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Progress in Neuro-psychopharmacology & Biological Psychiatry

Claudia Johanna Wagner, Cornelia Musenbichler, Lea Böhm, Katharina Färber, Anna-Isabell Fischer, Felicitas von Nippold, Merle Winkelmann, Tanja Richter-Schmidinger, Christiane Mühle, Johannes Kornhuber, Bernd Lenz
BACKGROUND: Major depressive disorder (MDD) is a highly prevalent and burdening mental illness. Approximately 30% of the major depressive episodes (MDE) are classified as therapy-refractory. Further knowledge of the pathophysiological mechanisms underlying MDD and predictive biomarkers are needed to improve treatment options. METHODS: Serum lipid levels were compared between patients with a current MDE (n = 130) or remitted MDD (n = 39) and healthy control subjects (n = 61) and associated with the severity (Hamilton Depression Rating Scale [HAMD] scores) and the prospective course of depression (direct follow-up of at median 20 days post-inclusion)...
February 16, 2019: Progress in Neuro-psychopharmacology & Biological Psychiatry
Andrew Winter, Rebecca Ahlbrand, Renu Sah
Individuals with fear-associated conditions such as panic disorder (PD) and posttraumatic stress disorder (PTSD) display increased emotional responses to interoceptive triggers, such as CO2 inhalation, that signal a threat to physiological homeostasis. Currently, effector systems and mechanisms underlying homeostatic modulation of fear memory are not well understood. In this regard, the renin angiotensin system (RAS), particularly the angiotensin receptor type 1 (AT1R), a primary homeostatic regulatory target, has gained attention...
February 15, 2019: Progress in Neuro-psychopharmacology & Biological Psychiatry
Kazue Hisaoka-Nakashima, Yoshiaki Tomimura, Toshiki Yoshii, Kazuto Ohata, Naoki Takada, Fang Fang Zhang, Yoki Nakamura, Keyue Liu, Hidenori Wake, Masahiro Nishibori, Yoshihiro Nakata, Norimitsu Morioka
Clinical evidence indicates that major depression is a common comorbidity of chronic pain, including neuropathic pain. However, the cellular basis for chronic pain-mediated major depression remains unclear. High-mobility group box 1 protein (HMGB1) has a key role in innate immune responses and appears to be have a role in mediating diverse disorders, including neuropathic pain and depression. The current study aimed to characterize neuropathic pain-induced changes in affect over time and to determine whether HMGB1 has a role in neuropathic pain-induced changes in affect...
February 11, 2019: Progress in Neuro-psychopharmacology & Biological Psychiatry
Silvia Papalini, Iris Lange, Jindra Bakker, Stijn Michielse, Machteld Marcelis, Marieke Wichers, Bram Vervliet, Jim van Os, Therese Van Amelsvoort, Liesbet Goossens, Koen Schruers
BACKGROUND: Exposure is the gold standard treatment for phobic anxiety and is thought to represent the clinical application of extinction learning. Reward sensitivity might however also represent a predictive factor for exposure therapy outcome, as this therapy promotes positive experiences and involves positive comments by the therapist. We hypothesized that high reward sensitivity, as expressed by elevated reward expectancy and reward value, can be associated with better outcome to exposure therapy specifically...
February 11, 2019: Progress in Neuro-psychopharmacology & Biological Psychiatry
Gabriel Gripp Fernandes, Alana Tercino Frias, Ailton Spiacci, Lucas C Pinheiro, José Eduardo Tanus-Santos, Hélio Zangrossi
Exposure of rats to an environment with low O2 levels evokes a panic-like escape behavior and recruits the dorsal periaqueductal gray (dPAG), which is considered to be a key region in the pathophysiology of panic disorder. The neurochemical basis of this response is, however, currently unknown. We here investigated the role played by nitric oxide (NO) within the dPAG in mediation of the escape reaction induced by hypoxia exposure. The results showed that exposure of male Wistar rats to 7% O2 increased nitrite levels, a NO metabolite, in the dPAG but not in the amygdala or hypothalamus...
February 10, 2019: Progress in Neuro-psychopharmacology & Biological Psychiatry
Rogerio R Gerbatin, Luiz Fernando Almeida Silva, Maurício S Hoffmann, Iuri D Della-Pace, Patricia Severo do Nascimento, Aline Kegler, Viviane Nogueira de Zorzi, Jane Marçal Cunha, Priscilla Botelho, João Bento Torres Neto, Ana Flavia Furian, Mauro Schneider Oliveira, Michele R Fighera, Luiz Fernando Freire Royes
Traumatic brain injury (TBI) is a devastating disease frequently followed by behavioral disabilities including post-traumatic epilepsy (PTE). Although reasonable progress in understanding its pathophysiology has been made, treatment of PTE is still limited. Several studies have shown the neuroprotective effect of creatine in different models of brain pathology, but its effects on PTE is not elucidated. Thus, we decided to investigate the impact of delayed and chronic creatine supplementation on susceptibility to epileptic seizures evoked by pentylenetetrazol (PTZ) after TBI...
