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REVIEW
The Accomplishments of KoCVAM in the Development and Implementation of Alternative Methods in Korea.
Nam-Hee Kang, JaeHo Oh
The Korean Center for the Validation of Alternative Methods (KoCVAM), which promotes the Three Rs principles and the use of alternative methods in Korea, has been operating within the Toxicological Screening and Testing Division of the Ministry of Food and Drug Safety (MFDS) since 2009. KoCVAM has exchanged opinions and information on the development and validation of non-animal alternative test methods as part of the International Cooperation on Alternative Test Methods (ICATM), and provided input into draft OECD Test Guidelines (TGs)...
April 16, 2024: Alternatives to Laboratory Animals: ATLA
#2
EDITORIAL
Judith C Madden
No abstract text is available yet for this article.
April 15, 2024: Alternatives to Laboratory Animals: ATLA
#3
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
April 13, 2024: Alternatives to Laboratory Animals: ATLA
#4
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
April 13, 2024: Alternatives to Laboratory Animals: ATLA
#5
JOURNAL ARTICLE
Markus Glaudo, Marc Urbach, Claudia Panfil, Stephanie Herkert, Mark Brown, Norbert Schrage
In the cosmetics sector, many products such as shampoos have a probability of accidental ocular exposure during their routine use. One very specific safety parameter is the residence time of the substance on the corneal surface, as prolonged exposure may cause injury. In this study, we developed a system that simulates corneal exposure to blinking and tear flow, for comparing the corneal clearance times of viscous detergent formulations. The Ex Vivo Eye Irritation Test (EVEIT), which uses corneal explants from discarded rabbit eyes from an abattoir, was used as the basis for the new system...
April 12, 2024: Alternatives to Laboratory Animals: ATLA
#6
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
April 9, 2024: Alternatives to Laboratory Animals: ATLA
#7
JOURNAL ARTICLE
Gerson Salay, Nádila Lucarelli, Thaís Moura Gascón, Samantha Sanches de Carvalho, Glaucia Raquel Luciano da Veiga, Beatriz da Costa Aguiar Alves Reis, Fernando Luiz Affonso Fonseca
The use of the brine shrimp Artemia salina (Leach) in acute toxicity assays has great potential due to its simplicity, low cost and reproducibility. In the current study, some of the variables that can influence the reliability of the assay in terms of test organism survival, were evaluated as part of its implementation in our laboratory. The quality and type of water used, the buffer components and other parameters (salinity, pH and dissolved oxygen level), were all evaluated for optimisation purposes. DMSO (dimethyl sulphoxide) was used as the test substance in the toxicity assay, to evaluate the concentration limits as a solvent in sample preparation...
April 5, 2024: Alternatives to Laboratory Animals: ATLA
#8
JOURNAL ARTICLE
Seyed Mobin Seyed Aliyan, Ali Roohbakhsh, Marzieh Jafari Fakhrabad, Zahar Salmasi, Mohammad Moshiri, Niosha Shahbazi, Leila Etemad
Methamphetamine (Meth) is a highly addictive stimulant. Its potential neurotoxic effects are mediated through various mechanisms, including oxidative stress and the initiation of the apoptotic process. Thymoquinone (TQ), obtained from Nigella sativa seed oil, has extensive antioxidant and anti-apoptotic properties. This study aimed to investigate the potential protective effects of TQ against Meth-induced toxicity by using an in vitro model based on nerve growth factor-differentiated PC12 cells. Cell differentiation was assessed by detecting the presence of a neuronal marker with flow cytometry...
March 6, 2024: Alternatives to Laboratory Animals: ATLA
#9
JOURNAL ARTICLE
Renata N C Nundes, Antonio E C C Almeida, Wlamir C Moura, Marcelo S Gonzalez, Humberto P Araújo
Antivenom therapy is the only specific treatment for snakebite envenomation, and antivenom potency determination is key in the efficacy assurance quality control process. Nowadays, this process relies on the in vivo murine model - thus, the development of alternative in vitro methods is imperative. In the current study, the principle of the proposed method is the ability of Bothrops venom to induce cytotoxic effects in Vero cells, and the capacity to evaluate the inhibition of this cytotoxicity by the respective antivenom...
March 4, 2024: Alternatives to Laboratory Animals: ATLA
#10
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
February 20, 2024: Alternatives to Laboratory Animals: ATLA
#11
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
February 15, 2024: Alternatives to Laboratory Animals: ATLA
#12
JOURNAL ARTICLE
Ester Alves Ferreira Bordini, Vitor de Toledo Stuani, Lígia Espoliar Correa, Fernanda Balestrero Cassiano, Marcella Fernandes Lovison, Maria Luisa Leite, Josimeri Hebling, Carlos Alberto de Souza Costa, Diana Gabriela Soares
In vitro models of the dental pulp microenvironment have been proposed for the assessment of biomaterials, to minimise animal use in operative dentistry. In this study, a scaffold/3-D dental pulp cell culture interface was created in a microchip, under simulated dental pulp pressure, to evaluate the cell-homing potential of a chitosan (CH) scaffold functionalised with calcium aluminate (the 'CHAlCa scaffold'). This microphysiological platform was cultured at a pressure of 15 cm H2 O for up to 14 days; cell viability, migration and odontoblastic differentiation were then assessed...
