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Cephalalgia: An International Journal of Headache

Kati Toom, Aire Raidvee, Katri-Helena Allas, Elina Floria, Kristiina Juhkami, Gustav Klimušev, Maria Leping, Margot Liidemann, Alexander Milovidov, Karita Liivak, Siiri Paiste, Gerli Paju, Karel Uhs, Marge Vaikjärv, Kristiina Veetõusme, Priit Välja, Mark Braschinsky
OBJECTIVE: To estimate the one-year prevalence of primary headaches, most importantly migraine and tension type headache, but also other primary headaches, in Estonia. METHODS: A population-based random sample of 2162 subjects in Tartu City and Tartu County were interviewed by telephone or face to face using a previously validated questionnaire. RESULTS: Of the 2162 contacted participants, 1215 (56%) fully completed the study. Of these, 502 (41...
February 11, 2019: Cephalalgia: An International Journal of Headache
Marco Lisicki, Kevin D'Ostilio, Gianluca Coppola, Vincenzo Parisi, Alain Maertens de Noordhout, Delphine Magis, Jean Schoenen, Felix Scholtes, Jan Versijpt
PURPOSE: The aim of this study was to evaluate the possibility that migraine patients exhibit specific age-related metabolic changes in the brain, which occur regardless of disease duration or the frequency of attacks. METHODS: We analysed the relation between brain glucose (18 F-fluorodeoxyglucose) uptake and age in healthy volunteers (n = 20) and episodic migraine patients (n = 19). In the latter, we additionally compared the correlation between 18 F-fluorodeoxyglucose uptake and disease duration and monthly migraine days...
February 11, 2019: Cephalalgia: An International Journal of Headache
David W Dodick, Michael L Reed, Kristina M Fanning, Sagar Munjal, Aftab Alam, Dawn C Buse, Todd J Schwedt, Richard B Lipton
BACKGROUND: Cutaneous allodynia is a common clinical feature of migraine that has been associated with reduced efficacy of acute migraine treatments and an increased risk of disease progression. OBJECTIVE: Identify factors associated with allodynia in a sample of adults with migraine. METHODS: An online survey panel was used to identify adults with migraine who averaged at least 1 monthly headache day over the previous 3 months. Data on sociodemographics, headache frequency, headache pain intensity, migraine symptom severity, medication use, depression and anxiety, and cutaneous allodynia (via the Allodynia Symptom Checklist) were obtained...
February 7, 2019: Cephalalgia: An International Journal of Headache
Mia Nielsen, Louise Ninett Carlsen, Signe Bruun Munksgaard, Ida Maria Storm Engelstoft, Rigmor Højland Jensen, Lars Bendtsen
BACKGROUND: Medication-overuse headache leads to high disability and decreased quality of life, and the best approach for withdrawal has been debated. AIM: To compare change in disability and quality of life between two withdrawal programs. METHODS: We randomized medication-overuse headache patients to program A (two months without acute analgesics or migraine medications) or program B (two months with acute medications restricted to two days/week) in a prospective, outpatient study...
February 7, 2019: Cephalalgia: An International Journal of Headache
Sigrid Børte, John-Anker Zwart, Synne Øien Stensland, Knut Hagen, Bendik S Winsvold
BACKGROUND: Migraine is known to run in families. While some clinical studies have indicated that migraine is disproportionally transmitted through the maternal line, this has not been examined in a population-based setting. METHODS: We utilized a large, population-based cohort study from Norway, the HUNT Study. Using a cross-sectional design, our sample consisted of 13,731 parents and 8970 offspring. Logistic regression was used to calculate odds ratios with 95% confidence intervals for active migraine and non-migrainous headache in offspring, given active maternal or paternal headache...
February 2, 2019: Cephalalgia: An International Journal of Headache
David W Dodick
BACKGROUND: Monoclonal antibodies that target calcitonin gene-related peptide or the canonical calcitonin gene-related peptide receptor have emerged as effective and well tolerated for the preventive treatment of migraine. These large molecules appear ideally suited for migraine prevention. They have an extended biological half-life, are administered either monthly or quarterly either by subcutaneous injection or intravenous infusion, require minimal or no dose-titration and have the potential for a rapid onset of effect compared to conventional oral preventive drugs...
January 19, 2019: Cephalalgia: An International Journal of Headache
Fahimeh Martami, Mansoureh Togha, Maryam Seifishahpar, Zeinab Ghorbani, Hossein Ansari, Tahereh Karimi, Soodeh Razeghi Jahromi
BACKGROUND: The current study was designed to assess the effect of supplementation with a 14-strain probiotic mixture on episodic and chronic migraine characteristics. METHODS: Forty episodic and 39 chronic migraine patients who completed this randomized double-blind controlled trial received two capsules of multispecies probiotic or placebo. The migraine severity was assessed by visual analog scale (VAS). The number of abortive drugs consumed, migraine days, frequency and duration of attacks were recorded on paper-based headache diaries...
