Octavio Daniel Reyes-Hernández, Gabriela Figueroa-González, Laura Itzel Quintas-Granados, Hector Hernández-Parra, Sheila I Peña-Corona, Hernán Cortés, Aliya Kipchakbayeva, Zhazira Mukazhanova, Solomon Habtemariam, Gerardo Leyva-Gómez, Dietrich Büsselberg, Javad Sharifi-Rad
Icaritin is a natural prenylated flavonoid derived from the Chinese herb Epimedium. The compound has shown antitumor effects in various cancers, especially hepatocellular carcinoma (HCC). Icaritin exerts its anticancer activity by modulating multiple signaling pathways, such as IL-6/JAK/STAT3, ER-α36, and NF-κB, affecting the tumor microenvironment and immune system. Several clinical trials have evaluated the safety and efficacy of icaritin in advanced HCC patients with poor prognoses, who are unsuitable for conventional therapies...
April 2024: Drug Development Research