Pinnita Prabhasawat, Chareenun Chirapapaisan, Chayachit Chitkornkijsin, Warinyupa Pinitpuwadol, Manutsawin Saiman, Anupong Veeraburinon
PURPOSE: To compare the degree of tear film instability and severity of meibomian gland dysfunction between subjects who use eyeliner and those who do not use eyeliner. METHODS: This cross-sectional study included 42 healthy volunteer women who had no dry eye symptoms (Ocular Surface Disease Index score < 13) and aged between 18 and 40 years. The subjects were classified into 2 groups: an eyeliner-use group (EL: regularly used eyeliner ≥3 d/wk and continuously used ≥6 mo) and a noneyeliner-use group as controls...
November 8, 2019: Cornea
Shaunak K Bakshi, John Graney, Eleftherios I Paschalis, Shweta Agarwal, Sayan Basu, Geetha Iyer, Christopher Liu, Bhaskar Srinivasan, James Chodosh
PURPOSE: The most commonly applied prosthetic devices for corneal blindness in the setting of severe cicatricial keratoconjunctivitis are the Boston keratoprosthesis type II and the modified osteo-odonto-keratoprosthesis, with these requiring either normal eyelid skin or a healthy cuspid tooth, respectively. For patients with neither attribute, we developed a new keratoprosthesis device combining positive aspects of both Boston keratoprosthesis type II and modified osteo-odonto-keratoprosthesis, which we have named the "Lux...
November 8, 2019: Cornea
Ellen H Koo, Roberto Pineda, Natalie Afshari, Allen Eghrari
PURPOSE: The transition to Descemet membrane endothelial keratoplasty (DMEK) is frequently challenging, requiring the adoption of new techniques, skills, and methods. We sought to draw on surgeons' initial experiences with DMEK to characterize the learning curve associated with this procedure and identify factors that could be linked to the frequency of primary graft failure (PGF) in the first 10 cases. METHODS: We invited corneal surgeons based in the United States who started performing the DMEK procedure within the past 2 years to answer a 12-question survey using an online survey platform...
November 8, 2019: Cornea
Prafulla K Maharana, Farin Shaikh, Shreya Nayak, Pranita Sahay
No abstract text is available yet for this article.
November 8, 2019: Cornea
Fu-Shi Quan, Hae-Ahm Lee, Hyun-Hee Kong, Eun-Kyung Moon
PURPOSE: The aim of this study was to reduce the cytotoxicity and improve the amoebicidal effect of polyhexamethylene biguanide (PHMB) at low concentrations by combining it with histone deacetylase (HDAC) inhibitors. METHODS: To reduce the cytotoxic effect on human corneal epithelial (HCE) cells, the concentration of PHMB was reduced to 0.0002%. To enhance the amoebicidal effect of PHMB, HDAC inhibitors such as suberoylanilide hydroxamic acid, MS275, or MC1568 were combined with it...
November 8, 2019: Cornea
Brian C Gilger, Elizabeth Crabtree, Liujiang Song, Telmo Llanga, Megan Cullen, Allison Blanchard, Jacklyn Salmon, Samirkumar Patel, Vladimir Zarnitsyn, Matthew Hirsch
PURPOSE: Drug delivery directly to the corneal stroma currently relies on microscopic injections that demonstrate low reproducibility and clinician-dependent variability. With use of biological drugs such as adeno-associated viral (AAV) vectors, precise and consistent drug deposition is critical to reduce concerns related to off-target transduction and the host's immune response to the viral capsid and/or transgene-derived product. Therefore, a precise corneal injection (PCI) microneedle was designed to allow accurate depth-specific injections into the corneal stroma in a macroscopic setting...
November 8, 2019: Cornea
Masomeh Mohebbi, Hadi Pilafkan, Amin Nabavi, Masoud Mirghorbani, Morteza Naderan
PURPOSE: To assess the efficacy and safety of combined intracameral sulfur hexafluoride and full-thickness corneal sutures in the treatment of acute corneal hydrops (CH). METHODS: This is an uncontrolled series of cases with keratoconus (KC), keratoglobus (KG), and pellucid marginal degeneration that presented with CH of recent onset. RESULT: Thirteen patients completed the study. The mean corneal thickness before treatment was 1,310 ± 556 μm, which significantly reduced to 660 ± 148 μm at week 1 postoperatively (P = 0...
November 8, 2019: Cornea
Tessnim R Ahmad, Neel D Pasricha, Jennifer Rose-Nussbaumer, Julius T Oatts, Julie M Schallhorn, Maanasa Indaram
PURPOSE: To report the clinical characteristics and outcomes of pediatric patients with keratoconus (KCN) who underwent corneal collagen cross-linking (CXL) under general anesthesia for developmental delay or inability to cooperate with topical anesthesia. METHODS: In this retrospective case series, we reviewed the medical charts of pediatric patients with KCN who had CXL under general anesthesia from January 2018 to April 2019. Baseline disease characteristics of patients with and without developmental delay were compared using the Pearson χ test and the t test...
November 7, 2019: Cornea
Pranita Sahay, Devesh Kumawat
No abstract text is available yet for this article.
