Ali I Gardezi, Zhongyu Yuan, Fahad Aziz, Sandesh Parajuli, Didier Mandelbrot, Micah R Chan, Brad C Astor
INTRODUCTION: The Center for Medicare and Medicaid Services (CMS) introduced an End Stage Renal Disease (ESRD) Prospective Payment System (PPS) in 2011 to increase the utilization of home dialysis modalities, including peritoneal dialysis (PD). Several studies have shown a significant increase in PD utilization after PPS implementation. However, its impact on patients with kidney allograft failure remains unknown. METHODS: We conducted an interrupted time series (ITS) analysis using data from the United States Renal Data System (USRDS) that include all adult kidney transplant recipients with allograft failure who started dialysis between 2005 and 2019...
May 16, 2024: American Journal of Nephrology
Olil Van Reeth, Ancuta Caliment, Isabel de la Fuente Garcia, Olivier Niel
INTRODUCTION Nephroprotection in pediatric chronic kidney disease (CKD) has a major positive impact, both on residual renal function and on quality of life, by delaying the need for renal replacement therapy. To this day, nephroprotective drugs used in children are mainly limited to angiotensin-converting-enzyme (ACE) inhibitors and angiotensin-receptor blockers; interestingly, as suggested by trials conducted in adults with CKD, sodium-glucose cotransporter 2 inhibitors (SGLT2i) might also be beneficial to pediatric patients...
May 11, 2024: American Journal of Nephrology
Natalie Gendy, Liam Brown, Mary Kate Staunton, Kanika Garg, Nora Hernandez Garcilazo, Long Qian, Yu Yamamoto, Ugochukwu Ugwuowo, Wassim Obeid, Lama Al-Qusairi, Andrew Bostom, Sherry G Mansour
INTRODUCTION: Kidney transplant recipients (KTRs) have increased risk of cardiovascular disease (CVD) mortality. We investigated vascular biomarkers, angiopoietin-1 and angiopoietin-2 (angpt-1, -2), in CVD development in KTRs. METHODS: This ancillary study from the FAVORIT, evaluates the associations of baseline plasma angpt-1,-2 levels in CVD development (primary outcome) and graft failure (GF) and death (secondary outcomes) in 2000 deceased donor KTRs. We used Cox regression to analyze the association of biomarker quartiles with outcomes...
May 10, 2024: American Journal of Nephrology
Maram M Alsulami, Nouf E Al-Otaibi, Walaa A Alshahrani, Abdulrahman Altheaby, Khalefa M Al Thiab, Lina I Alnajjar, Mohamed A Albekery, Reem F Almutairy, Mohammed Y Asiri, Sumaya N AlMohareb, Faisal Aqeel Alsehli, Alanoud T Binthuwaini, Alaa Almagthali, Sarah S Alwaily, Arwa Y Alzahrani, Fisal Alrohile, Afnan E Alqurashi, Hanan Alshareef, Hassan Almarhabi, Aisha Alharbi, Hessah Alrashidi, Raghad M Alamri, Faisal N Alnahari, Bilal Mohsin, Nasser O Odah, Wael T Habhab, Yasir A Alfi, Haifa A Alhaidal, Munirah Alghwainm, Khalid Al Sulaiman
INTRODUCTION: Kidney transplantation is a definitive treatment for end-stage renal disease. It is associated with improved life expectancy and quality of life. One of the most common complications following kidney transplantation is graft rejection. To our knowledge, no previous study has identified rejection risk factors in kidney transplant recipients in Saudi Arabia. Therefore, the purpose of this study was to determine the specific risk factors of graft rejection. METHODS: A multicenter case-control study was conducted at four transplant centers in Saudi Arabia...
April 26, 2024: American Journal of Nephrology
Matthew Ryan Weir
BACKGROUND: Proton pump inhibitors (PPI) are commonly prescribed medications for dyspepsia and gastroesophageal reflux. There are concerns about their use in the development of chronic kidney disease (CKD). SUMMARY: The available published literature fails to support an association with PPI and the development of CKD. Placebo-controlled trials demonstrate no difference on the incidence of CKD between placebo and PPI. If one examines the data according to the Bradford Hill perspective incorporating temporal relationship, strength of association, dose response relationship, replacement of findings, cessation of exposure, specificity of the association and consistency with other knowledge, one can only conclude that there is no consistent relationship between PPI use and the development of CKD, or its progression...
April 6, 2024: American Journal of Nephrology
Dustin Le, Deidra C Crews, Morgan E Grams, Josef Coresh, Jung-Im Shin
Introduction Case reports have suggested a causative role between sevelamer use and subsequent gastrointestinal bleeding (GIB), but no large observational studies have evaluated this association. Methods Using the United States Renal Data System database from 2015 to 2019, we examined the association between initiation of sevelamer (versus non-sevelamer containing phosphate binders) and GIB hospitalization as well as all-cause mortality among individuals on hemodialysis. We emulated a target trial using Cox regression models and inverse probability of treatment weights to estimate the adjusted hazard ratios (HR) across outcomes and subgroups...
