis from ethanol and its metabolites to A-HCC remains obscure...
April 12, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38607724/letter-to-the-editor-chronic-hepatitis-b-baseline-viral-load-and-on-treatment-liver-cancer-risk-a-multinational-cohort-study-of-hbeag-positive-patients
#5
JOURNAL ARTICLE
Taiyu He, Dazhi Zhang
No abstract text is available yet for this article.
April 12, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38607723/non-invasive-tests-for-alcohol-associated-liver-disease
#6
JOURNAL ARTICLE
Mads Israelsen, Wiramon Rungratanawanich, Maja Thiele, Suthat Liangpunsakul
Alcohol consumption is a global phenomenon and a major contributor to alcohol-associated liver disease (ALD). Detecting individuals at risk of ALD has been challenging, with only a small fraction of patients being identified at early stages compared to other chronic liver diseases. In response to this challenge, non-invasive tests (NITs) have become essential tools for the detection of ALD, offering opportunities for early identification and intervention to mitigate the disease burden. Non-invasive alcohol consumption biomarkers are crucial in estimating individuals' recent alcohol intake, providing valuable insights into their drinking patterns...
April 12, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38607699/letter-to-the-editor-endoscopy-for-potential-variceal-bleeding-within-12-hours-not-so-fast
#7
JOURNAL ARTICLE
Loren Laine, Alan N Barkun, Grigorios I Leontiadis
No abstract text is available yet for this article.
April 12, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38607698/acute-hepatic-porphyrias-a-guide-for-hepatologists
#8
JOURNAL ARTICLE
Akshata Moghe, Brendan M McGuire, Cynthia Levy
The acute hepatic porphyrias (AHPs) are a group of rare, inherited disorders of the heme biosynthesis pathway, usually manifesting with attacks of acute abdominal pain and other neurovisceral symptoms, with or without cutaneous manifestations. AHP are characterized by the accumulation of porphyrin precursors, porphobilinogen (PBG) and/or aminolevulinic acid (ALA), in the blood. The diagnosis is often missed or delayed due to both inadequate testing and the improper use of available laboratory tests. In this review, we describe the various clinical presentations of the four AHPs, elucidate the approach to diagnosis, and provide recommendations for immediate as well as long-term management...
April 12, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38598364/incidence-of-liver-cancer-in-young-adults-according-to-the-global-burden-of-disease-database-2019
#9
JOURNAL ARTICLE
Pojsakorn Danpanichkul, Majd B Aboona, Banthoon Sukphutanan, Siwanart Kongarin, Kwanjit Duangsonk, Cheng Han Ng, Mark D Muthiah, Daniel Q Huang, Yuya Seko, Luis Antonio Díaz, Juan Pablo Arab, Ju Dong Yang, Vincent L Chen, Donghee Kim, Mazen Noureddin, Suthat Liangpunsakul, Karn Wijarnpreecha
OBJECTIVE: The worldwide burden of cancer is increasing in younger populations. However, the epidemiology of primary liver cancer remains understudied in young adults compared to other cancer forms. METHODS: This study analyzed data from the Global Burden of Disease (GBD) study between 2010 and 2019 to assess the age-standardized incidence, mortality, and disability-adjusted life years (DALYs) associated with primary liver cancer in the young (15-49 y), stratified by region, nation, sociodemographic index, and sex...
