journal
https://read.qxmd.com/read/38588437/morphological-differentiation-of-corneal-inflammatory-cells-proposal-of-pragmatic-protocol
#1
JOURNAL ARTICLE
Fynn Schmitz, Rafael Klimas, Marie Spenner, Aurelian Schumacher, Alina Hieke, Tineke Greiner, Elena Enax-Krumova, Melissa Sgodzai, Miriam Fels, Jil Brünger, Sophie Huckemann, Philipp Stude, Martin Tegenthoff, Ralf Gold, Jörg Philipps, Anna Lena Fisse, Thomas Grüter, Kalliopi Pitarokoili, Jeremias Motte, Dietrich Sturm
PURPOSE: Corneal confocal microscopy is a noninvasive imaging technique to analyze corneal nerve fibers and corneal inflammatory cells (CICs). The amount of CICs is a potential biomarker of disease activity in chronic autoinflammatory diseases. To date, there are no standardized criteria for the morphological characterization of CICs. The aim was to establish a protocol for a standardized morphological classification of CICs based on a literature search and to test this protocol for applicability and reliability...
April 4, 2024: Cornea
https://read.qxmd.com/read/38563551/is-meibomian-gland-dysfunction-one-disease-heterogeneity-among-phenotypes
#2
JOURNAL ARTICLE
Colin K Kim, Elyana V T Locatelli, Amanda Prislovsky, Kimberly Cabrera, Ashlyn A Gary, Nawajes Mandal, Anat Galor
PURPOSE: The purpose of this study was to examine ocular surface symptoms, tear metrics, and tear cytokines by Meibomian gland dysfunction (MGD) features. METHODS: Symptom questionnaires and an ocular surface evaluation were performed on 40 individuals with varied MGD signs [Meibomian gland (MG) plugging, eyelid vascularity, meibum quality, and MG dropout]. Tear proteins were extracted off Schirmer strips and analyzed for 23 human inflammation-related proteins. Statistical analysis was performed to examine associations between dry eye metrics inflammatory proteins and MGD features...
April 2, 2024: Cornea
https://read.qxmd.com/read/38561842/changes-in-posterior-cornea-and-posterior-to-anterior-curvature-radii-ratio-1-year-after-lasik-prk-and-smile-treatment-of-myopia
#3
JOURNAL ARTICLE
Majid Moshirfar, David S Cha, Jordan M Santos, Michael S Herron, Phillip C Hoopes
PURPOSE: The purpose of this study was to compare changes in the posterior curvature and the posterior-anterior radii ratio of the cornea, 1 year postoperatively in laser in situ keratomileusis (LASIK), photorefractive keratectomy (PRK), and small incision lenticule extraction (SMILE). METHODS: This retrospective study was performed at a single surgical center. 199 eyes were included in the study from 119 patients with manifest refraction spherical equivalents from -7...
April 2, 2024: Cornea
https://read.qxmd.com/read/38557940/descemet-membrane-endothelial-keratoplasty-with-and-without-graft-deswelling-a-prospective-clinical-study
#4
JOURNAL ARTICLE
Johannes Menzel-Severing, Jennifer Prues-Hölscher, Lukas Jürgens, Gerd Geerling
PURPOSE: The purpose of this study was to assess whether omission of dextran from corneal organ culture medium alters the outcome of Descemet membrane endothelial keratoplasty. METHODS: Participation in this single-center, multisurgeon, prospective, randomized, comparative clinical trial was offered to patients scheduled for Descemet membrane endothelial keratoplasty between April 2020 and May 2022. Patients received grafts from corneas deswollen in organ culture medium-containing 6% dextran T-500 or from corneas that were not deswollen...
March 28, 2024: Cornea
https://read.qxmd.com/read/38557435/examining-tear-film-dynamics-using-the-novel-tear-film-imager
#5
JOURNAL ARTICLE
Simran Mangwani-Mordani, Drew Baeza, Kelly Acuna, Gal Antman, Alon Harris, Anat Galor
PURPOSE: The purpose of this study was to examine Tear Film Imager (TFI, AdOM, Israel) generated parameters across controls and dry eye (DE) subgroups and examine the changes in TFI parameters with contact lens (CL) placement. METHODS: The retrospective study (n = 48) was conducted at the Miami Veterans Hospital. Symptoms were assessed through validated questionnaires and signs of tear function by tear break-up time and Schirmer scores. Participants were grouped as 1) healthy, 2) evaporative, 3) aqueous deficient, and 4) mixed DE based on tear function...
