Mahvish Q Rahim, W Scott Goebel, John Delph, Esther Soundar
Pediatric apheresis collection of peripheral blood stem cells for autologous transplantation often requires use of a blood prime. We evaluated the relationship between pre-apheresis blood CD34+ counts and final CD34+ yield with use of a blood prime. Forty patients underwent apheresis stem cell collection in a 5 year period in our hospital, of which 27 required blood priming of the apheresis machine. Despite the blood prime group having significantly higher pre-apheresis CD34+ cell counts, this group processed a relatively higher volume of blood due to a higher dilutional effect and collected significantly less than predicted CD34+ cell yield...
May 27, 2023: Journal of Clinical Apheresis
Ding Wen Wu, Jessica Jacobson, Mark Lifshitz, Yanhua Li, Chen Lyu, Rachel Friedmann, Ronald Walsh, Evan Himchak, Kala Mohandas, Sadiqa Karim, Etan Marks, Sang Hwa Himchak, Timothy Hilbert
BACKGROUND: Patients with sickle cell disease (SCD) frequently undergo prophylactic red blood cell (RBC) exchange transfusion and simple transfusion (RCE/T) to prevent complications of disease, such as stroke. These treatment procedures are performed with a target hemoglobin S (HbS) of ≤30%, or a goal of maintaining an HbS level of <30% immediately prior to the next transfusion. However, there is a lack of evidence-based instructions for how to perform RCE/T in a way that will result in an HbS value <30% between treatments...
May 17, 2023: Journal of Clinical Apheresis
Sarika Agarwal, Ashish Maheshwari, Meenu Bajpai
INTRODUCTION: Liver transplant is a life-saving treatment, but due to the limited availability of suitable liver donors, ABO-incompatible liver transplants (ABOi-LT) are conducted to increase the availability of liver donors. Perioperative desensitization for ABOi-LT is an established strategy to circumvent the risk of graft rejection. A single prolonged session can be performed to achieve the desired titers to avoid using multiple immunoadsorption (IA) columns or off-label reuse of single-use columns...
May 16, 2023: Journal of Clinical Apheresis
Muharrem Yunce, Nakul Katyal, Grace Fortes Monis, Srikanth Muppidi
Neonatal Fc receptor (FcRn) blockade may represent a mechanism similar to plasma exchange (PLEX) in reducing immunoglobulin levels and thus have a broad implication for apheresis practitioners. Although only efgartigimod received FDA approval for myasthenia gravis in December 2021, multiple trials are currently underway with different FcRn therapies in a varied group of IgG antibody-mediated neurological and hematological disorders which are outlined in this review. In this review we discuss FcRn's mechanism of action, and its potential use in various neurological and non-neurological diseases...
May 15, 2023: Journal of Clinical Apheresis
Manasa S Reddy, Ahmad Alkashash, Andrew Nord, Anne Tetrick
BACKGROUND: Isovolemic hemodilution red cell exchange (IHD-RCE) is a modified form of the standard red cell exchange (STD-RCE), intended to reduce red cell requirements in patients with sickle cell disease (SCD). This retrospective crossover analysis of nine patients aims to add to the limited existing literature on IHD-RCE and address the equipoise regarding whether the benefits of (a) decreased RBC usage per exchange and (b) increased interprocedure interval (via lower fraction of cells remaining, FCR) can be observed at the same time, in the same patient...
April 24, 2023: Journal of Clinical Apheresis
Emily Davies, Sairah Khan, Yunchuan D Mo, Cyril Jacquot, Niti Dham, Pranava Sinha, Jennifer Webb
BACKGROUND: Cardiac transplants increasingly occur following placement of ventricular assist devices (VADs). A strong association exists between human leukocyte antigen (HLA) sensitization and VAD placement; however, desensitization protocols that utilize therapeutic plasma exchange (TPE) are fraught with technical challenges and are at increased risk of adverse events. In response to increased VAD utilization in our pre-transplant population, we developed a new institutional standard for TPE in the operating room...
April 12, 2023: Journal of Clinical Apheresis
Cassandra Hobbs, Heidi Green, Ritin Fernandez
Peripheral blood hematopoietic progenitor stem cells (HPSCs) are the most common source of stem cells for autologous and allogenic transplantation. Currently, systematic reviews comparing the collection efficiency of a continuous to an intermittent method are lacking despite the existence of primary studies. Therefore, the objective of this review was to synthesize the best available evidence to compare the efficiency of the continuous vs the intermittent method for the collection of hematopoietic progenitor stem cells required for HPC transplantation...
