journal
Journals Archives of Gerontology and Ge...

Archives of Gerontology and Geriatrics

https://read.qxmd.com/read/38878596/effect-of-aerobic-training-versus-resistance-training-for-improving-cardiorespiratory-fitness-and-body-composition-in-middle-aged-to-older-adults-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#1
REVIEW
Jianqun An, Zhanguo Su, Shangjie Meng
This systematic review and meta-analysis aimed to examine the influence of aerobic training (AT) versus resistance training (RT) on cardiorespiratory fitness and body composition in middle-aged to older adults. Four electronic databases including PubMed, Scopus, Cochrane CENTRAL, and web of science, as well as reference lists of included randomized controlled trials (RCTs) were searched from inception to April 2024. Data were pooled by the inverse-variance method and reported as mean differences (MDs) with 95 % confidence intervals (CIs)...
June 14, 2024: Archives of Gerontology and Geriatrics
https://read.qxmd.com/read/38878599/effects-of-pre-frailty-and-cognitive-reserve-on-mild-cognitive-impairment-among-community-dwelling-older-adults
#2
JOURNAL ARTICLE
Yanyan Li, Qinqin Liu, Huaxin Si, Wendie Zhou, Jiaqi Yu, Yanhui Bian, Cuili Wang
OBJECTIVE: We aimed to identify the effect of lifespan cognitive reserve and (pre)frailty on mild cognitive impairment (MCI) among older adults. MATERIALS AND METHODS: A total of 4420 older adults aged above 60 with intact cognition recruited in 2011/2012 were followed up in 2015 from the China Health and Retirement Longitudinal Study (CHARLS). The assessment of MCI was based on executive function, episodic memory, and visual-spatial ability. (Pre)frailty was assessed by the validated version of the Fried physical frailty phenotype scale...
June 12, 2024: Archives of Gerontology and Geriatrics
https://read.qxmd.com/read/38878598/effects-of-exercise-on-brain-derived-neurotrophic-factor-in-alzheimer-s-disease-models-a-systematic-review-and-meta-analysis
#3
REVIEW
Shiyan Zhang, Boya Gu, Kai Zhen, Liwen Du, Yuanyuan Lv, Laikang Yu
A growing body of research examining effects of exercise on brain-derived neurotrophic factor (BDNF) in Alzheimer's disease (AD) models, while due to differences in gender, age, disease severity, brain regions examined, and type of exercise intervention, findings of available studies were conflicting. In this study, we aimed to evaluate current evidence regarding effects of exercise on BDNF in AD models. Searches were performed in PubMed, Web of Science, Cochrane, and EBSCO electronic databases, through July 20, 2023...
June 12, 2024: Archives of Gerontology and Geriatrics
https://read.qxmd.com/read/38878597/volunteer-group-participation-and-subsequent-health-and-well-being-among-older-adults-in-japan-an-outcome-wide-longitudinal-approach
#4
JOURNAL ARTICLE
Motoki Tamura, Atsushi Nakagomi, Kazushige Ide, Katsunori Kondo, Toshiyuki Ojima, Tomo Takasugi, Koichiro Shiba
BACKGROUND: Prior studies have underscored the importance of studying volunteering in the East Asian context. However, no study has conducted a holistic assessment of the relationship between volunteering and the multidimensional health and well-being outcomes of East Asian populations using a strong study design for causal inference. To address this gap, this study examined the associations between volunteer group participation and the subsequent health and well-being of Japanese older adults...
June 12, 2024: Archives of Gerontology and Geriatrics
https://read.qxmd.com/read/38879349/editorial-correlates-of-loneliness-and-social-isolation-in-old-age
#5
EDITORIAL
André Hajek
No abstract text is available yet for this article.
June 11, 2024: Archives of Gerontology and Geriatrics
https://read.qxmd.com/read/38879348/editorial-health-related-quality-of-life-in-old-age
#6
EDITORIAL
André Hajek, Hans-Helmut König
No abstract text is available yet for this article.