March 28, 2024: Cornea
https://read.qxmd.com/read/38537133/analysis-of-graft-detachments-and-re-bubblings-after-450-descemet-membrane-endothelial-keratoplasty-procedures
#6
JOURNAL ARTICLE
Louise Massia Menkene, Tim Berger, Tarek Safi, Loïc Hamon, Cristian Munteanu, Berthold Seitz, Loay Daas
PURPOSE: To objectify the indication for re-bubbling by analyzing graft detachments (GDs) after Descemet membrane endothelial keratoplasty. METHODS: In this retrospective monocentric observational study, re-bubbling cases of 450 Descemet membrane endothelial keratoplasties and the percentage of the residual gas filling (RGF) in the anterior chamber on the first postoperative day were collected. The number/location/extent of GDs and the corneal thickness above GDs were analyzed using anterior segment optical coherence tomography...
March 27, 2024: Cornea
https://read.qxmd.com/read/38537076/clinical-outcomes-in-patients-with-traumatic-dehiscence-of-penetrating-keratoplasty-grafts
#7
JOURNAL ARTICLE
Jason Fan, Julia L Hudson, Akaanksh Shetty, Rahul Tonk, Harry W Flynn
PURPOSE: The purpose of this study was to report clinical characteristics and outcomes of surgical repair for patients with traumatic dehiscence of penetrating keratoplasty (PKP) grafts. METHODS: Retrospective, consecutive chart review of patients evaluated at Bascom Palmer Eye Institute between 2015 and 2020 with traumatic dehiscence of penetrating keratoplasty grafts. RESULTS: The study cohort consisted of 65 eyes of 65 patients. The mean age at presentation was 72 years (SD 18), with a male predominance (65%)...
March 27, 2024: Cornea
https://read.qxmd.com/read/38537067/conventional-epithelial-off-corneal-crosslinking-in-patients-with-progressive-keratoconus-10-year-outcomes
#8
JOURNAL ARTICLE
Jérémy Bordais, Myriam Cassagne, David Touboul, Valentine Saunier, Jacqueline Butterworth, François Malecaze, Vincent Soler, Pierre Fournié
PURPOSE: Corneal crosslinking (CXL) is the standard treatment of progressive keratoconus (KC). We evaluated the safety and 10-year outcomes of conventional "epithelial-off" CXL for progressive KC for the first time in a cohort in France. METHODS: We conducted a retrospective review of patients undergoing conventional CXL (Dresden protocol) in our tertiary ophthalmology department from 2006 to 2011 with 10-year follow-up. The primary outcome was change in preoperative versus postoperative keratometry measured by maximum keratometry (Kmax), steep keratometry (K2), flat keratometry (K1), mean keratometry (Km), and topographic cylinder...
March 27, 2024: Cornea
https://read.qxmd.com/read/38537127/response-to-letter-to-the-editor
#9
JOURNAL ARTICLE
Neel R Desai
No abstract text is available yet for this article.
March 26, 2024: Cornea
https://read.qxmd.com/read/38537125/efficacy-of-a-novel-antibiotic-drug-combination-toward-multidrug-resistant-ocular-pathogens
#10
JOURNAL ARTICLE
Lakshminarayanan Gowtham, Rachel A F Wozniak, Paul M Dunman, Esther Sheba, Prashant Garg, Joveeta Joseph
PURPOSE: Antimicrobial resistance is a global health threat, compounded by the reduction in the discovery of new antibiotics. A repurposed drugs-based approach could provide a viable alternative for the treatment of multidrug-resistant (MDR) bacterial infections. In this study, we sought to evaluate the in vitro efficacy of a novel drug combination, polymyxin B/trimethoprim (PT) + rifampin on MDR isolates from patients with bacterial keratitis in India. METHODS: Forty-three isolates, which included 20 Staphylococcus aureus, 19 Pseudomonas aeruginosa, 3 Pseudomonas stutzeri, and 1 Acinetobacter baumannii, were evaluated for their antibiotic resistance by minimum inhibitory concentration (MIC)...
