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Food and Chemical Toxicology | Page 2

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https://read.qxmd.com/read/31376412/cadmium-disrupts-the-dna-damage-response-by-destabilizing-rnf168
#21
Shuyuan Zhang, Shuailin Hao, Zhiyu Qiu, Ya Wang, Yuqin Zhao, Youhang Li, Wen Gao, Yan Wu, Chang Liu, Xingzhi Xu, Hailong Wang
Cadmium (Cd) is a dispensable element for the human body and is usually considered a carcinogen. Occupational and environmental Cd exposure leads to sustained cellular proliferation in some tissues and tumorigenesis via an unclear mechanism. Here, we evaluated the role of Cd in the DNA damage response (DDR). We found that Cd exposure causes extensive DNA double-strand breaks (DSBs) and prevents accumulation of ubiquitination signals at these sites of DNA damage. Cd treatment compromises 53BP1 and BRCA1 recruitment to DSBs induced by itself or DNA damaging agents and partially inactivates the G2/M checkpoint...
July 31, 2019: Food and Chemical Toxicology
https://read.qxmd.com/read/31374298/rifm-fragrance-ingredient-safety-assessment-3-3-dimethyl-5-2-2-3-trimethyl-3-cyclopenten-1-yl-4-penten-2-ol-cas-registry-number-107898-54-4
#22
A M Api, D Belsito, S Biserta, D Botelho, M Bruze, G A Burton, J Buschmann, M A Cancellieri, M L Dagli, M Date, W Dekant, C Deodhar, A D Fryer, S Gadhia, L Jones, K Joshi, A Lapczynski, M Lavelle, D C Liebler, M Na, D O'Brien, A Patel, T M Penning, G Ritacco, F Rodriguez-Ropero, J Romine, N Sadekar, D Salvito, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura, S Tsang
No abstract text is available yet for this article.
July 30, 2019: Food and Chemical Toxicology
https://read.qxmd.com/read/31374297/protective-effects-of-aronia-melanocarpa-juices-either-alone-or-combined-with-extracts-from-rosa-canina-or-alchemilla-vulgaris-in-a-rat-model-of-indomethacin-induced-gastric-ulcers
#23
Stefka Valcheva-Kuzmanova, Petko Denev, Miroslav Eftimov, Antoaneta Georgieva, Vasilena Kuzmanova, Atanas Kuzmanov, Krasimir Kuzmanov, Maria Tzaneva
The aim of the study was to investigate the effects of four Aronia melanocarpa-based juices in a rat model of indomethacin-induced gastric ulceration. THE JUICES WERE: AM1 and AM2 (produced from aronia fruits at 20 °C and 60 °C, respectively), AMRC (a mixture of AM2 with Rosa canina extract) and AMAV (aronia juice with Alchemilla vulgaris). Male Wistar rats were used. Each of the juices (10 ml/kg) was administered for 10 days. Indomethacin (30 mg/kg) was injected subcutaneously and after 4 h, the effects were estimated...
July 30, 2019: Food and Chemical Toxicology
https://read.qxmd.com/read/31369853/rifm-fragrance-ingredient-safety-assessment-%C3%AE-amylcinnamyl-alcohol-cas-registry-number-101-85-9
#24
A M Api, D Belsito, S Biserta, D Botelho, M Bruze, G A Burton, J Buschmann, M A Cancellieri, M L Dagli, M Date, W Dekant, C Deodhar, A D Fryer, S Gadhia, L Jones, K Joshi, A Lapczynski, M Lavelle, D C Liebler, M Na, D O'Brien, A Patel, T M Penning, G Ritacco, F Rodriguez-Ropero, J Romine, N Sadekar, D Salvito, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura, S Tsang
No abstract text is available yet for this article.
July 29, 2019: Food and Chemical Toxicology
https://read.qxmd.com/read/31369852/rifm-fragrance-ingredient-safety-assessment-isocyclocitral-cas-registry-number-1335-66-6
#25
A M Api, F Belmonte, D Belsito, S Biserta, D Botelho, M Bruze, G A Burton, J Buschmann, M A Cancellieri, M L Dagli, M Date, W Dekant, C Deodhar, A D Fryer, S Gadhia, L Jones, K Joshi, A Lapczynski, M Lavelle, D C Liebler, M Na, D O'Brien, A Patel, T M Penning, G Ritacco, F Rodriguez-Ropero, J Romine, N Sadekar, D Salvito, T W Schultz, I G Sipes, G Sullivan, Y Thakkar, Y Tokura, S Tsang
No abstract text is available yet for this article.
