journal
https://read.qxmd.com/read/37840527/polypathology-associated-neurodegeneration-after-remote-head-injury
#21
JOURNAL ARTICLE
Declan Brennan, Conor Delaney, Michael Farrell, Matthew Campbell, Colin P Doherty
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality worldwide. TBI ranges from mild to severe and is a recognized risk factor for later neurodegenerative conditions including chronic traumatic encephalopathy (CTE), Alzheimer disease (AD) and Parkinson disease (PD). The development of CTE is typically associated with repetitive exposure to mild TBI (mTBI), while a single moderate-to-severe TBI is considered a risk factor for AD and PD. Polypathology is common, and the lines between these conditions post TBI can be somewhat blurred...
2023: Clinical Neuropathology
https://read.qxmd.com/read/37840526/pick-s-disease-presenting-with-corticobasal-syndrome-a-case-report-and-clinicopathological-review
#22
REVIEW
Yuanyuan Gu, Qi Zhang, Stephen H Pasternak, Lee Cyn Ang
Pick's disease (PiD) is a rare form of frontal temporal lobar degeneration. The pathognomonic feature is atrophy of the frontotemporal lobes and intraneuronal deposits of 3R-τ inclusions, the Pick body. Corticobasal syndrome (CBS) is an atypical parkinsonian syndrome with a heterogeneous spectrum of underlying pathologies. We report a case of clinically diagnosed CBS with a post-mortem diagnosis of PiD and conduct a clinicopathological review of the literature on this unusual presentation.
2023: Clinical Neuropathology
https://read.qxmd.com/read/37489069/cerebral-amyloid-angiopathy-neuropathological-diagnosis-link-to-alzheimer-s-disease-and-impact-on-clinics
#23
JOURNAL ARTICLE
Dietmar Rudolf Thal, Klara Gawor
Cerebral amyloid angiopathy (CAA) is the most frequent cause of lobar hemorrhages in the brains of elderly individuals. It is characterized by the deposition of amyloidogenic proteins in the vessel wall of leptomeningeal and/or intracerebral blood vessels. Different proteins can cause CAA. Most frequently, the amyloid β protein (Aβ) is found to be deposited in CAA and indicates a link to Alzheimer's disease, because Aβ is known to be deposited in amyloid plaques characteristic of Alzheimer's disease...
2023: Clinical Neuropathology
https://read.qxmd.com/read/37341021/clinical-neuropathology-4-2023
#24
EDITORIAL
Christian Mawrin
No abstract text is available yet for this article.
2023: Clinical Neuropathology
https://read.qxmd.com/read/37078385/clinical-neuropathology-3-2023
#25
EDITORIAL
Christian Mawrin
No abstract text is available yet for this article.
2023: Clinical Neuropathology
https://read.qxmd.com/read/37073958/expression-of-pannexin1-in-lung-cancer-brain-metastasis-and-immune-microenvironment
#26
JOURNAL ARTICLE
Rober Abdo, Abdulaziz Bholat, Linda Jackson-Boeters, Danielle Johnston, Silvia Penuela, Qi Zhang
Brain metastases are the most common central nervous system malignancy, and the leading cause of cancer-related deaths. Non-small cell lung carcinomas (NSCLC) comprise the most common cell of origin. Immunotherapy, particularly checkpoint inhibitors, has emerged as the standard of care for many patients with advanced lung cancer. Pannexin1 (PANX1) is a transmembrane glycoprotein that forms large-pore channels and has been reported to promote cancer metastasis. However, the roles of PANX1 in lung cancer brain metastases and tumor immune microenvironment have not been characterized...
2023: Clinical Neuropathology
https://read.qxmd.com/read/36999511/update-on-quality-assurance-in-neuropathology-summary-of-the-round-robin-trials-on-tert-promoter-mutation-h3-3a-mutation-1p-19q-codeletion-and-kiaa1549-braf-fusion-testing-in-germany-in-2020-and-2021
#27
JOURNAL ARTICLE
Sandra Pohl, Lora Dimitrova, Maja Grassow-Narlik, Korinna Jöhrens, Till Acker, Hildegard Dohmen, Jochen Herms, Mario Dorostkar, Christian Hartmann, Martin Hasselblatt, Manuela Neumann, Guido Reifenberger, Jörg Felsberg, Ulrich Schüller, Saida Zoubaa, Julia Lorenz, Tanja Rothhammer-Hampl, Katrin Mauch-Mücke, Markus J Riemenschneider
We previously reported on the first neuropathological round robin trials operated together with Quality in Pathology (QuIP) GmbH in 2018 and 2019 in Germany, i.e., the trials on IDH mutational testing and MGMT promoter methylation analysis [1]. For 2020 and 2021, the spectrum of round robin trials has been expanded to cover the most commonly used assays in neuropathological institutions. In addition to IDH mutation and MGMT promoter methylation testing, there is a long tradition for 1p/19q codeletion testing relevant in the context of the diagnosis of oligodendroglioma...