March 29, 2024: American Journal of Nephrology
Mickaël Bobot, Jean-François Hak, Barbara Casolla, Jean-Daniel Dehondt, Stéphane Burtey, Emilie Doche, Laurent Suissa
INTRODUCTION: Patients with Chronic Kidney Disease (CKD) have an increased risk of stroke and CKD seems associated with worse outcome after a stroke. The main objective of our study RISOTTO was to evaluate the influence of CKD and Acute Kidney Injury (AKI) on the clinical outcome and mortality of ischemic stroke patients after thrombolysis and/or thrombectomy. METHODS: This multicenter cohort study included patients in the acute phase of ischemic stroke due to a large artery occlusion managed by thrombectomy...
March 18, 2024: American Journal of Nephrology
Yu-Lien Tsai, Meng-Hsuan Chung, Niang-Cheng Lin, Cheng-Yen Chen, Yao-Ping Lin, Ming-Tsun Tsai, Hsin-Lin Tsai, Yee-An Chen, Shuo-Ming Ou, Chi-Jen Chu, Tsai-Hung Wu, Chang-Youh Tsai
INTRODUCTION: Hepatitis B virus (HBV) infection is prevalent in Asia including Taiwan. We retrospectively evaluated the risk of HBV reactivation and clinical outcomes in HBV+ and HBV- kidney transplant recipients. METHODS: Patients who underwent kidney transplantation between January 2004 and December 2021 were reviewed. The outcomes of interest included risks of HBV reactivation and patient/graft survival. RESULTS: We identified 337 patients (47...
March 18, 2024: American Journal of Nephrology
Shubhi Pandey, Simon Kashfi, Susana Hong, Amar Kalaria, Agnes S Kim
BACKGROUND: Cancer, hypertension, and kidney disease are closely interrelated. Knowledge of the potential hypertensive and nephrotoxic effects of antineoplastic medications is critical to minimizing interruptions in cancer treatment. SUMMARY: Antineoplastic medications can cause hypertension, proteinuria, and kidney injury, often mediated by common mechanisms. Notably, inhibitors of the vascular endothelial growth factor pathway have the strongest association with both hypertension and proteinuria, typically acute in onset and often reversible after drug discontinuation...
March 17, 2024: American Journal of Nephrology
Arjunmohan Mohan, Pajaree Krisanapan, Supawit Tangpanithandee, Charat Thongprayoon, Swetha Rani Kanduri, Wisit Cheungpasitporn, Sandra M Herrmann
INTRODUCTION: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment. However, they pose the risk of immune-related adverse events, including ICI-mediated acute kidney injury (ICI-AKI). Recent studies have implicated proton pump inhibitors (PPIs) as potential contributors to ICI-AKI development. This meta-analysis examines the association between PPI use and ICI-AKI, exploring a potential modifiable risk factor in ICI therapy, while also reviewing the possible outcomes of ICI-AKI...
March 12, 2024: American Journal of Nephrology
Justine Serre, Alice Doreille, Laure Raymond, Gaspard Suc, Mickaël Bobot, Marine Dancer, Cédric Rafat, Laurent Mesnard
INTRODUCTION: Hypertensive nephrosclerosis (HN) ranks as one of the most frequent causes of chronic kidney disease (CKD), but its very existence has repeatedly been called into question, especially in young adults. Its diagnostic framework is established chiefly on non-specific clinical criteria and its defining histopathological set of features are in fact shared by numerous other conditions. Genetic testing based on exome sequencing (ES) has emerged as a comprehensive tool to detect Mendelian diseases in timely fashion in nephrology with a significant number of re-established diagnoses...
March 12, 2024: American Journal of Nephrology
Nagarjunachary Ragi, Kumar Sharma
BACKGROUND: Chronic kidney disease (CKD) presents a persistent global health challenge, characterized by complex pathophysiology and diverse progression patterns. Metabolomics has emerged as a valuable tool in unraveling the intricate molecular mechanisms driving CKD progression. SUMMARY: This comprehensive review provides a summary of recent progress in the field of metabolomics in kidney disease with a focus on spatial metabolomics to shed important insights to enhancing our understanding of CKD progression, emphasizing its transformative potential in early disease detection, refined risk assessment, and the development of targeted interventions to improve patient outcomes...
