Mateusz Wilk, Olena Zimba, Glenn Haugeberg, Mariusz Korkosz
Pain is a crucial factor in rheumatic disorders, and reducing it is a primary goal of successful treatment. Adaptive pain-coping strategies can enhance this improvement, but maladaptive approaches such as pain catastrophizing may worsen overall patient well-being. This narrative review aims to provide a concise overview of the existing knowledge on pain catastrophizing in the most prevalent specific rheumatic disorders. The objective of this study was to improve understanding of this phenomenon and its implications, as well as to pinpoint potential directions for future research...
April 12, 2024: Rheumatology International
Esha Kadam, Mahnoor Javaid, Parikshit Sen, Sreoshy Saha, Nelly Ziade, Jessica Day, Chris Wincup, Laura Andreoli, Ioannis Parodis, Ai Lyn Tan, Samuel Katsuyuki Shinjo, Dzifa Dey, Lorenzo Cavagna, Tulika Chatterjee, Johannes Knitza, Guochun Wang, Nicola Dalbeth, Tsvetelina Velikova, Simone Battista, Karen Cheng, Peter Boyd, Linda Kobert, Abraham Edgar Gracia-Ramos, Srijan Mittal, Ashima Makol, Carlos Enrique Toro Gutiérrez, Carlo V Caballero Uribe, Masataka Kuwana, Gerd-Rüdiger Burmester, Francis Guillemin, Elena Nikiphorou, Hector Chinoy, Vikas Aggarwal, Latika Gupta
INTRODUCTION: The growing recognition of holistic patient care highlights the various factors shaping the quality of life of individuals with autoimmune and rheumatic diseases (AIRDs). Beyond the traditional disease measures, there is an emerging acknowledgment of the less-explored aspects, including subjective well-being, social determinants of health, comorbidities, mental health, and medication adherence. Moreover, digital health services have empowered patients to engage actively in decision-making alongside clinicians...
April 12, 2024: Rheumatology International
Hannah Labinsky, Susann May, Katharina Boy, Sophie von Rohr, Manuel Grahammer, Sebastian Kuhn, Jessica Rojas-Restrepo, Ekaterina Vogt, Martin Heinze, Georg Schett, Felix Muehlensiepen, Johannes Knitza
Patients with axial spondyloarthritis (axSpA) require close monitoring to achieve the goal of sustained disease remission. Telehealth can facilitate continuous care while relieving scarce healthcare resources. In a mixed-methods proof-of-concept study, we investigated a hybrid telehealth care axSpA pathway in patients with stable disease over 6 months. Patients used a medical app to document disease activity (BASDAI and PtGA bi-weekly, flare questionnaire weekly). To enable a remote ASDAS-CRP (TELE-ASDAS-CRP), patients used a capillary self-sampling device at home...
April 11, 2024: Rheumatology International
Juliette Drouet, Clementina López-Medina, Benjamin Granger, Bruno Fautrel, Robert B M Landewe, Anna Molto, Cécile Gaujoux-Viala, Uta Kiltz, Maxime Dougados, Laure Gossec
Global health (GH) and health-related quality of life are patient priorities in axial spondyloarthritis (axSpA). Our objective was to assess the relative importance of disease-related factors including disease activity, and patient-related factors including comorbidities, to explain GH in axSpA. Post hoc cross-sectional analyses of 4 sets (COMOSPA, PERSPA, COMEDSPA, and DESIR) of patients fulfilling ASAS criteria for axSpA. GH was assessed through the ASAS Health Index (ASAS-HI) or the EuroQoL-5D-3L (EQ-5D)...
April 10, 2024: Rheumatology International
Akerke Auanassova, Marlen Yessirkepov, Olena Zimba, Sakir Ahmed, Prakashini Mruthyunjaya
Systemic vasculitides are among the less common disorders encountered in routine rheumatology practice. The low incidence and heterogeneous presentation at onset can potentially lead to delayed diagnosis. Not recognizing these in the early phase may prove detrimental, as some vasculitis may progress to a catastrophic course with major morbidity or mortality. The causes of diagnostic delay may vary among different types of vasculitis and may also be disease-, patient-, or physician-related. Disease-related factors include the myriad presentations with diverse and non-specific symptoms, mimicking other conditions like infections...
April 8, 2024: Rheumatology International
Anne Bech-Drewes, Kasper Bonnesen, Ellen-Magrethe Hauge, Morten Schmidt
Gout attacks are treated with uric-lowering and anti-inflammatory drugs. In patients with gout, non-steroidal anti-inflammatory drugs (NSAIDs) could be both cardiovascular beneficial, due to their anti-inflammatory actions, and cardiovascular hazardous, due to their prothrombotic, hypertensive, and proarrhythmic side effects. We, therefore, examined the risk of cardiovascular events associated with NSAID use in patients with gout. We conducted a nationwide, population-based case-crossover study of all Danes ≥ 18 years of age with first-time gout during 1997-2020, who experienced a cardiovascular event (myocardial infarction, ischemic stroke, congestive heart failure, atrial fibrillation/flutter, or cardiovascular death) (n = 59,150)...