June 11, 2024: Archives of Gerontology and Geriatrics
https://read.qxmd.com/read/38896974/combined-effects-of-genetic-predisposition-and-sleep-quality-on-acceleration-of-biological-ageing-findings-from-the-uk-biobank-cohort
#7
JOURNAL ARTICLE
Chenyu Zhao, Yongli Yang, Yuping Wang, Xiaocan Jia, Jingwen Fan, Nana Wang, Yacong Bo, Xuezhong Shi
OBJECTIVE: Genetic risks can accelerate ageing, yet better quality sleep may slow down it. We thus examined the interaction and combined effects of genetic predisposition and sleep quality on the risk of accelerate aging. METHODS: This study included 407,027 participants from the UK Biobank. Sleep index of each participant was retrieved from the following seven sleep behaviors: snoring, chronotype, daytime sleepiness, sleep duration, insomnia, nap and difficulties in getting up...
June 7, 2024: Archives of Gerontology and Geriatrics
https://read.qxmd.com/read/38878671/predictive-value-of-the-world-falls-guidelines-algorithm-within-the-ageless-melor-cohort
#8
JOURNAL ARTICLE
Soo Jin Sherry Lee, Maw Pin Tan, Sumaiyah Mat, Devinder Kaur Ajit Singh, Nor'Izzati Saedon, Kiirtaara Aravindhan, Xiang Jiang Xu, Kalavathy Ramasamy, Abu Bakar Abdul Majeed, Hui Min Khor
AIM: The World Falls Guidelines (WFG) Task Force published a falls risk stratification algorithm in 2022. However, its adaptability is uncertain in low- and middle-income settings such as Malaysia due to different risk factors and limited resources. We evaluated the effectiveness of the WFG risk stratification algorithm in predicting falls among community-dwelling older adults in Malaysia. METHODS: Data from the Malaysian Elders Longitudinal Research subset of the Transforming Cognitive Frailty into Later-Life Self-Sufficiency cohort study was utilized...
June 6, 2024: Archives of Gerontology and Geriatrics
https://read.qxmd.com/read/38878672/the-causal-relationship-between-sarcopenia-related-traits-and-ecg-indices-a-mendelian-randomization-study
#9
JOURNAL ARTICLE
Chunli Fu, Fei Yu, Xiangju Liu, Baoying Li, Xiaoli Li, Guangyu Zhang
BACKGROUND: Sarcopenia is a common geriatric condition closely associated with cardiovascular diseases and other health issues. This study aims to investigate the causal relationship between sarcopenia-related traits and electrocardiogram(ECG) indices. METHODS: We conducted a comprehensive analysis utilizing summary data from genome-wide association studies (GWAS) associated with sarcopenia-related traits, including hand grip strength, lean body mass, and walking pace...
June 5, 2024: Archives of Gerontology and Geriatrics
https://read.qxmd.com/read/38878595/effects-of-multimorbidity-and-polypharmacy-on-physical-function-in-community-dwelling-older-adults-a-3-year-prospective-cohort-study-from-the-sonic
#10
JOURNAL ARTICLE
Yuko Yoshida, Tatsuro Ishizaki, Yukie Masui, Yuri Miura, Kiyoaki Matsumoto, Takeshi Nakagawa, Hiroki Inagaki, Kae Ito, Yasumichi Arai, Mai Kabayama, Kei Kamide, Hiromi Rakugi, Kazunori Ikebe, Yasuyuki Gondo
BACKGROUND: We prospectively examined the effect of baseline multimorbidity and polypharmacy on the physical function of community-dwelling older adults over a three-year period. METHODS: The analysis included 1,401 older adults (51.5 % women) who participated in both wave 1 and wave 2 (3-year follow-up) of the Septuagenarians, Octogenarians, and Nonagenarians Investigation with Centenarians (SONIC) study. Grip strength and walking speed were binarized into poor/not poor physical function according to the frailty definition...
June 5, 2024: Archives of Gerontology and Geriatrics
https://read.qxmd.com/read/38861889/mitochondrial-quality-control-dysfunction-in-osteoarthritis-mechanisms-therapeutic-strategies-future-prospects
#11
REVIEW
Chiyuen Cheung, Shaoqin Tu, Yi Feng, Chuiming Wan, Hong Ai, Zheng Chen
Osteoarthritis (OA) is a prevalent chronic joint disease characterized by articular cartilage degeneration, pain, and disability. Emerging evidence indicates that mitochondrial quality control dysfunction contributes to OA pathogenesis. Mitochondria are essential organelles to generate cellular energy via oxidative phosphorylation and regulate vital processes. Impaired mitochondria can negatively impact cellular metabolism and result in the generation of harmful reactive oxygen species (ROS). Dysfunction in mitochondrial quality control mechanisms has been increasingly linked to OA onset and progression...