July 29, 2019: Food and Chemical Toxicology
https://read.qxmd.com/read/31369851/effect-of-chitosan-on-the-digestibility-and-molecular-structural-properties-of-lotus-seed-starch
#26
Mingjing Zheng, Suzhen Lei, Hongqiang Wu, Baodong Zheng, Yi Zhang, Hongliang Zeng
The effect of chitosan (CS) on the in vitro digestibility and molecular structural properties of lotus seed starch (LS), and the correlation matrix was studied. The addition of CS could delay the hydrolysis of LS due to a increased level of slowly digestible starch (SDS). LS-CS blends exhibited lower pasting viscosity, greater amylose content and higher ordered structure than LS alone. A significant correlation was found between the digestibility and molecular structural properties of LS-CS blends. Rapidly digestible starch content was positively correlated with viscosity and full width at half-maximum height (FWHH) at 480 cm-1 ; whereas, SDS content was negatively correlated with setback and FWHH...
July 29, 2019: Food and Chemical Toxicology
https://read.qxmd.com/read/31369850/identification-of-moracin-n-in-mulberry-leaf-and-evaluation-of-antioxidant-activity
#27
Jiaming Tu, Dingding Shi, Lingrong Wen, Yueming Jiang, Yupeng Zhao, Jiali Yang, Huiling Liu, Guangrong Liu, Bao Yang
Mulberry leaf is a newly accepted vegetable for daily diet. It tastes good and has multiple health benefits, including antioxidant and anti-inflammatory activities. However, the chemicals responsible for these health benefits remain unveiled. Prenylated phenolics are characteristic bioactive compounds in mulberry leaf, which are recognized as good antioxidants. In this work, moracin N was purified from mulberry leaf. It showed better antioxidant activities than resveratrol. The EC50 value of cellular antioxidant activity was 24...
July 29, 2019: Food and Chemical Toxicology
https://read.qxmd.com/read/31369849/rifm-fragrance-ingredient-safety-assessment-isobornyl-methyl-ether-cas-registry-number-5331-32-8
#28
A M Api, D Belsito, D Botelho, M Bruze, G A Burton, J Buschmann, M L Dagli, M Date, W Dekant, C Deodhar, M Francis, A D Fryer, L Jones, K Joshi, S La Cava, A Lapczynski, D C Liebler, D O'Brien, A Patel, T M Penning, G Ritacco, J Romine, N Sadekar, D Salvito, T W Schultz, I G Sipes, G Sullivan, Y Thakkar, Y Tokura, S Tsang
No abstract text is available yet for this article.
July 29, 2019: Food and Chemical Toxicology
https://read.qxmd.com/read/31369848/glucose-regulated-protein-75-in-foodborne-disease-models-induces-renal-tubular-necrosis
#29
Xuan Yang, Yijia Li, Lirong Zheng, Xiaoyun He, Yunbo Luo, Kunlun Huang, Wentao Xu
The incidence of kidney disease has increased rapidly in recent years. One major possible reason for this increase in nephrosis is from foodborne toxins. Since the mechanism of how foodborne toxins are involved in the process of nephrosis is largely unknown, the current study aims to establish a profile for how one of the major toxin threats, ochratoxin A (OTA), induce differential protein expression. In this proteomic study of rat kidneys, 75 kd glucose-regulated protein (Grp75) expression was found to be sensitized by a low concentration of OTA, but inhibited by high doses...
July 29, 2019: Food and Chemical Toxicology
https://read.qxmd.com/read/31369847/rifm-fragrance-ingredient-safety-assessment-%C3%AE-methylcinnamaldehyde-cas-registry-number-101-39-3
#30
A M Api, F Belmonte, D Belsito, S Biserta, D Botelho, M Bruze, G A Burton, J Buschmann, M A Cancellieri, M L Dagli, M Date, W Dekant, C Deodhar, A D Fryer, S Gadhia, L Jones, K Joshi, A Lapczynski, M Lavelle, D C Liebler, M Na, D O'Brien, A Patel, T M Penning, G Ritacco, F Rodriguez-Ropero, J Romine, N Sadekar, D Salvito, T W Schultz, I G Sipes, G Sullivan, Y Thakkar, Y Tokura, S Tsang
No abstract text is available yet for this article.
