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Journals Progress in Neuro-psychopharma...

Progress in Neuro-psychopharmacology & Biological Psychiatry

https://read.qxmd.com/read/39033955/sex-dependent-nonlinear-granger-connectivity-patterns-of-brain-aging-in-healthy-population
#1
JOURNAL ARTICLE
Yu Fu, Le Xue, Meng Niu, Yuanhang Gao, Yanyan Huang, Hong Zhang, Mei Tian, Cheng Zhuo
BACKGROUND: Brain aging is a complex process that involves functional alterations in multiple subnetworks and brain regions. However, most previous studies investigating aging-related functional connectivity (FC) changes using resting-state functional magnetic resonance images (rs-fMRIs) have primarily focused on the linear correlation between brain subnetworks, ignoring the nonlinear casual properties of fMRI signals. METHODS: We introduced the neural Granger causality technique to investigate the sex-dependent nonlinear Granger connectivity (NGC) during aging on a publicly available dataset of 227 healthy participants acquired cross-sectionally in Leipzig, Germany...
July 19, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/39032855/cognitive-changes-in-patients-with-unipolar-trd-treated-with-iv-ketamine-a-systematic-review
#2
REVIEW
Veronica Grasso, Gilmar Gutierrez, Najat Alzbeidi, Carolina Hernandorena, Gustavo H Vázquez
BACKGROUND: Unipolar treatment-resistant depression (MDD-TRD) is associated with neurocognitive impairment. Ketamine, an emerging treatment for MDD-TRD, may have neurocognitive benefits, but evidence remains limited. METHODS: We conducted a systematic search on EMBASE, Google Scholar, PsycINFO, and PubMed and included studies exploring the cognitive effects of intravenous (IV) ketamine treatment in the management of MDD-TRD following the PRISMA guidelines. We analyzed cognitive scale score changes pre- and post-IV ketamine treatment and the quality of the evidence using the Cochrane risk of bias tool and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE)...
July 18, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/39032854/semaglutide-ameliorated-autism-like-behaviors-and-dna-repair-efficiency-in-male-btbr-mice-by-recovering-dna-repair-gene-expression
#3
JOURNAL ARTICLE
Marwa H Hussein, Alaa A Alameen, Mushtaq A Ansari, Shakir D AlSharari, Sheikh F Ahmad, Mohamed S M Attia, Wedad Sarary, Ahmed Nadeem, Saleh A Bakheet, Sabry M Attia
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that is marked by impaired social interactions, and increased repetitive behaviors. There is evidence of genetic changes in ASD, and several of these altered genes are linked to the process of DNA repair. Therefore, individuals with ASD must have improved DNA repair efficiency to mitigate risks associated with ASD. Despite numerous milestones in ASD research, the disease remains incurable, with a high occurrence rate and substantial financial burdens...
July 18, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/39029651/disruption-of-relapse-to-cocaine-and-morphine-seeking-by-licl-induced-aversive-counterconditioning-following-memory-retrieval
#4
JOURNAL ARTICLE
Qian Tang, Zhonghao Li, Fushen Zhang, Lei Han, Weidan Pu
Substance use disorder is conceptualized as a form of maladaptive learning, whereby drug-associated memories, elicited by the presence of stimuli related to drug contexts or cues, contribute to the persistent recurrence of craving and the reinstatement of drug-seeking behavior. Hence, use of pharmacology or non-pharmacology way to disrupt drug-related memory holds promise to prevent relapse. Several studies have shown that memories can be unstable and susceptible to modification during the retrieval reactivation phase, termed the "reconsolidation time window"...
July 17, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/39029650/the-influence-of-novelty-detection-on-the-40-hz-auditory-steady-state-response-in-schizophrenia-a-novel-hypothesis-from-meta-analysis
#5
REVIEW
Shunsuke Sugiyama, Koji Inui, Kazutaka Ohi, Toshiki Shioiri
The 40-Hz auditory steady-state response (ASSR) is influenced not only by parameters such as attention, stimulus type, and analysis level but also by stimulus duration and inter-stimulus interval (ISI). In this meta-analysis, we examined these parameters in 33 studies that investigated 40-Hz ASSRs in patients with schizophrenia. The average Hedges' g random effect sizes were - 0.47 and - 0.43 for spectral power and phase-locking, respectively. We also found differences in ASSR measures based on stimulus duration and ISI...
