journal
https://read.qxmd.com/read/38488863/tofacitinib-therapy-for-severe-pyoderma-gangrenosum-in-a-patient-with-enteropathic-arthritis-a-case-based-review
#21
REVIEW
Aydan Köken Avşar, Tuba Demirci Yıldırım, İsmail Sarı
Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that is associated with systemic inflammatory conditions. Currently, there is no universally accepted standard therapy for PG, but immunosuppressive (IS) treatment seems essential. We report a patient here who was successfully treated with tofacitinib despite being PG-refractory to multiple anti-tumor necrosis factor alpha (anti-TNF) therapies and conventional IS. In addition, we performed a comprehensive review of all cases of PG treated with JAK inhibitors...
March 15, 2024: Rheumatology International
https://read.qxmd.com/read/38483561/associations-of-gender-with-sexual-functioning-loneliness-depression-fatigue-and-physical-function-amongst-patients-suffering-from-rheumatoid-arthritis-with-a-particular-focus-on-methotrexate-usage
#22
JOURNAL ARTICLE
Laila T Bay, Dorthe S Nielsen, Caroline Flurey, Annamaria Giraldi, Sören Möller, Christian Graugaard, Torkell Ellingsen
There is a lack of knowledge regarding methotrexate (MTX) usage in patients with rheumatoid arthritis (RA) and its possible links with gender, disease characterization and sexual functioning, loneliness, fatigue and depression. We, therefore, investigated the associations of gender with physical function, fatigue, depression, loneliness and sexual functioning with a particular focus on MTX usage. A cross-sectional study design was used. Inclusion criteria were RA diagnosis, age above 18 years and available data on MTX treatment 1 year after diagnosis...
March 14, 2024: Rheumatology International
https://read.qxmd.com/read/38472442/discovery-of-the-first-recorded-use-of-gout-as-a-medical-term-in-history-before-ad-1000
#23
LETTER
Francesco Maria Galassi, Elena Varotto, Veronica Papa, Marco Artico, Elena Percivaldi
No abstract text is available yet for this article.
March 12, 2024: Rheumatology International
https://read.qxmd.com/read/38472441/barriers-and-facilitators-in-diagnosing-axial-spondyloarthritis-a-qualitative-study
#24
JOURNAL ARTICLE
Charles A Hay, Jon Packham, James A Prior, Christian D Mallen, Sarah Ryan
INTRODUCTION: Diagnosis of axial spondyloarthritis (axSpA) is frequently delayed for years after symptom onset. However, little is known about patient and healthcare professional (HCP) perspectives on barriers and facilitators in axSpA diagnosis. This study explored the experiences and perceptions of both groups regarding the factors affecting the timely diagnosis of axSpA. METHOD: Semi-structured interviews with patients with axSpA and axSpA-interested HCPs from the United Kingdom (UK) were performed by telephone or Microsoft Teams and focussed on the individuals' perspective of the diagnostic journey for axSpA...
March 12, 2024: Rheumatology International
https://read.qxmd.com/read/38470502/breakthrough-sars-cov-2-infection-and-disease-flares-in-patients-with-rheumatoid-arthritis-result-from-covad-e-survey-study
#25
JOURNAL ARTICLE
Cristiana Sieiro Santos, Jun-Peng Chen, Elena Nikiphorou, Chi-Wei Tseng, Carlos Enrique Toro Gutiérrez, Ai Lyn Tan, Arvind Nune, Esha Kadam, Masataka Kuwana, Jessica Day, Sreoshy Saha, Tsvetelina Velikova, James B Lilleker, Carlo V Caballero-Uribe, Parikshit Sen, Hector Chinoy, Rohit Aggarwal, Vikas Agarwal, Latika Gupta, Yi-Ming Chen
COVID-19 has been suggested as a possible trigger of disease flares in patients with rheumatoid arthritis (RA). However, factors associated with disease flares remain unknown. This study aimed to identify factors associated with breakthrough infection (BIs) and disease flares in patients with RA following COVID-19. We analysed data from RA patients who participated in the COVID-19 vaccination in autoimmune diseases (COVAD) study. Demographic data, patient-reported outcomes, comorbidities, pharmacologic treatment and details regarding disease flares were extracted from the COVAD database...
March 12, 2024: Rheumatology International
https://read.qxmd.com/read/38461445/statin-induced-immune-mediated-necrotizing-myopathy-with-concomitant-increase-of-anti-hmgcr-and-anti-achr-antibodies
#26
REVIEW
Razmig Garabet, Sanjeev Herr, Nicole Griffin, Kuruganti Reddy
Statin-induced immune-mediated necrotizing myopathy (IMNM) is a rare systemic neuromuscular condition. We present a case of a patient with a severe phenotype of the disease that was found to have an increase in anti-HMGCR and anti-ACHR antibodies. A potential association between these antibodies have not been previously described. A 67-year-old male with hyperlipidemia, who was recently initiated on atorvastatin therapy, presented to the ED with progressive muscle weakness. Within a few days of admission, the patient developed complete flaccid paralysis and respiratory distress requiring intubation...