April 6, 2024: Rheumatology International
Kasper Yde Jensen, Jakob Lindberg Nielsen, Per Aagaard, Mikkel Jacobsen, Anders Nørkær Jørgensen, Rune Dueholm Bech, Ulrik Frandsen, Louise Pyndt Diederichsen, Henrik Daa Schrøder
Sporadic inclusion body myositis (sIBM) is a subgroup of idiopathic inflammatory myopathies characterised by progressive muscle weakness and skeletal muscle inflammation. Quantitative data on the myofibre morphology in sIBM remains scarce. Further, no previous study has examined fibre type association of satellite cells (SC), myonuclei number, macrophages, capillaries, and myonuclear domain (MD) in sIBM patients. Muscle biopsies from sIBM patients (n = 18) obtained previously (NCT02317094) were included in the analysis for fibre type-specific myofibre cross-sectional area (mCSA), SCs, myonuclei and macrophages, myonuclear domain, and capillarisation...
April 6, 2024: Rheumatology International
Bohdana Doskaliuk, Olena Zimba
The genus Borrelia encompasses a diverse group of spirochetes transmitted primarily by ticks, with Borrelia burgdorferi causing Lyme disease, which is prevalent in North America and Europe. Borrelia's structural adaptations and ability to persist in diverse host tissues underscore its pathogenic potential. Beyond traditional infectious responses, Borrelia engages in complex interactions with the host immune system, contributing to autoimmune mechanisms such as molecular mimicry and persistent infections. This intricate interplay manifests in symptoms resembling various autoimmune diseases, including systemic lupus erythematosus, dermatomyositis, local scleroderma, and systemic sclerosis...
April 5, 2024: Rheumatology International
Pia Elfving, Simo Kariniemi, Hannu Kautiainen, Vappu Rantalaiho, Lauri J Virta, Kari Puolakka, Merja K Laine
OBJECTIVES: The aim was to investigate, how pregnancies proceed in patients with systemic lupus erythematosus (SLE) compared to their individually matched population controls. MATERIAL AND METHODS: Adult incident SLE patients were identified from the register of new special reimbursement decisions for SLE drugs in 2000-2014. For each patient, 1-3 randomly selected controls from the Population Register Centre were matched. Data regarding pregnancies were obtained from the Finnish Medical Birth Register, Care Register and Register of Congenital Malformations until 2018...
April 2, 2024: Rheumatology International
Luise Holberg Lindgren, Annette de Thurah, Tanja Thomsen, Merete Lund Hetland, Mette Aadahl, Sofie Bech Vestergaard, Sara Danshøj Kristensen, Bente Appel Esbensen
When newly diagnosed with inflammatory arthritis (IA), acquiring self-management skills is beneficial, to enhance quality of life. The personal beliefs and mental representations patients hold about their illness, known as illness perception, significantly influence the development of these skills. Recognizing characteristics that affect illness perception is key to identifying patients requiring additional support for the development of self-management skills. This study aimed at identifying the sociodemographic and clinical characteristics associated with a negative illness perception...
April 2, 2024: Rheumatology International
Velichka Popova, Mariela Geneva-Popova, Stanislava Popova-Belova, Mladen Doykov, Stanislav Valkanov, Zguro Batalov, Aleksandar Marinkov, Rositsa Karalilova
ANCA-associated vasculitis (AAV) can affect multiple organs with severe life-threatening manifestations. Disease monitoring is difficult due to a lack of defined biomarkers. We aimed to assess the diagnostic role of serum interleukin-6 and vascular ultrasonography in AAV and subclinical atherosclerosis. The study included 20 AAV patients and two control groups of 34 patients with rheumatoid arthritis (RA) and 35 healthy controls. The levels of Il-6, carotid intima-media thickness test (CIMT), atherosclerotic plaque, and degree of stenosis were investigated...
March 30, 2024: Rheumatology International
Alexandros Panagiotopoulos, George E Fragoulis, Aikaterini Arida, Vassiliki-Kalliopi Bournia, Gerasimos Evangelatos, Kalliopi Fragkiadaki, Evrydiki Kravvariti, Katerina Laskari, Maria Mylona, Nikolaos Michalakeas, Nikolaos Papazoglou, Maria Pappa, Vassiliki Poulia, Stylianos Panopoulos, Sevastiani Ziarangali, Vasileios Papatheodorou, Maria G Tektonidou, Petros P Sfikakis
Data on COVID-19 re-infections in patients with systemic rheumatic diseases (SRDs) are lacking. We aimed to describe the course and outcomes of COVID-19 re-infections in these patients versus controls. In this single-center retrospective study, we included 167 consecutive SRD patients with at least one COVID-19 re-infection (mean age 47.3 years, females 70.7%). SRD patients were compared in terms of patient-perceived COVID-19 re-infection severity and hospitalizations/deaths with 167 age/sex-matched non-SRD controls...
