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Journals Journal of Traditional Chinese...

Journal of Traditional Chinese Medicine

https://read.qxmd.com/read/38767628/optimized-new-shengmai-powder-inhibits-myocardial-fibrosis-in-heart-failure-by-regulating-the-rat-sarcoma-rapidly-accelerated-fibrosarcoma-mitogen-activated-protein-kinase-kinase-extracellular-regulated-protein-kinases-signaling-pathway
#21
JOURNAL ARTICLE
Zhang Zeyu, Jia Zhuangzhuang, Song Yuwei, Zhang Xuan, Wang Ci, Wang Shuai, Zhang Peipei, Ren Qiuan, Wang Xianliang, Mao Jingyuan
OBJECTIVE: Exploring the effect of Optimized New Shengmai powder (, ONSMP) on myocardial fibrosis in heart failure (HF) based on rat sarcoma (RAS)/rapidly accelerated fibrosarcoma (RAF)/mitogen-activated protein kinase kinase (MEK)/extracellular regulated protein kinases (ERK) signaling pathway. METHODS: Randomized 70 Sprague-Dawley rats into sham ( n = 10) and operation ( n = 60) groups, then established the HF rat by ligating the left anterior descending branch of the coronary artery...
June 2024: Journal of Traditional Chinese Medicine
https://read.qxmd.com/read/38767627/transient-receptor-potential-vanilloid-1-involved-in-the-analgesic-effects-of-total-flavonoids-extracted-from-longxuejie
#22
JOURNAL ARTICLE
M O Xiaoqiang, Chen Yating, Yin Qian, Chen Haibo, Ban Qiang, L I Jun, Chen Su, Yao Jinguang
OBJECTIVE: To evaluate the analgesic effects of total flavonoids of Longxuejie ( Resina Dracaenae Cochinchinensis ) (TFDB) and explore the possible analgesic mechanism associated with transient receptor potential vanilloid 1 (TRPV1). METHODS: Whole-cell patch clamp technique was used to observe the effects of TFDB on capsaicin-induced TRPV1 currents. Rat experiments in vivo were used to observe the analgesic effects of TFDB. Western blot and immunofluorescence experiments were used to test the change of TRPV1 expression in DRG neurons induced by TFDB...
June 2024: Journal of Traditional Chinese Medicine
https://read.qxmd.com/read/38767626/chang-an-decoction-alleviates-endoplasmic-reticulum-stress-by-regulating-mitofusin-2-to-improve-colitis
#23
JOURNAL ARTICLE
Chen Youlan, Ding Mingming, Huang Chaoyuan, Zheng Yiyuan, Liu Fengbin
OBJECTIVE: To evaluate the protective effects of Chang'an decoction (, CAD) on colitis, and investigate the potential mechanisms underlying these effects from the perspectives of endoplasmic reticulum (ER) stress induced by mitofusin 2 (MFN2). METHODS: The composition of CAD was identified by liquid chromatography-mass spectrometry technology. A mice model of dextran sulfate sodium (DSS) induced colitis was established and therapeutic effects of CAD were determined by detecting body weight, disease activity index, colon length and histopathological changes...
June 2024: Journal of Traditional Chinese Medicine
https://read.qxmd.com/read/38767625/efficacy-of-substances-containing-3-types-of-active-ingredients-saponins-flavones-and-alkaloids-in-regulation-of-cytokines-in-autoimmune-diseases-a-systematic-review-and-meta-analysis-based-on-animal-studies
#24
JOURNAL ARTICLE
Zhu Ruifang, Zhang Jun, Lyu Yaru, Chen Yulu, Han Shifan, Wang Hongwei
OBJECTIVE: To investigate the efficacy of substances containing 3 types of active ingredients-saponins, flavones, and alkaloids on experimental animals with autoimmune diseases (AIDs). METHODS: The protocol for this systematic review and Meta-analysis was prospectively registered with PROSPERO (CRD42023395741). Searches were conducted in the China National Knowledge Infrastructure, Wanfang, Chinese Science and Technology Journals, China Biomedical, PubMed, Cochrane Library, and Embase databases to screen for animal studies investigating the therapeutic effects of saponins, flavones, or alkaloids on autoimmune diseases; consequently, corresponding data extraction tables were prepared...
