Michael A Weber, Dagmara Hering, David Nikoleishvili, Avtandil Imedadze, Gvantsa Dughashvili, Zurab Klimiashvili, Eter Bekaia, Tamar Shengelia, Mamuka Kabalava, Otar Goguadze, Tamar Emukhvari, Vitaly Druker, Terry Buelna, Richard Heuser, Shima Hashemian, Robert Provanzano
INTRODUCTION: We previously completed a trial of renal pelvic denervation for treating hypertension that reduced blood pressure by the 2-month primary endpoint. However, information on the durability of effectiveness is a critical requirement for device therapy and we now report data up to 12 months. METHODS: This was an open label single-arm feasibility study in patients with increased blood pressure despite taking an average of 2.7 medications. The key endpoint reported here was ambulatory blood pressure at 12 months following renal pelvic denervation...
August 31, 2023: American Journal of Nephrology
Raymond R Townsend
Is This REALLY Required?
August 31, 2023: American Journal of Nephrology
Hongyu Chen, Haoxian Tang, Jingtao Huang, Nan Luo, Xuan Zhang, Xin Wang
INTRODUCTION: The current prevalence of chronic kidney disease (CKD) is substantial, and CKD individuals face a heightened risk of mortality, encompassing both all-cause and cause-specific outcomes. The current study aims to investigate the potential impact of adhering to Life Essential 8 (LE8) on reducing mortality among CKD individuals. METHODS: Using the National Health and Nutrition Survey (NHANES) data from 2005 to 2018, we analyzed 22,420 United States adults (≥20 years old)...
August 17, 2023: American Journal of Nephrology
Shih-Wei Lai
No abstract text is available yet for this article.
August 17, 2023: American Journal of Nephrology
Samir Patel, Eduardo A Trujillo Rivera, Venkatesh K Raman, Charles Faselis, Virginia Wang, Jeffrey C Fink, Jeffrey M Roseman, Charity J Morgan, Sijian Zhang, Helen M Sheriff, Michael S Heimall, Wen-Chih Wu, Qing Zeng-Treitler, Ali Ahmed
INTRODUCTION: According to the United States Renal Data System (USRDS), patients with end-stage kidney disease (ESKD) on maintenance dialysis had higher mortality during early COVID-19 pandemic. Less is known about the effect of the pandemic on the delivery of outpatient maintenance hemodialysis, and its impact on death. We examined the effect of pandemic-related disruption on the delivery of dialysis treatment and mortality in patients with ESKD receiving maintenance hemodialysis in the Veterans Health Administration (VHA) facilities, the largest integrated national healthcare system in the United States...
July 31, 2023: American Journal of Nephrology
Wei-Shun Yang, Gwo-Tsann Chuang, Tony Pan-Hou Che, Li-Yun Chueh, Wen-Yi Li, Chih-Neng Hsu, Chia-Ni Hsiung, Hsiao-Chia Ku, Lin Yi Ching, Yi-Shun Chen, Siow-Wey Hee, Tien-Jyun Chang, Shiau-Mei Chen, Meng-Lun Hsieh, Hsiao-Lin Lee, Karen Chia-Wen Liao, Chen-Yang Shen, Yi-Cheng Chang
Background Chronic renal disease (CKD), defined by reduced estimated glomerular filtration rate (eGFR) and albuminuria, imposes huge health burden worldwide. Ethnicity-specific associations were frequently observed in genome-wide association studies (GWAS). In this research, we conducted GWAS of albuminuria in the non-diabetic population of Taiwan. Subjects and Methods Non-diabetic individuals aged 30 to 70 years and without cancer history were enrolled from the Taiwan Biobank. A total of 6,768 subjects received spot urine examination...
July 12, 2023: American Journal of Nephrology
Pongpratch Puapatanakul, Athiphat Banjongjit, Talerngsak Kanjanabuch, Jerasit Surintrspanont, Kroonpong Iampenkhae, Kearkiat Praditpornsilpa, Somchai Eiam-Ong, Vijitr Boonpucknavig
INTRODUCTION: More reports of thrombotic microangiopathy (TMA) in immunoglobulin A (IgA) nephropathy suggests its association with poor clinical outcomes. However, the prevalence and clinical significance of TMA in IgA nephropathy have not been widely studied in different populations. METHODS: Kidney biopsies of all patients with primary IgA nephropathy from 1995 to 2015 at King Chulalongkorn Memorial Hospital, Thailand, were retrospectively reviewed and reclassified by two pathologists following the Oxford MEST-C classification...
