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Journals Graefe's Archive for Clinical ...

Graefe's Archive for Clinical and Experimental Ophthalmology

https://read.qxmd.com/read/39007909/phacoemulsification-combined-with-kahook-dual-blade-goniotomy-versus-with-trabectome-in-the-treatment-of-open-angle-glaucoma
#1
JOURNAL ARTICLE
Dapeng Mou, Jin Wang, Huaizhou Wang, Ningli Wang
To compare the surgical effectiveness and safety of phacoemulsification combined with KDB (Phaco-KDB) and with Trabectome (Phaco-Trabectome) at 6 months follow-up in patients with open-angle glaucoma (OAG) METHODS: This comparative case series was conducted at Beijing Tongren Hospital, including patients diagnosed with OAG who underwent Phaco-KDB from November 2021 to April 2022 and Phaco-Trabectome from April 2017 to December 2017. Surgical success was defined as an IOP reduction ≥ 20% or a postoperative IOP ≤ 21 mmHg...
July 15, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38995353/one-year-choroidal-thickness-changes-after-photodynamic-therapy-for-central-serous-chorioretinopathy-evaluated-by-widefield-optical-coherence-tomography
#2
JOURNAL ARTICLE
Shota Sawaguchi, Nobuhiro Terao, Naoya Imanaga, Sorako Wakugawa, Yasunori Miyara, Ayano Oshiro, Marina Maehira, Yukihide Yamauchi, Hideki Koizumi
PURPOSE: To evaluate the changes in choroidal thickness 1 year after half-dose photodynamic therapy (PDT) for central serous chorioretinopathy (CSC) using widefield swept-source optical coherence tomography. METHODS: We retrospectively reviewed 21 patients with CSC who unilaterally underwent half-dose PDT and completed a 12-month follow-up. Choroidal thickness was evaluated before and after PDT within an 18-mm circular grid centered on the fovea subdivided into nine areas in the treated and untreated fellow eyes...
July 12, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38995352/two-year-outcomes-of-intravitreal-brolucizumab-for-neovascular-age-related-macular-degeneration-treat-extend-and-stop-protocol
#3
JOURNAL ARTICLE
Hana Yoshida, Satoru Inoda, Hidenori Takahashi, Ryota Takahashi, Yuto Hashimoto, Hironori Takahashi, Hidetoshi Kawashima, Yasuo Yanagi
PURPOSE: To investigate the real-world 2-year treatment outcomes of intravitreal brolucizumab (IVBr) for neovascular age-related macular degeneration (nAMD). METHODS: This multicenter, prospective, and interventional study included 53 eyes treated with brolucizumab from October 2020 to August 2021 at 3 institutions. A modified treat-and-extend (TAE) regimen with predefined discontinuation criteria was used. The mTAE regimen was discontinued if patients responded positively and achieved a treatment interval of 16 weeks twice with no sign of recurrence...
July 12, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38995351/disparities-in-glaucoma-and-macular-degeneration-healthcare-utilization-among-persons-living-with-dementia-in-the-united-states
#4
JOURNAL ARTICLE
Ali G Hamedani, Angela Y Chang, Yineng Chen, Brian L VanderBeek
PURPOSE: Dementia is common among patients with primary open angle glaucoma (POAG) and neovascular age-related macular degeneration (nAMD). This study compares visit frequency, diagnostic test utilization, and treatment patterns for POAG and nAMD among persons with vs. without dementia. METHODS: Optum's de-identified Clinformatics® Data Mart Database (January 1, 2000-June 30, 2022) was used for this study. Two cohorts were created from newly diagnosed POAG or nAMD patients...
July 12, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38995350/anti-vegf-therapy-for-the-long-term-management-of-diabetic-macular-edema-a-treat-to-target-strategy-based-on-macular-morphology
#5
REVIEW
Shintaro Nakao, Sentaro Kusuhara, Tomoaki Murakami
In an aging population, the prevalence and burden of diabetes mellitus, diabetic retinopathy, and vision-threatening diabetic macular edema (DME) are only expected to rise around the world. Similarly to other complications of diabetes mellitus, DME requires long-term management. This article aims to review the current challenges associated with the long-term management of DME, opportunities to improve outcomes for patients, and to develop a treat-to-target strategy based on macular morphology. At present, intravitreal anti-vascular endothelial growth factor (VEGF) therapy is the standard of care for the management of DME; however, best-achievable vision outcomes with treatment are reliant on frequent injections and close monitoring, which are difficult to maintain in current clinical practice because of the burden this imposes on patients...
July 12, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38990331/study-of-the-impact-of-the-vascular-systemic-risk-factors-on-peripapillary-vascular-density-by-optical-coherence-tomography-angiography
#6
JOURNAL ARTICLE
Cristina Tolosa-Tort, Emma Poza-Martin, Julian Garcia-Feijoo, Carmen Mendez-Hernandez
BACKGROUND: The focus of therapeutic tools in glaucoma has been mainly to control of intraocular pressure. Recently there has been a growing interest in investigating the relationship of vascular risk factors in the development of glaucoma. The aim of this study was to assess the association between systemic arterial hypertension, diabetes mellitus and hypercholesterolemia, and peripapillary vascularization measured by Optical Coherence Tomography Angiography (OCTA) in glaucoma and healthy subjects...
