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Journals Brazilian Journal of Medical a...

Brazilian Journal of Medical and Biological Research

https://read.qxmd.com/read/38808886/the-inhibitor-of-the-redox-activity-of-ape1-ref-1-apx2009-reduces-the-malignant-phenotype-of-breast-cancer-cells
#21
JOURNAL ARTICLE
P B Siqueira, M M S Rodrigues, Ĺ S S de Amorim, J A Rodrigues, M S Oliveira, A S Fonseca, B R B Pires, A L Mencalha
Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/REF-1) is a multifunctional protein acting on cellular signaling pathways, including DNA repair and redox activities. APE1/REF-1 has emerged as a target for cancer therapy, and its role in breast cancer models would reveal new strategies for cancer therapy. APX2009 is a specific APE1/REF-1 redox inhibitor whose anticancer properties have not been described in breast cancer cells. Here, we investigated the effect of the APX2009 treatment in the breast cancer cell lines MDA-MB-231 and MCF-7...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38808885/electro-acupuncture-modulated-mir-214-expression-to-prevent-chondrocyte-apoptosis-and-reduce-pain-by-targeting-bax-and-trpv4-in-osteoarthritis-rats
#22
JOURNAL ARTICLE
Jia He, Jia Zuo, Xiaochen Fan, Zhe Li
Osteoarthritis (OA) is a highly prevalent joint disorder characterized by progressive degeneration of articular cartilage, subchondral bone remodeling, osteophyte formation, synovial inflammation, and meniscal damage. Although the etiology of OA is multifactorial, pro-inflammatory processes appear to play a key role in disease pathogenesis. Previous studies indicate that electroacupuncture (EA) exerts chondroprotective, anti-inflammatory, and analgesic effects in preclinical models of OA, but the mechanisms underlying these potential therapeutic benefits remain incompletely defined...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38808884/fish-oil-supplementation-in-obese-rats-ameliorates-metabolic-syndrome-response
#23
JOURNAL ARTICLE
D M B Freitas, B A C Oliveira, L D V Henschel, M H A P C Oliveira, M Zazula, E Horlem, D F S Rodriguez, S R S Carvalhal, F Iagher, R Fernandez, K Naliwaiko, L C Fernandes
Accumulation of visceral adipose tissue is associated with metabolic syndrome (MS), insulin resistance, and dyslipidemia. Here we examined several morphometric and biochemical parameters linked to MS in a rodent litter size reduction model, and how a 30-day fish oil (FO) supplementation affected these parameters. On day 3 post-birth, pups were divided into groups of ten or three. On day 22, rats were split into control (C) and small litter (SL) until 60 days old. Then, after metabolic disturbance and obesity were confirmed, FO supplementation started for 30 days and the new groups were named control (C), FO supplemented (FO), obese (Ob), and obese FO supplemented (ObFO)...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38775548/prevalence-and-risk-factors-for-falls-among-older-chinese-adults-in-the-community-findings-from-the-clhls-study
#24
JOURNAL ARTICLE
Haodong Liang, Zijie Zhang, Haitian Lai, Tianzhao Tian
Older adults have a high prevalence of falls due to a decline in physiological functions and various chronic diseases. This study aimed to investigate the prevalence of and risk factors for falls among older individuals in the Chinese Longitudinal Healthy Longevity Survey (CLHLS). We collected information from 9737 older individuals (average age=84.26 years) from the CLHLS and used binary logistic regression analysis to explore the independent risk factors and protective factors for falls. The logistic regression analysis results are reported as adjusted odds ratios (aORs) and 95% confidence intervals (95%CIs)...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38775547/frzb-a-potential-prognostic-marker-for-head-and-neck-squamous-cell-carcinoma
#25
JOURNAL ARTICLE
Yunshan Li, Feihan Gu, Xu Huang, Wenkai Huang, Junwei Xiang, Jiayuan Yue, Yuanyin Wang, Ran Chen
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide, with approximately 600,000 new cases each year. A small number of HNSCCs are caused by human papillomavirus (HPV) infection. Frizzled related protein (FRZB) has been reported in many inflammatory diseases and cancers, but it is yet unclear how FRZB affects HNSCC, as well as its role and underlying mechanism. TIMER2 database was utilized to evaluate FRZB expression in cancer tissues, and FRZB expression in HNSCC tissues was confirmed by samples obtained from Gene Expression Omnibus...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38775546/adjuvant-induced-arthritis-promotes-vascular-hyporesponsiveness-to-phenylephrine-through-a-nitric-oxide-related-mechanism
