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Brazilian Journal of Medical and Biological Research | Page 2

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https://read.qxmd.com/read/30785481/fatty-acid-composition-of-vegetable-oil-blend-and-in-vitro-effects-of-pharmacotherapeutical-skin-care-applications
#21
M Guidoni, M M de Christo Scherer, M M Figueira, E F P Schmitt, L C de Almeida, R Scherer, S Bogusz, M Fronza
Vegetable oils have been used for a plethora of health benefits by their incorporation in foods, cosmetics, and pharmaceutical products, especially those intended for skin care. This study aimed to investigate the cutaneous benefits of a vegetable oil blend (VOB) formulation and its fatty acid composition. The anti-inflammatory activity was studied in macrophages of RAW 264.7 cells by investigating the release of nitric oxide (NO), superoxide anion generation (O2-), tumor necrosis factor-alpha (TNF-α), and interleukin 6 (IL-6)...
February 14, 2019: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/30785480/pre-analytical-parameters-associated-with-unsuccessful-karyotyping-in-myeloid-neoplasm-a-study-of-421-samples
#22
M F M Santos, F C A C Oliveira, R K Kishimoto, D Borri, F P S Santos, P V Campregher, P A A Silveira, N Hamerschlak, C L P Mangueira, F B Duarte, A H Crepaldi, M A Salvino, E D R P Velloso
Cytogenetics is essential in myeloid neoplasms (MN) and pre-analytical variables are important for karyotyping. We assessed the relationship between pre-analytical variables (time from collection to sample processing, material type, sample cellularity, and diagnosis) and failures of karyotyping. Bone marrow (BM, n=352) and peripheral blood (PB, n=69) samples were analyzed from acute myeloid leukemia (n=113), myelodysplastic syndromes (n=73), myelodysplastic syndromes/myeloproliferative neoplasms (n=17), myeloproliferative neoplasms (n=137), and other with conclusive diagnosis (n=6), and reactive disorders/no conclusive diagnosis (n=75)...
February 14, 2019: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/30785479/serotonin-induces-or-inhibits-neuritic-regeneration-of-leech-cns-neurons-depending-on-neuronal-identity
#23
J Vargas, A Alfaro-Rodríguez, J Perez-Orive
Recovery of motor function after central nervous system (CNS) injury is dependent on the regeneration capacity of the nervous system, which is a multifactorial process influenced, among other things, by the role of neuromodulators such as serotonin. The neurotransmitter serotonin can promote neuronal regeneration but there are also reports of it causing restriction, so it is important to clarify these divergent findings in order to understand the direct scope and side effects of potential pharmacological treatments...
February 14, 2019: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/30785478/kaempferol-suppresses-human-gastric-cancer-snu-216-cell-proliferation-promotes-cell-autophagy-but-has-no-influence-on-cell-apoptosis
#24
Fan Zhang, Cuimei Ma
Gastric cancer remains a serious threat to human health worldwide. Kaempferol is a plant-derived flavonoid compound with a wide range of pharmacological activities. This study aimed to investigate the effects of kaempferol on gastric cancer SNU-216 cell proliferation, apoptosis, and autophagy, as well as underlying potential mechanisms. Viability, proliferation, and apoptosis of SNU-216 cells after kaempferol treatment were evaluated using cell counting kit-8 assay, 5-btomo-2'-deoxyuridine incorporation assay, and annexin V-FITC/PI staining, respectively...
February 14, 2019: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/30785477/cirrhotic-cardiomyopathy-the-liver-affects-the-heart
#25
REVIEW
M V H Carvalho, P C Kroll, R T M Kroll, V N Carvalho
Cirrhotic cardiomyopathy historically has been confused as alcoholic cardiomyopathy. The key points for diagnosis of cirrhotic cardiomyopathy have been well explained, however this entity was neglected for a long time. Nowadays the diagnosis of this entity has become important because it is a factor that contributes significantly to morbidity-mortality in cirrhotic patients. Characteristics of cirrhotic cardiomyopathy are a hyperdynamic circulatory state, altered diastolic relaxation, impaired contractility, and electrophysiological abnormalities, particularity QT interval prolongation...