June 4, 2024: Archives of Gerontology and Geriatrics
https://read.qxmd.com/read/38851091/promoting-longevity-in-aged-liver-through-nlrp3-inflammasome-inhibition-using-tauroursodeoxycholic-acid-tudca-and-scd-probiotics
#12
JOURNAL ARTICLE
Burcu Baba, Taha Ceylani, Rafig Gurbanov, Eda Acikgoz, Seda Keskin, Hüseyin Allahverdi, Gizem Samgane, Huseyin Tombuloglu, Hikmet Taner Teker
This investigation explores the combined influence of SCD Probiotics and tauroursodeoxycholic acid (TUDCA) on liver health in elderly male Sprague-Dawley rats. Through the administration of intravenous TUDCA (300 mg/kg) and oral SCD Probiotics (3 mL at 1 × 10^8 CFU) daily for one week, this study evaluates the biomolecular composition, histopathological alterations, and inflammasome activity in the liver. Analytical methods encompassed ATR-FTIR spectroscopy integrated with machine learning for the assessment of biomolecular structures, RT-qPCR for quantifying inflammasome markers (NLRP3, ASC, Caspase-1, IL18, IL1β), and histological examinations to assess liver pathology...
June 3, 2024: Archives of Gerontology and Geriatrics
https://read.qxmd.com/read/38876081/depends-on-whom-you-ask-discordance-in-reporting-spousal-care-between-older-women-and-men-across-european-welfare-states
#13
JOURNAL ARTICLE
Ricardo Rodrigues, Cassandra Simmons, Eszter Zólyomi, Afshin Vafaei, Johan Rehnberg, Selma Kadi, Marco Socci, Stefan Fors, Susan P Phillips
PURPOSE: We aim to investigate systematic differences in reporting spousal care between caregivers and cared-for persons and their possible effects for the analysis of care regimes and correlation of care with health. MATERIALS AND METHODS: Using information on care provided/received from the Survey on Health, Ageing and Retirement in Europe (SHARE), we estimate the prevalence of spousal care and discordance between caregivers and cared-for persons in the reporting of care among caregiving dyads...
June 2, 2024: Archives of Gerontology and Geriatrics
https://read.qxmd.com/read/38851090/introducing-virtual-reality-to-older-adults-a-qualitative-analysis-of-a-co-design-innovation-with-care-staff
#14
JOURNAL ARTICLE
Raelene Wilding, Barbara Barbosa Neves, Jenny Waycott, Evonne Miller, Tabitha Porter, Jacqueline Johnston, Wendy James, Stefany Brajanovski, Josephine Wilson, Steven Baker, Glenda Caldwell
Previous studies of Virtual Reality (VR) in aged care settings have demonstrated that the benefits can be multiple, including improved social connection and engagement and reduced social isolation in later life. However, there remains a lack of widespread uptake of VR in aged care facilities. This prompts an important question: Given the potential benefits, why is there such poor engagement in VR by aged care facilities? The aim of this qualitative study is to investigate the experience of introducing VR into an aged care facility...
June 2, 2024: Archives of Gerontology and Geriatrics
https://read.qxmd.com/read/38876082/the-impact-of-social-isolation-on-functional-disability-in-older-people-a-multi-cohort-study
#15
JOURNAL ARTICLE
Eric Tsz-Chun Lai, Anson Kai Chun Chau, Irene Yuk-Ying Ho, Hideki Hashimoto, Chang-Yup Kim, Tung-Liang Chiang, Ya-Mei Chen, Michael Marmot, Jean Woo
OBJECTIVES: We assessed the relationship between social isolation and functional disability in older people. DESIGN: Comparison of longitudinal cohort studies. SETTING AND PARTICIPANTS: Harmonised longitudinal datasets from the United States, England, European countries, Japan, Korea, China and Hong Kong. METHODS: Social isolation was operationalised as a composite score with five domains, such as marital status, living alone, and social contact with others...