#26
JOURNAL ARTICLE
T S Araujo, M A Spadella, C P Carlos, C R Tirapelli, E F B Chagas, J C D Pinheiro, A B Chies
Arthritis has important cardiovascular repercussions. Phenylephrine-induced vasoconstriction is impaired in rat aortas in the early phase of the adjuvant-induced arthritis (AIA), around the 15th day post-induction. Therefore, the present study aimed to verify the effects of AIA on hyporesponsiveness to phenylephrine in rat aortas. AIA was induced by intradermal injection of Mycobacterium tuberculosis (3.8 mg/dL) in the right hind paw of male Wistar rats (n=27). Functional experiments in isolated aortas were carried out 15 days after AIA induction...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38775545/trichostatin-a-modified-vaccine-provides-superior-protection-against-ovarian-cancer-formation-and-development
#27
JOURNAL ARTICLE
Yingwei Liu, Tao Yi, Shenglan Meng, Xia Zhao, Xiancheng Chen, Yanna Zhang
More attention has been paid to immunotherapy for ovarian cancer and the development of tumor vaccines. We developed a trichostatin A (TSA)-modified tumor vaccine with potent immunomodulating activities that can inhibit the growth of ovarian cancer in rats and stimulate immune cell response in vivo. TSA-treated Nutu-19 cells inactivated by X-ray radiation were used as a tumor vaccine in rat ovarian cancer models. Prophylactic and therapeutic experiments were performed with TSA-modified tumor vaccine in rats...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38716986/giant-uterine-tumor-and-miscarriage-how-to-proceed
#28
E A Hase, L L Iervolino, H A Antico, N Bozzini, R P V Francisco
Expanding uterine masses can be the cause of pregnancy loss and add technical difficulties to uterus evacuation due to the intense anatomical distortion of the endocervical canal and uterine cavity. The literature is scarce in the peculiarities of the management of missed abortions in uterus with important distorted anatomies. We report a case of a primigravida patient who presented a rapid and expressive increase of abdominal volume due to a giant uterine mass, evolving to miscarriage. Ultrasound can be a useful tool, allowing visualization of the endocervical path and uterine cavity, helping to perform uterine evacuation in the presence of anatomical distortion without compromising the reproductive future...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38716985/coenzyme-q10-prevents-rankl-induced-osteoclastogenesis-by-promoting-autophagy-via-inactivation-of-the-pi3k-akt-mtor-and-mapk-pathways
#29
JOURNAL ARTICLE
Delu Zheng, Chenli Cui, Chengsong Ye, Chen Shao, Xiujing Zha, Ying Xu, Xu Liu, Can Wang
Coenzyme Q10 (CoQ10) is a potent antioxidant that is implicated in the inhibition of osteoclastogenesis, but the underlying mechanism has not been determined. We explored the underlying molecular mechanisms involved in this process. RAW264.7 cells received receptor activator of NF-κB ligand (RANKL) and CoQ10, after which the differentiation and viability of osteoclasts were assessed. After the cells were treated with CoQ10 and/or H2O2 and RANKL, the levels of reactive oxygen species (ROS) and proteins involved in the PI3K/AKT/mTOR and MAPK pathways and autophagy were tested...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38716984/crescentic-glomerulonephritis-due-to-linear-iga-anti-glomerular-basement-membrane-disease-report-of-a-rare-case
#30
JOURNAL ARTICLE
A G Monich, R F Romani, J L S Carneiro
Anti-glomerular basement membrane (GBM) disease is a rare and severe vasculitis that affects the glomerular and pulmonary capillaries and has an incidence of less than 2 cases per million individuals per year. Anti-GBM disease is mediated by autoantibodies against the α3 chain of type IV collagen. In the majority of cases, the autoantibodies are of the immunoglobulin G (IgG) class, with rare cases being mediated by immunoglobulin M (IgM) or immunoglobulin A (IgA); there are less than 15 IgA-mediated cases reported in the literature worldwide...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38716983/acupuncture-for-generalized-anxiety-disorder-a-study-protocol-for-a-randomized-controlled-trial
