Nancy R Newlin, Michael E Kim, Praitayini Kanakaraj, Tianyuan Yao, Timothy Hohman, Kimberly R Pechman, Lori L Beason-Held, Susan M Resnick, Derek Archer, Angela Jefferson, Bennett A Landman, Daniel Moyer
Data harmonization is necessary for removing confounding effects in multi-site diffusion image analysis. One such harmonization method, LinearRISH, scales rotationally invariant spherical harmonic (RISH) features from one site ("target") to the second ("reference") to reduce confounding scanner effects. However, reference and target site designations are not arbitrary and resultant diffusion metrics (fractional anisotropy, mean diffusivity) are biased by this choice. In this work we propose MidRISH: rather than scaling reference RISH features to target RISH features, we project both sites to a mid-space...
March 25, 2024: Magnetic Resonance Imaging