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Clinical Rheumatology

Emre Bilgin, Mutlu Hayran, Abdulsamet Erden, Berkan Armağan, Alper Sarı, Levent Kılıç, Ali Akdoğan, Ömer Karadağ, Şule Apraş Bilgen, Sedat Kiraz, İhsan Ertenli, Umut Kalyoncu
The author regrets that the original version of this article contained error. Figure 1 was shown in the wrong version, thus corrected figure is shown in this article.
February 19, 2019: Clinical Rheumatology
Mai Kawazoe, Kaichi Kaneko, Zento Yamada, Shotaro Masuoka, Satoshi Mizutani, Soichi Yamada, Kotaro Shikano, Hiroshi Sato, Makoto Kaburaki, Sei Muraoka, Shinichi Kawai, Toshihiro Nanki
OBJECTIVES: To assess the renal and non-renal efficacy of mycophenolate mofetil (MMF) in Japanese patients with systemic lupus erythematosus (SLE). METHODS: We conducted a retrospective study to assess the renal and non-renal efficacies of MMF in Japanese patients with systemic lupus erythematosus (SLE). We analyzed 14 patients with lupus nephritis (LN) who were given MMF, and 13 patients who received monthly intravenous cyclophosphamide (IVCY) as induction therapy, and a further 19 patients without LN who were treated with MMF, and 13 patients who took tacrolimus (TAC) to reduce glucocorticoid dosages...
February 18, 2019: Clinical Rheumatology
Cain C T Clark, Mohsen Taghizadeh, Mina Nahavandi, Sadegh Jafarnejad
Several studies have been conducted with the aim of investigating the effect of Omega(ω)-3 on different psoriasis indices including Psoriasis Area and Severity Index (PASI) score, erythema, scaling, itching, area involved, and infiltration. Nevertheless, a pooled analysis of trials that evaluated these variables has not been conducted. Therefore, the aim of this meta-analysis was to assess the efficacy of ω-3 fatty acids in treating patients with psoriasis. We searched through different electronic, references of retrieved articles, and previous related reviews databases up to November 2018...
February 18, 2019: Clinical Rheumatology
Shih-Yao Chen, Ming-Fei Liu, Pin-Yu Kuo, Chrong-Reen Wang
Elevated IL-17 levels with higher Th17 numbers are identified in systemic lupus erythematosus (SLE). STAT3 signaling plays a crucial role in the Th17 generation, and SOCS3 negatively regulates their formation. We investigated IL-17, STAT3, and SOCS3 expression, and analyzed their correlations to elucidate the regulatory mechanisms of IL-17 production in SLE. This study enrolled 32 patients, and venous mononuclear cells (MNCs) were isolated with further purification of CD4-positive T cells. IL-17 and SOCS3 levels were measured by real-time quantitative PCR, and pSTAT3/STAT3 expression was analyzed by immunoblot...
February 15, 2019: Clinical Rheumatology
K Lakota, K Perdan-Pirkmajer, S Sodin-Šemrl, S Čučnik, V Šubelj, K Prosenc, K Mrak Poljšak, M Tomšič, A Ambrožič, S Praprotnik
INTRODUCTION: Influenza may cause severe complications in patients with autoimmune inflammatory rheumatic disease (AIRD), to whom vaccinations are especially recommended. However, AIRD patients require cautious scrutiny of immunogenicity as they might exhibit poor antibody response to vaccination, especially when taking immunomodulatory medications. AIM: The aim was to determine immunogenicity of seasonal and pandemic influenza vaccine in AIRD patients, its timeline/persistence, and influence of medications on immune response...
February 14, 2019: Clinical Rheumatology
Fatma Alibaz-Oner, Rabia Ergelen, Aydan Mutis, Zeynep Erturk, Ruslan Asadov, Gonca Mumcu, Tulin Ergun, Haner Direskeneli
Vascular involvement, especially in young males, is seen in up to 40% of the patients with Behcet's disease (BD) and is a major cause of mortality and morbidity. In this study, we investigated vessel wall thickness (VWT) and dilatation in lower extremity veins with Doppler ultrasound (US) in male BD patients. Sixty-one male patients with BD, 37 healthy male controls (HC) and 27 male patients, with ankylosing spondylitis (AS), were included in the study. Venous Doppler US was performed by an experienced radiologist blinded to cases...
February 13, 2019: Clinical Rheumatology
Timo Tolppa, Isabella Plumptre, Maria Mouyis
No abstract text is available yet for this article.