April 8, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38563629/conserved-long-noncoding-rna-tilam-promotes-liver-fibrosis-through-interaction-with-pml-in-hepatic-stellate-cells
#10
JOURNAL ARTICLE
Cheng Sun, Chan Zhou, Kaveh Daneshvar, Amel Ben Saad, Arcadia J Kratkiewicz, Benjamin J Toles, Nahid Arghiani, Anja Hess, Jennifer Y Chen, Joshua V Pondick, Samuel R York, Wenyang Li, Sean Moran, Stefan Gentile, Raza Ur Rahman, Zixiu Li, Peng Zhou, Robert Sparks, Tim Habboub, Byeong-Moo Kim, Michael Y Choi, Silvia Affo, Robert F Schwabe, Yury V Popov, Alan C Mullen
BACKGROUND AND AIMS: Fibrosis is the common endpoint for all forms of chronic liver injury, and progression of fibrosis leads to the development of end-stage liver disease. Activation of hepatic stellate cells (HSCs) and their transdifferentiation into myofibroblasts results in the accumulation of extracellular matrix (ECM) proteins that form the fibrotic scar. Long noncoding (lnc) RNAs regulate the activity of HSCs and provide targets for fibrotic therapies. APPROACH AND RESULTS: We identified lncRNA TILAM located near COL1A1, expressed in HSCs, and induced with liver fibrosis in humans and mice...
April 2, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38557779/variants-in-autophagy-genes-mtmr12-and-fam134a-are-putative-modifiers-of-the-hepatic-phenotype-in-%C3%AE-1-antitrypsin-deficiency
#11
JOURNAL ARTICLE
Edgar N Tafaleng, Jie Li, Yan Wang, Tunda Hidvegi, Alex Soto-Gutierrez, Adam E Locke, Thomas J Nicholas, Yung-Chun Wang, Stephen Pak, Michael H Cho, Edwin K Silverman, Gary A Silverman, Sheng Chih Jin, Ira J Fox, David H Perlmutter
BACKGROUND AIMS: In the classical form of α1-antitrypsin deficiency a misfolded variant α1-antitrypsin Z accumulates in the endoplasmic reticulum of liver cells and causes liver cell injury by gain-of-function proteotoxicity in a sub-group of affected homozygotes but relatively little is known about putative modifiers. Here we carried out genomic sequencing in a uniquely affected family with an index case of liver failure and 2 homozygous siblings with minimal or no liver disease...
April 1, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38557474/management-of-coagulopathy-among-patients-with-cirrhosis-undergoing-upper-endoscopy-and-paracentesis-persistent-gaps-and-areas-of-consensus-in-a-multispecialty-delphi
#12
JOURNAL ARTICLE
Elliot B Tapper, Matthew A Warner, Rajesh P Shah, Juliet Emamaullee, Nancy M Dunbar, Michelle Sholzberg, Jacqueline N Poston, Robin J Soto, Ammar Sarwar, Anjana Pillai, Karina Reyner, Shivang Mehta, Marwan Ghabril, Timothy R Morgan, Stephen Caldwell
Background and Aims Patients with cirrhosis have abnormal coagulation indices such as a high international normalized ratio (INR) and low platelet count, but these do not correlate well with peri-procedure bleeding risk. We sought to develop consensus among the multiple stakeholders in cirrhosis care to inform process measures that can help improve the quality of the peri-procedure management of coagulopathy in cirrhosis. Approach and Results We identified candidate process measures for peri-procedure coagulopathy management in multiple contexts relating to the performance of paracentesis and upper endoscopy...
April 1, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38557414/nuclear-krt19-is-a-transcriptional-co-repressor-promoting-histone-deacetylation-and-liver-tumorigenesis
#13
JOURNAL ARTICLE
Shixun Han, Haonan Fan, Guoxuan Zhong, Lei Ni, Wenhao Shi, Yushan Fang, Chenliang Wang, Li Wang, Lang Song, Jianhui Zhao, Mei Tang, Bing Yang, Li Li, Xueli Bai, Qi Zhang, Tingbo Liang, Yanhui Xu, Xin-Hua Feng, Chen Ding, Dong Fang, Bin Zhao
BACKGROUND AND AIMS: Epigenetic reprogramming and escape from terminal differentiation are poorly understood enabling characteristics of liver cancer. Keratin 19 (KRT19), classically known to form the intermediate filament cytoskeleton, is a marker of stemness and worse prognosis in liver cancer. This study aimed to address the functional roles of KRT19 in liver tumorigenesis and to elucidate the underlying mechanisms. APPROACH AND RESULTS: Using multiplexed genome editing of hepatocytes in vivo, we demonstrated that KRT19 promoted liver tumorigenesis in mice...
