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Brazilian Journal of Medical and Biological Research | Page 2

M Guidoni, M M de Christo Scherer, M M Figueira, E F P Schmitt, L C de Almeida, R Scherer, S Bogusz, M Fronza
Vegetable oils have been used for a plethora of health benefits by their incorporation in foods, cosmetics, and pharmaceutical products, especially those intended for skin care. This study aimed to investigate the cutaneous benefits of a vegetable oil blend (VOB) formulation and its fatty acid composition. The anti-inflammatory activity was studied in macrophages of RAW 264.7 cells by investigating the release of nitric oxide (NO), superoxide anion generation (O2-), tumor necrosis factor-alpha (TNF-α), and interleukin 6 (IL-6)...
February 14, 2019: Brazilian Journal of Medical and Biological Research
M F M Santos, F C A C Oliveira, R K Kishimoto, D Borri, F P S Santos, P V Campregher, P A A Silveira, N Hamerschlak, C L P Mangueira, F B Duarte, A H Crepaldi, M A Salvino, E D R P Velloso
Cytogenetics is essential in myeloid neoplasms (MN) and pre-analytical variables are important for karyotyping. We assessed the relationship between pre-analytical variables (time from collection to sample processing, material type, sample cellularity, and diagnosis) and failures of karyotyping. Bone marrow (BM, n=352) and peripheral blood (PB, n=69) samples were analyzed from acute myeloid leukemia (n=113), myelodysplastic syndromes (n=73), myelodysplastic syndromes/myeloproliferative neoplasms (n=17), myeloproliferative neoplasms (n=137), and other with conclusive diagnosis (n=6), and reactive disorders/no conclusive diagnosis (n=75)...
February 14, 2019: Brazilian Journal of Medical and Biological Research
J Vargas, A Alfaro-Rodríguez, J Perez-Orive
Recovery of motor function after central nervous system (CNS) injury is dependent on the regeneration capacity of the nervous system, which is a multifactorial process influenced, among other things, by the role of neuromodulators such as serotonin. The neurotransmitter serotonin can promote neuronal regeneration but there are also reports of it causing restriction, so it is important to clarify these divergent findings in order to understand the direct scope and side effects of potential pharmacological treatments...
February 14, 2019: Brazilian Journal of Medical and Biological Research
Fan Zhang, Cuimei Ma
Gastric cancer remains a serious threat to human health worldwide. Kaempferol is a plant-derived flavonoid compound with a wide range of pharmacological activities. This study aimed to investigate the effects of kaempferol on gastric cancer SNU-216 cell proliferation, apoptosis, and autophagy, as well as underlying potential mechanisms. Viability, proliferation, and apoptosis of SNU-216 cells after kaempferol treatment were evaluated using cell counting kit-8 assay, 5-btomo-2'-deoxyuridine incorporation assay, and annexin V-FITC/PI staining, respectively...
February 14, 2019: Brazilian Journal of Medical and Biological Research
M V H Carvalho, P C Kroll, R T M Kroll, V N Carvalho
Cirrhotic cardiomyopathy historically has been confused as alcoholic cardiomyopathy. The key points for diagnosis of cirrhotic cardiomyopathy have been well explained, however this entity was neglected for a long time. Nowadays the diagnosis of this entity has become important because it is a factor that contributes significantly to morbidity-mortality in cirrhotic patients. Characteristics of cirrhotic cardiomyopathy are a hyperdynamic circulatory state, altered diastolic relaxation, impaired contractility, and electrophysiological abnormalities, particularity QT interval prolongation...
February 14, 2019: Brazilian Journal of Medical and Biological Research
A B Machin, L F Nascimento, K Mantovani, E B Machin
Exposure to air pollution is an important cause of hospital admissions due to respiratory diseases. Nevertheless, few studies use pollutant concentration data estimated by mathematical models. A time-series ecological study was developed, using data from hospitalizations due to respiratory diseases in people over 60 years of age, residents of Cuiabá, Brazil, during 2012, obtained from the Brazilian Ministry of Health. The independent variables were the concentrations of fine particulate matter (PM2.5) and carbon monoxide (CO) estimated by mathematical modeling, minimum temperature, and relative humidity (obtained from the Brazilian Meteorological Agency), and the number of forest fires...