July 29, 2019: Food and Chemical Toxicology
https://read.qxmd.com/read/31369846/rifm-fragrance-ingredient-safety-assessment-4-4a-5-9b-tetrahydroindeno-1-2-d-1-3-dioxine-cas-registry-number-18096-62-3
#31
A M Api, D Belsito, D Botelho, M Bruze, G A Burton, J Buschmann, M L Dagli, M Date, W Dekant, C Deodhar, M Francis, A D Fryer, L Jones, K Joshi, S La Cava, A Lapczynski, D C Liebler, D O'Brien, A Patel, T M Penning, G Ritacco, J Romine, N Sadekar, D Salvito, T W Schultz, I G Sipes, G Sullivan, Y Thakkar, Y Tokura, S Tsang
No abstract text is available yet for this article.
July 29, 2019: Food and Chemical Toxicology
https://read.qxmd.com/read/31369845/rifm-fragrance-ingredient-safety-assessment-cyclohexanemethanol-2-4-dimethyl-cas-registry-number-68480-15-9
#32
A M Api, D Belsito, S Biserta, D Botelho, M Bruze, G A Burton, J Buschmann, M A Cancellieri, M L Dagli, M Date, W Dekant, C Deodhar, A D Fryer, S Gadhia, L Jones, K Joshi, A Lapczynski, M Lavelle, D C Liebler, M Na, D O'Brien, A Patel, T M Penning, G Ritacco, F Rodriguez-Ropero, J Romine, N Sadekar, D Salvito, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura, S Tsang
No abstract text is available yet for this article.
July 29, 2019: Food and Chemical Toxicology
https://read.qxmd.com/read/31369844/rifm-fragrance-ingredient-safety-assessment-4-isopropyl-%C3%AE-methylcyclohexanethanol-cas-registry-number-67634-03-1
#33
A M Api, D Belsito, S Biserta, D Botelho, M Bruze, G A Burton, J Buschmann, M A Cancellieri, M L Dagli, M Date, W Dekant, C Deodhar, A D Fryer, S Gadhia, L Jones, K Joshi, A Lapczynski, M Lavelle, D C Liebler, M Na, D O'Brien, A Patel, T M Penning, G Ritacco, F Rodriguez-Ropero, J Romine, N Sadekar, D Salvito, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura, S Tsang
No abstract text is available yet for this article.
July 29, 2019: Food and Chemical Toxicology
https://read.qxmd.com/read/31365888/a-two-year-toxicology-study-of-bisphenol-a-bpa-in-sprague-dawley-rats-clarity-bpa-core-study-results
#34
L Camacho, S M Lewis, M M Vanlandingham, G R Olson, K J Davis, R E Patton, N C Twaddle, D R Doerge, M I Churchwell, M S Bryant, F M McLellen, K Woodling, R P Felton, M P Maisha, B E Juliar, G Gamboa da Costa, K B Delclos
We report the data from the guideline-compliant two-year toxicology study conducted as part of the Consortium Linking Academic and Regulatory Insights on Bisphenol A Toxicity (CLARITY-BPA). BPA (0, 2.5, 25, 250, 2,500, and 25,000 μg/kg body weight (bw)/day) was administered daily by gavage in 0.3% carboxymethylcellulose vehicle to NCTR Sprague-Dawley rats from gestation day 6 through the start of parturition and then directly to pups from the day after birth until postnatal day 21 (stop-dose arm) or continuously until termination at one or two years...
July 28, 2019: Food and Chemical Toxicology
https://read.qxmd.com/read/31365887/rifm-fragrance-ingredient-safety-assessment-methyl-ionone-mixture-of-isomers-cas-registry-number-1335-46-2
#35
A M Api, D Belsito, S Biserta, D Botelho, M Bruze, G A Burton, J Buschmann, M A Cancellieri, M L Dagli, M Date, W Dekant, C Deodhar, A D Fryer, S Gadhia, L Jones, K Joshi, A Lapczynski, M Lavelle, D C Liebler, M Na, D O'Brien, A Patel, T M Penning, G Ritacco, F Rodriguez-Ropero, J Romine, N Sadekar, D Salvito, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura, S Tsang
No abstract text is available yet for this article.