July 10, 2023: American Journal of Nephrology
Tomoki Tagaya, Hiroki Hayashi, Soshiro Ogata, Kazuo Takahashi, Shigehisa Koide, Daijo Inaguma, Midori Hasegawa, Yukio Yuzawa, Naotake Tsuboi
Introduction Furosemide, a loop diuretic, is often empirically used to treat acute decompensated heart failure (ADHF) initially. Conversely, decongestion using tolvaptan, an aquaretic, is thought to maintain renal function compared to furosemide. However, it has not been investigated in patients with advanced chronic kidney disease (CKD) at high risk of developing acute kidney injury (AKI). This study aimed to investigate AKI incidence using tolvaptan add-on treatment, compared to increased furosemide treatment for patients with ADHF complicated by advanced CKD...
June 29, 2023: American Journal of Nephrology
Ian M Greenlund, Naima Covassin, Virend K Somers
June 21, 2023: American Journal of Nephrology
Luojia Jiang, Haibo Xu
Introduction Short and long sleep durations have been associated with adverse health outcomes. The objective of this study was to examine the association between self-reported sleep duration and chronic kidney disease (CKD) in the general population on the basis of the National Health and Nutrition Examination Survey (NHANES) database. Methods A total of 28,239 adults aged ≥18 years who participated in the 2005-2014 NHANES were analyzed. CKD was defined as an estimated glomerular filtration rate <60 ml/min per 1...
June 12, 2023: American Journal of Nephrology
Fotini Iatridi, Marieta P Theodorakopoulou, Antonios Karpetas, Vasiliki Sgouropoulou, Areti Georgiou, Eleni Karkamani, Artemios Karagiannidis, Aikaterini Papagianni, Pantelis A Sarafidis
INTRODUCTION: Intradialytic-hypertension (IDHTN) is associated with increased risk of adverse outcomes. Patients with IDHTN have higher 44-hour blood pressure (BP) than patients without this condition. Whether the excess risk in these patients is due to the BP rise during dialysis per se or on elevated 44-h BP or other co-morbid conditions is uncertain. This study evaluated the association of IDHTN with cardiovascular events and mortality and the influence of ambulatory BP and other cardiovascular risk factors on these associations...
June 9, 2023: American Journal of Nephrology
Bingxin Jiang, Dongxu Tang, Neng Dai, Chen Huang, Yahang Liu, Ce Wang, Jiahuan Peng, Guoyou Qin, Yongfu Yu, Jiaohua Chen
INTRODUCTION: The cohort study aimed to assess the association of nighttime sleep duration and the change in nighttime sleep duration with chronic kidney disease (CKD), and whether the association between nighttime sleep duration and CKD differed by daytime napping. METHODS: This study included 11677 individuals of the China Health and Retirement Longitudinal Study (CHARLS) and used data from the 2011 baseline survey and four follow-up waves. Nighttime sleep duration was divided into three groups: short (<7h per night), optimal (7-9h), and long nighttime sleep duration (>9h)...
May 30, 2023: American Journal of Nephrology
Shujie Wang, Danni Hu, Yue-Qiang Li, Qing Lei, Liu Liu, Xiaofeng He, Min Han, Guangchang Pei, Rui Zeng, Gang Xu
INTRODUCTION: This observational cohort study evaluated the prognostic value of mast cells in the pathogenesis and progression of IgA nephropathy. METHODS: A total of 76 adult IgAN patients were enrolled into this study from Jan 2007 and June 2010. Immunohistochemistry and immunofluorescence were used to identify Tryptase positive mast cells in renal biopsy samples. Patients were classified into Tryptasehigh and Tryptaselow groups. Depending on an average of 96-month follow-up, the predictive value of Tryptase positive mast cells in IgAN progression was analysed...
May 26, 2023: American Journal of Nephrology
Xiejia Li, Abdul Rashid Qureshi, Mohamed E Suliman, Olof Heimburger, Peter Barany, Peter Stenvinkel, Bengt Lindholm
BACKGROUND: In patients with chronic kidney disease (CKD), high interleukin-6 (IL-6) and low albumin circulating concentrations are associated with worse outcomes. We examined the IL-6 to albumin ratio (IAR) as a predictor of risk of death in incident dialysis patients. METHODS: In 428 incident dialysis patients (median age 56 years, 62% men, 31% diabetes mellitus, 38% cardiovascular disease (CVD)), plasma IL-6 and albumin were measured at baseline to calculate IAR...