February 13, 2024: Alternatives to Laboratory Animals: ATLA
#13
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
February 13, 2024: Alternatives to Laboratory Animals: ATLA
#14
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
February 13, 2024: Alternatives to Laboratory Animals: ATLA
#15
EDITORIAL
Judith C Madden
No abstract text is available yet for this article.
February 7, 2024: Alternatives to Laboratory Animals: ATLA
#16
JOURNAL ARTICLE
Michael G Diemar, Mathieu Vinken, Marc Teunis, Cyrille A M Krul, Francois Busquet, Julia Dominika Zajac, Helena Kandarova, Raffaella Corvi, Matteo Z Rossi, Anastasiia Kharina, Louise Stab Bryndum, Michael Santillo, Denise Bloch, Olena Kucheryavenko, Demosthenes Panagiotakos, Vera Rogiers, Manon Beekhuijzen, Arianna Giusti, Abdulkarim Najjar, Carol Courage, Torben Koenig, Susanne Kolle, Harrie Boonen, Stephane Dhalluin, Julie Boberg, Boris P Müller, Predrag Kukic, Merel Ritskes-Hoitinga, Elena Grasselli, Tamara Zietek, Gilly Stoddart, Harm J Heusinkveld, Jose V Castell, Emilio Benfenati, Huan Yang, Simón Perera, Alicia Paini, Nynke I Kramer, Thomas Hartung, Manoe Janssen, Ellen Fritsche, Danyel G J Jennen, Matteo Piumatti, James Rathman, Jörg Marusczyk, Lucia Milec, Erwin L Roggen
The first Stakeholder Network Meeting of the EU Horizon 2020-funded ONTOX project was held on 13-14 March 2023, in Brussels, Belgium. The discussion centred around identifying specific challenges, barriers and drivers in relation to the implementation of non-animal new approach methodologies (NAMs) and probabilistic risk assessment (PRA), in order to help address the issues and rank them according to their associated level of difficulty. ONTOX aims to advance the assessment of chemical risk to humans, without the use of animal testing, by developing non-animal NAMs and PRA in line with 21st century toxicity testing principles...
January 18, 2024: Alternatives to Laboratory Animals: ATLA
#17
JOURNAL ARTICLE
Ashish Jhangiani, Vandana Panda, Aanchal Sukheja, Sneha Thomas, Piyush Dusseja, Siddhartha Pandya, Anand Chintakrindi
Over the last decade, Mycobacterium tuberculosis has mutated into a putative 'superbug', as treatments against it have failed due to increasing antimicrobial resistance. As a result, the rising incidence of multidrug-resistant tuberculosis (MDR-TB) is posing a significant public health threat, thus, the need to develop effective drugs for MDR-TB has become an urgent priority. To identify new drug candidates for the treatment of MDR-TB, the present study was based on mycobacterial shikimate kinase (MtSK) as the pharmacological target...
December 14, 2023: Alternatives to Laboratory Animals: ATLA
#18
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
December 11, 2023: Alternatives to Laboratory Animals: ATLA
#19
EDITORIAL
Judith C Madden
No abstract text is available yet for this article.
December 8, 2023: Alternatives to Laboratory Animals: ATLA
#20
JOURNAL ARTICLE
Renato Ivan de Ávila, Julia Fentem, Izabel Villela, Debora Somlo, Ana Marisa Fusco Almeida, Maria José S Mendes-Giannini, Andrezza Di Pietro Micali Canavez, Bruna Bosquetti, Carolina Motter Catarino, Desiree Cigaran Schuck, Bruna Nardy Valadares, Gustavo Facchini, Bianca Marigliani, Ana Carolina Migliorini Figueira, Rosângela Hickson, Daniela Morais Leme, Carlos Tagliati, Larissa C R de Souza, Silvya Stuchi Maria Engler, Lorena Rigo Gaspar Cordeiro, Janice Koepp, Jose Mauro Granjeiro, Humberto de Mello Brandao, Michele Munk, Katherine Antunes de Mattos, Bruna Pedralli, Marcella Miranda Siqueira Furtuoso Rodrigues, Ana Clara Stival, Jordana Andrade, Lara Barroso Brito, Thais Rosa Marques Dos Santos, Jacqueline Leite, Artur Christian Garcia da Silva, Marize Campos Valadares
The Brazilian National Network of Alternative Methods (RENAMA), which is linked to the Ministry of Science, Technology and Innovation, is currently comprised of 51 laboratories from CROs, academia, industry and government. RENAMA's aim is to develop and validate new approach methodologies (NAMs), as well as train researchers and disseminate information on their use - thus reducing Brazilian, and consequently Latin American, dependence on external technology. Moreover, it promotes the adoption of NAMs by educators and trained researchers, as well as the implementation of good laboratory practice (GLP) and the use of certified products...
December 7, 2023: Alternatives to Laboratory Animals: ATLA
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