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Graefe's Archive for Clinical and Experimental Ophthalmology

Eun Young Choi, Jae Yong Han, Hyukmin Lee, Sung Chul Lee, Hyoung Jun Koh, Sung Soo Kim, Min Kim
PURPOSE: Infectious endophthalmitis (IE) is a severe complication that can lead to blindness even with treatment. However, the impact of antibiotic resistance and early vitrectomy on its prognosis has scarcely been documented. This study investigated the impact of antibiotic resistance of pathogen and early vitrectomy on the prognosis of IE. METHODS: The medical records of 171 patients treated for IE at a tertiary referral center between 2007 and 2016 were retrospectively reviewed and analyzed for etiology, pathogen, drug resistance to vancomycin or third-generation cephalosporins, treatment types and timing, and visual outcomes...
February 13, 2019: Graefe's Archive for Clinical and Experimental Ophthalmology
Herbert Reitsamer, Chelvin Sng, Vanessa Vera, Markus Lenzhofer, Keith Barton, Ingeborg Stalmans
PURPOSE: To evaluate the effectiveness of an ab interno subconjunctival gelatin implant as primary surgical intervention in reducing intraocular pressure (IOP) and IOP-lowering medication count in medically uncontrolled moderate primary open-angle glaucoma (POAG). METHODS: In this prospective, non-randomized, open-label, multicenter, 2-year study, eyes with medicated baseline IOP 18-33 mmHg on 1-4 topical medications were implanted with (phaco + implant) or without (implant alone) phacoemulsification...
February 13, 2019: Graefe's Archive for Clinical and Experimental Ophthalmology
Markus Avar, Jens F Jordan, Matthias Neuburger, Diana Engesser, Jan Lübke, Alexandra Anton, Thomas Wecker
BACKGROUND: The minimally invasive ab-interno trabeculectomy (AIT) via electro-ablation with the Trabectome has been on the European market since 2009. Many studies have proven the safety and efficacy of the procedure. Up until now, studies investigating the long-term effect of AIT have been sparse. In this study, we present long-term results of AIT in patients with primary and secondary open-angle glaucoma. METHODS: In a retrospective monocentric study, the data of all the patients having undergone the procedure in 2010 at our institution were recorded...
February 9, 2019: Graefe's Archive for Clinical and Experimental Ophthalmology
Zakhar Shchomak, David Cordeiro Sousa, Inês Leal, Luís Abegão Pinto
PURPOSE: This literature review and meta-analysis aims to compare intraocular pressure (IOP) lowering efficacy, failure rates and loss of light perception (LP) rates 6 months after an IOP-lowering surgical procedure in neovascular glaucoma (NVG) eyes. METHODS: MEDLINE and EMBASE were used as data sources. Only studies including NVG patients who underwent two different surgical approaches were considered. The treatment effect measures were (i) weighted mean difference (WMD) for IOP reduction, (ii) risk ratio (RR) for failure rates and (iii) risk difference (RD) for loss of LP...
February 6, 2019: Graefe's Archive for Clinical and Experimental Ophthalmology
Bharati Matta, Puran S Bora, Adam J Neuhouser, Nalini S Bora
PURPOSE: Experimental autoimmune anterior uveitis (EAAU) is a clinically relevant animal model for human idiopathic anterior uveitis (IAU). The role of the immunomodulator transforming growth factor β2 (TGF-β2) in EAAU pathology is unknown. In this study, we investigated the regulatory role of TGF-β2 in EAAU. METHODS: EAAU was induced in male Lewis rats by footpad injection of melanin-associated antigen (MAA). TGF-β2 was administered intravenously (iv) in MAA-sensitized rats during the induction of EAAU, or after the clinical onset of uveitis...
February 5, 2019: Graefe's Archive for Clinical and Experimental Ophthalmology
Iku Kikuchi, Satoru Kase, Yuki Hashimoto, Kiriko Hirooka, Susumu Ishida
PURPOSE: This study aims to examine the relationship between ocular circulation changes and visual field defects in optic disk melanocytoma (ODM). METHODS: Five eyes of five patients were enrolled in this study. All patients were diagnosed with ODM in the Department of Ophthalmology, Hokkaido University Hospital from March 2009 to November 2017. Ophthalmological data including optical coherence tomography angiography (OCTA) and laser speckle flowgraphy (LSFG) findings were retrospectively analyzed...
February 4, 2019: Graefe's Archive for Clinical and Experimental Ophthalmology
Eleni Papageorgiou, Ioannis Asproudis, Gail Maconachie, Evangelia E Tsironi, Irene Gottlob
PURPOSE: The purpose of this review is to provide an update on current management and recent research for amblyopia treatment. Part I will review patching, atropine penalization, and pharmacological treatments. Part II will focus on perceptual learning, video gaming, and binocular dichoptic approaches. METHODS: A literature search was performed in PubMed, , Google Scholar, and reference lists of retrieved articles until December 20, 2018, for all papers containing "amblyopia treatment" or "amblyopia therapy...