March 26, 2024: Cornea
https://read.qxmd.com/read/38537111/letter-regarding-severity-classification-of-fuchs-endothelial-corneal-dystrophy-using-specular-or-confocal-microscopy
#11
JOURNAL ARTICLE
Alejandro Tello, Virgilio Galvis, Ruben D Berrospi, Andres G Marrugo, Fernando Quintero, Angélica M Prada, Lenny A Romero
No abstract text is available yet for this article.
March 26, 2024: Cornea
https://read.qxmd.com/read/38573840/topical-losartan-for-treating-corneal-haze-after-ultraviolet-a-riboflavin-collagen-cross-linking
#12
JOURNAL ARTICLE
Emily Grace Rodgers, Zaina Al-Mohtaseb, Allison J Chen
PURPOSE: The purpose of this study was to report our first clinical experience using topical losartan for the treatment of severe corneal haze after epithelium-off corneal cross-linking (CXL). METHODS: A 20-year-old man presented with clinically significant corneal haze in the right eye 1 month following Ultraviolet-A/Riboflavin Epithelium-off Collagen CXL. Haze progressed to a deep stromal scar, and vision was 20/150 with no improvement on refraction, 60 days after CXL...
March 22, 2024: Cornea
https://read.qxmd.com/read/38527222/fusion-flanged-intrascleral-intraocular-lens-fixation-technique-simple-safe-efficient
#13
JOURNAL ARTICLE
Pratan Piyasoonthorn, Puntanarach Gacivut
PURPOSE: To develop a new, sutureless intrascleral intraocular lens (IOL) fixation technique based on the Yamane double-needle and Canabrava 4-flanged techniques. METHODS: The Fusion-Flanged technique involves using a 7-0 polypropylene suture loop threaded through the eyelets of the IOL. Afterward, both ends of the suture are passed outside the eye through a 27-gauge needle. This technique creates a single flange by joining the 2 suture ends through handheld cautery, and this flange is then embedded into the scleral tunnel to securely fix the IOL in place...
March 21, 2024: Cornea
https://read.qxmd.com/read/38507558/reply
#14
JOURNAL ARTICLE
Boris E Malyugin, Maxim Gerasimov, Svetlana Kalinnikova
No abstract text is available yet for this article.
March 19, 2024: Cornea
https://read.qxmd.com/read/38488642/immediate-impact-on-tear-osmolarity-following-the-application-of-different-ocular-lubricants-in-patients-experiencing-moderate-dry-eye-symptoms
#15
JOURNAL ARTICLE
Edwin Correa Muñoz, Andrea Ocampo Patiño, Daniel Jiménez Marín, Laura Martínez Cadavid, Laura Ortega Quiroga, Daniel Gonzalez Lopera, Jorge Hernando Donado Gómez
PURPOSE: This study addresses the growing concern of Dry Eye Disease (DED), which has become increasingly prevalent due to modern lifestyles characterized by prolonged screen usage, global warming, polypharmacy, and extended life expectancy. METHODS: Grounded in the Dry Eye Workshop II (DEWSII) diagnosis framework, the study focuses on DED as a multifactorial condition affecting the ocular surface's tear film homeostasis. The study evaluates the short-term impact of 5 commercially available ocular lubricants on disrupting the hyperosmolar environment and determine whether these lubricants can offer potential treatment benefits for DED...
March 15, 2024: Cornea
https://read.qxmd.com/read/38483828/demographic-characteristics-clinical-presentations-and-risk-factors-impacting-visual-outcomes-in-peripheral-ulcerative-keratitis
#16
JOURNAL ARTICLE
Rohan Bir Singh, Sarah Atta, Divya Srikumaran, Vishal Jhanji
PURPOSE: To assess the demographic characteristics, ophthalmic and systemic presentations, and risk factors impacting the outcomes in patients diagnosed with peripheral ulcerative keratitis (PUK). METHODS: This retrospective study includes patients diagnosed with PUK at a tertiary care center over 13 years. A descriptive analysis of the demographics, clinical history, and presentation was performed. A reverse risk analysis was performed to assess the PUK resolution in patients with underlying autoimmune and non-autoimmune etiologies...
