Timur Tug, Julia C Duda, Max Menssen, Shannon Wilson Bruce, Frank Bringezu, Martina Dammann, Roland Frötschl, Volker Harm, Katja Ickstadt, Bernd-Wolfgang Igl, Marco Jarzombek, Rupert Kellner, Jasmin Lott, Stefan Pfuhler, Ulla Plappert-Helbig, Jörg Rahnenführer, Markus Schulz, Lea Vaas, Marie Vasquez, Verena Ziegler, Christina Ziemann
The alkaline comet assay is frequently used as in vivo follow-up test within different regulatory environments to characterize the DNA-damaging potential of different test items. The corresponding OECD Test guideline 489 highlights the importance of statistical analyses and historical control data (HCD) but does not provide detailed procedures. Therefore, the working group "Statistics" of the German-speaking Society for Environmental Mutation Research (GUM) collected HCD from five laboratories and >200 comet assay studies and performed several statistical analyses...
February 22, 2024: Regulatory Toxicology and Pharmacology: RTP