June 2024: Journal of Traditional Chinese Medicine
https://read.qxmd.com/read/38504548/complementary-and-alternative-medicine-on-cognitive-defects-and-neuroinflammation-after-sepsis
#25
JOURNAL ARTICLE
L I Zhenxuan, Wang Xuerui, Luis Ulloa, Ayman Youssef, Bai Yunjing, X U Xiaolong, Liu Qingquan
Sepsis-associated encephalopathy (SAE) is a common manifestation of sepsis, ranging from mild confusion and delirium to severe cognitive impairment and deep coma. SAE is associated with higher mortality and long-term outcomes, particularly substantial declines in cognitive function. The mechanisms of SAE probably include neuroinflammation that is mediated by systemic inflammation and ischemic lesions in the brain, a disrupted blood-brain barrier, oxidative stress, neurotransmitter dysfunction, and severe microglial activation...
April 2024: Journal of Traditional Chinese Medicine
https://read.qxmd.com/read/38504547/pharmacological-potential-of-l-p-royen-sapodilla-a-narrative-review
#26
JOURNAL ARTICLE
Priyanka Sharma, Aakash Deep, Harish Kumar, Nitin Bansal, Sanjiv Kumar, Arun, Davinder Kumar
Herbal medicine is safe and effective in treating various diseases. Traditional herbal medicine plays a tremendous role in treatment of various diseases and accompanying complications, hence herbal medicine requires remarkable attention in further research for the development of numerous active formulations for treatment of health troubles. The plant needs special consideration for development and research of unidentified compound and characterization of novel active molecules that overcome multiple pathological abnormalities...
April 2024: Journal of Traditional Chinese Medicine
https://read.qxmd.com/read/38504546/formulation-of-international-standards-of-chinese-medicine-technology-clinical-practice-guide-of-chinese-medicine-for-cough
#27
JOURNAL ARTICLE
Fang Hanyu, Hong Zheng, L I Deming, Zhang Hongchun, Shi Yihang, L I Xiaojuan, Sun Zengtao, Chen Wei, Zhang Chuchu, Z U Yaqi
OBJECTIVE: To formulate the first clinical practice guideline for the treatment of cough using Chinese medicine based on the grading of recommendations assessment, development, and evaluation (GRADE) systematic approach, including clinical evidence, evaluation of ancient literature, and expert consensus. METHODS: In the process of development, the regulation of "evidence-based, consensus-assisted, and empirical" was followed, and a comprehensive systematic approach of recommendation assessment, GRADE, evidence-based evaluation, expert consensus, and the Delphi method was used...
April 2024: Journal of Traditional Chinese Medicine
https://read.qxmd.com/read/38504545/effectivenss-of-electroacupuncture-for-skeletal-muscle-pain-in-parkinson-s-disease-a-clinical-randomized-controlled-trial
#28
RANDOMIZED CONTROLLED TRIAL
Wang Shaosong, Sun Jingqing, Feng Qingyin, L I Bin, Wang Xin, Yuan Fan, Cui Yingxue
OBJECTIVE: To explore the effect of electroacupuncture on skeletal muscle pain in Parkinson's disease (PD). METHODS: A single-center randomized controlled trial was conducted with sixty patients with Parkinson's disease with skeletal muscle pain were randomly divided into electroacupuncture group and sham acupuncture control group with 30 patients each. The electric acupuncture group was treated with electric acupuncture, while the control group was treated with Park needle pseudoacupuncture...
April 2024: Journal of Traditional Chinese Medicine
https://read.qxmd.com/read/38504544/effectiveness-and-safety-of-qidong-huoxue-decoction-in-treatment-of-acute-lung-injury-and-acute-respiratory-distress-syndrome-a-randomized-controlled-trial
#29
RANDOMIZED CONTROLLED TRIAL
Y U Zhengqiu, Y U Liuda, Chen Ye, L I Mingjing, Cai Wanru
OBJECTIVE: To evaluate the efficacy of Qidong Huoxue decoction (,QDHX) in treating acute lung injury and acute respiratory distress syndrome (ALI/ARDS) when used as an adjunctive treatment. METHODS: ALI/ARDS patients admitted to our medical intensive care unit were randomly allocated to the control group or the QDHX group and received standard therapy. The QDHX group received QDHX (50 mL per day for 14 d) orally or via a gastric tube. The primary outcome was measured according to Traditional Chinese Medicine (TCM) syndrome scores, with partial pressure of oxygen/fraction of inspired oxygen (PaO2 /FiO2 ) levels as the secondary outcome...
