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Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie

Gehan El-Akabawy, Neveen M El-Sherif
Ulcerative colitis is a common intestinal inflammatory disease characterized by upregulation of pro-inflammatory cytokines and oxidative stress. Zeaxanthin is a nutritional carotenoid that belongs to the xanthophyll family of pigments. It exerts potent anti-inflammatory and antioxidative effects. The present study aimed to evaluate the effect of zeaxanthin on acetic acid-induced ulcerative colitis in rats. Rats were randomly categorized into five groups: control, zeaxanthin, acetic acid, acetic acid + zeaxanthin, and acetic acid + prednisolone groups...
January 4, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Takashi Higuchi, Kei Kawaguchi, Kentaro Miyake, Hiromichi Oshiro, Zhiying Zhang, Sahar Razmjooei, Sintawat Wangsiricharoen, Kentaro Igarashi, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Scott D Nelson, Sarah M Dry, Yunfeng Li, Sant P Chawla, Frederick C Eilber, Shree Ram Singh, Hiroyuki Tsuchiya, Robert M Hoffman
Undifferentiated/unclassified soft-tissue sarcomas (USTS) is recalcitrant neoplasms that is usually treated with doxorubicin (DOX)-containing regimens as first-line therapy. Nanoparticle albumin-bound paclitaxel (nab-PTX) is a nanotechnology-based drug and is widely used in pancreatic cancer in combination with gemcitabine (GEM). The major goal of the present study was to determine the efficacy of nab-PTX in combination with GEM, compared to conventional drugs such as docetaxel (DOC), GEM combined with DOC, or first-line drug DOX on a USTS not-otherwise specified (USTS/NOS) from a striated muscle implanted in the right biceps femoris muscle of nude mice to establish a patient-derived orthotopic xenograft (PDOX) model...
January 4, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Yijun Qi, Lei Wang, Kaizhen Wang, Zhiqiang Peng, Yuanzhen Ma, Zhaoxu Zheng, Donghao Shang, Wentao Xu, Junfang Zheng
Differentially expressed (DE) microRNAs (miRNAs) in clear cell renal cell carcinoma (ccRCC) tissues from pooled samples were reported to affect the tumorigenesis and progression of ccRCC. However, systematic studies on the miRNA-mRNA regulatory networks involved in various pathways in all four stages of the disease are lacking. In this study, we applied microarray technology to perform an integrated analysis of the miRNome and transcriptome in ccRCC tissues from patients at different stages of ccRCC. A total of 604 DEmiRNAs and 6892 DEgenes (DEGs) were identified by comparison with corresponding adjacent normal tissues...
January 4, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Qiu Xiang, Juan Tang, Qin Luo, Jinfeng Xue, Yexing Tao, Honghui Jiang, Jing Tian, Caiwen Fan
Breast cancer is one of the most common malignancies and the leading cause of women's death, most of breast cancers are estrogen receptor-positive (ER+ ) breast cancer which can develop into advanced stage from early stage with treatment resistance. The purpose of this study was to investigate anti-ER+ breast cancer effects of 1,2,3,4,6-penta-O-galloyl-β-d-glucose (PGG) and its possible mechanisms. Cell viability was analyzed by MTT assay. The cell cycle distribution and apoptosis were detected by Flow cytometry...
January 4, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Amit Khurana, Sravani Tekula, Mohd Aslam Saifi, Pooladanda Venkatesh, Chandraiah Godugu
Nanoparticles (NPs) serve to reduce the toxicity, enhance bioactivity, improve targeting, and provide versatile means to control the release profile of the encapsulated moiety. Among different NPs, inorganic NPs of metals like Ag, Au, Ce, Fe, Se, Ti and Zn possess a significant place owing to their unique bioactivities in nanoforms. Selenium (Se) is an essential trace element. It is incorporated into selenoproteins as selenocysteine (Sec) representing the most important part of the active center of their enzymatic activities...
January 4, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Dongjian Chen, Chao Huang, Zhuo Chen
Lycopene is an aliphatic hydrocarbon carotenoid extracted from plants like tomatoes, papayas, and watermelons. Previous studies have shown that lycopene can exert prophylactic and/or therapeutic effects in different disorders, such as heart failure and neoplasm via anti-oxidative, anti-inflammatory, and anti-proliferative activities. In the central nervous system (CNS), lycopene also has prophylactic and/or therapeutic effects in different type of disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), cerebral ischemia, epilepsy, and depression...