2023: Clinical Neuropathology
https://read.qxmd.com/read/36999509/what-neuropathology-teaches-us-about-autoimmune-encephalitides-autoimmune-epilepsies-and-encephalomyelitides
#28
JOURNAL ARTICLE
Christian G Bien, Jan Bauer
Delineation of the autoimmune encephalitides with antibodies against neural surface antigens (anti- N -Methyl-D-aspartate, anti-leucine-rich glioma-inactivated protein 1, and others), autoimmune-associated epilepsies (Rasmussen encephalitis, paraneoplastic encephalitides, temporal lobe epilepsy with antibodies against glutamic acid decarboxylase), and encephalomyelitides with glial antibodies (neuromyelitis optica spectrum disorder, myelin oligodendrocyte glycoprotein antibody disease) has been a major advance in neurology...
2023: Clinical Neuropathology
https://read.qxmd.com/read/36970952/brain-biopsy-in-neurological-disease-of-unknown-etiology-a-single-center-12-year-retrospective-analysis
#29
JOURNAL ARTICLE
Andrew Lockhart, Josephine Heffernan, Ann Kennedy, Andrea Walsh, Ciara Heeney, Rosa Cheung, Rachel Howley, Jane Cryan, Alan Beausang, Michael Farrell, Francesca Brett
There are no international guidelines for brain biopsy in neurological disease of unknown etiology, yet most practicing neurologists will encounter difficult cases in which biopsy is considered. This patient cohort is heterogenous, and it is unclear in which circumstances biopsy is most useful. We performed an audit of brain biopsies reviewed in our neuropathology department from 2010 to 2021. Of 9,488 biopsies, 331 biopsies undertaken for an undiagnosed neurological disease were identified. Where documented, the commonest symptoms were hemorrhage, encephalopathy, and dementia...
2023: Clinical Neuropathology
https://read.qxmd.com/read/36708209/some-cns-sarcomas-seen-a-22-year-series
#30
REVIEW
Bette K Kleinschmidt-DeMasters, Ahmed Gilani
AIMS: Central nervous system (CNS) and spine are seldom impacted by primary or metastatic sarcomas. We reviewed our 22-year experience with metastatic versus primary mesenchymal sarcomas in adults versus pediatric patients, additionally asking how many might today undergo nomenclature changes using CNS World Health Organization, 5th edition criteria. MATERIALS AND METHODS: Case identification via text word search of pathology databases from our adult and pediatric referral hospitals, 2000 to August 2022, with exclusion of peripheral nervous system and primary chondro-osseous and notochordal tumors...
2023: Clinical Neuropathology
https://read.qxmd.com/read/36633374/pediatric-brain-tumors-origins-epidemiology-and-classification-the-2022-brain-tumor-epidemiology-consortium-meeting-report
#31
JOURNAL ARTICLE
Kimberly J Johnson, Luc Bauchet, Stephen S Francis, Johannes A Hainfellner, Carol Kruchko, Ching C Lau, Quinn T Ostrom, Michael E Scheurer, Yan Yuan
The Brain Tumor Epidemiology Consortium (BTEC) is an international organization that fosters collaboration among scientists focused on understanding the epidemiology of brain tumors with interests ranging from the etiology of brain tumor development and outcomes to the control of morbidity and mortality. The 2022 annual BTEC meeting with the theme "Pediatric Brain Tumors: Origins, Epidemiology, and Classification" was held in Lyon, France on June 20 - 22, 2022. Scientists from North America and Europe presented recent research and progress in the field...
2023: Clinical Neuropathology
https://read.qxmd.com/read/36366964/recurrent-high-grade-astroblastoma-with-mn1-bend2-fusion-in-spinal-cord-and-literature-review
#32
REVIEW
Dongjin Sun, Jing Liu, Liling Xiao, Hong Guan
Astroblastoma is an uncommon tumor of the central nervous system. It is variable in morphology, but the astroblastic pseudorosettes and vascular hyalinization are the most important features. Most astroblastomas occur in the cerebral hemisphere. We report a recurrent high-grade astroblastoma with MN1-BEND2 fusion in the spinal cord. Two lesions were found in the T5-7 level and T12-L1 level, and they were well defined in images. Rhabdoid and signet-ring-like cells were observed. It may be classified as a high-grade tumor due to cellularity, high mitotic count, and pleomorphism...