April 2024: Journal of Traditional Chinese Medicine
https://read.qxmd.com/read/38504543/effectiveness-and-safety-of-jiawei-xiaoyao-pill-in-the-treatment-of-premenstrual-syndrome-liver-depression-spleen-deficiency-and-blood-heat-syndrome-a-multi-center-randomized-placebo-controlled-trial
#30
JOURNAL ARTICLE
L I Xiyu, Yang Yanhong, Sun Jian, Nie Quanfang, Liu Lifen, L I Guifen, Y U Junping, Zhang Zhuangjin, X U Yi, Zou Ting, Shi Yun
OBJECTIVE: To investigate the effectiveness and safety of Jiawei Xiaoyao pill (,JXP) in the treatment of symptoms associated with premenstrual syndrome (PMS). METHODS: A total of 144 regularly menstruating women with PMS were recruited at 8 sites in China from August 2017 to December 2018, and randomized to receive either a JXP or a matching placebo (12 g/d, 6 g twice a day) for 3 menstrual cycles. The primary indicator was the reduced Daily Record of Severity of Problems (DRSP) scores in the luteal phase after 3 months of treatment...
April 2024: Journal of Traditional Chinese Medicine
https://read.qxmd.com/read/38504542/network-pharmacology-and-experimental-validation-to-reveal-the-pharmacological-mechanisms-of-sini-decoction-against-renal-fibrosis
#31
JOURNAL ARTICLE
Wang Yan, Deng Fanying, Liu Shiqi, Wang Yingli
OBJECTIVE: To investigate the mechanism by which Sini decoction (, SND) improves renal fibrosis (Rf) in rats based on transforming growth factor β1/Smad (TGF-β1/Smad) signaling pathway. METHODS: Network pharmacology was applied to obtain potentially involved signaling pathways in SND's improving effects on Rf. The targets of SND drug components and the targets of Rf were obtained by searching databases, such as the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCSMP) and GeenCard...
April 2024: Journal of Traditional Chinese Medicine
https://read.qxmd.com/read/38504541/moxibustion-of-zusanli-st36-and-shenshu-bl23-alleviates-the-inflammation-of-rheumatoid-arthritis-in-rats-through-regulating-macrophage-migration-inhibitory-factor-glucocorticoids-signaling
#32
JOURNAL ARTICLE
Zhang Linlin, Zhong Yumei, L U Wenting, Shang Yanan, Guo Yanding, Luo Xiaochao, Chen Yang, Luo Kun, H U Danhui, Y U Huiling, Zhou Haiyan
OBJECTIVE: To test the hypothesis that moxibustion may inhibit rheumatoid arthritis (RA) synovial inflammation by regulating the expression of macrophage migration inhibitory factor (MIF)/glucocorticoids (GCs). METHODS: Fifty male Sprague-Dawley rats were randomly divided into five groups ( n = 10 each): blank Control (CON) group, RA Model (RA) group, Moxibustion (MOX) group, MIF inhibitor (S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester (ISO-1) group, and Moxibustion + MIF inhibitor ISO-1 (MOX + ISO-1) group...
April 2024: Journal of Traditional Chinese Medicine
https://read.qxmd.com/read/38504540/mechanism-of-acupuncture-in-attenuating-cerebral-ischaemia-reperfusion-injury-based-on-nuclear-receptor-coactivator-4-mediated-ferritinophagy
#33
JOURNAL ARTICLE
Zhang Xinchang, Huang Zheng, Huang Peiyan, Yang Mengning, Zhang Zhihui, N I Guangxia
OBJECTIVE: To explore the effect of acupuncture treatment on cerebral ischaemia-reperfusion injury (CIRI) and reveal the underlying mechanism of the effect based on nuclear receptor coactivator 4 (NCOA4) mediated ferritinophagy. METHODS: Sprague-Dawley male rats were divided into four groups: the sham group, model group, acupuncture group, and sham acupuncture group. After 2 h of middle cerebral artery occlusion (MCAO), reperfusion was performed for 24 h to induce CIRI...