July 28, 2019: Food and Chemical Toxicology
https://read.qxmd.com/read/31365886/rifm-fragrance-ingredient-safety-assessment-2-cyclohexylpropanal-cas-registry-number-2109-22-0
#36
A M Api, F Belmonte, D Belsito, D Botelho, M Bruze, G A Burton, J Buschmann, M L Dagli, M Date, W Dekant, C Deodhar, A D Fryer, S Gadhia, L Jones, K Joshi, S La Cava, A Lapczynski, M Lavelle, D C Liebler, M Na, D O'Brien, T M Penning, G Ritacco, J Romine, N Sadekar, D Salvito, T W Schultz, I G Sipes, G Sullivan, Y Thakkar, Y Tokura, S Tsang
No abstract text is available yet for this article.
July 28, 2019: Food and Chemical Toxicology
https://read.qxmd.com/read/31365885/rifm-fragrance-ingredient-safety-assessment-%C3%AE-decalactone-cas-registry-number-706-14-9
#37
A M Api, F Belmonte, D Belsito, S Biserta, D Botelho, M Bruze, G A Burton, J Buschmann, M A Cancellieri, M L Dagli, M Date, W Dekant, C Deodhar, A D Fryer, S Gadhia, L Jones, K Joshi, A Lapczynski, M Lavelle, D C Liebler, M Na, D O'Brien, A Patel, T M Penning, G Ritacco, F Rodriguez-Ropero, J Romine, N Sadekar, D Salvito, T W Schultz, I G Sipes, G Sullivan, Y Thakkar, Y Tokura, S Tsang
No abstract text is available yet for this article.
July 28, 2019: Food and Chemical Toxicology
https://read.qxmd.com/read/31362089/rifm-fragrance-ingredient-safety-assessment-2-2-6-trimethylcyclohexanone-cas-registry-number-2408-37-9
#38
A M Api, D Belsito, D Botelho, M Bruze, G A Burton, J Buschmann, M L Dagli, M Date, W Dekant, C Deodhar, M Francis, A D Fryer, L Jones, K Joshi, S La Cava, A Lapczynski, D C Liebler, D O'Brien, A Patel, T M Penning, G Ritacco, J Romine, N Sadekar, D Salvito, T W Schultz, I G Sipes, G Sullivan, Y Thakkar, Y Tokura, S Tsang
No abstract text is available yet for this article.
July 27, 2019: Food and Chemical Toxicology
https://read.qxmd.com/read/31362088/dietary-intake-of-arsenic-cadmium-mercury-and-lead-by-the-population-of-catalonia-spain-analysis-of-the-temporal-trend
#39
Neus González, Josep Calderón, Antoni Rúbies, Isabel Timoner, Victòria Castell, José L Domingo, Martí Nadal
In 2017, a monitoring study was conducted in Catalonia (Spain) to analyse, in widely consumed foodstuffs, the concentrations of arsenic (As), cadmium (Cd), mercury (Hg) and lead (Pb), as well as those of inorganic As (InAs) and methylmercury (MeHg). Health risks were estimated for various population groups, classified according to age. A continued reduction of dietary exposure to these elements was observed when comparing the results from the current and previous studies performed during the last 17 years. This reduction would be associated to a decrease of As, Cd, Hg and Pb concentrations in food, as well as by changes in dietary habits...
July 27, 2019: Food and Chemical Toxicology
https://read.qxmd.com/read/31362087/rifm-fragrance-ingredient-safety-assessment-4-methoxybenzoic-acid-cas-registry-number-100-09-4
#40
A M Api, F Belmonte, D Belsito, S Biserta, D Botelho, M Bruze, G A Burton, J Buschmann, M A Cancellieri, M L Dagli, M Date, W Dekant, C Deodhar, A D Fryer, S Gadhia, L Jones, K Joshi, A Lapczynski, M Lavelle, D C Liebler, M Na, D O'Brien, A Patel, T M Penning, G Ritacco, F Rodriguez-Ropero, J Romine, N Sadekar, D Salvito, T W Schultz, I G Sipes, G Sullivan, Y Thakkar, Y Tokura, S Tsang
No abstract text is available yet for this article.
July 27, 2019: Food and Chemical Toxicology
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