January 24, 2019: Brazilian Journal of Medical and Biological Research
L C P Cardoso, N B Pinto, M E P Nobre, M R Silva, G M Pires, M J P Lopes, G S B Viana, L M R Rodrigues
The aim of this study was to evaluate the therapeutic effects of ultrasound (US)-mediated phonophoresis alone or in association with diclofenac diethylammonium (DCF) administered topically in animal models of inflammation. A pre-clinical, prospective, and randomized experimental study of quantitative and qualitative nature was carried out. Phonophoresis was performed using a therapeutic ultrasound apparatus in two distinct models of acute inflammation. Edema was induced by an intraplantar injection of carrageenan and measured by plethysmography...
January 24, 2019: Brazilian Journal of Medical and Biological Research
Guang-Jian Zhao, Zi-Ran Wang, Fan-Zhen Lin, Yan-Sen Cui, Shun-Liang Xu
Alteplase (tPA) intravenous thrombolysis is an effective treatment for acute ischemic stroke (AIS) when administered within 4.5 h of initial stroke symptoms. Here, its safety and efficacy were evaluated among AIS patients with a previous history of cerebral hemorrhage. Patients who arrived at the hospital within 4.5 h of initial stroke symptoms and who were treated with tPA intravenous thrombolysis or conventional therapies were analyzed. The 90-day modified Rankin scale (90-d mRS) was used alongside mortality and incidence of symptomatic intracerebral hemorrhage (SICH) rates to evaluate the curative effect of these therapies...
January 24, 2019: Brazilian Journal of Medical and Biological Research
V A R Pereira, K S Vedovelli, G Y Muller, Y F Depieri, D H C G Avelar, A H E de Amo, D R Jimenes, J N L Martins, A C Silvério, C R G Gomes, V A F Godoi, M M D Pedrosa
Non-diabetic individuals use hormones like insulin to improve muscle strength and performance. However, as insulin also leads the liver and the adipose tissue to an anabolic state, the purpose of this study was to investigate the effects of insulin on liver metabolism in trained non-diabetic Swiss mice. The mice were divided into four groups: sedentary treated with saline (SS) or insulin (SI) and trained treated with saline (TS) or insulin (TI). Training was made in a vertical stair, at 90% of the maximum load, three times per week...
January 24, 2019: Brazilian Journal of Medical and Biological Research
T S S Calandrini, L Miquilini, M R Laranjeiras-Neto, M T S Tongu, M P Silva, G S Souza, M I T Cortes
The visual system of women changes during pregnancy. Few reports have addressed the effects of pregnancy on color vision. We aimed to compare the color vision of women in the first, second, and third trimesters of pregnancy. Fifty women were divided into first (n=10), second (n=10), third trimester pregnancy groups (n=10), and non-pregnant group (n=20). We used the Farnsworth D15 and Lanthony desaturated D15 (D15d) tests. The hue ordering quantified the amount of error (C-index) and the chromatic selectivity of the errors (S-index)...
January 24, 2019: Brazilian Journal of Medical and Biological Research
(no author information available yet)
[This corrects the article doi: 10.1590/1414-431X20187526].
January 10, 2019: Brazilian Journal of Medical and Biological Research
Xindie Zhou, Lifeng Jiang, Yi Zhang, Junjie Zhang, Dong Zhou, Lidong Wu, Yong Huang, Nanwei Xu
Aggrecanase-2 (ADAMTS5) gene is responsible for aggrecan degradation that may contribute to cartilage destruction in a mouse osteoarthritis (OA) model. We aimed to investigate the effects of ADAMTS5 gene polymorphisms on OA risk in a Chinese population. A total of 300 OA patients and 300 controls were recruited and their genotypes for ADAMTS5 gene rs226794 and rs2830585 polymorphisms were determined using a custom-by-design 48-Plex single nucleotide polymorphism Scan™ kit. ADAMTS5-associated genes were identified by co-expression analysis and their functions were investigated by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses...
January 10, 2019: Brazilian Journal of Medical and Biological Research
E F Collares, L E A Troncon
Dipyrone (metamizole), acting through its main metabolites 4-methyl-amino-antipyrine and 4-amino-antipyrine, has established analgesic, antipyretic, and spasmolytic pharmacological effects, which are mediated by poorly known mechanisms. In rats, intravenously administered dipyrone delays gastric emptying (GE) of liquids with the participation of capsaicin-sensitive afferent fibers. This effect seems to be mediated by norepinephrine originating from the sympathetic nervous system but not from the superior celiac-mesenteric ganglion complex, which activates β2-adrenoceptors...
January 10, 2019: Brazilian Journal of Medical and Biological Research
A De Lorenzo, M Dutra, M A de Mattos, H C V Rey, E Tibirica
There is no definite recommendation for testing platelet aggregation (PA) in acute coronary syndromes (ACS) due to inconclusive evidence on the usefulness of platelet function tests to guide therapy and improve clinical outcomes. The evaluation of PA with multiple electrode impedance platelet aggregometry (MEA) may be useful to manage antiplatelet therapy and possibly influence patient outcome. The primary aim of this study was to measure PA with MEA in Brazilian patients with ACS and evaluate the association between PA and adverse clinical outcomes...