January 4, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Manuel Sacha, Laetitia Faucon, Emmanuelle Hamon, Isabelle Ly, Eleonore Haltner-Ukomadu
Topical formulations of non-steroidal anti-inflammatory drugs are often used to provide effective local drug concentration while limiting systemic exposure and associated adverse events. Formulation composition has great influence on the rate of transdermal drug transport through human skin. This study was performed to compare the ex vivo transdermal transport of diclofenac from three topical formulations, a 1% liposomal gel formulation of diclofenac sodium and two emulsion gel formulations, 1.16% and 2.32% diclofenac diethylamine (equivalent to 1% and 2% diclofenac sodium)...
January 3, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Wantong Zhang, Baochen Zhu, Jianxun Ren, Fang Lu, Yi Qi, Weiliang Weng, Rui Gao
The Sick Sinus Syndrome (SSS) is a serious life-threatening heart disease. It is important to establish a credible and stable sinus node damage model. In this study, we use two methods to construct an SSS damage model in rats. One is to inject sodium hydroxide to the SSS area through internal jugular vein. Another is to cause ischemia-reperfusion injury on the SSS area. 43 healthy SD rats were randomly divided into 4 groups, namely ischemia-reperfusion injury group (IRIG), inject sodium hydroxide group (ISHG), and propranolol group (PG) and the control group (CG)...
January 3, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Sean Hong Tan, Venkatanaidu Karri, Nicole Wuen Rong Tay, Kuan Hui Chang, Hui Yen Ah, Phui Qi Ng, Hui San Ho, Hsiao Wai Keh, Mayuren Candasamy
Neurodegenerative diseases are usually sporadic in nature and commonly influenced by a wide range of genetic, life style and environmental factors. A unifying feature of Alzheimer's disease (AD) and Parkinson's disease (PD) is the abnormal accumulation and processing of mutant or damaged intra and extracellular proteins; this leads to neuronal vulnerability and dysfunction in the brain. Through a detailed review of ubiquitin proteasome, mRNA splicing, mitochondrial dysfunction, and oxidative stress pathway interrelation on neurodegeneration can improve the understanding of the disease mechanism...
January 3, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Keke Gui, Xinchao Zhang, Fangyi Chen, Zhe Ge, Shichao Zhang, Xiaoxia Qi, Jing Sun, Zuochong Yu
Osteosarcoma, a common type of bone cancer in children, and represents an aggressive and fetal cancer worldwide. Osteosarcoma initiating cells are considered to be a subpopulation of cancer cells which contribute to the progression, recurrence, metastasis and multi-drug resistance of osteosarcoma. CD133 is considered to be one marker for osteosarcoma initiating cells. All-trans retinoic acid (ATRA), an active metabolite of vitamin A under the family retinoid, is an up-and-coming drug which was able to effectively treat various cancer initiating cells...
January 3, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Fuming Zhang, Xiaofang Sun, Ya Zhu, Wangsen Qin
Albeit microRNAs (miRNAs) have become increasingly appreciated for their essential roles in innate immune responses to viral infections; however, it is unknown how host miRNAs regulate influenza A virus (IAV)-induced inflammation. The aim of our study was to investigate the role of miR-146a in IAV replication in vitro and in vivo. In vitro, we found miR-146a was significantly upregulated in A549 cells with IAV infection. Overexpression of miR-146a promoted IAV replication, while downregulation of miR-146a repressed replication...
January 3, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Guizhen Zheng, Huijuan Ren, Hongqiang Li, Xiuhua Li, Tiancao Dong, Shumin Xu, Yanli Yan, Bingke Sun, Jianwen Bai, Yusheng Li
INTRODUCTION: The disruption of the balance between antioxidants and oxidants plays a vital role in the pathogenesis of acute lung injury (ALI). Evidence has shown that Lycium barbarum polysaccharide (LBP) has antioxidant feature. We examined the efficacy and mechanisms of LBP on hyperoxia-induced acute lung injury (ALI) in the present study. MATERIALS AND METHODS: C57BL/6 wild-type (WT) mice and nuclear factor erythroid 2-related factor 2 (Nrf2)-deficient (Nrf2-/- ) mice were used in the present study...
January 3, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Umar Muzaffer, V I Paul, Balupillai Agilan, N Rajendra Prasad
Solar ultraviolet-B radiation (UVB) has severe adverse effects on the structure and functions of the skin. Although, UVB (290-320 nm) represents only 5-10% of UV light reaching earth's surface, its contribution towards photoaging is tremendous. In this present study was investigate the photoprotective effect of methanolic extract of the male flower of J. regia L. (MEJR) against UVB induced photoaging in human epidermal keratinocytes (HaCaT). Cells were exposed to UVB-irradiation at a dose of 20 mJ/cm2 , induces the activation of several signaling pathways which are associated with oxidative stress and photoaging...