May 31, 2024: Archives of Gerontology and Geriatrics
https://read.qxmd.com/read/38870707/elevated-mtdna-content-in-rbcs-promotes-oxidative-stress-may-be-responsible-for-faster-senescence-in-men
#16
JOURNAL ARTICLE
Wenjie Zhou, Xianqun Xu, Daoxi Qi, Xiaokang Zhang, Fang Zheng
BACKGROUND: Both we and others have found that RBC counts are significantly lower in older compared to younger. However, when gender is factored in, a significant age-related decrease of RBC counts is observed only in men but not in women. METHODS: qPCR and confocal microscopy were used to detect the presence of mtDNA in RBCs. Flow cytometry and specific inhibitors were used to determine how RBCs uptake cf-mtDNA. The peripheral blood was collected from 202 young adults and 207 older adults and RBC and plasma were isolated...
May 31, 2024: Archives of Gerontology and Geriatrics
https://read.qxmd.com/read/38852372/greater-variability-in-hdl-c-was-associated-with-an-increased-risk-of-cognitive-decline-in-the-middle-and-elderly-chinese-a-cohort-study
#17
JOURNAL ARTICLE
Lili Luo, Wei Feng, Mei Mei, Xue Tian, Yuhan Zhao, Lulu Liu, Zemeng Zhao, Hui Luo, Xiuhua Guo, Lixin Tao, Xiangtong Liu, Xiaonan Wang, Yanxia Luo
BACKGROUND: Previous studies into relationship between high-density lipoprotein cholesterol (HDL-C) and cognitive decline were constrained to a single measurement, leaving the association between HDL-C variability and risk of cognitive decline unclear. METHODS: We identified 5930 participants from the China Health and Retirement Longitudinal Study (CHARLS) who were devoid for stroke, dementia, and memory-related diseases at baseline and underwent a minimum of 2 sequential health examinations during 2011-2015...
May 31, 2024: Archives of Gerontology and Geriatrics
https://read.qxmd.com/read/38821729/unique-compositional-signature-pathophysiology-and-clinical-implications-of-sarcopenic-obesity
#18
EDITORIAL
Liang-Kung Chen
No abstract text is available yet for this article.
May 28, 2024: Archives of Gerontology and Geriatrics
https://read.qxmd.com/read/38852373/single-cell-rna-sequencing-analysis-provides-novel-insights-into-the-role-of-apoptosis-related-genes-in-muscle-aging
#19
JOURNAL ARTICLE
Hua Guo, Yunyun Zhang, Xin Xiang, Na Tang, Wei Gao, Xiaochuan Cui
OBJECTIVE: This study employed a comprehensive single-cell analysis approach to explore the role of cell apoptosis-related genes in muscle aging. METHODS: The single-cell RNA sequencing data from the GSE143704 dataset were used to identify distinct cell clusters and assess gene expression patterns related to apoptosis activation. The "limma" package was used to identify hub genes, after which we performed Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis to identify relevant pathways...
May 27, 2024: Archives of Gerontology and Geriatrics
https://read.qxmd.com/read/38851092/total-saponins-from-panax-japonicus-regulated-the-intestinal-microbiota-to-alleviate-lipid-metabolism-disorders-in-aging-mice
#20
JOURNAL ARTICLE
Yaqi Hu, Shuwen Wang, Rui Wang, Yifan Zhang, Qi Yuan, Chengfu Yuan
Total saponins from Panax japonicus (TSPJ) have many beneficial physiological activities, particularly in alleviating the damages of aging and abnormal lipid metabolism. This work used mice models to investigate if TSPJ reduced obesity and regulated metabolic functions via the intestinal microbiota, the disturbance of which has been shown to cause aging-related diseases. The results showed that TSPJ significantly reduced the weight and blood lipid level of aging mice. Further analyses showed that TSPJ significantly inhibited adipogenesis, changed the composition of the intestinal flora, and protected the integrity of the intestinal barrier...
May 27, 2024: Archives of Gerontology and Geriatrics
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