journal
https://read.qxmd.com/read/38531121/a-next-generation-peripherally-restricted-cav%C3%AE-2%C3%AE-1-ligand-with-inhibitory-action-on-cav2-2-channels-and-utility-in-neuropathic-pain
#1
JOURNAL ARTICLE
Franz Kricek, Christine Ruf, Premji Meghani, Ivana A Souza, Maria A Gandini, Gerald W Zamponi, George Skouteris
The Voltage-Gated Calcium Channel (VGCC) auxiliary subunit Cavα2δ-1 (CACNA2D1) is the target/receptor of gabapentinoids which are known therapeutics in epilepsy and neuropathic pain. Following damage to the peripheral sensory nervous system, Cavα2δ-1 is upregulated in dorsal root ganglion (DRG) neurons in several animal models of chronic neuropathic pain. Gabapentinoids, such as gabapentin and pregabalin, engage with Cavα2δ-1 via binding an arginine residue (R241) within an RRR motif located at the N-terminus of human Cavα2δ-1...
March 25, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38531120/effects-of-endogenous-dha-milk-and-exogenous-dha-milk-on-oxidative-stress-and-cognition-in-samp8-mice
#2
JOURNAL ARTICLE
Xiaodan Wang, Huiquan Zhu, Baorong Chen, Yumeng Zhang, Akke Kok, Ariette van Knegsel, Shuwen Zhang, Xiaoyang Pang, Shilong Jiang, Bas Kemp, Jing Lu, Jiaping Lv
In this study, Senescence Accelerated Mice (SAMP8) were supplemented with exogenous DHA milk, endogenous DHA milk, normal milk, or 0.9 % saline solution. Enzyme-linked immunosorbent assay (ELISA), gas chromatography (GC), ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI MS/MS), and Morris water maze were used to characterize the effects of diet on oxidative stress and cognition in SAMP8 mice. Supplementation endogenous DHA milk or exogenous DHA milk can enhance the antioxidant capacity of mice organs...
March 25, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38522239/research-progress-on-sirtuins-sirts-family-modulators
#3
REVIEW
Mingkai Chen, Junfei Tan, Zihan Jin, Tingting Jiang, Jiabiao Wu, Xiaolong Yu
Sirtuins (SIRTs) represent a class of nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylases that exert a crucial role in cellular signal transduction and various biological processes. The mammalian sirtuins family encompasses SIRT1 to SIRT7, exhibiting therapeutic potential in counteracting cellular aging, modulating metabolism, responding to oxidative stress, inhibiting tumors, and improving cellular microenvironment. These enzymes are intricately linked to the occurrence and treatment of diverse pathological conditions, including cancer, autoimmune diseases, and cardiovascular disorders...
March 23, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38522238/kefir-peptides-mitigate-bleomycin-induced-pulmonary-fibrosis-in-mice-through-modulating-oxidative-stress-inflammation-and-gut-microbiota
#4
JOURNAL ARTICLE
Ying-Wei Lan, Ying-Cheng Chen, Chih-Ching Yen, Hsiao-Ling Chen, Min-Che Tung, Hueng-Chuen Fan, Chuan-Mu Chen
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive and life-threatening lung disease with high mortality rates. The limited availability of effective drugs for IPF treatment, coupled with concerns regarding adverse effects and restricted responsiveness, underscores the need for alternative approaches. Kefir peptides (KPs) have demonstrated antioxidative, anti-inflammatory, and antifibrotic properties, along with the capability to modulate gut microbiota. This study aims to investigate the impact of KPs on bleomycin-induced pulmonary fibrosis...
March 23, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38522237/involvement-of-cb-1-and-cb-2-receptors-in-neuroprotective-effects-of-cannabinoids-in-experimental-tdp-43-related-frontotemporal-dementia-using-male-mice
#5
JOURNAL ARTICLE
Claudia Gonzalo-Consuegra, Irene Santos-García, Laura García-Toscano, Raquel Martín-Baquero, Carmen Rodríguez-Cueto, Matthias B Wittwer, Pawel Dzygiel, Uwe Grether, Eva de Lago, Javier Fernández-Ruiz
BACKGROUND: The elevation of endocannabinoid levels through inhibiting their degradation afforded neuroprotection in CaMKIIα-TDP-43 mice, a conditional transgenic model of frontotemporal dementia. However, which cannabinoid receptors are mediating these benefits is still pending to be elucidated. METHODS: We have investigated the involvement of the CB1 and the CB2 receptor using chronic treatments with selective ligands in CaMKIIα-TDP-43 mice, analysis of their cognitive deterioration with the Novel Object Recognition test, and immunostaining for neuronal and glial markers in two areas of interest in frontotemporal dementia...
