Ye Gao, Fei Cao, Xinyi Tian, Qianping Zhang, Congcong Xu, Bowen Ji, Ye-An Zhang, Linan Du, Jun Han, Li Li, Siyu Zhou, Yuqiang Gong, Binyu Ying, Fang Gao-Smith, Shengwei Jin
Sepsis-induced acute respiratory distress syndrome (ARDS) causes significant fatalities worldwide and lacks pharmacological intervention. Alveolar fluid clearance (AFC) plays a pivotal role in the remission of ARDS and is markedly impaired in the pathogenesis of ARDS. Here, we demonstrated that erythropoietin could effectively ameliorate lung injury manifestations and lethality, restore lung function and promote AFC in a rat model of lipopolysaccharide (LPS)-induced ARDS. Moreover, it was proven that EPO-induced restoration of AFC occurs through triggering the total protein expression of ENaC and Na,K-ATPase channels, enhancing their protein abundance in the membrane, and suppressing their ubiquitination for degeneration...
March 21, 2024: Biomedicine & Pharmacotherapy