March 10, 2024: Rheumatology International
https://read.qxmd.com/read/38456909/baricitinib-for-anti-melanoma-differentiation-associated-protein-5-antibody-positive-dermatomyositis-associated-interstitial-lung-disease-a-case-series-and-literature-review-on-janus-kinase-inhibitors-for-the-disease
#27
REVIEW
Hiroaki Harada, Hirofumi Shoda, Haruka Tsuchiya, Makoto Misaki, Takayuki Sawada, Keishi Fujio
Anti-melanoma differentiation-associated protein 5 antibody-positive dermatomyositis (anti-MDA5-DM) is frequently complicated by progressive interstitial lung disease (ILD), the prognosis of which is poor, and management is a major challenge. We treated three patients with anti-MDA5-DM-associated ILD (anti-MDA5-DM-ILD) using the Janus kinase (JAK) inhibitor, baricitinib, which improved lung opacities and saved two patients. We reviewed 6 patients with anti-MDA5-DM-ILD who had been treated with tofacitinib at our institution...
March 8, 2024: Rheumatology International
https://read.qxmd.com/read/38451302/efficacy-of-lifestyle-interventions-in-the-management-of-systemic-lupus-erythematosus-a-systematic-review-of-the-literature
#28
Alexander Tsoi, Alvaro Gomez, Carina Boström, Denise Pezzella, Jun Weng Chow, Charlotte Girard-Guyonvarc'h, Tanja Stamm, Laurent Arnaud, Ioannis Parodis
We performed a systematic review to explore existing evidence regarding the efficacy of lifestyle interventions for the management of systemic lupus erythematosus (SLE). The search was conducted on the 22nd of June 2021 for publications between 1st of January 2000 and the date of search. Additional articles within the aforementioned timeframe and until December 2023 were added by hand searching. Databases utilized were Medline, Embase, Web of Science, and Cinahl. Lifestyle interventions were defined as any intervention encompassing one or more of the following: physical exercise, diet and nutrition, mental health, harmful exposures, sleep, and social relations...
March 7, 2024: Rheumatology International
https://read.qxmd.com/read/38451301/obesity-and-tobacco-smoking-are-independently-associated-with-poor-patient-reported-outcomes-in-sle-a-cross-sectional-study
#29
JOURNAL ARTICLE
Alvaro Gomez, Ioannis Parodis, Christopher Sjöwall
We investigated associations of obesity and tobacco smoking with health-related quality of life (HRQoL), pain, fatigue, and functional impairment in systemic lupus erythematosus (SLE). Furthermore, we explored whether there was an effect modification between these two factors. We included adult SLE patients from the Linköping University Hospital (n = 325) in the present cross-sectional analysis. We further included population-based controls and performed cardinality matching to balance age and sex distributions with cases (n = 224)...
March 7, 2024: Rheumatology International
https://read.qxmd.com/read/38438576/promoting-physical-activity-in-rheumatoid-arthritis-through-a-physiotherapist-led-behaviour-change-based-intervention-pippra-a-feasibility-randomised-trial
#30
JOURNAL ARTICLE
Louise Larkin, Seán McKenna, Tadhg Pyne, Paul Comerford, Anusha Moses, Ailish Folan, Stephen Gallagher, Liam Glynn, Alexander Fraser, Bente Appel Esbensen, Norelee Kennedy
Physical activity (PA) is recommended as a key component in the management of people with rheumatoid arthritis (RA). The objective of this study was to examine the feasibility of a physiotherapist led, behaviour change (BC) theory-informed, intervention to promote PA in people with RA who have low levels of current PA. A feasibility randomised trial (ClinicalTrials.gov NCT03644160) of people with RA over 18 years recruited from outpatient rheumatology clinics and classified as insufficiently physically active using the Godin-Shephard Leisure Time Physical Activity Questionnaire...
March 4, 2024: Rheumatology International
https://read.qxmd.com/read/38421427/clinical-care-standards-for-the-management-of-low-back-pain-a-scoping-review
#31
REVIEW
Gabriel S Alves, Gustavo E Z Vera, Chris G Maher, Giovanni E Ferreira, Gustavo C Machado, Rachelle Buchbinder, Rafael Z Pinto, Crystian B Oliveira
The objective of this study is to compare and contrast the quality statements and quality indicators across clinical care standards for low back pain. Searches were performed in Medline, guideline databases, and Google searches to identify clinical care standards for the management of low back pain targeting a multidisciplinary audience. Two independent reviewers reviewed the search results and extracted relevant information from the clinical care standards. We compared the quality statements and indicators of the clinical care standards to identify the consistent messages and the discrepancies between them...