July 17, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/39029649/neutrophil-lymphocyte-ratio-and-cognitive-performances-in-first-episode-patients-with-schizophrenia-and-healthy-controls
#6
JOURNAL ARTICLE
Jing Liang, Xiaoni Guan, Qianqian Sun, Yong Hao, Meihong Xiu
Abnormal immune and inflammatory responses are considered to contribute to schizophrenia (SZ). The neutrophil/lymphocyte ratio (NLR) is an inexpensive and reproducible marker of systemic inflammatory responses. Accumulating studies have demonstrated that NLR values are increased in SZ compared to healthy controls and closely related to clinical symptoms in antipsychotic-naïve first-episode SZ (ANFES) patients. However, to our knowledge, only one study has examined NLR in relation to neurocognition in 27 first-episode psychosis patients and 27 controls...
July 17, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/39029648/betaine-improves-meth-induced-depressive-like-behavior-and-cognitive-impairment-by-alleviating-neuroinflammation-via-nlrp3-inflammasome-inhibotion
#7
JOURNAL ARTICLE
Rongji Hui, Jiabao Xu, Maijie Zhou, Bing Xie, Meiqi Zhou, Ludi Zhang, Bin Cong, Chunling Ma, Di Wen
Methamphetamine abuse has been associated with central nervous system damage, contributing to the development of neuropsychiatric disorders such as depressive-like behavior and cognitive impairment. With the escalating prevalence of METH abuse, there is a pressing need to explore effective therapeutic interventions. Thus, the objective of this research was to investigate whether betaine can protect against depressive-like behavior and cognitive impairment induced by METH. Following intraperitoneal injections of METH in mice, varying doses of betaine were administered...
July 17, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/39019430/clozapine-as-a-mood-stabiliser-for-schizoaffective-disorder-effectiveness-during-a-three-month-follow-up
#8
JOURNAL ARTICLE
M Peraire, F Arnau-Peiró, A Benito, A Fuertes-Saiz, I Almodóvar, G Haro
Clozapine has shown signs of effectiveness in treating symptoms of schizoaffective disorder, although little research has been carried out to specifically assess this question. The objective of this current work was to analyse the mood-stabilising effectiveness and tolerability of clozapine in patients with schizoaffective disorder. This was a prospective, longitudinal, and quasi-experimental trial with three months of follow-up in patients with refractory schizoaffective disorder (PANSS score exceeding 80)...
July 15, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/39004333/effectiveness-of-pharmacological-interventions-for-managing-adhd-symptoms-in-individuals-with-autism-spectrum-disorder-a-systematic-review-and-meta-analysis
#9
JOURNAL ARTICLE
Paulo Levi Bezerra Martins, Gustavo César Parente Torquato, Gabriel Alberto Pinheiro Fernandes Dias, Isabel Bessa Leite, Thays Macedo Gaspar, Joel Porfírio, Danielle S Macedo
OBJECTIVES: This systematic review sought to provide evidence for the effectiveness of common pharmacological interventions used for treating attention deficit hyperactivity disorder (ADHD) symptoms in the autism spectrum disorder (ASD) population, considering studies attempting to find safe and effective drugs. METHODS: We searched for randomized controlled trials describing the effectiveness and/or safety profile of pharmacological interventions for treating ASD and ADHD or ASD with ADHD symptoms using three bibliographic databases: PubMed, Cochrane Library, and Embase...
July 12, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/39004332/cerebral-blood-flow-in-relation-to-peripheral-endothelial-function-in-youth-bipolar-disorder
#10
JOURNAL ARTICLE
Alysha A Sultan, Sudhir Karthikeyan, Anahit Grigorian, Kody G Kennedy, Megan Mio, Bradley J MacIntosh, Benjamin I Goldstein
INTRODUCTION: Anomalous cerebral blood flow (CBF) is evident in bipolar disorder (BD), however the extent to which CBF reflects peripheral vascular function in BD is unknown. This study investigated endothelial function, an index of early atherosclerosis and cardiovascular disease risk, in relation to CBF among youth with BD. METHODS: Participants included 113 youth, 13-20 years old (66 BD; 47 healthy controls [HC]). CBF was measured using arterial spin labeling with 3 T MRI...