February 14, 2019: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/30698228/effects-of-exposure-to-fine-particulate-matter-in-elderly-hospitalizations-due-to-respiratory-diseases-in-the-south-of-the-brazilian-amazon
#26
A B Machin, L F Nascimento, K Mantovani, E B Machin
Exposure to air pollution is an important cause of hospital admissions due to respiratory diseases. Nevertheless, few studies use pollutant concentration data estimated by mathematical models. A time-series ecological study was developed, using data from hospitalizations due to respiratory diseases in people over 60 years of age, residents of Cuiabá, Brazil, during 2012, obtained from the Brazilian Ministry of Health. The independent variables were the concentrations of fine particulate matter (PM2.5) and carbon monoxide (CO) estimated by mathematical modeling, minimum temperature, and relative humidity (obtained from the Brazilian Meteorological Agency), and the number of forest fires...
January 24, 2019: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/30698227/anti-inflammatory-and-antinociceptive-effects-of-phonophoresis-in-animal-models-a-randomized-experimental-study
#27
L C P Cardoso, N B Pinto, M E P Nobre, M R Silva, G M Pires, M J P Lopes, G S B Viana, L M R Rodrigues
The aim of this study was to evaluate the therapeutic effects of ultrasound (US)-mediated phonophoresis alone or in association with diclofenac diethylammonium (DCF) administered topically in animal models of inflammation. A pre-clinical, prospective, and randomized experimental study of quantitative and qualitative nature was carried out. Phonophoresis was performed using a therapeutic ultrasound apparatus in two distinct models of acute inflammation. Edema was induced by an intraplantar injection of carrageenan and measured by plethysmography...
January 24, 2019: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/30698226/the-safety-and-efficacy-of-tpa-intravenous-thrombolysis-for-treating-acute-ischemic-stroke-patients-with-a-history-of-cerebral-hemorrhage
#28
Guang-Jian Zhao, Zi-Ran Wang, Fan-Zhen Lin, Yan-Sen Cui, Shun-Liang Xu
Alteplase (tPA) intravenous thrombolysis is an effective treatment for acute ischemic stroke (AIS) when administered within 4.5 h of initial stroke symptoms. Here, its safety and efficacy were evaluated among AIS patients with a previous history of cerebral hemorrhage. Patients who arrived at the hospital within 4.5 h of initial stroke symptoms and who were treated with tPA intravenous thrombolysis or conventional therapies were analyzed. The 90-day modified Rankin scale (90-d mRS) was used alongside mortality and incidence of symptomatic intracerebral hemorrhage (SICH) rates to evaluate the curative effect of these therapies...
January 24, 2019: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/30698225/pros-and-cons-of-insulin-administration-on-liver-glucose-metabolism-in-strength-trained-healthy-mice
#29
V A R Pereira, K S Vedovelli, G Y Muller, Y F Depieri, D H C G Avelar, A H E de Amo, D R Jimenes, J N L Martins, A C Silvério, C R G Gomes, V A F Godoi, M M D Pedrosa
Non-diabetic individuals use hormones like insulin to improve muscle strength and performance. However, as insulin also leads the liver and the adipose tissue to an anabolic state, the purpose of this study was to investigate the effects of insulin on liver metabolism in trained non-diabetic Swiss mice. The mice were divided into four groups: sedentary treated with saline (SS) or insulin (SI) and trained treated with saline (TS) or insulin (TI). Training was made in a vertical stair, at 90% of the maximum load, three times per week...
January 24, 2019: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/30698224/preliminary-data-for-performance-in-hue-ordering-tests-during-pregnancy
#30
T S S Calandrini, L Miquilini, M R Laranjeiras-Neto, M T S Tongu, M P Silva, G S Souza, M I T Cortes
The visual system of women changes during pregnancy. Few reports have addressed the effects of pregnancy on color vision. We aimed to compare the color vision of women in the first, second, and third trimesters of pregnancy. Fifty women were divided into first (n=10), second (n=10), third trimester pregnancy groups (n=10), and non-pregnant group (n=20). We used the Farnsworth D15 and Lanthony desaturated D15 (D15d) tests. The hue ordering quantified the amount of error (C-index) and the chromatic selectivity of the errors (S-index)...