#31
RANDOMIZED CONTROLLED TRIAL
Xiayun Zhou, Guoao Shi, Ruiming Chen, Lingsan Hu, Zhongxian Li, Yifu Zhou, Pan Zhang, Xiang Ji, Min Peng, Kengyu Chen, Luda Yan, Peng Zhou
During the COVID-19 outbreak, there was a sharp increase in generalized anxiety disorder (GAD). Acupuncture therapy has the advantages of accurate clinical efficacy, safety and reliability, few adverse reactions, and no dependence, and is gradually becoming one of the emerging therapies for treating GAD. We present a study protocol for a randomized clinical trial with the aim of exploring the mechanism of brain plasticity in patients with GAD and evaluate the effectiveness and reliability of acupuncture treatment...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38716982/an-extensive-analysis-of-the-prognostic-and-immune-role-of-foxo1-in-various-types-of-cancer
#32
JOURNAL ARTICLE
Jie Li, Chao Wang, Xiao Xu, Jun Chen, Haijun Guo
Forkhead Box O1 (FOXO1) has been reported to play important roles in many tumors. However, FOXO1 has not been studied in pan-cancer. The purpose of this study was to reveal the roles of FOXO1 in pan-cancer (33 cancers in this study). Through multiple public platforms, a pan-cancer analysis of FOXO1 was conducted to obtained FOXO1 expression profiles in various tumors to explore the relationship between FOXO1 expression and prognosis of these tumors and to disclose the potential mechanism of FOXO1 in these tumors...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38716981/25-hydroxycholesterol-aggravates-oxygen-glucose-deprivation-reoxygenation-induced-pyroptosis-through-promoting-activation-of-nlrp3-inflammasome-in-h9c2-cardiomyocytes
#33
JOURNAL ARTICLE
Tao Jiang, Yong Li
25-hydroxycholesterol (25-HC) plays a role in the regulation of cell survival and immunity. However, the effect of 25-HC on myocardial ischemia/reperfusion (MI/R) injury remains unknown. Our present study aimed to investigate whether 25-HC aggravated MI/R injury through NLRP3 inflammasome-mediated pyroptosis. The overlapping differentially expressed genes (DEGs) in MI/R were identified from the GSE775, GSE45818, GSE58486, and GSE46395 datasets in Gene Expression Omnibus (GEO) database. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were conducted using the database of Annotation, Visualization and Integration Discovery (DAVID)...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38716980/moderate-physical-exercise-and-atp-modulate-the-p2x7-receptor-and-improve-cisplatin-induced-gastric-emptying-delay-in-rats
#34
JOURNAL ARTICLE
Y A Gomes, W L L Santos, C S Pinheiro, J S Severo, J C C Oliveira Júnior, A C A da Silva, B L B Dos Santos, C H L Rocha, A A Dos Santos, M T B da Silva
Patients undergoing chemotherapy with cisplatin commonly present gastrointestinal effects such as constipation and gastric emptying (GE) delay. Both the purinergic system and physical exercise modulate the gastrointestinal (GI) tract. In the current study, we investigated the role of ATP, physical exercise, and P2X7 receptor blocking on GE delay induced by cisplatin in rats. Male rats were divided into the following groups: control (C), cisplatin (Cis), exercise (Ex), Brilliant Blue G (BBG), ATP, Cis+Ex, Cis+ATP, Cis+BBG, Cis+Ex+BBG, Cis+Ex+BBG+ATP, and Cis+ATP+BBG...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38656076/could-nanotechnology-improve-exercise-performance-evidence-from-animal-studies
#35
REVIEW
M R Lima, B J Moreira, R Bertuzzi, A E Lima-Silva
This review provides the current state of knowledge regarding the use of nutritional nanocompounds on exercise performance. The reviewed studies used the following nanocompounds: resveratrol-loaded lipid nanoparticles, folic acid into layered hydroxide nanoparticle, redox-active nanoparticles with nitroxide radicals, and iron into liposomes. Most of these nutritional nanocompounds seem to improve performance in endurance exercise compared to the active compound in the non-nanoencapsulated form and/or placebo...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38656075/development-and-validation-of-a-clinical-prediction-model-for-prognostic-factors-in-patients-with-primary-pontine-hemorrhage
#36
JOURNAL ARTICLE
