Joanna Kosałka-Węgiel, Sabina Lichołai, Renata Pacholczak-Madej, Sylwia Dziedzina, Mamert Milewski, Piotr Kuszmiersz, Anna Korona, Jolanta Gąsior, Aleksandra Matyja-Bednarczyk, Helena Kwiatkowska, Lech Zaręba, Andżelika Siwiec-Koźlik, Paweł Koźlik-Siwiec, Anita Wach, Weronika Pociej-Marciak, Marek Sanak, Jacek Musiał, Stanisława Bazan-Socha, Mariusz Korkosz
Recent reports have demonstrated that endothelial injury is critical in the pathogenesis of systemic sclerosis (SSc) and is associated with increased levels of circulating inflammatory biomarkers. This study aims to analyze the serum concentrations of selected cytokines and evaluate their relationship with SSc clinics and the long-term course of the disease. This study included 43 SSc patients and 24 matched healthy controls. In both groups, we measured serum levels of inflammatory cytokines related to the inflammatory response, such as tumor necrosis factor (TNF)α, interferon (IFN)γ, interleukin (IL)-4, IL-6, IL-10, and IL-17, and fibroblast activation protein (FAP)...
December 5, 2023: Rheumatology International