July 11, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38985321/optical-coherence-tomography-homography-for-detection-of-retinal-displacement-a-validation-study
#7
JOURNAL ARTICLE
Koby Brosh, Eduardo Roditi, Aditya Bansal, Isabela Martins Melo, Michael J Potter, Rajeev H Muni
PURPOSE: Retinal displacement following rhegmatogenous retinal detachment (RRD) has been associated with inferior functional outcomes. Recent evidence using an overlay technique suggests that fundus-autofluorescence underestimates post-RRD repair retinal displacement. This study aims to validate the overlay technique in normal eyes and to determine its sensitivity and specificity at detecting retinal displacement. METHODS: We conducted a retrospective case series involving 66 normal eyes, each with at least two separate infrared (IR) images at different time points...
July 10, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38980349/subconjunctival-aflibercept-inhibits-corneal-angiogenesis-and-vegfr-3-cd11b-cells
#8
JOURNAL ARTICLE
Chang Ho Yoon, Jung Hwa Ko, Hyun Ju Lee, Hyun Beom Song, Joo Youn Oh
PURPOSE: This study aimed to investigate the effects of subconjunctival injection of aflibercept, a soluble protein decoy for VEGFR-1 and VEGFR-2, on corneal angiogenesis and VEGFR-expressing CD11b+ cells in a mouse model of suture-induced corneal neovascularization. METHODS: Corneal neovascularization was induced in BALB/c mice by placing three sutures on the cornea. Immediately after surgery, either 200 µg aflibercept (5 µL) or an equal volume of phosphate-buffered saline (PBS) was administered into the subconjunctival space...
July 9, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38976013/evaluation-of-peripheral-blood-inflammatory-biomarkers-in-sickle-cell-disease-with-and-without-retinopathy
#9
JOURNAL ARTICLE
Ömer Özer, Levent Doğan, Zeki Baysal, Hakan Basir, Ali Türker Çıftçı, Pınar Eröz, Emin Serbülent Güçlü
BACKGROUND: The aim of this study was to evaluate the clinical significance of blood-cell associated inflammation markers in patients with sickle cell disease (SCD) and sickle cell retinopathy (SCR). METHODS: Neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to lymphocyte ratio (MLR), systemic immune inflammation index (SIII), systemic inflammation response index (SIRI), systemic inflammation modulation index (SIMI) and aggregate systemic inflammation index (AISI) were calculated...
July 8, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38969777/the-use-of-intraluminal-preserflo-stenting-in-avoiding-early-postoperative-hypotony
#10
JOURNAL ARTICLE
Raoul Verma-Fuehring, Mohamad Dakroub, Ahmed Bamousa, Gunda Kann, Jost Hillenkamp, Daniel Kampik
PURPOSE: Postoperative hypotony following PRESERFLO MicroShunt (PMS) implantation is a frequent cause of complications such as choroidal detachment and hypotony maculopathy. This study aims at evaluating the impact of intraluminal stenting of the PMS during the early postoperative period. METHODS: We retrospectively analyzed the data of 97 patients who underwent PMS implantation with intraoperative placement of a Nylon 10-0 suture as intraluminal stent (PStent) and compared the outcomes to those of an existing database of the traditional MicroShunt implantation technique (PTrad, n = 120)...
July 6, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38969776/povidone-iodine-in-vitro-antiseptic-efficacy-as-a-function-of-exposure-duration-concentration-preparation-and-length-of-storage
#11
JOURNAL ARTICLE
Christina M Ambrosino, Leo L Shen, Heba Mahjoub, Warda Memon, Sean X Zhang, Mark P Breazzano
PURPOSE: Although 5% povidone-iodine (PVP-I) is frequently used as an ocular antiseptic agent, there is a lack of consensus regarding the effects of PVP-I concentration, storage after opening, and compounded preparation on PVP-I antisepsis. We performed a series of in-vitro experiments to determine the impact of these factors on PVP-I's inhibition of common causes of post-procedural eye infection. METHODS: Inhibition of microorganism growth was measured in-vitro as a function of active PVP-I exposure time...
July 5, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38967775/iol-calculation-using-six-formulas-in-children-undergoing-lens-extraction-and-primary-iol-implantation-with-and-without-posterior-optic-capture
#12
JOURNAL ARTICLE
Christoph Lwowski, Yaroslava Wenner, Eva Sapok, Thomas Kohnen
PURPOSE: To evaluate formulas for intraocular lens (IOL) calculation in children undergoing lens extraction and IOL implantation. METHODS: Retrospective, consecutive case series at the Department of Ophthalmology, Goethe University Frankfurt, Germany. We included eyes that received lens extraction and IOL implantation (SN60AT, Alcon, Fort Worth, TX) due to congenital or juvenile cataract. Preoperative assessments included biometry (IOLMaster 500/700, Carl Zeiss Meditec, Germany)...