April 2024: Journal of Traditional Chinese Medicine
https://read.qxmd.com/read/38504539/mechanisms-of-dangua-fang-in-multi-target-and-multi-method-regulation-of-glycolipid-metabolism-based-on-phosphoproteomics
#34
JOURNAL ARTICLE
Heng Xianpei, Wang Zhita, L I Liang, Yang Liuqing, Huang Suping, Jin Lang, H E Weidong
OBJECTIVE: To explore the mechanism of Dangua Fang (, DGR) in multi-target and multi-method regulation of glycolipid metabolism based on phosphoproteomics. METHODS: Sprague-Dawley rats with normal glucose levels were randomly divided into three groups, including a conventional diet control group (Group A), high-fat-high-sugar diet model group (Group B), and DGR group (Group C, high-fat-high-sugar diet containing 20.5 g DGR). After 10 weeks of intervention, the fasting blood glucose (FBG), 2 h blood glucose [PBG; using the oral glucose tolerance test (OGTT)], hemoglobin A1c (HbA1c), plasma total cholesterol (TC), and triglycerides (TG) were tested, and the livers of rats were removed to calculate the liver index...
April 2024: Journal of Traditional Chinese Medicine
https://read.qxmd.com/read/38504538/protective-effect-of-modified-huangqi-chifeng-decoction-on-immunoglobulin-a-nephropathy-through-toll-like-receptor-4-myeloid-differentiation-factor-88-nuclear-factor-kappa-b-signaling-pathway
#35
JOURNAL ARTICLE
L I Liusheng, Zhao Mingming, Chang Meiying, S I Yuan, Zhao Jinning, Yang Bin, Zhang Yu
OBJECTIVE: To examine the nephroprotective mechanism of modified Huangqi Chifeng decoction (, MHCD) in immunoglobulin A nephropathy (IgAN) rats. METHODS: To establish the IgAN rat model, the bovine serum albumin, lipopolysaccharide, and carbon tetrachloride 4 method was employed. The rats were then randomly assigned to the control, model, telmisartan, and high-, medium-, and low-dose MHCD groups, and were administered the respective treatments via intragastric administration for 8 weeks...
April 2024: Journal of Traditional Chinese Medicine
https://read.qxmd.com/read/38504537/protective-effect-of-thyroid-and-restores-of-ovarian-function-of-buzhong-yiqi-granule-on-experimental-autoimmune-thyroiditis-in-female-rats
#36
JOURNAL ARTICLE
Wang Yuezhu, Zhang Yuyang, Qiao Jiajun, L U Yuyuan, Xia Zhongyuan
OBJECTIVE: To observe the effects of Buzhong Yiqi granule on thyroid function and ovarian function in rats with experimental autoimmune thyroiditis (EAT). METHODS: EAT model was replicate by using the method of mixing and injecting porcine thyroglobulin with Freund's adjuvant and high iodine. Rats were randomly divided into normal control (NC) group, EAT model (EAT) group, selenium yeast (PC) group, low dose Buzhong Yiqi (BZYQ-L) group, medium dose Buzhong Yiqi (BZYQ-M) group and high dose Buzhong Yiqi (BZYQ-H) group...
April 2024: Journal of Traditional Chinese Medicine
https://read.qxmd.com/read/38504536/yemazhui-ameliorates-lipopolysaccharide-induced-acute-lung-injury-modulation-of-the-toll-like-receptor-4-nuclear-factor-kappa-b-nod-like-receptor-family-pyrin-domain-containing-3-protein-signaling-pathway-and-intestinal-flora-in-rats
#37
JOURNAL ARTICLE
Ren Li, Hai Yang, Yang Xue, Luo Xianqin
OBJECTIVE: To investigate the impact of Yemazhui ( Herba Eupatorii Lindleyani , HEL) against lipopolysaccharide (LPS)-induced acute lung injury (ALI) and explore its underlying mechanism in vivo . METHODS: The chemical constituents of HEL were analyzed by ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry method. Then, HEL was found to suppress LPS-induced ALI in vivo . Six-week-old male Sprague-Dawley rats were randomly divided into 6 groups: control, LPS, Dexamethasone (Dex), HEL low dose 6 g/kg (HEL-L), HEL medium dose 18 g/kg (HEL-M) and HEL high dose 54 g/kg (HEL-H) groups...