January 3, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Waleed A Mohamed, Rania M Salama, Mona F Schaalan
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases in which the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (PKB or Akt) pathway is deregulated in response to phosphatase and tensin homolog (PTEN) overexpression. Lactoferrin (LF), a multifunctional iron-binding glycoprotein, is involved in AD pathology; however, direct evidence of its impact upon AD remains unclear. To elucidate LF's role in AD, the possible protective mechanism post-LF administration for 3 months was investigated in AD patients by observing changes in the p-Akt/PTEN pathway...
January 3, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Nitima Tatiya-Aphiradee, Waranya Chatuphonprasert, Kanokwan Jarukamjorn
Garcinia mangostana (mangosteen) pericarp has antibacterial effects; however, information regarding its anti-inflammatory activity in vivo is limited. The anti-inflammatory effect of G. mangostana pericarp extract against methicillin-resistant Staphylococcus aureus (MRSA)-induced superficial skin infection was investigated in mice using a tape stripping model. G. mangostana pericarp ethanolic extract (GME) and its constituent, α-mangostin, were topically administered to mice with MRSA-induced superficial skin infection...
January 3, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Xin Liu, Kai Chen, Yuxin Zhuang, Yu Huang, Yukun Sui, Yubin Zhang, Lin Lv, Guohua Zhang
Paeoniflorin (PF) is a main bioactive component of the root of Paeonia lactiflora Pal, and previous investigations suggest that it may impact cardiac remodeling in spontaneous hypertensive rats (SHR) via the MAPK signaling pathway. Thus, the purpose of this investigation was to examine the impacts of paeoniflorin cardiac function in SHR rats. Cardiac function and blood pressure were observed using echocardiography and non-invasive tail pressure gauge. Heart histopathology was assessed by histological staining and transmission electron microscopy...
January 3, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Sarayu A Pai, Renuka P Munshi, Falguni H Panchal, Ila-Shruti Gaur, Snehal N Mestry, Malvika S Gursahani, Archana R Juvekar
BACKGROUND: Chronic consumption of fructose causes obesity and nonalcoholic fatty liver disease (NAFLD). Currently available therapies have limitations; hence there is a need to screen new molecules. Plumbagin is a naphthoquinone present in the roots of Plumbago species which has hypolipidemic and hepatoprotective activities. METHODS: Rats were divided into five groups: normal control, disease control, orlistat, plumbagin (0.5 mg/kg and 1 mg/kg body weight)...
January 3, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Haifa A S ALHaithloul, Mohammed F Alotaibi, May Bin-Jumah, Hassan Elgebaly, Ayman M Mahmoud
Olive leaf extract (OLE) has potential health benefits and protects against cytotoxicity in different organs. However, nothing has yet been reported on its potential to prevent cyclophosphamide (CP)-induced nephrotoxicity. This study investigated the possible protective effect of OLE on CP-induced kidney injury in rats, focusing on oxidative stress, inflammation, apoptosis and Nrf2/ARE/HO-1 signaling. Rats received 100 or 200 mg/kg body weight OLE for 15 days and a single injection of 150 mg/kg CP at day 16...
January 3, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Majid Saeedi, Masoumeh Eslamifar, Khadijeh Khezri, Solmaz Maleki Dizaj
In recent years, the researchers and drug designers have given growing attention to new nanotechnology strategies to improve drug delivery to the central nervous system (CNS). Nanotechnology has a great potential to affect the treatment of neurological disorders, mainly Alzheimer's disease, Parkinson's disease, brain tumors, and stroke. With regard to neurodegeneration, several studies showed that nanomaterials have been successfully used for the treatments of CNS disorders. In this regard, nanocarriers have facilitated the targeted delivery of chemotherapeutics resulting in the efficient inhibition of disease progression in malignant brain tumors...
January 3, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Bo-Han Zhang, Chuan-An Shen, Bi-Wei Zhu, Hua-Ying An, Bo Zheng, Sheng-Bo Xu, Jia-Chen Sun, Peng-Chao Sun, Wen Zhang, Jia Wang, Jia-Ying Liu, Ya-Qian Fan
A microRNA (miRNA) is a single-stranded, small and non-coding RNA molecule that contains 20-25 nucleotides. More than 2000 miRNAs have been identified in human genes since the first miRNA was discovered in Caenorhabditis elegans in the early 1990s. miRNAs play a crucial role in various biological processes by regulating gene expression through post-transcriptional mechanisms. The alterations of their levels are associated with various diseases, such as glucometabolic disorder and lipid metabolism disorder. In recent years, miRNAs have been proved to be involved in regulating the functions of pancreatic β-cells, insulin resistance and other biological behaviors related to glucometabolic disorder and the pathogenesis of diabetes mellitus (DM)...
January 3, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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