Milton Packer
Renal anemia is treated with erythropoiesis-stimulating agents (ESA), even though epoietin alfa and darbepoietin increase the risk of cardiovascular death and thromboembolic events, including stroke. Hypoxia-inducible factor prolyl hydroxylase domain (HIF-PHD) inhibitors have been developed as an alternative to ESAs, producing comparable increases in hemoglobin. However, in advanced chronic kidney disease, HIF-PHD inhibitors can increase the risk of cardiovascular death, heart failure and thrombotic events to a greater extent than that with ESAs, indicating that there is a compelling need for safer alternatives...
May 16, 2023: American Journal of Nephrology
Cortney N Steele, Ester S Oh, Wei Wang, Heather Farmer-Bailey, Berenice Y Gitomer, Michel Chonchol, Kristen L Nowak
INTRODUCTION: Cerebrovascular dysfunction, characterized by increased brain pulsatile flow, reduced cerebrovascular reactivity, and cerebral hypoperfusion precedes the onset of dementia and is linked to cognitive dysfunction. Autosomal dominant polycystic kidney disease (ADPKD) may increase the risk of dementia, and intracranial aneurysms are more prevalent in ADPKD patients. However, cerebrovascular function has not been previously characterized in patients with ADPKD. METHODS: Using transcranial Doppler, we compared middle cerebral artery (MCA) pulsatility index (PI; cerebrovascular stiffness) and MCA blood velocity response to hypercapnia (normalized for blood pressure and end-tidal CO2; cerebrovascular reactivity) in patients with early-stage ADPKD vs...
May 16, 2023: American Journal of Nephrology
Yuxiuzi Xiao, Zuomiao Xiao
INTRODUCTION: Kidney stones (KSs) are associated with hematuria and renal failure and pose a significant clinical and public health concern. Diabetes is associated with a higher risk of KSs. In addition, α-Klotho (Klotho), as a novel anti-aging protein, is associated with kidney disease, diabetes, and complications and may participate in the pathological mechanism of KSs. However, studies that used large population-based database research are limited. Therefore, this study aimed to investigate whether or not KS prevalence is associated with serum Klotho levels in diabetic adults in the United States...
May 15, 2023: American Journal of Nephrology
Liu Yang, Yong Liu, Sijie Zhou, Qi Feng, Yanfang Lu, Dongwei Liu, Zhangsuo Liu
Kidney diseases involving renal cell injury, such as acute kidney injury (AKI), chronic kidney disease (CKD), polycystic kidney disease (PKD), renal cancer, and kidney stones, remain a global burden. Several pathways that affect cell sensitivity to ferroptosis have been identified within the last decade, and multiple studies have shown a close association between ferroptosis and renal cell injury. Ferroptosis is a type of nonapoptotic iron-dependent cell death caused by an excess of iron-dependent lipid peroxides...
May 5, 2023: American Journal of Nephrology
Laura C Plantinga, Alexis A Bender, Megan Urbanski, Courtney Hoge, Jessica Joseph, Kelli Damron, Clarica J Douglas-Ajayi, Fran Rickenbach, Jennifer Craft Morgan, Bernard G Jaar
INTRODUCTION: Suboptimal dialysis care may be in part due to staff issues such as job dissatisfaction, burnout, work overload, high staff turnover, and inconsistent training. Here, we leveraged data collected in a recent national survey to provide an initial, comprehensive description of current work experiences of U.S. dialysis care providers. METHODS: We conducted a cross-sectional survey of 1240 active U.S. dialysis clinic staff members (physicians, advanced practice providers, nurse managers/clinic coordinators, nurses, social workers, dietitians, and patient care technicians), who were recruited via emails to society membership lists...
April 7, 2023: American Journal of Nephrology
Anand Narayanan, Patrick Cunningham, Malavika Mehta, Theodore Lang, Mary Hammes
INTRODUCTION: Coronavirus disease (COVID-19) is a global pandemic which continues to cause systemic inflammation leading to multi-system organ damage including acute kidney injury (AKI) and thrombotic complications. We hypothesize that D-dimer level predicts an increased risk of acute kidney injury and thrombotic complications in COVID-19. METHODS: This was a retrospective cohort study performed at a single center academic center. Patients hospitalized with COVID-19 between Jan 1, 2020 through Jan 1, 2021 were included in the analysis...
April 5, 2023: American Journal of Nephrology
Amit Pal Singh, Roberto Kalil, Matthew R Weir
Background Diabetes mellitus and hypertension are the leading causes of cardiovascular disease in renal transplant recipients. This review looks at the potential role of sodium-glucose co-transporter 2 inhibitors (SGLT2is) and reviews the management strategies for hypertension in this population. Summary Large-scale clinical trials are needed to study the potential cardiorenal benefits and risks of complications in renal transplant recipients. Future clinical trials are also needed to define optimal blood pressure treatment goals and therapies and how they influence graft and patient survival...