February 13, 2019: Clinical Rheumatology
Basant Elnady, Nashwa K El Shaarawy, Noha Mohammed Dawoud, Tohamy Elkhouly, Dalia El-Sayed Desouky, Eman Nabil ElShafey, Mohamed S El Husseiny, Johannes J Rasker
OBJECTIVE: To evaluate ultrasonographic subclinical inflammatory synovitis and enthesitis in psoriasis patients, without clinical arthritis or enthesitis compared with healthy controls, with a 2-year follow-up to study the associated incidence of psoriatic arthritis (PsA). METHODS: A total of 109 consecutive psoriasis vulgaris patients without clinical signs of PsA and 90 healthy controls were included from two tertiary medical centers. Subjects underwent dermatological examination, PASI score evaluation for severity of psoriasis, musculoskeletal examination using 68/66 joints count for tenderness and swollen joints...
February 12, 2019: Clinical Rheumatology
Yidian Dong, Ping Li, Tingshuang Xu, Liqi Bi
OBJECTIVES: To investigate the effective serum level of etanercept biosimilar in Chinese patients with ankylosing spondylitis (AS) who achieve AS Disease Activity Score-C-reactive protein (ASDAS-CRP) < 2.1, and the effect of antidrug antibodies on drug levels and clinical efficacy. METHODS: Our study enrolled 60 patients with AS who were treated with etanercept biosimilar. Serum and clinical data were collected at baseline and treatment weeks 4, 12, and 24. Drug levels and antidrug antibody levels were measured using an enzyme-linked immunosorbent assay while tumour necrosis factor (TNF)-α levels were measured using cytometric bead array...
February 12, 2019: Clinical Rheumatology
Christian Johana Baños-Hernández, José Eduardo Navarro-Zarza, Richard Bucala, Jorge Hernández-Bello, Isela Parra-Rojas, María Guadalupe Ramírez-Dueñas, Samuel García-Arellano, Luis Alexis Hernández-Palma, Andrea Carolina Machado-Sulbarán, José Francisco Muñoz-Valle
INTRODUCTION: Systemic sclerosis (SSc) is a complex autoimmune disease, characterized by microvascular lesions, autoimmunity, and fibrosis. It is suggested that MIF participates in the amplification of the proinflammatory process in SSc; moreover, the promoter polymorphisms - 794 CATT5-8 (rs5844572) and - 173G>C (rs755622) in the MIF gene have been associated with an increase in MIF serum levels in several autoimmune diseases. The aim of this study was to analyze the relationship of the - 794 CATT5-8 and - 173G>C MIF polymorphisms with mRNA expression, MIF serum levels, and the Th1/Th2/Th17 cytokine profile in SSc...
February 12, 2019: Clinical Rheumatology
Zhi-Xiang Huang, Wei-Ming Deng, Xin Guo, Zheng-Ping Huang, Yu-Kai Huang, Chu-Lan Lin, Tian-Wang Li
OBJECTIVES: Hip arthritis plays a critical role in the prognosis of ankylosing spondylitis (AS). Dose reduction of tumor necrosis factor inhibitors preserves general improvement of AS, so this study attempted to examine the equivalence between Yisaipu® tapering and conventional therapy for hip arthritis in AS patients, using clinical parameters and magnetic resonance image (MRI). METHODS: AS patients received this etanercept-biosimilar injections (50 mg/week) in the first 12 weeks...
February 12, 2019: Clinical Rheumatology
Yukai Wang, Shaoqi Chen, Zhangzhang Lin, Jianqun Lin, Xuezhen Xie, Qisheng Lin, Guangzhou Du, Xiufeng Huang, Marco Matucci-Cerinic, Daniel E Furst
In the past decade, lung ultrasound (LUS) B-lines and serum Krebs von den Lungen-6 (KL-6) antigen have been recognized as biomarkers of the connective tissue disease-associated interstitial lung diseases (CTD-ILDs). Robust data have demonstrated that B-lines total numbers and KL-6 levels are correlated with high-resolution computed tomography findings, pulmonary function test, and some clinical parameters in CTD-ILDs. However, limited data are available regarding the use of these two biomarkers to follow CTD-ILDs...
February 11, 2019: Clinical Rheumatology
Florencia S Pierini, Marina Scolnik, Valeria Scaglioni, Florencia Mollerach, Enrique R Soriano
BACKGROUND/OBJECTIVE: Our objective was to estimate incidence and prevalence rates of granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) using data from a university hospital-based health management organization (HIMCO) in Latin America. METHODS: Multiple methods for case finding were used to ensure complete ascertainment. GPA was diagnosed if fulfilling ACR 1990 criteria or a clinical diagnosis was made by an experienced rheumatologist. For MPA, a clinical diagnosis made by an experienced rheumatologist in concordance with Chapel Hill 2012 consensus...
February 11, 2019: Clinical Rheumatology
Lili Jiang, Youlian Wang, Qinglin Peng, Xiaoming Shu, Guochun Wang, Xiaomu Wu
OBJECTIVE: We aimed to investigate the clinical value of checking serum chitinase-3-like-1 protein (YKL-40) levels in anti-MDA5 antibody-positive dermatomyositis (anti-MDA5+ DM) patients. METHODS: One hundred and five consecutive anti-MDA5+ DM patients and 44 healthy controls were enrolled in this study. Baseline and follow-up serum YKL-40 were detected by ELISA. We evaluated the association of YKL-40 with rapidly progressive interstitial lung disease (RPILD), severity of interstitial lung disease (ILD), and ILD-related survival...