February 29, 2024: Rheumatology International
https://read.qxmd.com/read/38393386/antiphospholipid-syndrome-thrombosis-and-vaccination-in-the-covid-19-pandemic
#32
REVIEW
Tatjana Zekić, Andrej Belančić
Thrombosis is one of the many signs of antiphospholipid syndrome (APS) and COVID-19 infection. Although the mechanisms contributing to thrombosis in APS and COVID-19 are relatively similar, this remains an open subject. Even now (when the COVID-19 pandemic has subsided), there is no conclusive solution to APS and COVID-19 co-occurrence. The presence of newly generated antiphospholipid antibodies (aPLs) in COVID-19 infection may or may not be connected to the diagnosis of APS. The prevalence of aPLs is substantial in severe COVID-19 but not related to thrombosis or a worse outcome...
February 23, 2024: Rheumatology International
https://read.qxmd.com/read/38376558/re-evaluation-of-dietary-interventions-in-rheumatoid-arthritis-can-we-improve-patient-conversations-around-food-choices
#33
REVIEW
Prakriti Sharma, Shannon Brown, Elke M Sokoya
Rheumatoid arthritis (RA) is one of over 100 different types of autoimmune conditions. In RA, the cells of the immune system attack the tissue lining the joints, triggering inflammation. A large body of research suggests that the underlying trigger(s) of RA are unique to an individual. For example, increased risk of RA can be driven by smoking tobacco in one individual and mercury exposure in another. Due to the development of next-generation sequencing technology, the critical role of the microbiota in shaping RA risk has been elucidated...
February 20, 2024: Rheumatology International
https://read.qxmd.com/read/38363321/poor-obstetric-outcomes-in-women-with-takayasu-arteritis-a-retrospective-cohort-study
#34
JOURNAL ARTICLE
Erdal Bodakçi, Döndü Üsküdar Cansu, Cengiz Korkmaz
The objective of this study was to assess the pregnancy outcomes in a cohort of patients who experienced pregnancies before and/or after being diagnosed with Takayasu's arteritis (TA). The present investigation encompassed a total of 88 pregnancies seen in a cohort of 35 patients who met the criteria outlined by the American College of Rheumatology in 1990 for the classification of Takayasu arteritis (TA). Pregnancies were classified into two categories. 1. Pregnancies that occurred before the diagnosis (pre-d or pre-TA) 2...
February 16, 2024: Rheumatology International
https://read.qxmd.com/read/38349401/progression-of-subclinical-atherosclerosis-in-ankylosing-spondylitis-a-10-year-prospective-study
#35
JOURNAL ARTICLE
Aikaterini Arida, George E Fragoulis, Dimitrios Terentes-Printzios, George Konstantonis, Athanasios D Protogerou, Charalambos Vlachopoulos, Maria Tektonidou, Petros P Sfikakis
Chronic systemic inflammation contributes to increased CVD burden in Ankylosing Spondylitis (AS). Since long-term follow-up data on subclinical atherosclerosis acceleration are lacking, we examined its progression in contemporary AS patients during 10 years. Fifty-three (89% male, aged 50.4 (36.3-55.9) years,) non-diabetic, CVD-free AS patients and 53 age-sex-matched non-diabetic, control individuals were re-evaluated after 9.2-10.2 years by ultrasonography for carotid/femoral atheromatosis, pulse wave velocity (PWV) and intima-media thickness (IMT), performed by the same operator/protocol...
February 13, 2024: Rheumatology International
https://read.qxmd.com/read/38340159/validity-and-reliability-of-measurement-of-peripheral-oxygen-saturation-during-the-6-minute-walk-test-in-patients-with-systemic-sclerosis
#36
JOURNAL ARTICLE
Amanda Lynggaard Elkjær, Esben Uggerby Næser, Katja Thorup Aaen, Henrik Lynge Hovgaard, Peter Juhl-Olsen, Elisabeth Bendstrup, Klaus Søndergaard
Peripheral oxygen saturation (SpO2 ) using the fingers may have important limitations due to Raynaud's phenomenon and sclerodactyly in patients with systemic sclerosis (SSc). Sensors located at more central body positions may be more accurate as these as less prone to Raynaud attacks. To determine the validity and reliability of the SpO2 measured at the finger, forehead, and earlobe during the 6-Minute Walk Test (6MWT). Eighty two patients with SSc had an arterial line placed while performing the 6MWT. Peripheral oxygen saturation was simultaneously measured by finger, forehead, and earlobe sensors and compared to the arterial oxygen saturation (SaO2 ) measured before and after the 6MWT...