April 1, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38551848/erratum-hdv-rna-and-liver-disease-progression-what-do-we-know
#14
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
March 29, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38551831/erratum-aasld-practice-guidance-on-acute-on-chronic-liver-failure-and-the-management-of-critically-ill-patients-with-cirrhosis
#15
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
March 29, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38546299/pathological-polyploidy-and-liver-repair-failure-in-rad51-deficient-mice
#16
JOURNAL ARTICLE
Andrew W Duncan
No abstract text is available yet for this article.
March 28, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38546296/single-cell-based-molecular-classification-in-systematic-treatment-of-hepatocellular-carcinoma-from-in-silico-to-bedside
#17
JOURNAL ARTICLE
Tuo Deng, Gang Chen
No abstract text is available yet for this article.
March 28, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38546288/nutritional-aspects-of-prehabilitation-in-adults-with-cirrhosis-awaiting-liver-transplant
#18
JOURNAL ARTICLE
Christofer Cruz, Carla M Prado, Chelsia Gillis, Robert Martindale, Chantal Bémeur, Jennifer C Lai, Puneeta Tandon
Malnutrition, sarcopenia (low muscle mass), and physical frailty have gained increasing recognition in candidates for liver transplant (LT) as these conditions can impact postoperative functional capacity. Multidimensional prehabilitation programs have been proposed as a safe intervention in adults awaiting LT but the nutritional pillar of prehabilitation has been understudied. This review summarizes the nutritional recommendations for prehabilitation for individuals with cirrhosis awaiting LT. Three major aspects of nutritional prehabilitation are discussed: (1) Assess: Evaluate nutritional status and assess for malnutrition, sarcopenia, and frailty to guide the nutritional prehabilitation intervention intensity, increasing across universal, targeted, and specialist levels; (2) Intervene: Prescribe a nutritional prehabilitation intervention to meet established nutrition guidelines in cirrhosis with a targeted focus on improving nutritional status and muscle health; (3) Reassess: Follow-up based on the required intensity of nutritional care with as needed intervention adjustment...
March 28, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38546278/mesenchymal-stem-cells-alleviate-mouse-liver-fibrosis-by-inhibiting-pathogenic-function-of-intrahepatic-b-cells
#19
JOURNAL ARTICLE
Xudong Feng, Bing Feng, Jiahang Zhou, Jinfeng Yang, Qiaoling Pan, Jiong Yu, Dandan Shang, Lanjuan Li, Hongcui Cao
BACKGROUND AIMS: The immunomodulatory characteristics of mesenchymal stem cells (MSCs) make them a promising therapeutic approach for liver fibrosis (LF). Here, we postulated that MSCs could potentially suppress the pro-fibrotic activity of intrahepatic B cells, thereby inhibiting LF progression. APPROACH RESULTS: Administration of MSCs significantly ameliorated LF as indicated by reduced myofibroblast activation, collagen deposition, and inflammation. The treatment efficacy of MSCs can be attributed to decreased infiltration, activation, and pro-inflammatory cytokine production of intrahepatic B cells...
March 28, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38537154/the-future-of-liver-transplantation
#20
JOURNAL ARTICLE
Sandy Feng, Garrett R Roll, Foad J Rouhani, Alberto Sanchez Fueyo
Over the last 50 years, liver transplantation has evolved into a procedure routinely performed in many countries worldwide. Those able to access this therapy frequently experience a miraculous risk-benefit ratio since, particularly if they face imminently life threatening disease. Over the decades, the success of liver transplantation, with dramatic improvements in early post-transplant survival, has aggressively driven demand. However, in spite of the emergence of living donors to augment deceased donors as a source of organs, supply has lagged far behind demand...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
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