March 24, 2023: American Journal of Nephrology
Minoru Murakami, Naohiko Fujii, Eiichiro Kanda, Kan Kikuchi, Atsushi Wada, Takayuki Hamano, Ikuto Masakane
INTRODUCTION: Vascular access usage varies widely across countries. Previous studies have evaluated the association of clinical outcomes with the three types of vascular access, namely arteriovenous fistula (AVF), arteriovenous graft (AVG), and tunneled and cuffed central venous catheter (TC-CVC). However, little is known regarding the association between arterial superficialization (AS) and the mortality of patients. METHODS: A nationwide cohort study was conducted using data from the Japanese Society for Dialysis Therapy Renal Data Registry (2006-2007)...
March 14, 2023: American Journal of Nephrology
John G Rizk, Jui-Ting Hsiung, Yousif Arif, Leila Hashemi, Keiichi Sumida, Csaba P Kovesdy, Kamyar Kalantar-Zadeh, Elani Streja
OBJECTIVE: Hypertriglyceridemia, a component of the metabolic syndrome, is a known independent predictor of albuminuria and chronic kidney disease (CKD) in the general population. Previous studies have shown that the relationship of triglycerides with outcomes changes across stages of CKD. Our objective is to examine the association of triglycerides independent of other metabolic syndrome components with renal outcomes in diabetic patients with or without CKD. RESEARCH DESIGN AND METHODS: This retrospective cohort study included diabetic US veteran patients with valid data on triglycerides (TG), estimated glomerular filtration rate (eGFR) and albuminuria (UACR), between fiscal years 2004 to 2006...
March 8, 2023: American Journal of Nephrology
Daniel Khan, Nan Zhang, Bassam G Abu Jawdeh, Sundararaman Swaminathan, Sumi Nair, Mira T Keddis
INTRODUCTION: This study describes patient characteristics and examines graft function of kidney transplant recipients (without primary hyperoxaluria) with elevated plasma oxalate (POx) and enteric risk factors prior to transplant at our institution. METHODS: Kidney transplant recipients between 2012 to 2020 with elevated POx at the time of kidney transplant evaluation were included. A matched control cohort was gathered using patient/donor age, living/deceased donor type, panel reactive antibody (PRA), kidney donor profile index (KDPI), and human leukocyte antigen (HLA) mismatch as matching variables...
February 13, 2023: American Journal of Nephrology
Katherine R Tuttle, Jonathan Matthew Wilson, Yanzhu Lin, Hui-Rong Qian, Federica Genovese, Morten Asser Karsdal, Kevin L Duffin, Fady T Botros
INTRODUCTION: In the AWARD-7 study in patients with type 2 diabetes and moderate-to-severe chronic kidney disease, once-weekly dulaglutide slowed the decline in estimated glomerular filtration rate (eGFR) and decreased the urine albumin/creatinine ratio compared to insulin glargine at the end of 52 weeks of treatment. In this exploratory post hoc analysis, changes in two fibrosis biomarkers, serum PRO-C6 (type VI collagen formation) and urine C3M (type III collagen degradation) were evaluated...
February 8, 2023: American Journal of Nephrology
Iain C Macdougall, Amy Mewborn Meadowcroft, Allison Blackorby, Borut Cizman, Alexander R Cobitz, Sergio Godoy, Vivekanand Jha, Kirsten L Johansen, Gearoid McMahon, Gregorio T Obrador, Muh Geot Wong, Ajay K Singh
INTRODUCTION: Hyporesponsiveness to erythropoiesis-stimulating agents (ESAs) affects 10-15% of the chronic dialysis population. We explored baseline characteristics and predictors of ESA hyporesponsiveness in a global randomized cardiovascular outcomes study comparing an investigational hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), daprodustat, with conventional ESA treatment. METHODS: ASCEND-D (NCT02879305) recruited 2964 chronic dialysis patients receiving ESA treatment (standardized to weekly intravenous [IV] epoetin) who were iron replete at baseline...
February 3, 2023: American Journal of Nephrology
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January 19, 2023: American Journal of Nephrology
Jiajia Liu, Zhongyuan Liu, Tao Zhao, Tao Su, Qizhuang Jin
INTRODUCTION: This study aimed to elucidate the coagulation disorders in non-ICU patients with acute kidney injury (AKI) and their contribution to clotting-related outcomes of intermittent kidney replacement therapy (KRT). METHODS: We included non-ICU-admitted patients with AKI requiring intermittent KRT, clinically having a risk of bleeding and against systemic anticoagulant use during KRT between April and December 2018. The premature termination of treatment due to circuit clotting was considered a poor outcome...