February 9, 2019: Clinical Rheumatology
Doaa Hassan Sayed Attia, Rasha A Abdel Noor, Shaimaa Salah
OBJECTIVES: The frequency of different vasculitides and their characteristics vary among different regions. The identification of geographic disparities of disease phenotypes helps the development of international criteria, allowing the classification of patients of different ethnicities. This study aimed to describe the frequency, characteristics, course, response to treatment, and outcome of the different adulthood vasculitides in Egypt. METHODS: This was a multicenter study in which the medical records of adult Egyptian patients diagnosed with vasculitis between 2002 and 2018 were retrospectively reviewed...
February 9, 2019: Clinical Rheumatology
Yan Hong, Pengxian Shi, Xia Liu, Liu Yang, Kang Li, Feng Xu, Shaoshan Liang, Zhengzhao Liu, Haitao Zhang, Yinghua Chen, Weixin Hu
OBJECTIVES: To retrospectively investigate the clinical and histological features and outcomes of ANCA-associated glomerulonephritis (AAGN) with different ANCA serotypes. METHOD: A total of 467 AAGN patients were divided into MPO-AAGN (MPO) and PR3-AAGN (PR3) groups according to ANCA serotype. Clinical and histological features and renal outcomes were compared. RESULTS: In this study, 429 (91.9%) patients tested positive for MPO-ANCA, and 38 (8...
February 8, 2019: Clinical Rheumatology
Shruti Bhattacharya, Akhilesh Yadav, Amita Aggarwal
Recently, an increase in CD163+ macrophages in ileal biopsies from ankylosing spondylitis patients and an increase in intermediate monocytes in enthesitis-related arthritis (ERA) have been reported. Thus, we studied sCD163 levels as M2 macrophage marker in serum and synovial fluid (SF) of ERA children and CD163 expression on monocyte subsets. Serum samples from ERA patients and healthy controls (HC) were assayed for sCD163 (ELISA). Serum and SF from ERA patients were analyzed when available from same patient (paired samples)...
February 8, 2019: Clinical Rheumatology
Naim Mahroum, Abdulla Watad, Shmuel Tiosano, Ashraf Hejly, Hussein Mahagna, Roy Waknin, Doron Comaneshter, Arnon D Cohen, Howard Amital
BACKGROUND AND OBJECTIVES: Rheumatoid arthritis (RA) is the most common inflammatory joint disorder presenting also with extra-articular manifestations. As many other autoimmune diseases, it has been suggested that infectious diseases might contribute to its emergence. Hepatitis viruses were suggested by several reports as a trigger of RA onset. We aimed to assess the association between RA and chronic hepatitis B viral infection (HBV). METHODS: Patients with RA were compared with age- and sex-matched controls regarding the proportion of chronic HBV infection in a case-control study...
February 8, 2019: Clinical Rheumatology
Şerife Gül Karadağ, Ayşe Tanatar, Hafize Emine Sönmez, Figen Çakmak, Aysel Kıyak, Sevgi Yavuz, Mustafa Çakan, Nuray Aktay Ayaz
OBJECTIVES: Henoch-Schönlein purpura (HSP) is the most common vasculitis of children. The aim of this study is to evaluate the demographic and clinic findings of patients with HSP and also to determine predictive factors for assessing the development of gastrointestinal system (GIS) and renal involvement. METHODS: This study was performed prospectively among children with HSP who are under 18 years of age and being followed-up in the Pediatric Rheumatology Unit of Health Sciences University Kanuni Sultan Süleyman Training and Research Hospital between January 2016 and January 2018...
February 8, 2019: Clinical Rheumatology
Hiromi Shimada, Tomohiro Kameda, Kenji Kanenishi, Nobuyuki Miyatake, Shusaku Nakashima, Risa Wakiya, Mikiya Kato, Taichi Miyagi, Mai Mahmoud Fahmy Mansour, Toshiyuki Hata, Norimitsu Kadowaki, Hiroaki Dobashi
OBJECTIVES: We examined the effect of biologic disease-modifying anti-rheumatic drugs on the time to pregnancy in patients with rheumatoid arthritis who hope to become mothers. Additionally, we evaluated adverse pregnancy outcomes and risk factors of these drugs. METHOD: We retrospectively investigated 25 pregnancies of 19 patients who were taking disease-modifying anti-rheumatic drugs. In 15 pregnancies, patients continued biologic disease-modifying anti-rheumatic drugs until conception (group A)...
February 7, 2019: Clinical Rheumatology
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