Tu M Tran, Huong Duong, Clemence Bonnet, Ashkan Kashanchi, Arjun Buckshey, Anthony J Aldave
PURPOSE: To describe the causes and prevalence of moderate-to-severe visual impairment (MSVI) and blindness from corneal diseases, as well as corneal transplantation across Asia. METHODS: A meta-analysis of the published literature to identify population-based surveys conducted from 2008 to 2019 in 22 Asian countries regarding the prevalence and causes of MSVI and blindness from corneal disease, and a review of national corneal transplant data and eye bank statistics...
June 4, 2020: Cornea
Albert Y Cheung, Enrica Sarnicola, Medi Eslani, Elizabeth Wright, Jens Goebel, David K Hooper, Amit Govil, Khaliq H Kurji, Edward J Holland
PURPOSE: To describe the outcomes of allograft ocular surface stem cell transplantation (OSST) and the complication profile of systemic immunosuppression (SI) in pediatric patients with limbal stem cell deficiency. METHODS: This was a retrospective interventional case series from a single tertiary referral institution of 20 eyes from 13 patients who 1) underwent allograft OSST surgery, 2) were 18 years or less at time of OSST, and 3) received SI with 4) a minimum of 12-months follow-up...
June 4, 2020: Cornea
Payton M Boere, Clemence Bonnet, Ricardo F Frausto, Simon S M Fung, Anthony J Aldave
PURPOSE: To investigate the presence of pre-Descemet corneal dystrophy (PDCD) in association with X-linked ichthyosis (XLI) in an 11-year-old boy using multimodal imaging and genetic analysis. METHODS: Corneal opacities were examined and imaged with slit-lamp biomicroscopy, anterior segment optical coherence tomography, noncontact specular microscopy, and in vivo confocal microscopy. Cytogenomic array analysis was performed using genomic DNA isolated from the patient...
June 1, 2020: Cornea
Doowon Huh, Khoa D Tran, Megan M W Straiko, Matthew W McCarthy, Angela S Loo, Thomas J Walsh, Christopher S Sales
PURPOSE: To investigate the antimycotic activity of amphotericin B deoxycholate that has been previously frozen for 28 days before supplementation of Optisol-GS. METHODS: Triplicate Optisol-GS samples were inoculated with 10 colony-forming units (CFU) of Candida albicans. Each set of triplicate cultures was supplemented with 2.5 μg/mL of amphotericin B that was either freshly resuspended and never frozen, frozen overnight at -20°C and thawed, or frozen at -20°C for 4 weeks and thawed...
June 1, 2020: Cornea
Daniel L Kornberg, Saira Prabhu, Christopher S Sales, Ryan S Williams, Jameson Clover, Khoa D Tran
PURPOSE: To ascertain whether offsetting the Descemet membrane endothelial keratoplasty (DMEK) punch can expand the donor pool in conjunction with prepunched and preloaded services by recapturing the corneas otherwise excluded by the conventional central clear zone criteria. METHODS: In this retrospective review of corneas recovered and processed for DMEK by a single eye bank between March 2017 and October 2018, corneas failing to meet the conventional central clear zone requirement during initial evaluation (defined as an area in the central cornea where an 7...
June 1, 2020: Cornea
Yi Wei Goh, Akilesh Gokul, Mohammad E Yadegarfar, Hans Vellara, William Shew, Dipika Patel, Charles N J McGhee, Mohammed Ziaei
PURPOSE: Keratoconus progression should be treated with corneal cross-linking (CXL) in a timely manner. This study aimed to investigate patient factors associated with keratoconus progression between time of listing and at time of CXL. METHODS: Prospective observational study at a tertiary center. Ninety-six eyes of 96 patients with keratoconus. Demographic, clinical, and tomographic parameters were analyzed to determine the risk factors for keratoconus progression...