May 24, 2023: American Journal of Nephrology
Michael Jonas, Amos J Simon, Boris Gilburd, Jacob Schneiderman
INTRODUCTION: Renal ischemia and reperfusion (IR) injury introduces cellular stress and is the main cause of acute kidney damage. Renal cells exposed to noxious stress induce the expression of the pleiotropic hormone leptin. As we have previously revealed a deleterious stress-related role for leptin expression, these results suggested that leptin is also involved in pathological renal remodeling. The systemic functions of leptin preclude the study of its local effects using conventional approaches...
May 24, 2023: American Journal of Nephrology
Ji Hyeon Park, Hayne Cho Park, Do Hyoung Kim, Young Ki Lee, AJin Cho
Background The number of elderly patients with end-stage renal disease (ESRD) is increasing worldwide. However, decision-making about elderly patients with ESRD remains complex because of the lack of studies, especially in very elderly patients (75 years). We examined the characteristics of very elderly patients starting hemodialysis (HD) and the associated mortality and prognostic factors. Methods Data were analyzed retrospectively using a nationwide cohort registry, the Korean Renal Data System. Patients who started HD between January 2016 and December 2020 were included and divided into three groups according to age at HD initiation (<65, 65-74, and 75 years)...
May 18, 2023: American Journal of Nephrology
Cortney N Steele, Ester S Oh, Wei Wang, Heather Farmer-Bailey, Berenice Y Gitomer, Michel Chonchol, Kristen L Nowak
INTRODUCTION: Cerebrovascular dysfunction, characterized by increased brain pulsatile flow, reduced cerebrovascular reactivity, and cerebral hypoperfusion precedes the onset of dementia and is linked to cognitive dysfunction. Autosomal dominant polycystic kidney disease (ADPKD) may increase the risk of dementia, and intracranial aneurysms are more prevalent in ADPKD patients. However, cerebrovascular function has not been previously characterized in patients with ADPKD. METHODS: Using transcranial Doppler, we compared middle cerebral artery (MCA) pulsatility index (PI; cerebrovascular stiffness) and MCA blood velocity response to hypercapnia (normalized for blood pressure and end-tidal CO2; cerebrovascular reactivity) in patients with early-stage ADPKD vs...
May 16, 2023: American Journal of Nephrology
Yuxiuzi Xiao, Zuomiao Xiao
INTRODUCTION: Kidney stones (KSs) are associated with hematuria and renal failure and pose a significant clinical and public health concern. Diabetes is associated with a higher risk of KSs. In addition, α-Klotho (Klotho), as a novel anti-aging protein, is associated with kidney disease, diabetes, and complications and may participate in the pathological mechanism of KSs. However, studies that used large population-based database research are limited. Therefore, this study aimed to investigate whether or not KS prevalence is associated with serum Klotho levels in diabetic adults in the United States...
May 15, 2023: American Journal of Nephrology
Laura C Plantinga, Alexis A Bender, Megan Urbanski, Courtney Hoge, Jessica Joseph, Kelli Damron, Clarica J Douglas-Ajayi, Fran Rickenbach, Jennifer Craft Morgan, Bernard G Jaar
INTRODUCTION: Suboptimal dialysis care may be in part due to staff issues such as job dissatisfaction, burnout, work overload, high staff turnover, and inconsistent training. Here, we leveraged data collected in a recent national survey to provide an initial, comprehensive description of current work experiences of U.S. dialysis care providers. METHODS: We conducted a cross-sectional survey of 1240 active U.S. dialysis clinic staff members (physicians, advanced practice providers, nurse managers/clinic coordinators, nurses, social workers, dietitians, and patient care technicians), who were recruited via emails to society membership lists...
April 7, 2023: American Journal of Nephrology
Anand Narayanan, Patrick Cunningham, Malavika Mehta, Theodore Lang, Mary Hammes
INTRODUCTION: Coronavirus disease (COVID-19) is a global pandemic which continues to cause systemic inflammation leading to multi-system organ damage including acute kidney injury (AKI) and thrombotic complications. We hypothesize that D-dimer level predicts an increased risk of acute kidney injury and thrombotic complications in COVID-19. METHODS: This was a retrospective cohort study performed at a single center academic center. Patients hospitalized with COVID-19 between Jan 1, 2020 through Jan 1, 2021 were included in the analysis...
April 5, 2023: American Journal of Nephrology
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