January 31, 2019: Graefe's Archive for Clinical and Experimental Ophthalmology
Byunghoon Chung, Seonghee Choi, Yong Woo Ji, Eung Kweon Kim, Kyoung Yul Seo, Tae-Im Kim
PURPOSE: To compare objective accommodation of phakic and pseudophakic eyes between two different age groups. METHODS: Eighty-three eyes (83 participants aged ≥ 40 years) with a visual acuity of 20/25 or better, and refractive error < spherical - 1.0 diopters (D) and cylindrical 1.0 D, were included. Forty-four patients had undergone phacoemulsification and monofocal intraocular lens implantation and were examined 6 months post-surgery. Participants were divided into groups 1 (pseudophakic, age < 60 years), 2 (pseudophakic, ≥ 60 years), 3 (phakic, < 60 years), and 4 (phakic, ≥ 60 years)...
January 30, 2019: Graefe's Archive for Clinical and Experimental Ophthalmology
Martin Dominik Leclaire, Gerburg Nettels-Hackert, Jeannette König, Annika Höhn, Tilman Grune, Constantin E Uhlig, Uwe Hansen, Nicole Eter, Peter Heiduschka
PURPOSE: To examine the reaction of microglial cells (MG) when incubated with lipofuscin (LP) in vitro with emphasis on the immunological reaction of the MG toward LP and the suppression of this reaction by immunomodulatory agents. MG are involved in the pathogenesis of degenerative eye disorders such as age-related macular degeneration (AMD). LP is a heterogeneous waste material that accumulates in the retinal pigment epithelium (RPE) cells with advancing age. LP is known to have toxic effects on RPE cells and therefore an elevated LP-derived fundus autofluorescence is a risk factor for AMD development...
January 28, 2019: Graefe's Archive for Clinical and Experimental Ophthalmology
Shuxin Fan, Xiaoyan Ding, Pinhong Rao, Yingfeng Zheng, Fuxiang Mao, Youjin Hu, Xialin Liu, Guoping Fan
PURPOSE: The aim of this study was to identify the morphological features of the retina and choroid in Macaca fascicularis of different ages using multimodal imaging. METHODS: A total of 27 Macaca fascicularis with no ocular diseases were studied (mean age, 104.2 months; range, 1.2-223.6 months). Multimodal imaging was obtained from each subject. The morphological features were compared within four subgroups according to age. RESULTS: On spectrum-domain optical coherence tomography (SD-OCT), four hyper-reflective bands could be observed in the outer retina in non-infant macaques (21/21, 100%), while the interdigitation zone could not be observed in the six infant macaques...
January 25, 2019: Graefe's Archive for Clinical and Experimental Ophthalmology
Federico Ricci, Giovanni Staurenghi, Monica Varano, Chiara Eandi, Tommaso Lupieri Sinibaldi, Laura Colombo, Marta Bartezaghi, Stefania Bassanini
PURPOSE: To evaluate criteria driving retreatment with ranibizumab in Italian patients with myopic choroidal neovascularization (mCNV). METHODS: OLIMPIC was a 12-month, phase IIIb, open-label study. Patients with active mCNV were treated with ranibizumab 0.5 mg according to the European label. The study assessed local criteria in Italy driving retreatment decisions with ranibizumab; and the efficacy, safety, and tolerability of ranibizumab. RESULTS: The mean (standard deviation [SD]) age of treated patients (N = 200) was 61...
January 24, 2019: Graefe's Archive for Clinical and Experimental Ophthalmology
Asimina Mataftsi, Nikolaos Kappos, Paraskevi Riga, Stamatia Kokkali, Paraskevi Malamaki, Periklis Brazitikos, Anna-Bettina Haidich
PURPOSE: Log-scaled crowded charts using standardized testing protocol are essential for precise and reproducible visual acuity (VA) testing regarding amblyopia. Despite common acceptance of these standards, current VA testing clinical practice shows considerable diversity. The purpose of this retrospective literature review was to investigate the methodology of VA measurement and reporting in pediatric ophthalmology literature regarding amblyopia. METHODS: We searched PubMed for clinical trials regarding amblyopia, published from January 1994 to July 2016...
January 24, 2019: Graefe's Archive for Clinical and Experimental Ophthalmology
Qian Chen, Ruiqi Ma, Lu Gan, Hui Ren, Yifei Yuan
PURPOSE: Conventional imaging techniques are not sensitive enough to reveal detailed structures of lacrimal drainage system (LDS) and its surrounding tissue (ST). Our study aimed to explore utility of ultrasound biomicroscopy (UBM) in assessment of small masses at the medial canthal region and compare performance of UBM with conventional imaging techniques. METHODS: We prospectively recruited cases with small mass (long axis < 1 cm) at the medial canthal region (upper LDS-located area) from June 2017 to October 2018...