February 8, 2019: Progress in Neuro-psychopharmacology & Biological Psychiatry
Bahareh Peyrovian, Joshua D Rosenblat, Zihang Pan, Michelle Iacobucci, Elisa Brietzke, Roger S McIntyre
Cognitive dysfunction is a principal determinant of functional impairment in major depressive disorder (MDD) and often persists during periods of euthymia. Abnormalities in the glutamate system, particularly in N-methyl-d-aspartate receptors (NMDARs) activity, have been shown to contribute to both mood and cognitive symptoms in MDD. The current narrative review aims to evaluate the potential pro-cognitive effects of targeting the glycine site of NMDARs in the treatment of psychiatric disorders, with a special focus on how these results may apply to MDD...
February 6, 2019: Progress in Neuro-psychopharmacology & Biological Psychiatry
Nela Pivac
No abstract text is available yet for this article.
January 30, 2019: Progress in Neuro-psychopharmacology & Biological Psychiatry
Wei-Syun Hu, Cheng-Li Lin
BACKGROUND AND AIMS: We analyze the incidence of suicide attempt in a Taiwanese population following admission to hospital between 2000 and 2010 for atrial fibrillation (AF). METHODS: Using a large National Health Insurance Research Database in Taiwan, the study cohort and the comparison cohort were 1-fold matched according to propensity score method. Cox proportion hazard regression models were used to examine the effect of AF on the risk of suicide attempt, and were shown as hazard ratios (HRs) and 95% confidence intervals (CIs)...
January 29, 2019: Progress in Neuro-psychopharmacology & Biological Psychiatry
Rocío Guerrero, Bruno Ribeiro Do Couto, Juana M Hidalgo, Francisco Carceles, Guillermo Molina, M Luisa Laorden, Cristina Núñez, M Victoria Milanés
Accumulating evidence indicates that dopamine (DA) D3 receptor (DAD3R) antagonists appear highly promising in attenuating cocaine reward and relapse in preclinical models of addiction. In the present study, we investigated the effects of the selective DAD3R antagonist SB-277011-A on the reinstatement of cocaine-induced conditioned place preference (CPP) produced by a priming dose of cocaine, by social defeat stress and by two kinds of physiological stressors (restraint and tail pinch) in male adult mice. We also explored reinstatement-related plasma corticosterone levels (as marker of stress response) and the effects of blocking DAD3R...
January 29, 2019: Progress in Neuro-psychopharmacology & Biological Psychiatry
Tobias Schwippel, Philipp A Schroeder, Andreas J Fallgatter, Christian Plewnia
Repetitive Transcranial Magnetic Stimulation (rTMS) is a neuromodulatory treatment intervention, which can be used to alleviate symptoms of mental disorders. Theta-burst stimulation (TBS), an advanced, patterned form of TMS, features several advantages regarding applicability, treatment duration and neuroplastic effects. This clinical review summarizes TBS studies in mental disorders and tinnitus and discusses effectivity and future directions of clinical TBS research. Following the PRISMA guidelines, the authors included 47 studies published until July 2018...
January 29, 2019: Progress in Neuro-psychopharmacology & Biological Psychiatry
Yafang Yang, Xiaohan Li, Jing Zhao, Mengying Xue, Mengfei Zhang, Chunlan Wang, Hongyu Song, Linlin He, Wenxuan Guo, Pingyuan Gong
BACKGROUNDS: Alexithymia refers to the difficulties in identifying and describing one's own emotions, lacking of imagination, and an externally oriented thinking style. Studies up to date have examined the associations of the 5-HTTLPR and COMT Val158Met polymorphisms with alexithymia. However, the previous findings were mixed. METHODS: We replicated the associations by scoring on alexithymia with the 20-item Toronto Alexithymia Scale and genotyping the polymorphisms of 5-HTTLPR and COMT Val158Met in a large population of college students (N = 1698)...
January 29, 2019: Progress in Neuro-psychopharmacology & Biological Psychiatry
Ian Robertson, Amy Cheung, Xiaoduo Fan
In patients with schizophrenia, insomnia is a common yet often overlooked comorbidity. With sleep disturbances inextricably linked to increased severity of schizophrenia and worsening clinical outcomes, insomnia is an important therapeutic target within this patient population. Thus, through a review of the current literature, this paper reiterates the important etiological link between these two conditions, while evaluating the safety, efficacy, and limitations of current therapeutic options for the treatment of comorbid insomnia in schizophrenia...
January 29, 2019: Progress in Neuro-psychopharmacology & Biological Psychiatry
Ruiyang Ge, Jonathan Downar, Daniel M Blumberger, Zafiris J Daskalakis, Raymond W Lam, Fidel Vila-Rodriguez
Repetitive transcranial magnetic stimulation (rTMS) is a first-line option for treatment-resistant depression (TRD), but prediction of treatment outcome remains a clinical challenge. The present study aimed to compare structural and functional covariance networks (SCNs and FCNs) between remitters and nonremitters. We determined the predictive capacities of SCNs and FCNs to discriminate the two groups. Fifty TRD patients underwent a course of rTMS to the left dorsolateral prefrontal cortex. They were categorized into remitters (n = 22) and nonremitters (n = 28) based on HDRS≤7 at the end of treatment...