January 10, 2019: Brazilian Journal of Medical and Biological Research
Wei-Jia Zhang, Ying Liu, Jie-Shu Wei, Ya-Li Wu
Many compounds of ginsenosides show anti-inflammatory properties. However, their anti-inflammatory effects in intervertebral chondrocytes in the presence of inflammatory factors have never been shown. Increased levels of pro-inflammatory cytokines are generally associated with the degradation and death of chondrocytes; therefore, finding an effective and nontoxic substance that attenuates the inflammation is worthwhile. In this study, chondrocytes were isolated from the nucleus pulposus tissues, and the cells were treated with ginsenoside compounds and IL-1β, alone and in combination...
2019: Brazilian Journal of Medical and Biological Research
J C Milan-Mattos, F F Anibal, N M Perseguini, V Minatel, P Rehder-Santos, C A Castro, F A Vasilceac, S M Mattiello, L H Faccioli, A M Catai
The term inflammaging is now widely used to designate the inflammatory process of natural aging. During this process, cytokine balance is altered, presumably due to the loss of homeostasis, thus contributing to a greater predisposition to disease and exacerbation of chronic diseases. The aim of the study was to analyze the relationship between pro-inflammatory markers and age in the natural aging process of healthy individuals. One hundred and ten subjects were divided into 5 groups according to age (22 subjects/group)...
2019: Brazilian Journal of Medical and Biological Research
D I Braghirolli, B Caberlon, D Gamba, Jftc Petry, M L Dias, P Pranke
Currently, there is great clinical need for suitable synthetic grafts that can be used in vascular diseases. Synthetic grafts have been successfully used in medium and large arteries, however, their use in small diameter vessels is limited and presents a high failure rate. In this context, the aim of this study was to develop tissue engineering scaffolds, using poly(trimethylene carbonate-co-L-lactide) (PTMCLLA), for application as small diameter vascular grafts. For this, copolymers with varying trimethylene carbonate/lactide ratios - 20/80, 30/70, and 40/60 - were submitted to electrospinning and the resulting scaffolds were evaluated in terms of their physicochemical and biological properties...
2019: Brazilian Journal of Medical and Biological Research
Yao Hu, Jing Hu
This study aimed to detect the expression of the long non-coding RNA (lncRNA) antisense non-coding RNA in the INK4 locus (ANRIL) and evaluate its correlation with disease risk, stenosis degree, inflammation, as well as overall survival (OS) in coronary artery disease (CAD) patients. A total of 230 patients who underwent diagnostic coronary angiography were consecutively recruited and assigned to CAD group (n=125) or control group (n=105) according to presence or absence of CAD. Gensini score was calculated to assess the severity of coronary artery damage...
2019: Brazilian Journal of Medical and Biological Research
P J Santos-Neto, E H Sena-Santos, D P Meireles, I S Santos, I M Bensenor, P A Lotufo
Carotid artery assessment by ultrasound is a non-invasive evaluation of subclinical atherosclerosis and a predictor of cardiovascular events. However, ultrasound examinations are operator-dependent. In the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), ultrasound images have been acquired from more than 10,000 participants. In this article, we describe the reproducibility of carotid intima-media thickness (CIMT), carotid plaque detection, and carotid plaque score (defined as the number of arterial sites with plaques) using ELSA-Brasil protocol, in a subset of 118 participants...
2019: Brazilian Journal of Medical and Biological Research
J M Santos, V A Mendonça, V G C Ribeiro, R Tossige-Gomes, S F Fonseca, A C N Prates, J Flor, A C C Oliveira, J B Martins, B C C Garcia, H R Leite, P H S Figueiredo, M Bernardo-Filho, A C R Lacerda
The objective of this study was to investigate the effect of whole body vibration (WBV) exercise on oxidative stress markers in a group of women with fibromyalgia (FM) compared to a group of healthy women (CT). Twenty-one women diagnosed with FM and 21 age- and weight-matched healthy women were enrolled the study. Plasma oxidative stress markers (primary outcomes) were evaluated at rest and after WBV, and included thiobarbituric acid reactive substances (TBARS), iron reduction capacity (FRAP), superoxide dismutase antioxidant enzymes activity (SOD), and catalase (CAT)...
2019: Brazilian Journal of Medical and Biological Research
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