April 8, 2023: Journal of Clinical Apheresis
Prashant Pandey, Divya Setya, Arghyadeep Marik, Shweta Ranjan, Supriya Kumari, Saikat Mandal, Praveen Kumar
BACKGROUND: Therapeutic apheresis procedures are becoming an increasingly integral part of modern medical practice, be it as a part of therapy or pre-conditioning regimes for solid organ transplants. In our center, we follow the American Society for Apheresis (ASFA) guidelines for categorizing these procedures. However, lack of a centralized registry for therapeutic apheresis in India, lack of consolidated data as well as a resource-constrained setting prevent it from being utilized to its full potential...
April 8, 2023: Journal of Clinical Apheresis
Emily Mason, Kati Dawson, Jack Rhodes, James Kelley, Erin Goodhue Meyer, Toby L Simon
BACKGROUND: Safe, efficient, and reliable innovations among donation systems are needed to meet the growing global demand for source plasma. This study assessed the ability of a new donation system to collect appropriate product weights based on the US Food and Drug Administration nomogram for source plasma collections. Procedure duration and safety endpoints were also collected. STUDY DESIGN AND METHODS: The Rika Plasma Donation System (Terumo BCT, Inc., Lakewood, CO) was evaluated in a prospective, open-label, multicenter study...
April 2, 2023: Journal of Clinical Apheresis
Jinghui Wu, Guanyi Chen, Lihua Wang, Pan Wang, Yue Han, Lei Yang, Xilin Ouyang
BACKGROUND: Preoperative autologous blood donation (PAD) is used for elective surgical procedures with a predictable blood loss. But a downward trend in PAD is due to the fact that patients with preoperative whole blood donation or two-unit red cell apheresis cannot avoid receiving allogenic blood during intensive surgery. To improve the clinical application of PAD, this study explores the feasibility of large-volume autologous red blood cells (RBCs) donation by a pilot trial in a small cohort of Chinese...
March 23, 2023: Journal of Clinical Apheresis
Laura Cooling, John Sherbeck
BACKGROUND: Ethylene oxide (EtO) is a volatile, ringed toxic ether used to sterilize heat-labile plastics including apheresis sets. In the 1980s, EtO-associated severe hypersensitivity reactions during hemodialysis led to widespread adoption of alternative sterilization for dialysis kits but not apheresis tubing sets. We now report several cases of EtO-type hypersensitivity reactions in autologous donors undergoing hematopoietic progenitor cell collection (HPCC). MATERIALS AND METHODS: A 10-year retrospective review of allergic EtO-type reactions in adults undergoing HPCC on the COBE Spectra and SPECTRA Optia was performed...
March 14, 2023: Journal of Clinical Apheresis
Natthapon Rattanathamsakul, Sasitorn Siritho, Shanthi Viswanathan, Fu Liong Hiew, Metha Apiwattanakul, Kevin Tan, Umapathi N Thirugnanam, Tianrong Yeo, Amy M L Quek, Riwanti Estiasari, Rabani Remli, Seinn Mya Mya Aye, Ohnmar Ohnmar, Nghia T T Hoang, Paul M Pasco
INTRODUCTION: Therapeutic plasma exchange (TPE) for neuroimmunological disorders has played an important role in the Southeast Asian region. This study investigates the challenges of performing TPE within the region. METHOD: A questionnaire-based survey was conducted and launched to 15 South East Asian Therapeutic Plasma Exchange Consortium (SEATPEC) members from seven countries in January 2021. It included demographics, TPE techniques, indications, challenges, timing, outcome measurement, and access to laboratory testing in each local center...
March 9, 2023: Journal of Clinical Apheresis
Sarah Cain, Frederick V Plapp, Amitava Dasgupta, Zhan Ye
Although in the majority of patients (90%), the bite wound of brown recluse spider resolves spontaneously, some patients may experience a severe reaction requiring hospitalization. A 25-year-old male developed severe hemolytic anemia, jaundice, and other complications following a brown recluse spider bite on his posterior right thigh. He was treated with methylprednisolone, antibiotics, and red blood cells (RBCs) transfusion without response. Therapeutic plasma exchange (TPE) was added to the treatment regimen, and his hemoglobin (Hb) was eventually stabilized, leading to significant clinical improvement...