January 23, 2019: Graefe's Archive for Clinical and Experimental Ophthalmology
Reika Kono, Hiroshi Ohtsuki, Fumiko Kishimoto, Ichiro Hamasaki, Yuki Morizane, Fumio Shiraga
PURPOSE: This study aimed to investigate the characteristics of the extraocular muscles and the orbital connective tissue pulleys in Japanese patients with age-related distance esotropia (ARDE) and high myopia using magnetic resonance imaging (MRI). METHODS: This was a retrospective case-series study. High-resolution coronal MRI scans of 12 orbits were obtained in 6 patients with ARDE and high myopia (age range: 51-69 years). We analyzed the images to determine the positions of the rectus muscle pulleys relative to the center of the globe, the integrity of the lateral rectus-superior rectus muscle (LR-SR) band, and the LR angle (the angle between the major axis of the LR and the vertical plane)...
January 22, 2019: Graefe's Archive for Clinical and Experimental Ophthalmology
Kenneth G-J Ooi, Anupam Rao, Jonathan S-K Goh, Gary Gracie, Svetlana Cherepanoff, Michele C Madigan, Stephanie L Watson
PURPOSE: 3-Hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR), the rate-limiting enzyme of cholesterol production, has been found to contribute to lipid secretion from skin sebaceous glands and hair follicles. We assessed for HMGCR expression in human eyelid tissue and in immortalized human meibomian gland epithelial cells (HMGECs) using immunohistochemistry. METHODS: Full thickness human eyelid specimens in archival paraffin blocks were obtained. A section from each block was stained with hematoxylin and eosin and examined by an ocular pathologist for validation of tissue pathology...
January 21, 2019: Graefe's Archive for Clinical and Experimental Ophthalmology
Yung Ju Yoo, Hee Kyung Yang, Jong-Mo Seo, Kwang Gi Kim, Jeong-Min Hwang
PURPOSE: To validate the effectiveness of the selective wavelength filter analysis with infrared photographs for diagnosing small-angle esotropia in children under age 4. METHODS: This is a retrospective, observational, case-control study. A total of 83 esotropes with an esodeviation of ≤ 16 prism diopters (PD) and 75 orthotropic controls under 4 years of age were included. Full-face infrared photographs were taken with a selective wavelength filter in front of either eye...
January 19, 2019: Graefe's Archive for Clinical and Experimental Ophthalmology
Marc M Abitbol
No abstract text is available yet for this article.
January 19, 2019: Graefe's Archive for Clinical and Experimental Ophthalmology
Tsukasa Hanemoto, Koichiro Mukai, Hiroyuki Matsushima, Tadashi Senoo, Tadahiko Kozawa, Yasuhiro Takahashi, Hirohiko Kakizaki
PURPOSE: To disclose histological advantages of intrascleral fixation of intraocular lens haptics, in comparison with scleral suture fixation, in a study with rabbits. METHODS: Ten white rabbits, 10 weeks of age, were used in this experimental histopathological study. After unilateral lensectomy and anterior vitrectomy, an intraocular lens haptic was inserted into one eye of each rabbit. Intrascleral fixation was performed in five rabbits, whereas scleral suture fixation was performed in the others...
January 19, 2019: Graefe's Archive for Clinical and Experimental Ophthalmology
Laura Kuehlewein, Ludger Schöls, Pablo Llavona, Alexander Grimm, Saskia Biskup, Eberhart Zrenner, Susanne Kohl
PURPOSE: Posterior column ataxia and retinitis pigmentosa (PCARP) is a rare form of syndromic RP associated with mutations in the FLVCR1 gene. Recent evidence has suggested a spectrum in the phenotype depending on the genotype. METHODS: Six individuals with retinitis pigmentosa (RP) carrying mutations in the FLVCR1 gene underwent detailed ophthalmological examinations at the Center for Ophthalmology and two of these also an extensive neurological examination at the Department of Neurology in Tuebingen, Germany...
January 17, 2019: Graefe's Archive for Clinical and Experimental Ophthalmology
Henrik Barth, Sven Crafoord, Karin Arnér, Fredrik Ghosh
PURPOSE: To investigate the inflammatory response of current and future potential vitreous substitutes in an experimental in vivo vitrectomy model. METHODS: Twenty-five gauge pars plana vitrectomy was performed in the right eye of 60 pigmented rabbits, with subsequent injection of 0.5-1.0 ml of Healaflow® (cross-linked hyaluronic acid, n = 12), Bio-Alcamid® (polyalkylimide, n = 8), silicone oil (n = 12), or balanced saline solution (BSS, n = 28)...
January 17, 2019: Graefe's Archive for Clinical and Experimental Ophthalmology
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