July 12, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/39002929/neurocognitive-and-clinical-profile-of-male-patients-with-substance-use-disorder-in-early-remission-phase-with-and-without-comorbid-depression
#11
JOURNAL ARTICLE
Julia E Marquez-Arrico, Judit Catalán-Aguilar, José Francisco Navarro, Ana Adan
Substance Use Disorder (SUD) represents one of the most frequent conditions worldwide which commonly coexists with major depressive disorder (MDD). This comorbidity (SUD + MDD) is one of the most prevalent with patients showing certain social and clinical characteristics that could lead to a worsening of their cognitive performance. However, despite these particularities, only a few studies have addressed the possible differences in cognitive performance between patients with SUD + MDD compared with those with SUD-only patients...
July 11, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/39002928/a-unified-approach-to-investigating-4-dpf-zebrafish-larval-behaviour-through-a-standardised-light-dark-assay
#12
JOURNAL ARTICLE
Courtney Hillman, James Kearn, Matthew O Parker
Zebrafish have emerged as a dynamic research model in the domains of neuropsychopharmacology, biological psychiatry and behaviour. Working with larvae ≤4 days post-fertilisation (dpf) offers an avenue for high-throughput investigation whilst aligning with the 3Rs principles of animal research. The light/dark assay, which is the most used behavioural assay for larval neuropharmacology research, lacks experimental reliability and standardisation. This study aimed to formulate a robust, reproducible and standardised light/dark behavioural assay using 4 dpf zebrafish larvae...
July 11, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/39002927/association-between-reduced-plasma-bdnf-concentration-and-mmse-scores-in-both-chronic-schizophrenia-and-mild-cognitive-impairment
#13
JOURNAL ARTICLE
Martin Gredicak, Matea Nikolac Perkovic, Gordana Nedic Erjavec Croatia, Suzana Uzun, Oliver Kozumplik, Dubravka Svob Strac, Nela Pivac
Reduced brain derived neurotrophic factor (BDNF) concentration is reported to be associated with a cognitive decline in schizophrenia, depending on the stage of the disease. Aim of the study was to examine the possible association between plasma BDNF and cognitive decline in chronic stable schizophrenia and mild cognitive impairment (MCI). The study included 123 inpatients of both sexes with schizophrenia, 123 patients with MCI and 208 healthy control subjects. Cognitive abilities were assessed using mini mental state examination (MMSE), Clock Drawing test (CDT) and cognitive subscale of the Positive and Negative Syndrome Scale (PANSS)...
July 11, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/39002926/a-network-analysis-of-catatonia-symptoms-across-diagnoses
#14
JOURNAL ARTICLE
Gauld Christophe, Paul Expert, Thomas Fovet, Ali Amad
BACKGROUND: Catatonia, as a transdiagnostic construct, manifests across various psychiatric and non-psychiatric conditions. Understanding how symptom variations impact the catatonia construct and differ across primary diagnoses (schizophrenia, bipolar disorder, unipolar depression, and neurological/metabolic/immunological condition) is essential to refine diagnostic and therapeutic approaches. This study aims to compare the symptom networks and centrality measures of these diagnoses. METHODS: We conducted a network analysis using Bush-Francis Catatonia Rating Scale (BFCRS) data from 118 patients, examining centrality measures and network comparisons across the four primary diagnostic groups...
July 11, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/39002925/microrna-dysregulation-in-glutamate-and-dopamine-pathways-of-schizophrenia-from-molecular-pathways-to-diagnostic-and-therapeutic-approaches
#15
REVIEW
Parya Alizadeh Khosroshahi, Mohammad Ghanbari
Schizophrenia is a complex psychiatric disorder, and genetic and environmental factors have been implicated in its development. Dysregulated glutamatergic and dopaminergic transmission pathways are involved in schizophrenia development. Besides genetic mutations, epigenetic dysregulation has a considerable role in dysregulating molecular pathways involved in schizophrenia. MicroRNAs (miRNAs) are small, non-coding RNAs that target specific mRNAs and inhibit their translation into proteins. As epigenetic factors, miRNAs regulate many genes involved in glutamate and dopamine signaling pathways; thereby, their dysregulation can contribute to the development of schizophrenia...