January 25, 2019: Progress in Neuro-psychopharmacology & Biological Psychiatry
Jin-Mei Chen, Qing-Wei Li, Jian-Sheng Liu, Guo-Xin Jiang, Jian-Ren Liu, Sheng-Di Chen, Qi Cheng
BACKGROUND: Transient receptor potential canonical (TRPC) 6 inhibits Aβ in Alzheimer's disease (AD) mouse brain and improves the behavioral performance. AIMS: To evaluate the association of TRPC6 expression in peripheral leucocytes from AD and mild cognitive impairment (MCI) patients and to explore its potential value in early diagnosis of AD. METHODS: TRPC6 mRNA levels in peripheral leucocytes were detected by quantitative real-time PCR...
January 23, 2019: Progress in Neuro-psychopharmacology & Biological Psychiatry
Stephanie M Gorka, Lynne Lieberman, Kayla A Kreutzer, Vivian Carrillo, Anna Weinberg, Stewart A Shankman
Studies suggest that individuals with alcohol use disorder (AUD) display abnormal neural error-processing, measured via the error-related negativity (ERN). The nature of the error-related abnormalities in AUD is unclear, however, as prior research has yielded discrepant findings. In addition, no study to date has attempted to characterize the dispositional nature of the ERN in AUD and directly test to what extent ERN amplitude reflects a risk factor, disease marker, and/or scar of AUD psychopathology. The current study compared ERN amplitude across 244 adult volunteers in the following five groups: 1) current AUD (n = 39), 2) AUD in remission (n = 60), 3) at-risk for AUD (n = 43), 4) psychiatric controls with comparable rates of internalizing psychopathology as the AU groups (n = 53), and 5) healthy controls with no lifetime history of psychopathology (n = 49)...
January 23, 2019: Progress in Neuro-psychopharmacology & Biological Psychiatry
Christiane Mühle, Brianna Barry, Christian Weinland, Johannes Kornhuber, Bernd Lenz
OBJECTIVE: Alcohol use disorders inflict a great individual and societal burden. Although sex hormone effects have been implicated in alcohol dependence, research has mostly neglected estrogen activities and female alcohol-dependent patients. Here, we investigated associations of estrogen receptor 1 (ESR1) genetics and serum estradiol activities with aspects of alcohol dependence. METHOD: Serum estradiol activities of early-abstinent alcohol-dependent in-patients (n[♂] = 113, n[♀] = 87) were followed for at median 5 days and compared with healthy controls (n[♂] = 133, n[♀] = 107)...
January 21, 2019: Progress in Neuro-psychopharmacology & Biological Psychiatry
Andrea Vereczkei, Omar Abdul-Rahman, Zsuzsa Halmai, Geza Nagy, Anna Szekely, Aniko Somogyi, Gabor Faludi, Zsofia Nemoda
INTRODUCTION: The activation of the ATP-gated P2RX7 (purinergic receptor P2X, ligand-gated ion channel, 7) produces microglial activation, a process which has been demonstrated in depression, bipolar disorder, and schizophrenia. Emerging data over the last years highlighted the importance of P2X7 cation channel as a potential drug target for these central nervous system disorders. The Gln460Arg (rs2230912) polymorphism of the P2RX7 gene has been widely studied in mood disorders, however the results are still controversial...
January 18, 2019: Progress in Neuro-psychopharmacology & Biological Psychiatry
Verônica Tironi Dias, Higor Zuquetto Rosa, Lívia Ferraz D'avila, Luciana Taschetto Vey, Raquel Cristine Silva Barcelos, Marilise Escobar Burger
Drug abuse and addiction are overwhelming health problems mainly during adolescence. Based on a previous study of our research group, the rats that received modafinil (MD) during the adolescence showed less preference for amphetamine (AMPH) in adulthood. Our current hypothesis is that MD will show beneficial effects against AMPH preference and abstinence symptoms during adolescence, a critical lifetime period when drug hedonic effects are more pronounced. We investigated the influence of MD pretreatment on AMPH preference in conditioned place preference (CPP) paradigm in adolescent rats and anxiety-like symptoms during drug withdrawal (48 h after the last AMPH dose) in elevated plus maze (EPM) task...
January 18, 2019: Progress in Neuro-psychopharmacology & Biological Psychiatry
Saravana Babu Chidambaram, A G Rathipriya, Srinivasa Rao Bolla, Abid Bhat, Bipul Ray, Arehslly Marappa Mahalakshmi, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozhi, Musthafa Mohamed Essa, Gilles J Guillemin, Ramesh Chandra, Meena Kishore Sakharkar
Dendritic spines are small, thin, specialized protrusions from neuronal dendrites, primarily localized in the excitatory synapses. Sophisticated imaging techniques revealed that dendritic spines are complex structures consisting of a dense network of cytoskeletal, transmembrane and scaffolding molecules, and numerous surface receptors. Molecular signaling pathways, mainly Rho and Ras family small GTPases pathways that converge on actin cytoskeleton, regulate the spine morphology and dynamics bi-directionally during synaptic activity...
January 14, 2019: Progress in Neuro-psychopharmacology & Biological Psychiatry
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