June 1, 2020: Cornea
Megan M Tuohy, Leslie M Niziol, Shazhad I Mian, Dena Ballouz, David Bosch, Maria A Woodward
PURPOSE: The aim of this investigation was to study the patient-reported outcomes of patients with microbial keratitis (MK) using the 9-item National Eye Institute-Visual Function Questionnaire (NEI VFQ-9). METHODS: Using the Sight Outcomes Research Collaborative ophthalmology electronic health record repository, patients with MK and control patients who completed the NEI VFQ-9 within 7 days of their appointment were identified. The questionnaire is scored as a mean of the 9 items on a scale from 0 to 100, with higher scores indicating better functioning...
June 1, 2020: Cornea
Kanae Kayukawa, Koji Kitazawa, Koichi Wakimasu, Sanjay V Patel, John Bush, Chie Sotozono, Shigeru Kinoshita
PURPOSE: To investigate the key factors associated with eyes with an endothelial cell density (ECD) of ≥2000 cells/mm at 5 years after corneal transplantation. METHODS: This retrospective cohort study included 174 eyes that underwent penetrating keratoplasty by 1 corneal specialist surgeon at the Baptist Eye Institute, Kyoto, Japan, from 1998 through 2011 and that were carefully followed for over 5 years postoperative. In all operated eyes, corneal ECD was measured at 1, 2, 3, 4, and 5 years postoperative...
May 29, 2020: Cornea
Alfred Basilious, Simon S M Fung, Asim Ali
PURPOSE: To describe the presentation and management of limbal stem cell dysfunction in ichthyosis follicularis, alopecia, and photophobia (IFAP) syndrome. METHODS: A retrospective case report. RESULTS: A 6-day-old male infant was diagnosed with IFAP syndrome based on family history and a mutation detected in the MBTPS2 gene. Initial examination showed hyperkeratotic eyelids, madarosis, and lagophthalmos, but otherwise clear corneas. He developed bilateral central corneal epithelial defects spontaneously 6 months later, which were managed with aggressive lubrication, prophylactic antibiotics, and bilateral permanent lateral tarsorrhaphies at 7 months of age...
May 29, 2020: Cornea
Sibel Ozdogan, Cigdem Sonmez, Demet Yolcu, Mustafa Gungormus
PURPOSE: Opiorphin is an endogenous inhibitor of enkephalin-degrading enzymes. It has a strong analgesic effect in chemical and mechanical pain models. We aimed to evaluate the tear opiorphin levels in ocular pain caused by corneal foreign bodies and demonstrate whether there is any correlation with pain levels obtained from the Visual Analog Scale (VAS) score and tear opiorphin level. METHODS: Thirty-two healthy individuals and 34 individuals diagnosed with corneal foreign bodies were included in this study...
May 29, 2020: Cornea
Marcello N Colombo-Barboza, Luiz R Colombo-Barboza, Maria Margarida N Colombo-Barboza, Guilherme N Colombo-Barboza
PURPOSE: To compare laser in situ keratomileusis flaps created at the programmed target thickness of 120 μm using the LenSx multifunctional and the FS200 single-functional femtosecond lasers as evaluated by anterior segment optical coherence tomography (AS-OCT). METHODS: This was a prospective, comparative, consecutive, blinded, nonrandomized study. Patients with stable refraction for over a year were consecutively allocated to the LenSx group or the FS200 group (n = 66; 33 patients in each group)...
May 29, 2020: Cornea
Karen L Christopher, Christopher T Hood, Shahzad I Mian, Bernadete Ayres
PURPOSE: To evaluate clinical and ultrasonographic findings associated with advanced microbial keratitis with concurrent endophthalmitis. METHODS: We performed a retrospective analytical study of patients with severe microbial keratitis who underwent ocular ultrasonography for possible endophthalmitis at our institution over a 5-year period. Ocular and medical history, ocular examination findings, microbiology results, and ultrasonographic features were collected...