January 8, 2019: Cephalalgia: An International Journal of Headache
Juan A Pareja, Mónica Álvarez, Alba Cárcamo, Talía Liaño, Gil Rodríguez-Caravaca, María-Luz Cuadrado
INTRODUCTION: In this report we describe a series of patients with a previously undescribed headache. METHODS: Over a 4-year period, we recruited 14 patients with a distinctive type of head pain of unknown cause that did not meet diagnostic criteria for other primary headaches. RESULTS: Nine women and five men with a mean age of 49.6 years (standard deviation, 17.8) presented with spontaneous headache attacks lasting 2-15 minutes. In each attack, the pain was localized to a region of one side of the head...
January 6, 2019: Cephalalgia: An International Journal of Headache
Parisa Hajihashemi, Gholamreza Askari, Fariborz Khorvash, Mohammad Reza Maracy, Mojgan Nourian
PURPOSE: The present study aimed to determine the effects of combined supplementation of Coenzyme Q10 with L-carnitine on mitochondrial metabolic disorders marker and migraine symptoms among migraine patients. METHODS: A total of 56 men and women, between 20-40 years of age with migraine headache, participated in this randomized, double-blind, placebo-controlled, parallel study. The subjects were randomly assigned to receive either 30 mg/day Coenzyme Q10 and 500 mg/day L-carnitine at the same time and/or placebo tablets for 8 weeks...
January 6, 2019: Cephalalgia: An International Journal of Headache
Levent Ertugrul Inan, Nurten Inan, Hanzade Aybuke Unal-Artık, Ceyla Atac, Gulcin Babaoglu
OBJECTIVES: The importance and popularity of peripheral nerve block procedures have increased in the treatment of migraine. Greater occipital nerve (GON) block is a commonly used peripheral nerve block method, and there are numerous researches on its use in migraine treatment. MATERIALS AND METHODS: A search of PubMed for English-language randomized controlled trials (RCT) and open studies on greater occipital nerve block between 1995 and 2018 was performed using greater occipital nerve, headache, and migraine as keywords...
January 6, 2019: Cephalalgia: An International Journal of Headache
Kelly Hensley, Jim Pretorius, Brian Chan, Keith Page, Hantao Liu, Chang Choi, Di Shi, Cen Xu, Lars Edvinsson, Silke Miller
BACKGROUND: To further understand the role of pituitary adenylate cyclase-activating polypeptide 1 (PAC1) receptors in headache disorders, we mapped their expression in tissues of the trigemino-autonomic system by immunohistochemistry and in situ hybridization. METHODS: To optimize screening for monoclonal antibodies suitable for immunohistochemistry on formalin-fixed, paraffin-embedded tissues, we developed a new enzyme-linked immunosorbent assay using formalin-fixed, paraffin-embedded cells overexpressing human PAC1 receptors...
December 24, 2018: Cephalalgia: An International Journal of Headache
Stefano Magon, Arne May, Anne Stankewitz, Peter J Goadsby, Christoph Schankin, Messoud Ashina, Faisal M Amin, Christian L Seifert, M Mallar Chakravarty, Jannis Müller, Till Sprenger
BACKGROUND: Several previous studies have investigated cortical abnormalities, specifically cortical thickness, in patients with migraine, with variable results. The relatively small sample sizes of most previous studies may partially explain these inconsistencies. OBJECTIVE: To investigate differences of cortical thickness between control subjects and migraineurs in a large cohort. METHODS: Three Tesla MRI data of 131 patients (38 with and 93 without aura) and 115 control subjects were analysed...
December 10, 2018: Cephalalgia: An International Journal of Headache
Ana Sardoeira, Gonçalo Cação, Sofia Pina, Ana Paula Sousa, Joana Damásio
BACKGROUND: Short-lasting unilateral neuralgiform headaches include those with conjunctival injection and tearing and with cranial autonomic symptoms. Most frequently reported as idiopathic, there is a growing number of symptomatic cases described. CASE REPORT: A 57-year old man presented a 16-year history of right hemifacial short-lasting pain attacks accompanied by ipsilateral autonomic symptoms and simultaneous malar contractions. Brain MRI disclosed a right acoustic neuroma compressing the right facial nerve and a venous developmental anomaly perpendicular to the right facial nerve root entry zone, without lesions affecting the trigeminal nerve...