March 23, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38522236/growth-and-differentiation-factor-15-a-link-between-inflammaging-and-cardiovascular-disease
#6
REVIEW
Balázs Bence Nyárády, Loretta Zsuzsa Kiss, Zsolt Bagyura, Béla Merkely, Edit Dósa, Orsolya Láng, László Kőhidai, Éva Pállinger
Age-related disorders are closely linked to the accumulation of senescent cells. The senescence-associated secretory phenotype (SASP) sustains and progresses chronic inflammation, which is involved in cellular and tissue dysfunction. SASP-related growth and differentiation factor-15 (GDF-15) is an immunoregulatory cytokine that is coupled to aging and thus may have a regulatory role in the development and maintenance of atherosclerosis, a major cause of cardiovascular disease (CVD). Although the effects of GDF-15 are tissue-specific and dependent on microenvironmental changes such as inflammation, available data suggest that GDF-15 has a significant role in CVD...
March 23, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38522235/empagliflozin-mitigates-cardiac-hypertrophy-through-cardiac-rsk-nhe-1-inhibition
#7
JOURNAL ARTICLE
Sha Chen, Kenneth Overberg, Zakiya Ghouse, Markus W Hollmann, Nina C Weber, Ruben Coronel, Coert J Zuurbier
BACKGROUND: SGLT2i reduce cardiac hypertrophy, but underlying mechanisms remain unknown. Here we explore a role for serine/threonine kinases (STK) and sodium hydrogen exchanger 1(NHE1) activities in SGLT2i effects on cardiac hypertrophy. METHODS: Isolated hearts from db/db mice were perfused with 1 µM EMPA, and STK phosphorylation sites were examined using unbiased multiplex analysis to detect the most affected STKs by EMPA. Subsequently, hypertrophy was induced in H9c2 cells with 50 µM phenylephrine (PE), and the role of the most affected STK (p90 ribosomal S6 kinase (RSK)) and NHE1 activity in hypertrophy and the protection by EMPA was evaluated...
March 23, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38522241/the-effects-of-nardosinone-on-levodopa-intervention-in-the-treatment-of-parkinson-s-disease
#8
JOURNAL ARTICLE
Mengmeng Liu, Jingwen Xue, Yuxin Cao, Zhuangzhuang Hao, Yuqing Wang, Jiayuan Li, Tingyue Jiang, Jinli Shi
BACKGROUND: The roots and rhizomes of Nardostachys jatamansi DC. are reported to be useful for the treatment of Parkinson's disease (PD). Previous research has also shown that Nardosinone, the main active component isolated from Nardostachys jatamansi DC., exhibits the potential to treat PD. AIM OF THE STUDY: To investigate how the effects of Nardosinone could assist levodopa in the treatment of PD, how this process changes the intestinal flora, and to explore the effective forms of Nardosinone in the intestinal flora...
March 22, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38522240/an-anti-gd2-aptamer-based-bifunctional-spherical-nucleic-acid-nanoplatform-for-synergistic-therapy-targeting-mdm2-for-retinoblastoma
#9
JOURNAL ARTICLE
Shijing Wang, Yan Zhao, Fei Yao, Pengxue Wei, Lan Ma, Shaochong Zhang
Retinoblastoma (RB) is a type of pediatric solid tumor in the fundus. The lack of precision therapies combined with the difficulty of delivering small interfering RNA (siRNA) into the eyes means that there is currently no nucleic acid-based therapy for RB in clinical practice. Here, we reported on anti-GD2 and glutathione-responsive spherical nucleic acids (SNAs), loaded with siRNA and the inhibitor NVP-CGM097, which jointly blocked the oncogenic factor n in RB cells (Y79 and WERI-RB-1). The SNAs were formed through the self-assembly of bifunctional cholesterol amphiphiles containing aptamers that specifically targeted GD2-positive RB cells, allowing for the formation of an SNA with a dense DNA shell...
March 22, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38520871/controllers-of-histone-methylation-modifying-enzymes-in-gastrointestinal-cancers
#10
REVIEW
Ling Li, Qing Song, Jing Zhou, Qing Ji
Gastrointestinal (GI) cancers have been considered primarily genetic malignancies, caused by a series of progressive genetic alterations. Accumulating evidence shows that histone methylation, an epigenetic modification program, plays an essential role in the different pathological stages of GI cancer progression, such as precancerous lesions, tumorigenesis, and tumor metastasis. Histone methylation-modifying enzymes, including histone methyltransferases (HMTs) and demethylases (HDMs), are the main executor of post-transcriptional modification...