May 29, 2020: Cornea
Pelin Kiyat, Melis Palamar, Bengu Gerceker Turk, Ayse Yagci
PURPOSE: To evaluate dry eye and quantitative and qualitative changes of meibomian glands with meibography in patients with pemphigus. METHODS: Twenty left eyes of 20 patients with pemphigus (group 1) and 20 left eyes of 20 age- and sex-matched healthy volunteers (group 2) were enrolled. Dry eye was evaluated with Oxford scale scoring, tear film breakup time, Schirmer 1 tests, and Ocular Surface Disease Index score assessments. Morphological changes and dropout ratio of meibomian glands were evaluated by upper and lower eyelid meibography (SL-D701; Topcon, IJssel, The Netherlands)...
May 29, 2020: Cornea
Swati Singh, Sayan Basu
No abstract text is available yet for this article.
May 29, 2020: Cornea
Austin S Nakatsuka, Mark D Mifflin
No abstract text is available yet for this article.
May 29, 2020: Cornea
Hye Jee Kim, Jin Hyoung Park
PURPOSE: To evaluate the clinical efficacy and safety of immediate manual meibomian gland expression (MGX) after LipiFlow thermal pulsation (TearScience Inc, Morrisville, NC) for obstructive meibomian gland dysfunction and to compare the LipiFlow only and MGX after LipiFlow. METHODS: Patients who underwent immediate manual MGX after LipiFlow or who received only LipiFlow treatment were included. Thirty eyes from 15 patients were enrolled in each group. All patients underwent 3 treatments at monthly intervals...
May 28, 2020: Cornea
Yvonne Wang, Jimena Tatiana Carreno-Galeano, Rohan Bir Singh, Reza Dana, Jia Yin
PURPOSE: To evaluate the long-term outcomes of surgical occlusion of lacrimal puncta using thermal cautery in the management of ocular surface diseases. METHODS: We reviewed medical records of 80 consecutive patients from a single academic center who underwent punctal cauterization. Patient demographics, ocular history, symptoms, and signs of ocular surface diseases pre- and post-cauterization were recorded. RESULTS: A total of 80 patients (171 puncta) were included, with an average age of 59 years and a follow-up duration of 27 months...
May 27, 2020: Cornea
Pere Català, Wessel Vermeulen, Timo Rademakers, Antoon van den Bogaerdt, Pieter Jan Kruijt, Rudy M M A Nuijts, Vanessa L S LaPointe, Mor M Dickman
PURPOSE: This study compares the effect of the transport of conventionally prestripped Descemet membrane endothelial keratoplasty (DMEK) tissue with the DMEK revolutionary advanced Preloadable Injection Device (RAPID) preloaded transport system from Geuder AG (Heidelberg, Germany). Endothelial cell loss, tissue integrity, endothelial cell phenotype, and viability were assessed and compared. METHODS: Twelve DMEK grafts were prestripped by the cornea bank and transported using the following 2 conditions: conventional flask (n = 6) or a preloaded transport cartridge (DMEK RAPID, n = 6)...
May 27, 2020: Cornea
Myrsini Petrelli, Judith Cohen, Kattayoon Hashemi, Michael A Grentzelos, George D Kymionis
PURPOSE: To report an unusual case of a patient with keratoconus and acute hydrops complicated with corneal perforation and describe its management using a new surgical approach. METHODS: A case report and new surgical approach description. RESULTS: A 47-year-old female patient with a history of keratoconus and implantable contact lens surgery presented at our institute with symptoms of acute corneal hydrops in her right eye. On examination, best corrected visual acuity was of counting fingers in the involved eye...
May 25, 2020: Cornea
Eva Vanhonsebrouck, Mieke Van De Walle, Willem Lybaert, Vibeke Kruse, Dimitri Roels
PURPOSE: To report the first case of corneal graft rejection presumably associated with pembrolizumab immunotherapy. METHODS: Case report and literature review. RESULTS: An asymptomatic 85-year-old woman with a history of bilateral penetrating keratoplasty presented for a follow-up visit with bilateral diffuse keratic precipitates and subepithelial infiltrates. There were no anterior chamber cells. Bilateral subclinical corneal graft rejection was suspected...
May 25, 2020: Cornea
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