2023: Clinical Neuropathology
https://read.qxmd.com/read/36366963/colloid-cyst-with-hyphal-like-structures-a-rarity-that-mimics-actinomycosis-of-athe-third-ventricle
#33
JOURNAL ARTICLE
Dirar Aldabek, Martina Deckert, Christian Mawrin, Jan-Peter Warnke
Colloid cysts are histologically well defined and consist of three main components, a capsule, with an underlying epithelial layer, and a mucinous heart. In our case, we present a 35-year-old female with acute deterioration of level of consciousness. An emergent CT scan showed a cystic lesion occluding the intraventricular foramen. The lesion was endoscopically excised through a transfrontal approach. Microscopic examination of the resected specimen revealed hyphal-like structures (HLS). This rare finding was first described by Dodds and Powers in 1977 and, in its microscopic nature, it mimics actinomyces of the third ventricle...
2023: Clinical Neuropathology
https://read.qxmd.com/read/36519936/clinical-neuropathology-1-2023
#34
JOURNAL ARTICLE
Christian Mawrin
No abstract text is available yet for this article.
December 15, 2022: Clinical Neuropathology
https://read.qxmd.com/read/36472392/clinical-raman-spectroscopy-of-brain-tumors-from-an-interdisciplinary-perspective
#35
JOURNAL ARTICLE
Roberta Galli, Tareq A Juratli, Ortrud Uckermann
Raman spectroscopy is an optical technology that probes tissue composition and is envisioned for clinical applications in neurosurgery. Here, we provide an overview of basic and translational research addressing brain tumor delineation and diagnosis and identify potential scenarios for routine clinical use of Raman spectroscopy. Moreover, we discuss the practical technical requirements in the context of daily use as well as open questions regarding automated tissue assessment.
December 6, 2022: Clinical Neuropathology
https://read.qxmd.com/read/36472391/clasmatodendrosis-brief-review-of-an-underreported-neuropathological-finding
#36
JOURNAL ARTICLE
Sumit Das
No abstract text is available yet for this article.
December 6, 2022: Clinical Neuropathology
https://read.qxmd.com/read/36458450/neuropathological-features-of-adult-onset-neuronal-intranuclear-inclusion-disease-with-fluid-attenuated-inversion-recovery-high-intensity-signals-in-the-cerebellar-paravermal-area-from-an-early-stage-a-case-report
#37
JOURNAL ARTICLE
Taku Homma, Utako Nagaoka, Yasuhiro Nakata, Jun Sone, Asuka Funai, Aki Murayama, Cisato Tamai, Takashi Komori, Kazushi Takahashi
Neuronal intranuclear inclusion disease (NIID) is a neurological disorder characterized by eosinophilic intranuclear inclusions (INI) in systemic organs and various cell types. High-intensity signals along the corticomedullary junction on diffusion-weighted imaging and presence of cellular p62-INI in skin biopsy are known indicators for NIID. Furthermore, GGC repeat expansion in NOTCH2NLC is a characteristic genetic alteration in patients with NIID. This report presents the clinical and detailed pathological features of a male older adult with NIID...
December 2, 2022: Clinical Neuropathology
https://read.qxmd.com/read/36305103/clinical-neuropathology-6-2022
#38
JOURNAL ARTICLE
Christian Mawrin
No abstract text is available yet for this article.
October 28, 2022: Clinical Neuropathology
https://read.qxmd.com/read/36278300/distal-hereditary-neuropathy-associated-with-a-novel-mutation-in-alanyl-aminoacyl-trna-synthetase
#39
JOURNAL ARTICLE
Yuan Yuan, Daojun Hong, Xuguang Gao, Jun Zhang
To report a new genetic cause of distal hereditary motor neuropathy (dHMN), which is likely associated with worsening during pregnancy. We collected the clinical data of a patient with severe weakness of the lower limbs induced by repeated pregnancy and performed relevant experimental examinations, including neuromuscular electrophysiological examination, neuromuscular biopsy, and genetic testing. The patient reported weakness of the right lower extremity after delivery of the first child. Initially, the right foot was weak during lifting, and symptoms gradually progressed to weakness when landing on the toe during walking...
October 24, 2022: Clinical Neuropathology
https://read.qxmd.com/read/36278299/uncommon-histopathological-features-of-cytomegalovirus-encephalitis-and-measles-inclusion-body-encephalitis-on-autopsy-in-two-patients-with-primary-immunodeficiency
#40
JOURNAL ARTICLE
Ankur Jindal, Deepti Suri, Kirti Gupta, Ashwani Kumar, Vignesh Pandiarajan, Rakesh Kumar Pilania, Sandesh Guleria, Amit Rawat, Sameer Vyas, Anmol Bhatia, Surjit Singh, Bishan Dass Radotra
PURPOSE: To describe the neuropathological findings in two patients with primary immunodeficiency who had fatal viral encephalitis. MATERIALS AND METHODS: Severe combined immunodeficiency (SCID) was confirmed in case 1 by genetic testing, while case 2 had features suggestive of combined immunodeficiency; however, whole exome sequencing showed no pathogenic variants. Autopsies were performed in both cases after an informed consent. A detailed sampling of the brain including extracranial organs was conducted...
October 24, 2022: Clinical Neuropathology
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