March 22, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38520870/unveil-the-mechanism-for-ehmt-a-novel-triterpenoid-inhibits-proliferation-and-induces-apoptosis-in-colon-cancer-through-ros-mediated-jnk-signaling-pathway
#11
JOURNAL ARTICLE
Qiushuang Wu, Min Song, Siyuan Luo, Libin Guo, Qingwen Zhang, Hang Fai Kwok
Colon cancer ranks among the most prevalent malignancies worldwide, trailing only lung and breast cancer in incidence. Despite the availability of numerous therapeutic strategies, the burden of new cases and fatalities remains high in countries undergoing socioeconomic transitions. Natural products offer promising avenues for developing more effective and less toxic anticancer agents, expanding the clinical arsenal. In this investigation, we isolated a triterpenoid, (21 S,23 R,24 R)-21,23-epoxy-24-hydroxy-21-methoxytirucalla-7,25-dien-3-one (EHMT), from the fruits of Melia azedarach L...
March 22, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38520869/targeted-inhibition-of-stat3-tyr705-by-xanthatin-alleviates-osteoarthritis-progression-through-the-nf-%C3%AE%C2%BAb-signaling-pathway
#12
JOURNAL ARTICLE
Yangjun Xu, Zhuolin Chen, Xuanyuan Lu, Jiewen Zheng, Xuewen Liu, Tan Zhang, Wanlei Yang, Yu Qian
The transcription factor, signal transducer, and stimulator of transcription 3 (STAT3) is a potential target in osteoarthritis (OA) treatment. Although xanthatin (XA), a biologically active substance derived from Xanthium strumarium L, specifically inhibits STAT3 phosphorylation at Tyr705, the mechanism underlying its inhibitory effect on OA progression remains unclear. In this study, our objective was to explore the therapeutic effects exerted by XA on OA and the underlying molecular mechanisms. The effects of XA treatment on mouse OA models subjected to destabilization of the medial meniscus using medial collateral ligament transection, as well as on interleukin-1β (IL-1β)-induced mouse chondrocytes, were examined...
March 22, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38520868/bioactive-compounds-from-nature-antioxidants-targeting-cellular-transformation-in-response-to-epigenetic-perturbations-induced-by-oxidative-stress
#13
REVIEW
Abdelhakim Bouyahya, Saad Bakrim, Sara Aboulaghras, Kawtar El Kadri, Tarik Aanniz, Asaad Khalid, Ashraf N Abdalla, Ahmed A Abdallah, Chrismawan Ardianto, Long Chiau Ming, Nasreddine El Omari
Oxidative stress results from a persistent imbalance in oxidation levels that promotes oxidants, playing a crucial role in the early and sustained phases of DNA damage and genomic and epigenetic instability, both of which are intricately linked to the development of tumors. The molecular pathways contributing to carcinogenesis in this context, particularly those related to double-strand and single-strand breaks in DNA, serve as indicators of DNA damage due to oxidation in cancer cases, as well as factors contributing to epigenetic instability through ectopic expressions...
March 22, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38520867/the-role-of-mir-155-in-urologic-malignancies
#14
REVIEW
Maolei Shen, Tao Chen, Xin Li, Shankun Zhao, Xinsheng Zhang, Liying Zheng, Biao Qian
MicroRNAs (miRNAs) are a class of short non-coding RNAs that play a crucial role in regulating gene expression across multiple levels. They are involved in a wide range of physiological processes, including proliferation, differentiation, apoptosis, and cell cycle control. In recent years, miRNAs have emerged as pivotal regulatory molecules in the development and progression of tumors. Among these, miR-155 has garnered significant attention due to its high expression in various diseases, particularly urologic malignancies...
March 22, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38520866/harnessing-pd-1-cell-membrane-coated-paclitaxel-dimer-nanoparticles-for-potentiated-chemoimmunotherapy
#15
JOURNAL ARTICLE
Nannan Hu, Han Xue, Ting Zhang, Yuxin Fan, Fenglin Guo, Zhimin Li, Mingge Huo, Xingang Guan, Guofu Chen
Chemoimmunotherapy has emerged as a promising strategy for improving the efficacy of cancer treatment. Herein, we present PD-1 receptor-presenting membrane-coated paclitaxel dimers nanoparticles (PD-1@PTX2 NPs) for enhanced treatment efficacy. PD-1 cell membrane-cloaked PTX dimer exhibited effective cellular uptake and increased cytotoxicity against cancer cells. PD-1@PTX2 NPs could selectively bind with PD-L1 ligands expressed on breast cancer cells. Our nanoparticles exhibit a remarkable tumor growth inhibition rate of 71...