February 10, 2024: Rheumatology International
https://read.qxmd.com/read/38321330/telerehabilitation-lessons-from-the-covid-19-pandemic-and-future-perspectives
#37
REVIEW
Burhan Fatih Kocyigit, Meirgul I Assylbek, Marlen Yessirkepov
The coronavirus disease 2019 (COVID-19) pandemic has had an enormous effect on healthcare, notably rehabilitation for neurological, rheumatological, musculoskeletal, and cognitive diseases. Telerehabilitation provides rehabilitation services via multiple modalities, such as real-time chats, computerized consultations, and distant evaluations, emphasizing assessment, diagnosis, and intervention. While the use of telerehabilitation had restrictions before COVID-19, regulatory changes have accelerated its adoption, broadening therapy provision beyond traditional healthcare settings...
February 6, 2024: Rheumatology International
https://read.qxmd.com/read/38319377/exploring-5-year-changes-in-general-and-skin-health-related-quality-of-life-in-psoriatic-arthritis-patients
#38
JOURNAL ARTICLE
Mateusz Wilk, Brigitte Michelsen, Katarzyna Łosińska, Arthur Kavanaugh, Mariusz Korkosz, Glenn Haugeberg
Psoriatic arthritis (PsA) carries a severe disease burden, often leading to deterioration of health-related quality of life (HRQoL). Different comorbidities that are relatively prevalent in PsA are also responsible for compromised HRQoL. To assess real-world data of a 5-year follow-up cohort of PsA patients, focusing on changes in general HRQoL, skin HRQoL, and comorbidities. In this prospective observational study, 114 outpatients diagnosed with PsA were examined at baseline and after 5 years. Data collection included demographics, clinical disease activity measures, and patient-reported outcome measures (PROMs)...
February 6, 2024: Rheumatology International
https://read.qxmd.com/read/38319376/cross-sectional-analysis-of-cardiovascular-disease-and-risk-factors-in-patients-with-spondyloarthritis-a-real-life-evidence-from-biostar-nationwide-registry
#39
JOURNAL ARTICLE
Mehmet Tuncay Duruöz, Hatice Bodur, Şebnem Ataman, Gülcan Gürer, Özgür Akgül, Hasan Fatih Çay, Erhan Çapkın, İlhan Sezer, Aylin Rezvani, Meltem Alkan Melikoğlu, İlker Yağcı, Fatma Gül Yurdakul, Feride Nur Göğüş, Ayhan Kamanlı, Remzi Çevik, Lale Altan
The association between spondyloarthritis and cardiovascular (CV) diseases is complex with variable outcomes. This study aimed to assess the prevalence rates of CV diseases and to analyze the impact of CV risk factors on CV disease in patients with spondyloarthritis. A multi-center cross-sectional study using the BioSTAR (Biological and Targeted Synthetic Disease-Modifying Antirheumatic Drugs Registry) database was performed on patients with spondyloarthritis. Socio-demographic, laboratory, and clinical data were collected...
February 6, 2024: Rheumatology International
https://read.qxmd.com/read/38300269/glucocorticoid-discontinuation-rate-and-risk-factors-for-relapses-in-a-contemporary-cohort-of-patients-with-giant-cell-arteritis
#40
JOURNAL ARTICLE
Christina Tsalapaki, Argyro Lazarini, Evaggelia Argyriou, Vassiliki Dania, Kyriaki Boki, Gerasimos Evangelatos, Alexios Iliopoulos, Maria Pappa, Petros P Sfikakis, Maria G Tektonidou, Athanasios Georgountzos, Euripidis Kaltsonoudis, Paraskevi Voulgari, Alexandros A Drosos, Evaggelos Theotikos, Charalampos Papagoras, Theodoros Dimitroulas, Alexandros Garyfallos, Evaggelia Kataxaki, Georgios Vosvotekas, Dimitrios Boumpas, Emilia Hadziyannis, Dimitrios Vassilopoulos
The rates of relapses and therapy discontinuation in patients with giant cell arteritis (GCA) in the modern therapeutic era have not been defined. We aimed to evaluate the glucocorticoid (GC) discontinuation rate and the factors associated with relapses in a contemporary GCA cohort. Patient and treatment data were collected cross-sectionally at first evaluation and 2 years later (second evaluation), in a multicenter, prospective GCA cohort. Predictors of relapses were identified by logistic regression analyses...
February 1, 2024: Rheumatology International
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