January 24, 2019: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/30726313/erratum-for-participation-of-hepatic-%C3%AE-%C3%AE-adrenoceptors-and-at1-receptors-in-glucose-release-and-portal-hypertensive-response-induced-by-adrenaline-or-angiotensin-ii-braz-j-med-biol-res-2018-51-12-e7526
#31
(no author information available yet)
[This corrects the article doi: 10.1590/1414-431X20187526].
January 10, 2019: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/30652828/genetic-variation-of-aggrecanase-2-adamts5-in-susceptibility-to-osteoarthritis
#32
Xindie Zhou, Lifeng Jiang, Yi Zhang, Junjie Zhang, Dong Zhou, Lidong Wu, Yong Huang, Nanwei Xu
Aggrecanase-2 (ADAMTS5) gene is responsible for aggrecan degradation that may contribute to cartilage destruction in a mouse osteoarthritis (OA) model. We aimed to investigate the effects of ADAMTS5 gene polymorphisms on OA risk in a Chinese population. A total of 300 OA patients and 300 controls were recruited and their genotypes for ADAMTS5 gene rs226794 and rs2830585 polymorphisms were determined using a custom-by-design 48-Plex single nucleotide polymorphism Scan™ kit. ADAMTS5-associated genes were identified by co-expression analysis and their functions were investigated by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses...
January 10, 2019: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/30652827/effects-of-dipyrone-on-the-digestive-tract
#33
E F Collares, L E A Troncon
Dipyrone (metamizole), acting through its main metabolites 4-methyl-amino-antipyrine and 4-amino-antipyrine, has established analgesic, antipyretic, and spasmolytic pharmacological effects, which are mediated by poorly known mechanisms. In rats, intravenously administered dipyrone delays gastric emptying (GE) of liquids with the participation of capsaicin-sensitive afferent fibers. This effect seems to be mediated by norepinephrine originating from the sympathetic nervous system but not from the superior celiac-mesenteric ganglion complex, which activates β2-adrenoceptors...
January 10, 2019: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/30652826/evaluation-of-platelet-activity-by-multiple-electrode-impedance-aggregometry-in-acute-coronary-syndromes-pilot-study-in-a-brazilian-tertiary-care-public-hospital
#34
A De Lorenzo, M Dutra, M A de Mattos, H C V Rey, E Tibirica
There is no definite recommendation for testing platelet aggregation (PA) in acute coronary syndromes (ACS) due to inconclusive evidence on the usefulness of platelet function tests to guide therapy and improve clinical outcomes. The evaluation of PA with multiple electrode impedance platelet aggregometry (MEA) may be useful to manage antiplatelet therapy and possibly influence patient outcome. The primary aim of this study was to measure PA with MEA in Brazilian patients with ACS and evaluate the association between PA and adverse clinical outcomes...
January 10, 2019: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/31116315/two-new-mixed-ligand-coordination-polymers-based-on-multi-n-chelating-ligand-inhibit-yap-expression-and-induce-caspase-mediated-spinal-tumor-cell-apoptosis
#35
Yi Fu Sun, Li Wei Shao, Qi Chen, Xu Gao, Fang Li, Chang Yan Wu
Two new coordination polymers [Zn (bdc)(bpybzimH2)](DMF)0.5 (1, H2bdc=1,4-dicarboxybenzene, bpybzimH2=6,6'-bis-(1H-benzoimidazol-2-yl)-2,2'-bipyridine, DMF=N,N-dimethylformamide) and [Co (bpybzimH2)(sbc)]H2O (2, H2sbc=4-mercaptobenzoic acid) have been successfully prepared under solvothermal conditions using the multi-N chelating organic ligand bpybzimH2 as the foundational building block. In addition, the Cell Counting Kit-8 assay was conducted to evaluate the anti-proliferation activity of compounds 1 and 2 against human spinal tumor cells OPM-2...