November 7, 2019: Cornea
Luis Fernández-Vega-Cueto, Carlos Lisa, Miguel Naveiras, David Madrid-Costa, José F Alfonso
PURPOSE: To evaluate the efficacy and safety of femtosecond laser-assisted in situ keratomileusis (FemtoLASIK) to correct the residual refractive error after Descemet membrane endothelial keratoplasty (DMEK). METHODS: This case series study included 7 eyes that underwent FemtoLASIK after a DMEK surgery. The refractive error, uncorrected (UDVA) and corrected (CDVA) distance visual acuities, corneal topography (Sirius, CSO, Italy), and anterior segment optical coherence tomography (Visante, Carl Zeiss-Meditec AG, Jena, Germany) were registered at each postoperative follow-up visit...
November 7, 2019: Cornea
Kristin E Hirabayashi, David Mark, Jackson Lau, Charles C Lin
PURPOSE: To describe a case of postsurgical corneal decompensation in a patient with Fuchs endothelial dystrophy with a sectoral Descemet detachment and corneal edema that was successfully managed with a targeted Descemet stripping only (DSO) procedure. METHODS: This is a case report and review of the literature. RESULTS: A female patient with Fuchs endothelial dystrophy presented with a 6-month history of a persistent sectoral Descemet membrane detachment after cataract surgery with overlying corneal edema...
November 7, 2019: Cornea
Noor Haziq Saliman, Philip B Morgan, Andrew S MacDonald, Carole Maldonado-Codina
PURPOSE: To investigate the inflammatory response of the ocular surface with different soft contact lens (CL) replacement frequencies and materials. METHODS: Twenty soft CL wearers were required to wear 3 lens types: reusable Acuvue 2 (A2), reusable Acuvue Oasys (AO), and daily disposable Acuvue Oasys (AODD), for 1 week in random sequence in 1 eye with the nonlens-wearing eye acting as a control. Three methods were used to assess the subclinical response: tear cytokine evaluation, in vivo confocal microscopy (IVCM), and impression cytology...
November 7, 2019: Cornea
Philip W Dockery, Katelyn Joubert, John S Parker, Jack S Parker
PURPOSE: To describe two cases of suprachoroidal hemorrhage during Descemet membrane endothelial keratoplasty (DMEK). METHODS: Two patients with pseudophakic bullous keratopathy (PBK) underwent DMEK and proceeded to develop intraoperative suprachoroidal hemorrhage. Reports of both cases are documented, including potential risk factors, intraoperative events, and postoperative outcomes and interventions. RESULTS: Both cases required premature abortion of the operation following the abrupt onset of significant posterior pressure indicating potential suprachoroidal hemorrhage...
November 5, 2019: Cornea
Li Mei Zhang, Yang Lu, Lan Gong
PURPOSE: To test the hypothesis that pterygium presents with both refractive and anatomical changes, especially short axial length. METHODS: A retrospective, hospital-based cross-sectional study included 521 eyes from 521 patients who were enrolled through a community survey by Shanghai Heping Eye Hospital was conducted. Patients with primary pterygium in at least 1 eye were considered the pterygium group, and those with normal eyes were considered the nonpterygium group...
November 5, 2019: Cornea
Alperen Bahar, Gökhan Pekel
PURPOSE: To investigate the effects of the light intensity of the recording room where eye examinations are conducted on the evaluation of lens and corneal clarity. METHOD: This cross-sectional and comparative study used 63 eyes of 32 participants. Corneal and lenticular optical densitometries, pachymetry, corneal volume, anterior segment volume, and anterior chamber depth measurements were taken with the Scheimpflug imaging system when the lights in the recording room were on (80 lux) and off (3 lux)...
November 5, 2019: Cornea
Sunita Chaurasia, Muralidhar Ramappa, Mohini Annapurna, Chitra Kannabiran
PURPOSE: To evaluate parents of probands affected with autosomal recessive congenital hereditary endothelial dystrophy (CHED) for clinical signs of Fuchs endothelial corneal dystrophy (FECD) and to determine the genotypes of the SLC4A11 gene in the probands and their parents. METHODS: This study involved 9 patients affected with CHED from 8 families. The parents of such probands were examined to investigate for possible signs of FECD although they did not present with any visual complaints...
November 5, 2019: Cornea
Majid Moshirfar, Anisha N Somani, Uma Vaidyanathan, Yasmyne C Ronquillo, Phillip C Hoopes
PURPOSE: To report a case of pressure-induced interlamellar stromal keratitis (PISK) after small-incision lenticule extraction (SMILE) for the correction of myopic astigmatism in the United States. METHODS: We report the case of a 27-year-old man who underwent uneventful SMILE surgery and presented with pressure-induced stromal keratitis. Anterior and posterior segment examination, uncorrected distance visual acuity, refraction, intraocular pressure, and pachymetry values are reported from this time period...
October 30, 2019: Cornea
Joanne Ho, Hoon Jung, Michael Banitt
PURPOSE: This study compares endothelial cell loss (ECL) between donor grafts loaded in the Geuder Glass Cannula and the Coronet EndoGlide made specifically for Descemet membrane endothelial keratoplasty (DMEK). METHODS: Prestripped tissues using the submerged cornea using backgrounds away (SCUBA) technique were obtained from an eye bank. Donor grafts were loaded with the Geuder Glass Cannula or Coronet DMEK EndoGlide. Grafts were then ejected directly onto a glass slide, stained, and imaged with confocal fluorescent microscopy...
October 30, 2019: Cornea
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