March 3, 2024: American Journal of Nephrology
Joseph Stavas, Arnold L Silva, Thomas D Wooldridge, Ahmed Aqeel, Theodore Saad, Rachita Prakash, George Bakris
INTRODUCTION: Autologous cell-based therapies (CBT) to treat Chronic Kidney Disease (CKD) with diabetes are novel and can potentially preserve renal function and decelerate disease progression. CBT dosing schedules are in early development and may benefit from individual bilateral organ dosing and kidney-dependent function to improve efficacy and durability. The objective of this open-label, phase 2 randomized controlled trial (RCT) is to evaluate participants' response to rilparencel (Renal Autologous Cell Therapy-REACT®) following bilateral percutaneous kidney injections into the kidney cortex with a prescribed dosing schedule versus re-dosing based on biomarker triggers...
February 29, 2024: American Journal of Nephrology
Alaa T Makawi, Yahya M K Tawfik, Dave L Dixon, Gearoid M McMahon, Leo F Buckley
No abstract text is available yet for this article.
February 28, 2024: American Journal of Nephrology
Ashley D Troutman, Shruthi Srinivasan, Corinne E Metzger, Paul B Fallen, Neal Chen, Kalisha D O'Neill, Matthew R Allen, Annabel Biruete, Sharon M Moe, Keith G Avin
INTRODUCTION: Chronic kidney disease (CKD) negatively affects musculoskeletal health, leading to reduced mobility and quality of life. In healthy populations, carnitine supplementation and aerobic exercise have been reported to improve musculoskeletal health. However, there are inconclusive results regarding their effectiveness and safety in CKD. We hypothesized that carnitine supplementation and individualized treadmill exercise would improve musculoskeletal health in CKD. METHODS: We used a spontaneously progressive CKD rat model (Cy/+ rat) (n=11-12/gr): 1) Cy/+ (CKD-Ctrl), 2) CKD-carnitine (CKD-Carn), and 3) CKD-treadmill (CKD-TM)...
February 20, 2024: American Journal of Nephrology
(no author information available yet)
No abstract text is available yet for this article.
February 16, 2024: American Journal of Nephrology
Elizabeth Crouch, Nick Yell, Laura Herbert, Teri Browne, Peiyin Hung
INTRODUCTION: Rural areas face significant disparities in dialysis care compared to urban areas due to limited access to dialysis facilities, longer travel distances, and a shortage of healthcare professionals. The objective of this study is to conduct a national examination of rural-urban differences in quality of dialysis care offered across counties in the U.S. METHODS: Data was gathered from Medicare-certified dialysis facilities in 2020 from the Centers for Medicare & Medicaid Services website...
February 11, 2024: American Journal of Nephrology
Hongyun Wang, Hongyan Liu, Hong Cheng, Xue Xue, Yamei Ge, Xiaoqin Wang, Jun Yuan
INTRODUCTION: To explore the renoprotective effects of Klotho on podocyte injury mediated by complement activation and autoantibodies in idiopathic membranous nephropathy (IMN). METHODS: Rat passive Heymann nephritis (PHN) was induced as an IMN model. Urine protein levels, serum biochemistry, kidney histology, and podocyte marker levels were assessed. In vitro, sublytic podocyte injury was induced by C5b-9. The expression of Klotho, transient receptor potential channel 6 (TRPC6), and cathepsin L (CatL); its substrate synaptopodin; and the intracellular Ca2+ concentration were detected via immunofluorescence...
February 8, 2024: American Journal of Nephrology
Mayuko Hori, Hiroshi Takahashi, Chika Kondo, Fumihito Hayashi, Shigehiro Tokoroyama, Yoshiko Mori, Makoto Tsujita, Yuichi Shirasawa, Asami Takeda, Kunio Morozumi, Shoichi Maruyama
INTRODUCTION: Sarcopenia and vitamin D deficiency are highly prevalent among patients undergoing haemodialysis. Although vitamin D deficiency, assessed using serum 25-hydroxyvitamin D (25(OH)D) levels, is known to be associated with sarcopenia in the general population, whether serum 25(OH)D levels are associated with sarcopenia in patients undergoing haemodialysis with suppressed renal activation of 25(OH)D remains unclear. This study aimed to examine the association between serum 25(OH)D levels and sarcopenia in patients undergoing haemodialysis...
February 2, 2024: American Journal of Nephrology
Steven Fishbane, Deborah J Clegg, Edgar V Lerma, Anjay Rastogi, Jeffrey Budden, Isabelle Morin, Warren Wen, Frédérique Menzaghi, Joel Topf
Black and African American (AA) people are over-represented in the kidney failure population; therefore, the safety and efficacy of difelikefalin in Black/AA patients was evaluated. This was a post hoc, pooled exploratory subgroup analysis of the Phase 3 KALM-1 and -2 studies. Patients undergoing hemodialysis (HD) who had moderate-to-severe chronic kidney disease-associated pruritus (CKD-aP) at enrollment were stratified into self-reported Black/AA or White subgroups. Patients were randomized (1:1) to receive intravenous (IV) difelikefalin 0...
January 22, 2024: American Journal of Nephrology
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.