Anquan Hu, Heyan Qin, Shina Wu, Xiaolin Zhao, Yumeng Li, Feng Chen, Tao Liu
We aimed to develop a prognostic model for primary pontine hemorrhage (PPH) patients and validate the predictive value of the model for a good prognosis at 90 days. A total of 254 PPH patients were included for screening of the independent predictors of prognosis, and data were analyzed by univariate and multivariable logistic regression tests. The cases were then divided into training cohort (n=219) and validation cohort (n=35) based on the two centers. A nomogram was developed using independent predictors from the training cohort to predict the 90-day good outcome and was validated from the validation cohort...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38656074/integrative-analyses-of-genetic-characteristics-associated-with-skeletal-endothelial-cells
#37
JOURNAL ARTICLE
Zhanhui Wang, Bowen Hu, Xiaoming Chen, Zheng Zhang, Lu Liu, Nan Li, Chun Liang
The osseous vascular endothelium encompasses a vast intricate framework that regulates bone remodeling. Osteoporosis, an age-associated systemic bone disease, is characterized by the degeneration of the vascular architecture. Nevertheless, the precise mechanisms underpinning the metamorphosis of endothelial cells (ECs) with advancing age remain predominantly enigmatic. In this study, we conducted a systematic analysis of differentially expressed genes (DEGs) and the associated pathways in juvenile and mature femoral ECs, utilizing data sourced from the Gene Expression Omnibus (GEO) repositories (GSE148804) and employing bioinformatics tools...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38656073/induced-acute-hyperglycemia-modifies-the-barrier-function-of-the-intestinal-epithelium-by-tissue-inflammation-and-tight-junction-disruption-resulting-in-hydroelectrolytic-secretion-in-an-animal-model
#38
JOURNAL ARTICLE
F J W S Siqueira, F A P Rodrigues, S A Ribeiro, H N Veras, F C S Ferreira, R C L Siqueira, A A Dos Santos, A Havt, A A M Lima
Diabetic-metabolic syndrome (MetS-D) has a high prevalence worldwide, in which an association with the rupture of the intestinal epithelium barrier function (IEBF) has been pointed out, but the functional and morphological properties are still not well understood. This study aimed to evaluate the impact of acute hyperglycemia diabetes on intestinal tight junction proteins, metabolic failure, intestinal ion and water transports, and IEBF parameters. Diabetes was induced in male Rattus norvegicus (200-310 g) with 0...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38656072/effect-of-whole-body-vibration-stimulation-on-plasma-soluble-tnf-receptors-in-elderly-with-sarcopenia-a-randomized-controlled-trial
#39
RANDOMIZED CONTROLLED TRIAL
H C Almeida, V K S Lage, R Taiar, J M Santos, F A de Paula, A Rapin, D C Sá-Caputo, M Bernardo-Filho, A C R Lacerda, V A Mendonça
Sarcopenia is a pathology resulting from a progressive and severe loss of muscle mass, strength, and function in the course of aging, which has deleterious consequences on quality of life. Among the most widespread studies on the issue are those focused on the effect of different types of physical exercise on patients with sarcopenia. This randomized controlled study aimed to compare the effects of a whole-body vibration exercise (WBV) session on the inflammatory parameters of non-sarcopenic (NSG, n=22) and sarcopenic elderly (SG, n=22)...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38656071/probiotics-prebiotics-and-synbiotics-in-childhood-diarrhea
#40
REVIEW
E M S Martins, L C Nascimento da Silva, M S Carmo
Acute diarrhea is the second leading cause of morbidity and mortality attributed to infections in children under five years of age worldwide, with 1.7 million annual estimated cases and more than 500,000 deaths. Although hydroelectrolytic replacement is the gold standard in treating diarrhea, it does not interfere with the restoration of the intestinal microbiota. Several studies have searched for an adequate alternative in restructuring intestinal homeostasis, finding that treatments based on probiotics, prebiotics, and synbiotics are effective, which made such treatments increasingly present in clinical practice by reducing illness duration with minimal side effects...
2024: Brazilian Journal of Medical and Biological Research
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