April 2024: Journal of Traditional Chinese Medicine
https://read.qxmd.com/read/38504535/efficacy-of-sailuotong-on-neurovascular-unit-in-amyloid-precursor-protein-presenilin-1-transgenic-mice-with-alzheimer-s-disease
#38
JOURNAL ARTICLE
Sun Linjuan, L I Chengfu, Liu Jiangang, L I Nannan, Han Fuhua, Qiao Dandan, Tao Zhuang, Zhan Min, Chen Wenjie, Zhang Xiaohui, Tong Chenguang, Chen Dong, Qi Jiangxia, Liu Yang, Liang Xiao, Zheng Xiaoying, Zhang Yunling
OBJECTIVE: To discuss the influence of Sailuotong (, SLT) on the Neurovascular Unit (NVUs) of amyloid precursor protein (APP)/presenilin-1(PS1) mice and evaluate the role of gas supplementation in activating blood circulation during the progression of Alzheimer's disease (AD). METHODS: The mice were allocated into the following nine groups: (a) the C57 Black (C57BL) sham-operated group (control group), (b) ischaemic treatment in C57BL mice (the C57 ischaemic group), (c) the APP/PS1 sham surgery group (APP/PS1 model group), (d) ischaemic treatment in APP/PS1 mice (APP/PS1 ischaemic group), (e) C57BL mice treated with aspirin following ischaemic treatment (C57BL ischaemic + aspirin group), (f) C57BL mice treated with SLT following ischaemic treatment (C57BL ischaemic + SLT group), (g) APP/PS1 mice treated with SLT (APP/PS1 + SLT group), (h) APP/PS1 mice treated with donepezil hydrochloride following ischaemic treatment (APP/PS1 ischaemic + donepezil hydrochloride group) and (i) APP/PS1 mice treated with SLT following ischaemic treatment (APP/PS1 ischaemic + SLT group)...
April 2024: Journal of Traditional Chinese Medicine
https://read.qxmd.com/read/38504534/gehua-jiejiu-dizhi-decoction-ameliorates-alcoholic-fatty-liver-in-mice-by-regulating-lipid-and-bile-acid-metabolism-and-with-exertion-of-antioxidant-stress-based-on-4dlabel-free-quantitative-proteomic-study
#39
JOURNAL ARTICLE
Han Min, Y I Xu, You Shaowei, W U Xueli, Wang Shuoshi, H E Diancheng
OBJECTIVE: To analyze the effect and molecular mechanism of Gehua Jiejiu Dizhi decoction (, GJDD) on alcoholic fatty live disease (AFLD) by using proteomic methods. METHODS: The male C57BL/6J mouse were randomly divided into four groups: control group, model group, GJDD group and resveratrol group. After the AFLD model was successfully prepared by intragastric administration of alcohol once on the basis of the Lieber-DeCarli classical method, the GJDD group and resveratrol group were intragastrically administered with GJDD (4900 mg/kg) and resveratrol (400 mg/kg) respectively, once a day for 9 d...
April 2024: Journal of Traditional Chinese Medicine
https://read.qxmd.com/read/38504533/emodin-suppresses-alkali-burn-induced-corneal-inflammation-and-neovascularization-by-the-vascular-endothelial-growth-factor-receptor-2-signaling-pathway
#40
JOURNAL ARTICLE
Zheng Xueying, Guo Liang, Lai Siyi, L I Fengyue, Liang Mingli, Liu Wanting, Meng Chun, Liu Guanghui
OBJECTIVE: To investigate the effects of emodin on alkali burn-induced corneal inflammation and neovascularization. METHODS: The ability of emodin to target vascular endothelial growth factor receptor 2 (VEGFR2) was predicted by molecular docking. The effects of emodin on the invasion, migration, and proliferation of human umbilical vein endothelial cells (HUVEC) were determined by cell counting kit-8, Transwell, and tube formation assays. Analysis of apoptosis was performed by flow cytometry...
April 2024: Journal of Traditional Chinese Medicine
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