November 27, 2018: Cephalalgia: An International Journal of Headache
Nunu Lt Lund, Agneta Henriette Snoer, Poul Jørgen Jennum, Rigmor Højland Jensen, Mads Christian J Barloese
BACKGROUND AND AIM: Cluster headache attacks exhibit a nocturnal predilection, but little is known of long-term sleep and circadian rhythm. The aim was to compare actigraphy measures, firstly in episodic cluster headache patients in bout and in remission and, secondly, to compare each disease phase with controls. METHODS: Episodic cluster headache patients (ICHD III-beta), from the Danish Headache Center and healthy, age- and sex-matched controls participated. Sleep and activity were measured using actigraphy continuously for 2 weeks, along with sleep diaries and, for patients, also attack registration...
November 23, 2018: Cephalalgia: An International Journal of Headache
Igor Petrusic, Michele Viana, Marko Dakovic, Peter J Goadsby, Jasna Zidverc-Trajkovic
OBJECTIVES: Currently, there is no scoring system for assessing the complexity of migraine aura. Our goal was to develop a Migraine Aura Complexity Score that synthesizes the quantity and quality of aura symptoms and to test its applicability in neuroimaging studies. METHODS: Patients with migraine aura were interviewed in order to obtain characteristics of migraine aura. Explorative and confirmatory analyses were used to develop the Migraine Aura Complexity Score...
November 20, 2018: Cephalalgia: An International Journal of Headache
Jr-Wei Wu, Yen-Feng Wang, Jong-Ling Fuh, Jiing-Feng Lirng, Shih-Pin Chen, Shu-Shya Hseu, Shuu-Jiun Wang
OBJECTIVES: Several brain and spinal magnetic resonance imaging signs have been described in spontaneous intracranial hypotension. Their correlations are not fully studied. This study aimed to explore potential mechanisms underlying cerebral neuroimaging findings and to examine associations among spinal and brain magnetic resonance imaging signs. METHODS: We conducted a retrospective review of magnetic resonance myelography and brain magnetic resonance imaging records of patients with spontaneous intracranial hypotension...
December 2018: Cephalalgia: An International Journal of Headache
Alberto Terrin, Giulia Toldo, Mario Ermani, Federico Mainardi, Ferdinando Maggioni
BACKGROUND: Migraine with aura may mimic an acute ischemic stroke, so that an improper administration of thrombolytic treatment can expose migrainous patients to severe adverse effects. METHODS: This systematic review quantifies the relevance of migraine with aura among stroke mimics, checking for thrombolysis' safety in these patients. We reviewed the literature after 1995, distinguishing from studies dealing with stroke mimics treated with systemic thrombolysis and those who were not treated with systemic thrombolysis...
December 2018: Cephalalgia: An International Journal of Headache
Mas Ahmed, Catriona Boyd, Radhika Vavilikolanu, Bushra Rafique
AIM: To examine the characteristics of visual symptoms during attacks of migraine in children and adolescents. METHOD: A qualitative analysis of prospectively collected data over 5 years, on characteristics of visual symptoms during migraine attacks. Diagnosis of migraine and aura was based on the International Classification of Headache Disorders 3rd edition beta version. We also provided the opportunity for patients to illustrate their visual aura symptoms to aid in diagnosis...
December 2018: Cephalalgia: An International Journal of Headache
Jeffrey M Gelfand, Amy A Gelfand, Peter J Goadsby, Bryan S Benn, Laura L Koth
OBJECTIVE: To describe the frequency of migraine and predictors of having migraine in sarcoidosis patients. METHODS: The ID migraine questionnaire was administered to a well-phenotyped observational cohort of sarcoidosis patients (most of whom were seeking specialty care) and healthy controls. Predictors of migraine status were examined using univariate and multivariable logistic regression. RESULTS: Migraine was seen in 29% of 96 patients with sarcoidosis and 13% of 39 healthy controls, ( p = 0...
December 2018: Cephalalgia: An International Journal of Headache
Denise E Chou, Marianna Shnayderman Yugrakh, Dana Winegarner, Vernon Rowe, Deena Kuruvilla, Jean Schoenen
OBJECTIVE: To assess the safety and efficacy of external trigeminal nerve stimulation for acute pain relief during migraine attacks with or without aura via a sham-controlled trial. METHODS: This was a double-blind, randomized, sham-controlled study conducted across three headache centers in the United States. Adult patients who were experiencing an acute migraine attack with or without aura were recruited on site and randomly assigned 1:1 to receive either verum or sham external trigeminal nerve stimulation treatment (CEFALY Technology) for 1 hour...
November 17, 2018: Cephalalgia: An International Journal of Headache
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