March 6, 2023: Journal of Clinical Apheresis
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No abstract text is available yet for this article.
June 2023: Journal of Clinical Apheresis
Laura Connelly-Smith, Caroline R Alquist, Nicole A Aqui, Jan C Hofmann, Reinhard Klingel, Oluwatoyosi A Onwuemene, Christopher J Patriquin, Huy P Pham, Amber P Sanchez, Jennifer Schneiderman, Volker Witt, Nicole D Zantek, Nancy M Dunbar
The American Society for Apheresis (ASFA) Journal of Clinical Apheresis (JCA) Special Issue Writing Committee is charged with reviewing, updating, and categorizing indications for the evidence-based use of therapeutic apheresis (TA) in human disease. In the Ninth Edition, the JCA Special Issue Writing Committee has incorporated systematic review and evidence-based approaches in the grading of evidence and categorization of apheresis indications to make recommendations on the use of apheresis in a wide variety of diseases and conditions...
April 2023: Journal of Clinical Apheresis
Rossana Putzulu, Alberto Romano, Aldo Mancino, Andrea Corbingi, Giuseppina Massini, Stefano Mastrangelo, Silvia Maria Pulitanò, Marco Piastra, Mauro Pittiruti, Antonio Ruggiero, Nicola Piccirillo
The use of peripheral blood hematopoietic stem cells for bone marrow reconstitution after myeloablative therapy is well established in children with malignant disorders. However, the peripheral blood hematopoietic stem cells collection in very low-body weight (≤10 kg) children remains a significant challenge because of technical and clinical issues. A male newborn affected by atypical teratoid rhabdoid tumor, diagnosed prenatally, received two cycles of chemotherapy following surgical resection...
March 1, 2023: Journal of Clinical Apheresis
Yong Xia, Hui Xue, Jing Li, Yanyan Yu, Wei Huang, Chuchu Zhou, Tingting Shi, Yanxia Cheng, Caihong Zhang, Shuang Liu, Zongchang Song, Sha Xu, Jinxing Lou
PURPOSE: Citrate reaction is one of the main adverse events in peripheral blood mononuclear cell (MNC) collection. The aim of this study was to elucidate the risk factors for citrate reaction in patients with advanced solid tumor collection and to construct a nomogram to predict the risk. METHODS: One hundred forty-eight patients with advanced solid tumor who underwent peripheral blood MNC collection in our hospital between January 2021 to December 2021 were selected...
February 9, 2023: Journal of Clinical Apheresis
Yandy Marx Castillo-Aleman, Yendry Ventura-Carmenate, Ottorino Del Foco, May Ann-Martinez
No abstract text is available yet for this article.
February 2023: Journal of Clinical Apheresis
Xiang Luo, Xiaoling Li, Xiaoyan Lai, Lu Ke, Jing Zhou, Man Liu, Longxiang Cao, Lingyan Fu
INTRODUCTION: Sepsis is life-threatening organ dysfunction caused by infection-related inflammatory response. Therapeutic plasma exchange (TPE) can remove inflammatory mediators and benefit patients in different disease settings. However, no solid evidence showed the efficacy and safety of TPE in sepsis. METHODS: This study was a secondary analysis of a randomized controlled trial. Critically ill patients with sepsis were divided into two groups according to whether treated with TPE...
February 2023: Journal of Clinical Apheresis
Angelica Vivero, Alexis R Peedin, Yuanzheng Gao, Julie Katz Karp
Hematopoietic stem cell transplants (HSCTs) are widely used in the treatment of hematologic malignancies and bone marrow failure syndromes. ABO compatibility is typically of secondary importance, and up to 50% of HSCT are performed in ABO-incompatible pairings. In the literature, pure red cell aplasia (PRCA) occurs in 1% to 50% of all major/bidirectional ABO-incompatible stem cell transplants, but treatment of PRCA remains heterogeneous. Here, we report two cases in which patients with transfusion-dependent PRCA following HSCT were successfully treated with therapeutic plasma exchange (TPE)...
January 26, 2023: Journal of Clinical Apheresis
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