July 11, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38992486/white-matter-substrates-underlying-morphological-awareness-deficit-in-chinese-children-with-developmental-dyslexia
#16
JOURNAL ARTICLE
Xiaoyu Xu, Xiaojing Song, Lizi Lin, Ning Pan, Yuying Jin, Si Tan, Muqing Cao, Yingqian Chen, Jingxian Zhao, Xintong Su, Kaize Yang, Jin Jing, Xiuhong Li
BACKGROUND: Morphological awareness (MA) deficit is strongly associated with Chinese developmental dyslexia (DD). However, little is known about the white matter substrates underlying the MA deficit in Chinese children with DD. METHODS: In the current study, 34 Chinese children with DD and 42 typical developmental (TD) children were recruited to complete a diffusion magnetic resonance imaging scan and cognitive tests for MA. We conducted linear regression to test the correlation between MA and DTI metrics, the structural abnormalities of the tracts related to MA, and the interaction effect of DTI metrics by group on MA...
July 9, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38972502/resting-state-dynamic-functional-connectivity-in-major-depressive-disorder-a-systematic-review
#17
REVIEW
Shuting Sun, Chang Yan, Shanshan Qu, Gang Luo, Xuesong Liu, Fuze Tian, Qunxi Dong, Xiaowei Li, Bin Hu
As a novel measure, dynamic functional connectivity (dFC) provides insight into the dynamic nature of brain networks and their interactions in resting-state, surpassing traditional static functional connectivity in pathological conditions such as depression. Since a comprehensive review is still lacking, we then reviewed forty-five eligible papers to explore pathological mechanisms of major depressive disorder (MDD) from perspectives including abnormal brain regions and functional networks, brain state, topological properties, relevant recognition, along with longitudinal studies...
July 5, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38950842/co-stimulation-of-muscarinic-m1-and-m4-acetylcholine-receptors-prevents-later-cocaine-reinforcement-in-male-and-female-mice-but-not-place-conditioning
#18
JOURNAL ARTICLE
Abhishek Shankar Balakrishnan, Lærke Bornø Engelhardt Johansen, Craig W Lindsley, P Jeffrey Conn, Morgan Thomsen
Acute stimulation of M1 or M4 muscarinic cholinergic receptors reduces cocaine abuse-related effects in mice and rats. The combined activation of these receptor subtypes produces synergistic effects on some behavioural endpoints in mice. M1 and M1  + M4 receptor stimulation in a cocaine vs. food choice assay in rats and microdialysis in rats showed delayed and lasting "anticocaine effects". Here, we tested whether these putative lasting neuroplastic changes are sufficient to occlude the reinforcing effects of cocaine at the behavioural level in mice...
June 29, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38950841/investigating-7-8-dihydroxyflavone-to-combat-maternal-immune-activation-effects-on-offspring-gene-expression-and-behaviour
#19
JOURNAL ARTICLE
Brendan Gillespie, Ariel Dunn, Suresh Sundram, Rachel Hill
Infection during pregnancy is a substantial risk factor for the unborn child to develop autism or schizophrenia later in life, and is thought to be driven by maternal immune activation (MIA). MIA can be modelled by exposing pregnant mice to Polyinosinic: polycytidylic acid (Poly-I:C), a viral mimetic that induces an immune response and recapitulates in the offspring many neurochemical features of ASD and schizophrenia, including altered BDNF-TrkB signalling and disruptions to excitatory/inhibitory balance. Therefore, we hypothesised that a BDNF mimetic, 7,8-Dihydroxyflavone (7,8-DHF), administered prophylactically to the dam may prevent the neurobehavioural sequelae of disruptions induced by MIA...
June 29, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38950840/dopamine-d2-like-receptors-on-conditioned-and-unconditioned-fear-a-systematic-review-of-rodent-pharmacological-studies
#20
REVIEW
Camila de Oliveira Alves, Isabelle Waku, Joyce Nonato Chiossi, Amanda Ribeiro de Oliveira
Growing evidence supports dopamine's role in aversive states, yet systematic reviews focusing on dopamine receptors in defensive behaviors are lacking. This study presents a systematic review of the literature examining the influence of drugs acting on dopamine D2-like receptors on unconditioned and conditioned fear in rodents. The review reveals a predominant use of adult male rats in the studies, with limited inclusion of female rodents. Commonly employed tests include the elevated plus maze and auditory-cued fear conditioning...
June 29, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
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