2019: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/31116314/the-erbb2-gene-polymorphisms-rs2643194-rs2934971-and-rs1058808-are-associated-with-increased-risk-of-gastric-cancer
#36
K C Vázquez-Ibarra, A R Bustos-Carpinteyro, A García-Ruvalcaba, M T Magaãa-Torres, R Gutiérrez-Aguilar, M E Marín-Contreras, E Santiago-Luna, J Y Sánchez-López
Gastric cancer (GC) is the third most lethal type of cancer worldwide. Single nucleotide polymorphisms (SNPs) in regulatory sites or coding regions can modify the expression of genes involved in gastric carcinogenesis, as ERBB2, which encodes for the tyrosine-kinase receptor HER-2. The aim of this work was to analyze the association of the polymorphisms: rs2643194, rs2517951, rs2643195, rs2934971, and rs1058808 with GC, as they have not yet been analyzed in GC patients, as well as to report their frequency in the general Mexican population (GMP)...
2019: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/31116313/impact-of-enhanced-recovery-after-surgery-on-postoperative-rehabilitation-inflammation-and-immunity-in-gastric-carcinoma-patients-a-randomized-clinical-trial
#37
Wu-Ke Wang, Chao-Yong Tu, Chu-Xiao Shao, Wei Chen, Qing-Yun Zhou, Jing-De Zhu, Hong-Tao Xu
We determined the effects of enhanced recovery after surgery (ERAS) in patients undergoing radical surgery for gastric carcinoma. Sixty patients undergoing radical gastrectomy for gastric carcinoma in Lishui Hospital between March and October 2016 were randomized to receive either ERAS (30 patients) or conventional care (30 patients, controls). Clinical, economic, and laboratory indices were analyzed. ERAS patients showed faster recovery and shorter postoperative hospital stays than the controls (P<0.05)...
2019: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/31116312/segmental-resection-combined-with-anoplasty-for-the-treatment-of-circumferential-mixed-hemorrhoids
#38
Jing Wu, Keqiang Yu, Changyao Lv, Wenzhu Lu, Hongbo He
Circumferential mixed hemorrhoids are very difficult to treat non-surgically. Therefore, it is important to explore the surgical methods for its complete resolution as well as maintenance of normal anal anatomy and function. The present study was designed to evaluate the effect of segmented and plastic hemorrhoidectomy (SPH) on patients with circumferential mixed hemorrhoids. A total of 300 patients with circumferential mixed hemorrhoids were divided into experimental group (n=150) undergoing SPH and control group (n=150) undergoing Milligan-Morgan hemorrhoidectomy...
2019: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/31116311/antinociceptive-and-anti-inflammatory-activities-of-a-triterpene-rich-fraction-from-himatanthus-drasticus
#39
S C X de-Almeida, Â C F da-Silva, N R T Sousa, I H F Amorim, B G Leite, K R T Neves, J G M Costa, C F B Felipe, G S de-Barros Viana
Himatanthus drasticus (Mart.) Plumel belongs to the Apocynaceae family and the latex from its trunk bark (Hd) is known as "janaguba milk". This latex is widely used in Northeast Brazil, mainly in the Cariri region, for its gastroprotective, anti-inflammatory, and antitumor properties. The objective of this study was to investigate a triterpene-rich fraction (FJNB) from H. drasticus latex on acute models of nociception and inflammation and to clarify its mechanisms of action. Wistar rats or Swiss mice were subjected to the carrageenan-induced paw edema test or the formalin test, respectively, after the acute oral treatment with FJNB...
2019: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/31116257/evaluation-of-the-effects-of-uncaria-rhynchophylla-alkaloid-extract-on-lps-induced-preeclampsia-symptoms-and-inflammation-in-a-pregnant-rat-model
#40
Liang-Zhi Wu, Xiao-Min Xiao
Excessive pro-inflammatory cytokines result in adverse pregnancy outcomes, including preeclampsia-like phenotypes, and fetal growth restriction. Anti-inflammation might be an effective therapy. The aim of this research was to investigate whether Uncaria rhynchophylla alkaloid extract (URE), a highly safe anti-inflammation constituent of the herb, can inhibit inflammation and improve clinical characteristics of preeclampsia in a lipopolysaccharide (LPS)-induced preeclampsia rat model. The rat model was established by daily administration of LPS (1 μg/kg body weight per day) from gestational day (GD) 14 to 19...
2019: Brazilian Journal of Medical and Biological Research
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