March 29, 2024: Rheumatology International
Joanna Kosałka-Węgiel, Radosław Dziedzic, Andżelika Siwiec-Koźlik, Magdalena Spałkowska, Mamert Milewski, Joanna Żuk-Kuwik, Lech Zaręba, Stanisława Bazan-Socha, Mariusz Korkosz
BACKGROUND: Lupus nephritis (LN) manifests systemic lupus erythematosus (SLE) and is characterized by various clinical and laboratory features. This study aimed to comprehensively evaluate the characteristics of LN patients according to the time of LN diagnosis: early-onset (LN diagnosed within one year from SLE diagnosis) vs. delayed-onset (LN diagnosed more than one year after SLE diagnosis). METHODS: We conducted a retrospective analysis of medical records from all SLE patients treated at the University Hospital in Kraków, Poland, from 2012 to 2022...
March 28, 2024: Rheumatology International
Changhong Li, Yuanyuan Wang, Rong Mu, Jinxia Zhao, Zhongqiang Yao, Jiayu Zhai, Yinji Jin, Rui Liu, Defeng Liu, Kai Hong, Hui Jiang, Zhe Zhang
OBJECTIVE: The objective of this study was to analyze and compare the effects of different urate-lowering agents on testicular functions in men with gout in a clinical setting. METHODS: In this prospective cohort study (Clinical Trial Registration Number: NCT04213534), a total of 49 male patients aged 18-45 years with gout were enrolled. They were divided into three groups and received treatment with either allopurinol, febuxostat or benzbromarone for a duration of 3 months...
March 27, 2024: Rheumatology International
William B Grant
No abstract text is available yet for this article.
March 27, 2024: Rheumatology International
Norma K Biln, Nick Bansback, Kam Shojania, Lorri Puil, Mark Harrison
We aimed to (1) identify existing triage approaches for referral of patients with suspected inflammatory arthritis (IA) from primary care physicians (PCP) to rheumatologists, (2) describe their characteristics and methodologies for clinical use, and (3) report their level of validation for use in a publicly funded healthcare system. The comprehensive search strategy of multiple databases up to October 2023 identified relevant literature and focussed on approaches applied at the PCP-Rheumatologist referral stage...
March 26, 2024: Rheumatology International
Konrad Kaleta, Julia Krupa, Wiktoria Suchy, Anna Sopel, Mariusz Korkosz, Jarosław Nowakowski
Endothelial dysfunction (ED) is defined as an impairment in the vasodilatory, anti-thrombotic, and anti-inflammatory properties of the cells that make up the lining of blood vessels. ED is considered a key step in the development of atherosclerotic cardiovascular disease. The association between ED and systemic inflammatory diseases is well established. However, the prevalence and clinical significance of ED in psoriatic arthritis (PsA) have been investigated to a lesser extent. This review aims to explore the link between ED and PsA, including ED in macro- and microcirculation, as well as risk factors for its occurrence in PsA and its relationship with atherosclerosis in PsA...
March 24, 2024: Rheumatology International
Nihal Yilmaz, Meryem Kösehasanoğulları
To investigate and compare the effectiveness of Nintendo Wii games and home exercises on balance functions in patients with osteoporosis, an important disease adversely affecting balance functions. The patients included in the study were randomized into two groups the Wii exercise group (n = 30) and the home exercise group (n = 30). Wii exercise group performed balance exercises with a Nintendo Wii device and balance board three times a week for 12 weeks under the supervision of a physiotherapist in the hospital, and home exercise group was prescribed home exercises three days a week for 12 weeks...
March 22, 2024: Rheumatology International
Aliya Botabekova, Chokan Baimukhamedov, Olena Zimba, Pankti Mehta
Rhupus, in the broad sense, refers to an overlap between rheumatoid arthritis (RA) and lupus. However, there is a paucity of data on the appropriate diagnostic/classification criteria that should be used to define rhupus. Hence, we undertook this narrative review to analyze the clinical characteristics, radiology, and treatment with a focus on diagnostic challenges and defining features of rhupus. The databases of Medline/PubMed, Scopus, and DOAJ were searched for relevant articles using the following keywords: ("Rhupus"), ("lupus" AND "erosive" AND "arthritis"), and ("lupus" AND "rheumatoid arthritis" AND "overlap")...
March 21, 2024: Rheumatology International
Zaid Al-Ghazawi, Amwaj Al-Farajat, Ahmad A Toubasi, Hind B Abu Tawileh, Aya Qteish, Tariq N Aladily, Fatima Alnaimat
Aplastic anemia (AA) is a rare, potentially catastrophic hematopoiesis failure manifested by pancytopenia and bone marrow aplasia. AA occurrence in Systemic Lupus Erythematosus (SLE) patients is extremely rare. The diagnosis may be delayed due to other possible pancytopenia etiologies. Confirmation of peripheral cytopenias diagnosis necessitates a bone marrow aspiration. The management of AA is challenging, and the literature reported using glucocorticoids, danazol, plasmapheresis, cyclophosphamide, intravenous immunoglobulin, and cyclosporine...
March 21, 2024: Rheumatology International
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