2023: American Journal of Nephrology
Panagiotis Theofilis, Aikaterini Vordoni, Rigas G Kalaitzidis
BACKGROUND: Individuals with end-stage renal disease on chronic hemodialysis (HD) may encounter numerous HD-associated complications, including intradialytic hypertension (IDHYPER). Although blood pressure (BP) follows a predictable course in the post-HD period, BP levels during the session may vary across the individuals. Typically, a decline in BP is noted during HD, but a significant proportion of patients exhibit a paradoxical elevation. SUMMARY: Several studies have been conducted to understand the complexity of IDHYPER, but much remains to be elucidated in the future...
2023: American Journal of Nephrology
Seok Hui Kang, Bo Yeon Kim, Eun Jung Son, Gui Ok Kim, Jun Young Do
INTRODUCTION: There were insufficient pieces of evidence regarding the effect of the two drugs (allopurinol and febuxostat) on patient survival in hemodialysis (HD) patients. Herein, we aimed to compare the efficacy of uric acid-lowering drugs (ULDs) or the type of the drug on patient survival using a representative sample of maintenance HD patients in South Korea. METHODS: This study used data from a national HD quality assessment program and the claims data. Use of ULDs was defined as more than one prescription during the 6 months of each HD quality assessment period...
2023: American Journal of Nephrology
Victor Ortiz-Soriano, Augusto Cama-Olivares, Lucas J Liu, Brian Armentrout, Durham Colohan, Ruchir Paladiya, Seda Babroudi, Juan-Carlos Aycinena, Javier A Neyra
INTRODUCTION: In 2017, the Centers for Medicare and Medicaid Services allowed survivors of hospitalized acute kidney injury requiring dialysis (AKI-D) who were ambulatory and still dependent on hemodialysis (HD) to receive treatment in outpatient dialysis facilities. This policy change generated the ongoing need to improve AKI-D care in the outpatient setting. METHODS: Quality improvement study in adult patients admitted to an outpatient HD unit with the diagnosis of AKI-D...
2023: American Journal of Nephrology
Qian Zhao, Yapeng He, Ning Wu, Lili Wang, Jinghua Dai, Juzi Wang, Ji Ma
INTRODUCTION: Chronic kidney disease is estimated to become the fifth leading cause of death globally by 2040. Due to the high incidence of fatigue in patients with end-stage renal disease without reliable pharmacological treatments, more and more studies on non-pharmacological interventions to improve physical function appear; which might be the best approach remains unknown. This study aimed to compare and rank the efficacy of all known non-pharmacological interventions on improving physical function from multiple outcomes for adults with end-stage renal disease...
2023: American Journal of Nephrology
Cheng-Wen Yang, Mei-Chen Lin, Kai-Hsiang Shu, Kuei-Tung Tung, Wan-Chuan Tsai, Ju-Yeh Yang, Mei-Fen Pai, Hon-Yen Wu, Yen-Ling Chiu, Yu-Sen Peng, Shih-Ping Hsu, Shi-Heng Wang, Szu-Yu Pan
INTRODUCTION: Although high-dose erythropoiesis-stimulating agent (ESA) has been shown to increase mortality risk and adverse cardiovascular events in hemodialysis patients, the safety of extremely low-dose ESA is unclear. METHODS: We retrospectively analyzed the association between ESA dose and mortality in the monthly dosing range of 0-43,000 U of equivalent epoetin alfa in 304 Taiwan hemodialysis patients by using Cox proportional hazard model and cubic spline model...
2023: American Journal of Nephrology
Ziyuan Huang, Ji Zhang, Bo Chen, Duo Li, Xiaohan You, Yin Zhou, Wenxian Qiu, Xiaokai Ding, Chaosheng Chen
INTRODUCTION: The clinical significance of persistent hematuria degrees has not been expounded in primary IgA nephropathy (IgAN) and requires further research. METHODS: From January 2003 to May 2022, a total of 684 IgAN patients with persistent hematuria were enrolled to conduct a retrospective single-center study. Patients whose hematuria degree at baseline was higher than the second tertiles of the whole were included in the high-degree hematuria cohort (Hh), and the low-degree hematuria cohort (Lh) was constructed with 1:1 matched cases from the rest according to age, gender, and estimated glomerular filtration rate (eGFR) at baseline and follow-up time...
2023: American Journal of Nephrology
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