March 14, 2024: Cornea
https://read.qxmd.com/read/38478761/correlations-of-corneal-endothelial-morphology-and-corneal-thickness-with-anterior-segment-parameters-in-healthy-individuals
#17
JOURNAL ARTICLE
Efthymios Karmiris, Anastasia Tsiogka, Konstantinos Tsiripidis, Evangelia Papakonstantinou, Ilias Georgalas, Evangelia Chalkiadaki
PURPOSE: The purpose of this study was to investigate the associations between central corneal endothelial cell density (ECD), endothelial morphology, and corneal thickness (central corneal thickness) with the anterior chamber depth, corneal volume (CV), white-to-white (WTW) distance, mean anterior chamber angle (CAmean), and gender in healthy individuals. METHODS: This observational study included 136 healthy volunteers. The ECD, coefficient of variation of cell area, and hexagonal cell appearance ratio (%Hex) were measured by means of specular microscopy...
March 13, 2024: Cornea
https://read.qxmd.com/read/38478758/descemet-membrane-endothelial-keratoplasty-as-treatment-for-late-onset-interface-fluid-syndrome-after-laser-in-situ-keratomileusis
#18
JOURNAL ARTICLE
Marcela Huertas-Bello, Karen Sem, Diego E Alba, Kendall E Donaldson, Ellen H Koo
PURPOSE: We herein present Descemet membrane endothelial keratoplasty (DMEK) as an effective surgical means of treatment for the management of interface fluid syndrome (IFS) in a series of cases with distant history of laser in situ keratomileusis (LASIK). METHODS: Three cases from a single institution were included. All patients had documented IFS in the setting of history of LASIK. All 3 patients underwent DMEK for the treatment of IFS. Visual acuity, clinical findings, pachymetry, endothelial cell count, and anterior segment optical coherence tomography were recorded...
March 13, 2024: Cornea
https://read.qxmd.com/read/38478757/development-of-crystalline-corneal-opacities-steroid-keratopathy-in-dogs-after-treatment-with-ophthalmic-corticosteroids
#19
JOURNAL ARTICLE
Katelin R Quantz, Kamontip K Jongnarangsin, Christine D Harman, Kristin L Koehl, Amanda L Jacobson, Nambi Nallasamy, Gillian C Shaw, Christopher G Pirie, András M Komáromy
PURPOSE: To retrospectively evaluate and describe the relationship between the use of topical corticosteroids and the development of crystalline corneal opacities (steroid keratopathy) in a colony of research Beagles and Beagle-derived dogs. METHODS: Medical records of 73 purpose-bred Beagles and Beagle-derived dogs were reviewed from June 2012 to May 2021. All dogs were treated with topical ophthalmic corticosteroids for at least 21 days. In addition to regular ophthalmic examination, some dogs also had a systemic lipid profile (n = 6) performed to work up further and characterize the crystalline corneal opacities...
March 13, 2024: Cornea
https://read.qxmd.com/read/38478754/outcomes-of-simple-limbal-epithelial-transplantation-without-amniotic-membrane-grafting-in-unilateral-limbal-stem-cell-deficiency-a-case-series-of-6-patients
#20
JOURNAL ARTICLE
Neha Jain, Vikas Mittal, Dharma Sanandiya
PURPOSE: This study describes the technique of simple limbal epithelial transplantation (SLET) without amniotic membrane grafting (AMG) in limbal stem cell deficiency (LSCD). METHODS: Retrospective, interventional case series of 6 patients who underwent SLET without AMG were included. The procedure followed the standard technique, involving limbal biopsy from the healthy eye, resection of symblephera, and pannus dissection in the affected eye. Following host bed preparation, limbal explants were placed on the bare cornea and secured with fibrin glue...
March 13, 2024: Cornea
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