July 5, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38963460/targeted-lipidomics-uncovers-oxylipin-perturbations-and-potential-circulation-biomarkers-in-bietti-s-crystalline-dystrophy
#13
JOURNAL ARTICLE
Qian Li, Cong Wang, Shengjuan Zhang, Zhongjie Fu, Xiaodong Jiao, Zibing Jin, J Fielding Hejtmancik, Huan Miao, Simeng Qi, Xiaoyan Peng
PURPOSE: Abnormalities in lipid metabolism have been proposed in Bietti's crystalline dystrophy (BCD). We aim to characterize the lipid profiles in a case-control study. METHODS: All participants were genetically confirmed by CYP4V2 gene sequencing and underwent chorioretinopathy evaluation by calculating the percentages of AF atrophy (PAFA). Fasting blood samples of BCD patients and controls were collected, and plasma was analyzed for routine lipid profiles. Targeted lipidomic evaluation includes long chain polyunsaturated fatty acids (LCPUFA) and associated eicosanoid metabolites...
July 4, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38958721/correction-lamellar-macular-hole-in-highly-myopic-eyes-and-insights-into-its-development-evolution-and-treatment-a-mini-review
#14
Tso-Ting Lai, Yun Hsia, Chung-May Yang
No abstract text is available yet for this article.
July 3, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38953984/adherence-of-studies-involving-artificial-intelligence-in-the-analysis-of-ophthalmology-electronic-medical-records-to-ai-specific-items-from-the-consort-ai-guideline-a-systematic-review
#15
REVIEW
Niveditha Pattathil, Tin-Suet Joan Lee, Ryan S Huang, Eleanor R Lena, Tina Felfeli
PURPOSE: In the context of ophthalmologic practice, there has been a rapid increase in the amount of data collected using electronic health records (EHR). Artificial intelligence (AI) offers a promising means of centralizing data collection and analysis, but to date, most AI algorithms have only been applied to analyzing image data in ophthalmologic practice. In this review we aimed to characterize the use of AI in the analysis of EHR, and to critically appraise the adherence of each included study to the CONSORT-AI reporting guideline...
July 2, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38951226/in-vivo-confocal-microscopy-predicts-cytomegalovirus-as-the-cause-of-chronic-or-recurrent-anterior-uveitis-among-chinese
#16
JOURNAL ARTICLE
Stephanie Hiu-Wai Kwok, Ka Wai Kam, Eugenie Mok, Alvin L Young
PURPOSE: To evaluate and compare endothelial features by in-vivo confocal microscopy (IVCM) in Chinese eyes with chronic or recurrent anterior uveitis (AU) with and without cytomegalovirus (CMV). METHODS: A double-masked, cross-sectional case-control study at a tertiary eye clinic. RESULTS: Thirty eyes of 30 subjects were analyzed. Fifteen eyes (50%) were CMV positive, while fifteen eyes were negative for herpes simplex virus, varicella zoster virus and CMV...
July 1, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38951225/magnetized-forceps-for-intraocular-foreign-body-removal-which-one-is-suitable
#17
JOURNAL ARTICLE
Melih Parlak, Jens Ulrich Werner, Armin Wolf
INTRODUCTION: Magnetic intraocular foreign bodies can be removed with magnetized disposable forceps. Aim of this study is to compare the forceps magnetizability of different size, form and manufacturer. METHODS: The forceps were magnetized using an established procedure. The inducible magnetic flux density was measured at the tip of the forceps. The mass that can be lifted with the magnetized forceps was then tested using steel balls in BSS solution. The weight of the metal parts of the forceps was measured...
June 29, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38949667/relationship-between-oxidative-stress-level-and-diabetic-retinopathy-severity
#18
LETTER
Tatsu Okabe, Hiroshi Kunikata, Masayuki Yasuda, Toru Nakazawa
No abstract text is available yet for this article.
June 29, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38940958/the-epidemiology-of-nonpowder-firearm-related-eye-trauma-in-the-united-states
#19
EDITORIAL
Julia S Gillette, Olivia Waldman, Kenan Zaidat, Paul B Greenberg
No abstract text is available yet for this article.
June 28, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38916723/correlation-between-mental-status-and-prevalence-of-asthenopia-in-chinese-college-students
#20
JOURNAL ARTICLE
Zhongjun Tang, Xiaoxue Zhang, Chiwen Cheng, Yupeng Xu, Guoying Deng, Xingtao Zhou, Shengtao Liu
BACKGROUND: The purpose of this study was to identify the possible association between mental status and the risk of self-reported asthenopia among college students in China. METHODS: Ten thousand students were randomly assessed in the study using a self-reported asthenopia questionnaire. Their demographic characteristics and mental status were recorded. Univariate analysis was performed to preliminarily select potential risk and protective factors. Then, multivariate logistic regression was used to estimate odds ratios for the selected risk factors of interest...
June 25, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
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