March 22, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38520865/a-novel-combined-therapeutic-strategy-of-nano-en-ir-lip-mediated-photothermal-therapy-and-stem-cell-inhibition-for-gastric-cancer
#16
JOURNAL ARTICLE
Liping Yang, Yan-E Du, Fangli Liao, Tong Huang, Yadong Liu, Junzhao Liu, Can Wang, Zhu Zhan, Yang Cao, Zhigang Wang, Weixian Chen
Recurrence and metastasis of gastric cancer is a major therapeutic challenge for treatment. The presence of cancer stem cells (CSCs) is a major obstacle to the success of current cancer therapy, often leading to treatment resistance and tumor recurrence and metastasis. Therefore, it is important to develop effective strategies to eradicate CSCs. In this study, we developed a combined therapeutic strategy of photothermal therapy (PTT) and gastric cancer stem cells (GCSCs) inhibition by successfully synthesizing nanoliposomes loaded with IR780 (photosensitizer) and EN4 (c-Myc inhibitor)...
March 22, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38520864/neuroprotective-effects-of-the-salidroside-derivative-shpl-49-via-the-bdnf-trkb-gap43-pathway-in-rats-with-cerebral-ischemia
#17
JOURNAL ARTICLE
Suxin You, Zhouyun Ma, Pei Zhang, Wenwen Xu, Changsen Zhan, Nina Sang, Jiazhen Xu, Feiyun Wang, Jiange Zhang
Ischemic stroke is a common intravascular disease and one of the leading causes of death and disability. The salidroside derivative SHPL-49, which we previously synthesized, significantly attenuates cerebral ischemic injury in a rat model of permanent middle cerebral artery occlusion. To explore the neuroprotective mechanism of SHPL-49, the effects of SHPL-49 on the expression levels of neurotrophic factors in neurons and microglia and the polarization of microglia were investigated in the present study. SHPL-49 activated the brain-derived neurotrophic factor (BDNF) pathway, decreased the number of degenerated neurons, and accelerated neurogenesis in rats with cerebral ischemia...
March 22, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38520872/resveratrol-protects-against-myocardial-ischemic-injury-in-obese-mice-via-activating-sirt3-foxo3a-signaling-pathway-and-restoring-redox-homeostasis
#18
JOURNAL ARTICLE
Xi Zhu, En Ma, Yixuan Ge, Meng Yuan, Xiaowei Guo, Jun Peng, Weidong Zhu, Dan-Ni Ren, Da Wo
BACKGROUND: Increasing global overweight and obesity rates not only increase the prevalence of myocardial infarction (MI), but also exacerbate ischemic injury and result in worsened prognosis. Currently, there are no drugs that can reverse myocardial damage once MI has occurred, therefore discovering drugs that can potentially limit the extent of ischemic damage to the myocardium is critical. Resveratrol is a polyphenol known for its antioxidant properties, however whether prolonged daily intake of resveratrol during obesity can protect against MI-induced damage remains unexplored...
March 21, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38518606/inhibition-the-ubiquitination-of-enac-and-na-k-atpase-with-erythropoietin-promotes-alveolar-fluid-clearance-in-sepsis-induced-acute-respiratory-distress-syndrome
#19
JOURNAL ARTICLE
Ye Gao, Fei Cao, Xinyi Tian, Qianping Zhang, Congcong Xu, Bowen Ji, Ye-An Zhang, Linan Du, Jun Han, Li Li, Siyu Zhou, Yuqiang Gong, Binyu Ying, Fang Gao-Smith, Shengwei Jin
Sepsis-induced acute respiratory distress syndrome (ARDS) causes significant fatalities worldwide and lacks pharmacological intervention. Alveolar fluid clearance (AFC) plays a pivotal role in the remission of ARDS and is markedly impaired in the pathogenesis of ARDS. Here, we demonstrated that erythropoietin could effectively ameliorate lung injury manifestations and lethality, restore lung function and promote AFC in a rat model of lipopolysaccharide (LPS)-induced ARDS. Moreover, it was proven that EPO-induced restoration of AFC occurs through triggering the total protein expression of ENaC and Na,K-ATPase channels, enhancing their protein abundance in the membrane, and suppressing their ubiquitination for degeneration...
March 21, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38518605/exploring-the-therapeutic-potential-of-regulatory-t-cell-in-rheumatoid-arthritis-insights-into-subsets-markers-and-signaling-pathways
#20
REVIEW
Qin-Yi Su, Huan-Cheng Li, Xiao-Jing Jiang, Zhong-Qing Jiang, Yan Zhang, He-Yi Zhang, Sheng-Xiao Zhang
Rheumatoid arthritis (RA) is a complex autoimmune inflammatory rheumatic disease characterized by an imbalance between immunological reactivity and immune tolerance. Regulatory T cells (Tregs), which play a crucial role in controlling ongoing autoimmunity and maintaining peripheral tolerance, have shown great potential for the treatment of autoimmune inflammatory rheumatic diseases such as RA. This review aims to provide an updated summary of the latest insights into Treg-targeting techniques in RA. We focus on current therapeutic strategies for targeting Tregs based on discussing their subsets, surface markers, suppressive function, and signaling pathways in RA...
March 21, 2024: Biomedicine & Pharmacotherapy
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